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Stellar and black hole feedback heat and disperse surrounding cold gas clouds, launching gas flows off circumnuclear and galactic disks, producing a dynamic interstellar medium. On large scales bordering the cosmic web, feedback drives enriched gas out of galaxies and groups, seeding the intergalactic medium with heavy elements. In this way, feedback shapes galaxy evolution by shutting down star formation and ultimately curtailing the growth of structure after the peak at redshift 2–3. To understand the complex interplay between gravity and feedback, we must resolve both the key physics within galaxies and map the impact of these processes over large scales, out into the cosmic web. The Advanced X-ray Imaging Satellite (AXIS) is a proposed X-ray probe mission for the 2030s with arcsecond spatial resolution, large effective area, and low background. AXIS will untangle the interactions of winds, radiation, jets, and supernovae with the surrounding interstellar medium across the wide range of mass scales and large volumes driving galaxy evolution and trace the establishment of feedback back to the main event at cosmic noon. This white paper is part of a series commissioned for the AXIS Probe mission concept; additional AXIS white papers can be found at the AXIS website. [ABSTRACT FROM AUTHOR]

The nature and origin of supermassive black holes (SMBHs) remain an open matter of debate within the scientific community. While various theoretical scenarios have been proposed, each with specific observational signatures, the lack of sufficiently sensitive X-ray observations hinders the progress of observational tests. In this white paper, we present how AXIS will contribute to solving this issue. With an angular resolution of 1.5″ on-axis and minimal off-axis degradation, we designed a deep survey capable of reaching flux limits in the [0.5–2] keV range of approximately 2 × 10−18 erg s−1 cm−2 over an area of 0.13 deg2 in approximately 7 million seconds (7 Ms). Furthermore, we planned an intermediate depth survey covering approximately 2 deg2 and reaching flux limits of about 2 × 10−17 erg s−1 cm−2 in order to detect a significant number of SMBHs with X-ray luminosities (LX) of approximately 1042 erg s−1 up to z∼10. These observations will enable AXIS to detect SMBHs with masses smaller than 105 M⊙, assuming Eddington-limited accretion and a typical bolometric correction for Type II AGN. AXIS will provide valuable information on the seeding and population synthesis models of SMBHs, allowing for more accurate constraints on their initial mass function (IMF) and accretion history from z∼0–10. To accomplish this, AXIS will leverage the unique synergy of survey telescopes such as the JWST, Roman, Euclid, Vera Rubin Telescope, and the new generation of 30 m class telescopes. These instruments will provide optical identification and redshift measurements, while AXIS will discover the smoking gun of nuclear activity, particularly in the case of highly obscured AGN or peculiar UV spectra as predicted and recently observed by the JWST in the early Universe. [ABSTRACT FROM AUTHOR]

We present an analysis showcasing how the Advanced X-ray Imaging Satellite (AXIS), a proposed NASA Probe-class mission, will significantly increase our understanding of supermassive black holes undergoing mergers—from kpc to sub-pc scales. In particular, the AXIS point spread function, field of view, and effective area are expected to result in (1) the detection of hundreds to thousands of new dual AGNs across the redshift range 0 < z < 5 and (2) blind searches for binary AGNs that are exhibiting merger signatures in their light curves and spectra. AXIS will detect some of the highest-redshift dual AGNs to date, over a large range of physical separations. The large sample of AGN pairs detected by AXIS (over a magnitude more than currently known) will result in the first X-ray study that quantifies the frequency of dual AGNs as a function of redshift up to z = 4 . [ABSTRACT FROM AUTHOR]

