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455 results on '"Leemans, C. René"'

5. The course of health-related quality of life in the first 2 years after a diagnosis of head and neck cancer: the role of personal, clinical, psychological, physical, social, lifestyle, disease-related, and biological factors

Author

Verdonck-de Leeuw, Irma M., Korsten, Laura H.A., van Nieuwenhuizen, Annette, Baatenburg de Jong, Rob J., Brakenhoff, Ruud H., Buffart, Laurien M., Lamers, Femke, Langendijk, Johannes A., Leemans, C. René, Smit, Jan H., Sprangers, Mirjam A., Takes, Robert P., Terhaard, Chris H. J., Lissenberg-Witte, Birgit I., and Jansen, Femke

Published
2023
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11. Study retention and attrition in a longitudinal cohort study including patient-reported outcomes, fieldwork and biobank samples: results of the Netherlands quality of life and Biomedical cohort study (NET-QUBIC) among 739 head and neck cancer patients and 262 informal caregivers

Author

Jansen, Femke, Brakenhoff, Ruud H., Baatenburg de Jong, Rob J., Langendijk, Johannes A., Leemans, C. René, Takes, Robert P., Terhaard, Chris H. J., Smit, Jan H., and Verdonck-de Leeuw, Irma M.

Published
2022
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19. Cost-utility and cost-effectiveness of a guided self-help head and neck exercise program for patients treated with total laryngectomy: Results of a multi-center randomized controlled trial

Author

Jansen, Femke, Coupé, Veerle M.H., Eerenstein, Simone E.J., Cnossen, Ingrid C., van Uden-Kraan, Cornelia F., de Bree, Remco, Doornaert, Patricia, Halmos, György B., Hardillo, José A.U., van Hinte, Gerben, Honings, Jimmie, Leemans, C. René, and Verdonck-de Leeuw, Irma M.

Published
2021
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25. European white paper: oropharyngeal dysphagia in head and neck cancer

Author

Baijens, Laura W. J., Walshe, Margaret, Aaltonen, Leena-Maija, Arens, Christoph, Cordier, Reinie, Cras, Patrick, Crevier-Buchman, Lise, Curtis, Chris, Golusinski, Wojciech, Govender, Roganie, Eriksen, Jesper Grau, Hansen, Kevin, Heathcote, Kate, Hess, Markus M., Hosal, Sefik, Klussmann, Jens Peter, Leemans, C. René, MacCarthy, Denise, Manduchi, Beatrice, Marie, Jean-Paul, Nouraei, Reza, Parkes, Claire, Pflug, Christina, Pilz, Walmari, Regan, Julie, Rommel, Nathalie, Schindler, Antonio, Schols, Annemie M. W. J., Speyer, Renee, Succo, Giovanni, Wessel, Irene, Willemsen, Anna C. H., Yilmaz, Taner, and Clavé, Pere

Published
2021
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26. Recommendations for head and neck surgical oncology practice in a setting of acute severe resource constraint during the COVID-19 pandemic: an international consensus

Author

Mehanna, Hisham, Hardman, John C, Shenson, Jared A, Abou-Foul, Ahmad K, Topf, Michael C, AlFalasi, Mohammad, Chan, Jason Y K, Chaturvedi, Pankaj, Chow, Velda Ling Yu, Dietz, Andreas, Fagan, Johannes J, Godballe, Christian, Golusiński, Wojciech, Homma, Akihiro, Hosal, Sefik, Iyer, N Gopalakrishna, Kerawala, Cyrus, Koh, Yoon Woo, Konney, Anna, Kowalski, Luiz P, Kraus, Dennis, Kuriakose, Moni A, Kyrodimos, Efthymios, Lai, Stephen Y, Leemans, C Rene, Lennon, Paul, Licitra, Lisa, Lou, Pei-Jen, Lyons, Bernard, Mirghani, Haitham, Nichols, Anthonny C, Paleri, Vinidh, Panizza, Benedict J, Parente Arias, Pablo, Patel, Mihir R, Piazza, Cesare, Rischin, Danny, Sanabria, Alvaro, Takes, Robert P, Thomson, David J, Uppaluri, Ravindra, Wang, Yu, Yom, Sue S, Zhu, Yi-ming, Porceddu, Sandro V, de Almeida, John R, Simon, Chrisian, and Holsinger, F Christopher

