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Given its excellent safety profile,10 topical STS appears as a promising treatment option for calcinosis cutis. Successful treatment of calcinosis cutis with a topical sodium thiosulphate preparation containing 20% zinc oxide in a patient with sclerotic graft-versus-host disease As observed in our patient, smaller lesions and localized calcinosis cutis can resolve completely after intralesional or topical administration of STS.8 In a recent retrospective evaluation of GvHD patients with calcinosis cutis, four had received treatment with STS but only one improved.4 However, the details of STS treatment were not specified in that report. [Extracted from the article]