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We present Chandra X-ray Observatory observations and Space Telescope Imaging Spectrograph spectra of NGC 5972, one of the 19 'Voorwerpjes' galaxies. This galaxy contains an extended emission-line region (EELR) and an arcsecond scale nuclear bubble. NGC 5972 is a faded active galactic nucleus (AGN), with EELR luminosity suggesting a 2.1 dex decrease in L bol in the last ∼5 × 104 yr. We investigate the role of AGN feedback in exciting the EELR and bubble given the long-term variability and potential accretion state changes. We detect broad-band (0.3–8 keV) X-ray emission in the near-nuclear regions, coincident with the [O  iii ] bubble, as well as diffuse soft X-ray emission coincident with the EELR. The soft nuclear (0.5–1.5 keV) emission is spatially extended and the spectra are consistent with two apec thermal populations (∼0.80 and ∼0.10 keV). We find a bubble age >2.2 Myr, suggesting formation before the current variability. We find evidence for efficient feedback with |$P_{\textrm {kin}}/L_{\textrm {bol}}\sim 0.8~{{\ \rm per\ cent}}$|⁠ , which may be overestimated given the recent L bol variation. [O  iii ] kinematics show a 300 km s−1 high-ionization velocity consistent with disturbed rotation or potentially the line-of-sight component of a ∼780 km s−1 thermal X-ray outflow capable of driving strong shocks to photoionize the precursor material. We explore possibilities to explain the overall jet, radio lobe and EELR misalignment including evidence for a double supermassive black hole which could support a complex misaligned system. [ABSTRACT FROM AUTHOR]

Claudins, the integral tight junction (TJ) proteins that regulate paracellular permeability and cell polarity, are frequently dysregulated in cancer; however, their role in neoplastic progression is unclear. Here, we demonstrated that knockout of Cldn18, a claudin family member highly expressed in lung alveolar epithelium, leads to lung enlargement, parenchymal expansion, increased abundance and proliferation of known distal lung progenitors, the alveolar epithelial type II (AT2) cells, activation of Yes-associated protein (YAP), increased organ size, and tumorigenesis in mice. Inhibition of YAP decreased proliferation and colony-forming efficiency (CFE) of [Cldn18.sup.-/-] AT2 cells and prevented increased lung size, while CLDN18 overexpression decreased YAP nuclear localization, cell proliferation, CFE, and YAP transcriptional activity. CLDN18 and YAP interacted and colocalized at cell-cell contacts, while loss of CLDN18 decreased YAP interaction with Hippo kinases p-LATS1/2. Additionally, [Cldn18.sup.-/-] mice had increased propensity to develop lung adenocarcinomas (LuAd) with age, and human LuAd showed stage-dependent reduction of CLDN18.1. These results establish CLDN18 as a regulator of YAP activity that serves to restrict organ size, progenitor cell proliferation, and tumorigenesis, and suggest a mechanism whereby TJ disruption may promote progenitor proliferation to enhance repair following injury., Introduction Apical junctional complexes (AJCs) in polarized epithelia are composed of adherens junctions (AJs) and tight junctions (TJs) (1, 2) that mediate intercellular adhesion and paracellular permeability to ions and [...]

Author(s): Claudio Ricci (corresponding author) [1, 2, 3]; Benny Trakhtenbrot [4]; Michael J. Koss [4, 5]; Yoshihiro Ueda [6]; Kevin Schawinski [4]; Kyuseok Oh [4]; Isabella Lamperti [4]; Richard Mushotzky [...]

We present oxygen abundances relative to hydrogen (O/H) in the narrow line regions (NLRs) gas phases of Seyferts 1 (Sy 1s) and Seyferts 2 (Sy 2s) active galactic nuclei (AGNs). We used fluxes of the optical narrow emission line intensities [ |$3\, 500\lt \lambda ($| Å |$)\lt 7\, 000$| ] of 561 Seyfert nuclei in the local Universe (z ≲ 0.31) from the second catalogue and data release (DR2) of the BAT AGN Spectroscopic Survey, which focuses on the Swift -BAT hard X-ray (≳ 10 keV) detected AGNs. We derived O/H from relative intensities of the emission lines via the strong-line methods. We find that the AGN O/H abundances are related to their hosts stellar masses and that they follow a downward redshift evolution. The derived O/H together with the hard X-ray luminosity (L X) were used to study the X-ray luminosity–metallicity (L X– Z NLR) relation for the first time in Seyfert galaxies. In contrast to the broad-line focused (L X– Z BLR) studies, we find that the L X– Z NLR exhibit significant anticorrelations with the Eddington ratio (λEdd) and these correlations vary with redshifts. This result indicates that the low-luminous AGNs are more actively undergoing interstellar medium enrichment through star formation in comparison with the more luminous X-ray sources. Our results suggest that the AGN is somehow driving the galaxy chemical enrichment, as a result of the inflow of pristine gas that is diluting the metal rich gas, together with a recent cessation on the circumnuclear star-formation. [ABSTRACT FROM AUTHOR]