Published
2020
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29. Role of eHealth application Oncokompas in supporting self-management of symptoms and health-related quality of life in cancer survivors: a randomised, controlled trial

Author

van der Hout, Anja, van Uden-Kraan, Cornelia F, Holtmaat, Karen, Jansen, Femke, Lissenberg-Witte, Birgit I, Nieuwenhuijzen, Grard A P, Hardillo, José A, Baatenburg de Jong, Robert J, Tiren-Verbeet, Nicolette L, Sommeijer, Dirkje W, de Heer, Koen, Schaar, Cees G, Sedee, Robert-Jan E, Bosscha, Koop, van den Brekel, Michiel W M, Petersen, Japke F, Westerman, Matthijs, Honings, Jimmie, Takes, Robert P, Houtenbos, Ilse, van den Broek, Wim T, de Bree, Remco, Jansen, Patricia, Eerenstein, Simone E J, Leemans, C René, Zijlstra, Josée M, Cuijpers, Pim, van de Poll-Franse, Lonneke V, and Verdonck-de Leeuw, Irma M

Published
2020
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37. Mental healthcare utilization among head and neck cancer patients: A longitudinal cohort study.

Author

Jansen, Femke, Lissenberg‐Witte, Birgit I., Hardillo, Jose A., Takes, Robert P., de Bree, Remco, Lamers, Femke, Langendijk, Johannes A., Leemans, C. René, and Verdonck‐de Leeuw, Irma M.

Subjects
HEAD & neck cancer, MENTAL health services, MEDICAL care use, SOCIAL anxiety, CANCER patients, GENERALIZED estimating equations, SENSATION seeking, COHORT analysis
Abstract

Objective: To investigate utilization of mental healthcare among head and neck cancer (HNC) patients from diagnosis to 2 years after treatment, in relation to psychological symptoms, mental disorders, need for mental healthcare, and sociodemographic, clinical and personal factors. Methods: Netherlands Quality of life and Biomedical Cohort study data as measured before treatment, at 3 and 6 months, and at 1 and 2 years after treatment was used (n = 610). Data on mental healthcare utilization (iMCQ), psychological symptoms (Hospital Anxiety and Depression Scale, Cancer Worry Scale), mental disorders (CIDI interview), need for mental healthcare (Supportive Care Needs Survey Short‐Form 34, either as continuous outcome indicating the level of need or dichotomized into unmet need (yes/no)) and several sociodemographic, clinical and personal factors were collected. Factors associated with mental healthcare utilization were investigated using generalized estimating equations (p < 0.05). Results: Of all HNC patients, 5%–9% used mental healthcare per timepoint. This was 4%–14% in patients with mild‐severe psychological symptoms, 4%–17% in patients with severe psychological symptoms, 15%–35% in patients with a mental disorder and 5%–16% in patients with an unmet need for mental healthcare. Among all patients, higher symptoms of anxiety, a higher need for mental healthcare, lower age, higher disease stage, lower self‐efficacy and higher social support seeking were significantly associated with mental healthcare utilization. Conclusion: Mental health care utilization among HNC patients is limited, and is related to psychological symptoms, need for mental healthcare, and sociodemographic, clinical and personal factors. [ABSTRACT FROM AUTHOR]

Published
2024
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39. Clinical Validity of a Prognostic Gene Expression Cluster-Based Model in Human Papillomavirus–Positive Oropharyngeal Carcinoma

