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Technetium-99m human serum albumin (99mTc-HSA) is an important radiopharmaceutical required in nuclear medicine studies. However, the risk of transfusion-transmitted infection remains a major safety concern. Autopreparation of serum component acquired from patient provides a 'personal-exclusive' source for radiolabeling. This paper is to evaluate the practicality of onsite elusion and subsequent radiolabeling efficacy for serum albumin. Results showed that the autologous elute contained more albumin fraction than serum without extraction procedure. Good radiochemical purity and stability were demonstrated after radiolabeling. Biodistribution study showed that labeled albumin accumulated immediately in the lung, liver, and kidney. It was cleared steadily and excreted in the urine. The biologic half-life was defined, and all samples passed the pyrogenicity and sterility tests. In conclusion, autoalbumin could be extracted and radiolabeled properly in a nuclear medicine setting. Moreover, the risk of transfusion-transmitted infection associated with nonautologous, multisource [sup.99m]Tc-HSA agents can be reduced., 1. Introduction Technetium-99m-labeled human serum albumin ([sup.99m]Tc-HSA) is an important radiopharmaceutical commonly used in nuclear medical services. It is routinely used in lymphoscintigraphic studies, sentinel lymph node mapping, blood pool [...]

• Right Chi pulse corresponds to the changes in the large intestine. • SE 10―50 Hz and SE 13―50 Hz of the right Chi was significantly increased after the colectomy. • SE 13―50 Hz of the right Chun was significantly decreased after the colectomy. • The radial augmentation index (AI) of the right Chi was significantly reduced after the colectomy. In Traditional Chinese Medicine (TCM), manual palpation of the radial pressure pulse (RPP) has remained a traditional method of clinical diagnoses for centuries. Arterial mechanics have been studied by various researchers. Time-domain and frequency-domain analyses of the RPP has typically provided a quantitative and non-biased assessment that gives complex physiological and pathological information. To date, no preceding research has clarified the relationship of the radial pulse and the large intestine in TCM theory. In this pre-post intervention study, we compared the RPP parameters of patients with colorectal cancer before and after colectomy. Thirty patients aged between 18 and 80 years old from the Department of Colorectal Surgery in Taichung Tzu Chi Hospital, Taiwan were enrolled into this study based on predefined inclusion and exclusion criteria before the colectomy. The assessment of RPP was performed before the colectomy and within 24 h after the colectomy. The mean value of the spectral energy (SE 0―10 Hz , SE 10―50 Hz , and SE 13―50 Hz) and the radial augmentation index (AI) were obtained. We observed that the SE 10―50 Hz and SE 13―50 Hz of the right Chy was significantly increased after the colectomy while the SE 13―50 Hz of the right Chun was significantly decreased after the colectomy procedures. The radial AI of the right Chy was significantly reduced after the colectomy compared to the remaining pulse positions. To our best knowledge, this preliminary study is the first attempt to investigate the influence of colectomy on the radial pulse parameters in patients with colorectal cancer. The major findings from this study include a significant reduction of the radial AI at the right Chy pulse, and a significant difference in the SE at the right Chy and Chun pulses after colectomy. It is also the first study using modern scientific tools to validate the TCM theory that the right Chy pulse corresponds to the changes in the large intestine through surgical removal of the visceral organs. [ABSTRACT FROM AUTHOR]