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410 results on '"Liu, Xiaoye"'

1. Bone-marrow-homing lipid nanoparticles for genome editing in diseased and malignant haematopoietic stem cells

Author

Lian, Xizhen, Chatterjee, Sumanta, Sun, Yehui, Dilliard, Sean A., Moore, Stephen, Xiao, Yufen, Bian, Xiaoyan, Yamada, Kohki, Sung, Yun-Chieh, Levine, Rachel M., Mayberry, Kalin, John, Samuel, Liu, Xiaoye, Smith, Caroline, Johnson, Lindsay T., Wang, Xu, Zhang, Cheng Cheng, Liu, David R., Newby, Gregory A., Weiss, Mitchell J., Yen, Jonathan S., and Siegwart, Daniel J.

Published
2024
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3. Identification of FDA-approved drugs that induce heart regeneration in mammals

Author

Ahmed, Mahmoud Salama, Nguyen, Ngoc Uyen Nhi, Nakada, Yuji, Hsu, Ching-Cheng, Farag, Ayman, Lam, Nicholas T., Wang, Ping, Thet, Suwannee, Menendez-Montes, Ivan, Elhelaly, Waleed M., Lou, Xi, Secco, Ilaria, Tomczyk, Mateusz, Zentilin, Lorena, Pei, Jimin, Cui, Miao, Dos Santos, Matthieu, Liu, Xiaoye, Liu, Yan, Zaha, David, Walcott, Gregory, Tomchick, Diana R., Xing, Chao, Zhang, Cheng Cheng, Grishin, Nick V., Giacca, Mauro, Zhang, Jianyi, and Sadek, Hesham A.

Published
2024
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22. LvbHLH13 Regulates Anthocyanin Biosynthesis by Activating the LvMYB5 Promoter in Lily (Lilium 'Viviana').

Author

An, Wenzhong, Sun, Yibo, Gao, Zhenhua, Liu, Xiaoye, Guo, Qi, Sun, Shaokun, Zhang, Minghui, Han, Yutong, Irfan, Muhammad, Chen, Lijing, and Ma, Di

Subjects
TRANSCRIPTION factors, CONSERVED sequences (Genetics), FLAVONOIDS, GENE expression, ARABIDOPSIS proteins, ANTHOCYANINS
Abstract

Anthocyanins, constituents of flavonoid compounds prevalent in plants, possess significant value in both plant development and human nutrition. The regulation of anthocyanin biosynthesis primarily involves the orchestration of MYB, bHLH, and WD40 transcription factors. Consequently, the bHLH family assumes a pivotal role in modulating plant developmental processes. In the present investigation, a transcription factor, denoted as LvbHLH13, was identified as a positive regulator of anthocyanin pigmentation in lily petals. LvbHLH13 is classified within the IIId subgroup of Arabidopsis bHLH proteins. Functional analyses involving the transient expression and gene silencing of LvbHLH13 revealed its capacity to enhance and diminish anthocyanin accumulation, respectively, by modulating the LvMYB5 expression, thereby influencing the downstream structural gene expression. The overexpression of LvbHLH13 resulted in an increase in the expression of the downstream structural genes related to anthocyanin synthesis, whereas silencing of LvbHLH13 correspondingly decreased the expression. Yeast one-hybrid and EMSA assays demonstrated the interaction between LvbHLH13 and the LvMYB5 promoter, leading to the activation of anthocyanin biosynthesis. A further luciferase (LUC) analysis corroborated the stimulatory effect of LvbHLH13 on the LvMYB5 promoter sequence. Consequently, LvbHLH13 assumed a crucial role in lily-petal pigmentation. A yeast two-hybrid analysis revealed that LvbHLH13 diverged from typical bHLH transcription factor behavior as it did not form a complex with MYB to regulate anthocyanin biosynthesis. This discrepancy could be attributed to the deletion of the N-terminal conserved sequence of LvbHLH13. This study provides a new bHLH candidate and bHLH-MYB partner to explore the anthocyanin regulatory network in further research and provides new opportunities for breeding lilies with various anthocyanin contents. These findings lay a theoretical foundation for subsequent investigations into lily flower coloring mechanisms. [ABSTRACT FROM AUTHOR]

Published
2024
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23. Genome-Wide Identification of the Soybean AlkB Homologue Gene Family and Functional Characterization of GmALKBH10Bs as RNA m 6 A Demethylases and Expression Patterns under Abiotic Stress.