Author

Cavalieri, Stefano, Serafini, Mara S., Carenzo, Andrea, Canevari, Silvana, Brakenhoff, Ruud H., Leemans, C. René, Nauta, Irene H., Hoebers, Frank, van den Hout, Mari F. C. M., Scheckenbach, Kathrin, Hoffmann, Thomas K., Ardighieri, Laura, Poli, Tito, Quattrone, Pasquale, Locati, Laura D., Licitra, Lisa, and De Cecco, Loris

Published
2021
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40. Predictive value of quantitative 18F-FDG-PET radiomics analysis in patients with head and neck squamous cell carcinoma

Author

Martens, Roland M., Koopman, Thomas, Noij, Daniel P., Pfaehler, Elisabeth, Übelhör, Caroline, Sharma, Sughandi, Vergeer, Marije R., Leemans, C. René, Hoekstra, Otto S., Yaqub, Maqsood, Zwezerijnen, Gerben J., Heymans, Martijn W., Peeters, Carel F. W., de Bree, Remco, de Graaf, Pim, Castelijns, Jonas A., and Boellaard, Ronald

Published
2020
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43. Critical Issues in Head and Neck Oncology

Author

Vermorken, Jan B., Budach, Volker, Leemans, C. René, Machiels, Jean-Pascal, Nicolai, Piero, and O'Sullivan, Brian

Subjects
Head and Neck Cancer, Predictive markers, Non-orophayngeal head and neck cancer, Induction chemotherapy, Radiation Oncology, Surgical Oncology, Liquid biopsies, Precision medicine, HNSCC, Nasopharynx cancer, Immunotherapy, Personalized Medicine, thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology, thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKS Medical imaging::MKSH Medical imaging: radiology
Abstract

This is an open access book. With a wealth of exciting data emerging in this rapidly evolving field this book will review the state-of-the-art knowledge with emphasis on multidisciplinary decision and management of head and neck cancer. The book provides significant detail on a wide range of topics including: the role of new targets for treatment, immunotherapy, resistance mechanisms, standardizing molecular profiling programs, and new methods to guide therapeutic approaches. In addition different disease situations are addressed including different treatment approaches in primary disease and in recurrent and/or metastatic disease as well as new developments in pathology, surgery and reconstruction techniques, new systemic therapies in salivary gland cancer, and supportive care and follow-up. All disciplines involved in the treatment of head & neck cancer are covered with a focus on translation into daily practice. The 8th-THNO is designed for medical oncologists, head and neck surgeons, radiation oncologists, otolaryngologists, and other medical professionals involved in the treatment of patients with head and neck cancer.

Published
2023
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45. Privacy-preserving distributed learning of radiomics to predict overall survival and HPV status in head and neck cancer

Author

Bogowicz, Marta, Jochems, Arthur, Deist, Timo M., Tanadini-Lang, Stephanie, Huang, Shao Hui, Chan, Biu, Waldron, John N., Bratman, Scott, O’Sullivan, Brian, Riesterer, Oliver, Studer, Gabriela, Unkelbach, Jan, Barakat, Samir, Brakenhoff, Ruud H., Nauta, Irene, Gazzani, Silvia E., Calareso, Giuseppina, Scheckenbach, Kathrin, Hoebers, Frank, Wesseling, Frederik W. R., Keek, Simon, Sanduleanu, Sebastian, Leijenaar, Ralph T. H., Vergeer, Marije R., Leemans, C. René, Terhaard, Chris H. J., van den Brekel, Michiel W. M., Hamming-Vrieze, Olga, van der Heijden, Martijn A., Elhalawani, Hesham M., Fuller, Clifton D., Guckenberger, Matthias, and Lambin, Philippe

Published
2020
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48. Changes in Sexuality and Sexual Dysfunction over Time in the First Two Years after Treatment of Head and Neck Cancer.

Author

Stone, Margot A., Lissenberg-Witte, Birgit I., de Bree, Remco, Hardillo, Jose A., Lamers, Femke, Langendijk, Johannes A., Leemans, C. René, Takes, Robert P., Jansen, Femke, and Verdonck-de Leeuw, Irma M.