This article assesses the impact of reunification on the Bundestag from a historical institutionalist perspective. Accordingly, it focuses on procedural development and parties' behaviour. More specifically, it analyses parties' control of the legislative agenda and their willingness to obstruct this agenda. Prior to reunification, the Bundestag emerged as a working legislature with decentralised agenda control. Even though the Bundestag was vulnerable to obstruction, especially by questioning the quorum, obstructive behaviour virtually ceased after 1951. After reunification, the Bundestag's vulnerability was increased when a plenary 'core time' was introduced in 1995. However, all parties, including the one most directly related to reunification, the Left Party, continued to abstain from exploiting procedural loopholes. Only the AfD as the other post-1990 newcomer (albeit less directly related to reunification) did so by questioning the quorum to an unprecedented extent after it entered the Bundestag in 2017. So far, this systematic obstruction has only led to a path-dependent procedural reform. If, however, the AfD continues with this behaviour, it can be regarded as a threat to legislative democracy at least indirectly related to German reunification. [ABSTRACT FROM AUTHOR]

Changing-look (CL) AGN are unique probes of accretion onto supermassive black holes (SMBHs), especially when simultaneous observations in complementary wavebands allow investigations into the properties of their accretion flows. We present the results of a search for CL behaviour in 412 Swift -BAT detected AGN with multiple epochs of optical spectroscopy from the BAT AGN Spectroscopic Survey (BASS). 125 of these AGN also have 14–195  keV ultra-hard X-ray light curves from Swift -BAT which are contemporaneous with the epochs of optical spectroscopy. Eight CL events are presented for the first time, where the appearance or disappearance of broad Balmer line emission leads to a change in the observed Seyfert type classification. Combining with known events from the literature, 21 AGN from BASS are now known to display CL behaviour. Nine CL events have 14–195  keV data available, and five of these CL events can be associated with significant changes in their 14–195  keV flux from BAT. The ultra-hard X-ray flux is less affected by obscuration and so these changes in the 14–195 keV band suggest that the majority of our CL events are not due to changes in line-of-sight obscuration. We derive a CL rate of 0.7–6.2 per cent on 10–25 yr time-scales, and show that many transitions happen within at most a few years. Our results motivate further multiwavelength observations with higher cadence to better understand the variability physics of accretion onto SMBHs. [ABSTRACT FROM AUTHOR]

The dreissenids, quagga mussel Dreissena bugensis and zebra mussel D. polymorpha, are invasive freshwater mussels in Europe and North America. These species strongly impact aquatic ecosystems, such as the food web through their high abundance and filtration rate. They spread quickly within and between waterbodies, and have the ability to colonize various substrates and depths. The zebra mussel invaded and established in Swiss lakes in the 1960s, whereas the quagga mussel was not detected until 2014. We collected all available data from cantonal as well as local authorities and other institutions to describe the colonization pattern of quagga mussels in perialpine lakes north of the Alps. We also collected data regarding the distribution of larval stages of the mussels, the so-called veliger larvae. We observed that in lakes colonized by the quagga mussel, veligers are present the whole year round, whereas they are absent in winter in lakes with only zebra mussels. Additionally, we present detailed information about the invasion and colonization pattern of quagga mussels in Lake Constance. Quagga mussels colonized the lakeshore within a few years (~ 2016-2018), outcompeted zebra mussels, and have reached densities > 5000 ind. m-2 in the littoral zone, even at 80 m densities above 1000 ind. m-2 were found at some locations. At the end of the article, we discussed possibilities on how the spread of quagga mussels within and among northern perialpine lakes should be monitored and prevented in the future. [ABSTRACT FROM AUTHOR]