Author

Zhao, Jie, Yang, Tengfeng, Liu, Peng, Liu, Huijie, Zhang, Hui, Guo, Sichao, Liu, Xiaoye, Chen, Xiaoguang, and Chen, Mingjia

Subjects
GENE expression, GENE families, ABIOTIC stress, CHROMOSOME duplication, PLANT development
Abstract

Soybean (Glycine max (L.) Merr) is one of the most important crops worldwide, but its yield is vulnerable to abiotic stresses. In Arabidopsis, the AlkB homologue (ALKBH) family genes plays a crucial role in plant development and stress response. However, the identification and functions of its homologous genes in soybean remain obscured. Here, we identified a total of 22 ALKBH genes in soybean and classified them into seven subfamilies according to phylogenetic analysis. Gene duplication events among the family members and gene structure, conserved domains, and motifs of all candidate genes were analyzed. By comparing the changes in the m6A levels on mRNA from hair roots between soybean seedlings harboring the empty vector and those harboring the GmALKBH10B protein, we demonstrated that all four GmALKBH10B proteins are bona fide m6A RNA demethylases in vivo. Subcellular localization and expression patterns of the GmALKBH10B revealed that they might be functionally redundant. Furthermore, an analysis of cis-elements coupled with gene expression data demonstrated that GmALKBH10B subfamily genes, including GmALKBH10B1, GmALKBH10B2, GmALKBH10B3, and GmALKBH10B4, are likely involved in the cis-elements' response to various environmental stimuli. In summary, our study is the first to report the genome-wide identification of GmALKBH family genes in soybean and to determine the function of GmALKBH10B proteins as m6A RNA demethylases, providing insights into GmALKBH10B genes in response to abiotic stresses. [ABSTRACT FROM AUTHOR]

Published
2024
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26. Supplementary Fig. 1B from LILRB3 Supports Immunosuppressive Activity of Myeloid Cells and Tumor Development

Author

Huang, Ryan, primary, Liu, Xiaoye, primary, Kim, Jaehyup, primary, Deng, Hui, primary, Deng, Mi, primary, Gui, Xun, primary, Chen, Heyu, primary, Wu, Guojin, primary, Xiong, Wei, primary, Xie, Jingjing, primary, Lewis, Cheryl, primary, Homsi, Jade, primary, Yang, Xing, primary, Zhang, Chengcheng, primary, He, Yubo, primary, Lou, Qi, primary, Smith, Caroline, primary, John, Samuel, primary, Zhang, Ningyan, primary, An, Zhiqiang, primary, and Zhang, Cheng Cheng, primary

Published
2024
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27. Data from LILRB3 Supports Immunosuppressive Activity of Myeloid Cells and Tumor Development

Author

Huang, Ryan, primary, Liu, Xiaoye, primary, Kim, Jaehyup, primary, Deng, Hui, primary, Deng, Mi, primary, Gui, Xun, primary, Chen, Heyu, primary, Wu, Guojin, primary, Xiong, Wei, primary, Xie, Jingjing, primary, Lewis, Cheryl, primary, Homsi, Jade, primary, Yang, Xing, primary, Zhang, Chengcheng, primary, He, Yubo, primary, Lou, Qi, primary, Smith, Caroline, primary, John, Samuel, primary, Zhang, Ningyan, primary, An, Zhiqiang, primary, and Zhang, Cheng Cheng, primary

Published
2024
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28. Supplementary Tables from LILRB3 Supports Immunosuppressive Activity of Myeloid Cells and Tumor Development

Author

Huang, Ryan, primary, Liu, Xiaoye, primary, Kim, Jaehyup, primary, Deng, Hui, primary, Deng, Mi, primary, Gui, Xun, primary, Chen, Heyu, primary, Wu, Guojin, primary, Xiong, Wei, primary, Xie, Jingjing, primary, Lewis, Cheryl, primary, Homsi, Jade, primary, Yang, Xing, primary, Zhang, Chengcheng, primary, He, Yubo, primary, Lou, Qi, primary, Smith, Caroline, primary, John, Samuel, primary, Zhang, Ningyan, primary, An, Zhiqiang, primary, and Zhang, Cheng Cheng, primary