Subjects
HEAD & neck cancer treatment, FEMALE reproductive organ diseases, SEXUAL dysfunction, IMPOTENCE, ORGASM, PAIN, HUMAN sexuality, HEAD & neck cancer, INDIVIDUALIZED medicine, CANCER patients, PENILE erection, CHEMORADIOTHERAPY, T-test (Statistics), RESEARCH funding, QUALITY of life, INTRACLASS correlation, CHI-squared test, DESCRIPTIVE statistics, QUESTIONNAIRES, MALE reproductive organ diseases, SEXUAL excitement, DATA analysis software, LONGITUDINAL method
Abstract

Simple Summary: Many head and neck cancer patients report sexual problems. A deterioration in sexuality and sexual dysfunction from baseline to 3 months after treatment was observed especially in patients treated with chemoradiation. This effect seems to differ between men and women. Men reported change in erectile function, orgasm, satisfaction with intercourse, and overall satisfaction, while women reported change in desire, arousal, and orgasm. These findings are helpful to improve information on sexuality and sexual care in head and neck cancer patients. The aim of this study was to investigate changes in sexuality and sexual dysfunction in head and neck cancer (HNC) patients in the first two years after treatment, in relation to the type of treatment. Data were used of 588 HNC patients participating in the prospective NETherlands Quality of life and Biomedical Cohort Study (NET-QUBIC) from diagnosis to 3, 6, 12 and 24 months after treatment. Primary outcome measures were the International Index of Erectile Function (IIEF) and the Female Sexual Function Index (FSFI). The total scores of the IIEF and FSFI were dichotomized into sexual (dys)function. In men, type of treatment was significantly associated with change in erectile function, orgasm, satisfaction with intercourse, and overall satisfaction. In women, type of treatment was significantly associated with change in desire, arousal, and orgasm. There were significant differences between treatment groups in change in dysfunctional sexuality. A deterioration in sexuality and sexual dysfunction from baseline to 3 months after treatment was observed especially in patients treated with chemoradiation. Changes in sexuality and sexual dysfunction in HNC patients were related to treatment, with an acute negative effect of chemoradiation. This effect on the various domains of sexuality seems to differ between men and women. [ABSTRACT FROM AUTHOR]

Published
2023
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49. Changes in multidisciplinary team decisions in a high volume head and neck oncological center following those made in its preferred partner.

Author

Hendrickx, Jan-Jaap, Mennega, Tommy, Uppelschoten, Jeroen M., and Leemans, C. René

Subjects
HEAD & neck cancer, SYMPTOMS, CANCER treatment, CANCER patients, NECK
Abstract

Objective: Head and neck cancer care is highly complex, and multidisciplinary team meetings (MDTs) are vital for improved outcomes. In the Netherlands, head and neck cancer care is practiced in eight high-volume head and neck oncologic centers (HNOC) and six affiliated hospitals preferred partner (PP) centers. Patients treated in the PP are presented and discussed in the HNOC. To evaluate the importance of these mandatory and decisive steps in decision making, we have assessed the changes in treatment. Materials and methods: Retrospective evaluation of head and neck cancer patients referred between January 2011 and October 2018 for a MDT evaluation to the HNOC was conducted. The differences in MDT recommendation were classified with regards to major and minor changes. Results: Management recommendation(MR) changed after 113 of 515 MDT discussions within the PP (487 patients; 22%), of which 86 cases (16%) were major changes. In 67 cases (59.3%), escalation of management was recommended, while in 43 cases (38.1%) de-escalation was recommended. Conclusion: There was a high rate of change of MRs, when comparing the PP recommendations with the HNOC recommendations. Since patient and tumor characteristics seem unable to predict these changes, we recommend all patients be seen for a clinical presentation, revision of diagnostics, and MDT discussion in a high volume HNOC. [ABSTRACT FROM AUTHOR]

Published
2023
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