Published
2024
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29. Supplementary Fig. 2 from LILRB3 Supports Immunosuppressive Activity of Myeloid Cells and Tumor Development

Author

Huang, Ryan, primary, Liu, Xiaoye, primary, Kim, Jaehyup, primary, Deng, Hui, primary, Deng, Mi, primary, Gui, Xun, primary, Chen, Heyu, primary, Wu, Guojin, primary, Xiong, Wei, primary, Xie, Jingjing, primary, Lewis, Cheryl, primary, Homsi, Jade, primary, Yang, Xing, primary, Zhang, Chengcheng, primary, He, Yubo, primary, Lou, Qi, primary, Smith, Caroline, primary, John, Samuel, primary, Zhang, Ningyan, primary, An, Zhiqiang, primary, and Zhang, Cheng Cheng, primary

Published
2024
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30. Supplementary Fig. 3 from LILRB3 Supports Immunosuppressive Activity of Myeloid Cells and Tumor Development

Author

Huang, Ryan, primary, Liu, Xiaoye, primary, Kim, Jaehyup, primary, Deng, Hui, primary, Deng, Mi, primary, Gui, Xun, primary, Chen, Heyu, primary, Wu, Guojin, primary, Xiong, Wei, primary, Xie, Jingjing, primary, Lewis, Cheryl, primary, Homsi, Jade, primary, Yang, Xing, primary, Zhang, Chengcheng, primary, He, Yubo, primary, Lou, Qi, primary, Smith, Caroline, primary, John, Samuel, primary, Zhang, Ningyan, primary, An, Zhiqiang, primary, and Zhang, Cheng Cheng, primary

Published
2024
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34. Probio‐M9, a breast milk‐originated probiotic, alleviates mastitis and enhances antibiotic efficacy: Insights into the gut–mammary axis.

Author

Yu, Jie, Li, Weicheng, Xu, Ruibo, Liu, Xiaoye, Gao, Guangqi, Kwok, Lai‐Yu, Chen, Yongfu, Sun, Zhihong, Liu, Wenjun, and Zhang, Heping

Subjects
PEARSON correlation (Statistics), LABORATORY rats, WHOLE genome sequencing, MAMMARY glands, SINGLE nucleotide polymorphisms
Abstract

A study examined the use of a probiotic called Probio-M9 in treating mastitis and improving antibiotic treatment. The researchers found that Probio-M9 effectively reduced mastitis symptoms, decreased inflammation, and enhanced the response to antibiotics. It also had an impact on the gut microbiome and the immune system. The study suggests that Probio-M9 can move from the gut to the mammary tissue during bacterial mastitis and lactation. These findings provide insight into the connection between the gut and mammary glands and the potential benefits of probiotics. [Extracted from the article]

Published
2024
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35. Can low‐dose intravenous bevacizumab be as effective as high‐dose bevacizumab for cerebral radiation necrosis?

Author

Gao, Miaomiao, primary, Wang, Xin, additional, Wang, Xiaofeng, additional, Niu, Gengmin, additional, Liu, Xiaoye, additional, Zhao, Shuzhou, additional, Wang, Yue, additional, Yu, Huiwen, additional, Huo, Siyuan, additional, Su, Hui, additional, Song, Yongchun, additional, Wang, Xiaoguang, additional, Zhuang, Hong‐Qing, additional, and Yuan, Zhi‐Yong, additional

Published
2023
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36. LILRB3 supports immunosuppressive activity of myeloid cells and tumor development

Author

Huang, Ryan, primary, Liu, Xiaoye, additional, Kim, Jaehyup, additional, Deng, Hui, additional, Deng, Mi, additional, Gui, Xun, additional, Chen, Heyu, additional, Wu, Guojin, additional, Xiong, Wei, additional, Xie, Jingjing, additional, Lewis, Cheryl, additional, Homsi, Jade, additional, Yang, Xing, additional, Zhang, Chengcheng, additional, He, Yubo, additional, Lou, Qi, additional, Smith, Caroline, additional, John, Samuel, additional, Zhang, Ningyan, additional, and An, Zhiqiang, additional

Published
2023
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