95 results on '"Lurati Buse, Giovanna"'
Search Results
2. Perioperative copeptin: predictive value and risk stratification in patients undergoing major noncardiac surgery—a prospective observational cohort study
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Kamber, Firmin, Roth, Sebastian, Bolliger, Daniel, Seeberger, Esther, Nienhaus, Johannes, Mueller, Christian, Lurati Buse, Giovanna, and Mauermann, Eckhard
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- 2024
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3. Association of preoperative beta-blocker use and cardiac complications after major noncardiac surgery: a prospective cohort study
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Mueller, Philip, Burri, Katrin, Weder, Samantha, Skolozubova, Daria, Horvat-Csoti, Sonja, Doebele, Niklas, Schaer, Marco, Heimbach, Bent, Lopez-Ayala, Pedro, Seeberger, Esther, Doyle, Nadine, Meissner, Kathrin, Glarner, Noemi, Puelacher, Christian, Gualandro, Danielle M., Pargger, Mirjam, Huré, Gabrielle, Maiorano, Silvia, Strebel, Ivo, Fried, Simona, Bolliger, Daniel, Steiner, Luzius A., Lampart, Andreas, Lurati Buse, Giovanna, Mujagic, Edin, Lardinois, Didier, Kindler, Christoph, Guerke, Lorenz, Schaeren, Stefan, Mueller, Andreas, Clauss, Martin, Buser, Andreas, Hammerer-Lercher, Angelika, and Mueller, Christian
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- 2024
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4. Pathological findings associated with the updated European Society of Cardiology 2022 guidelines for preoperative cardiac testing: an observational cohort modelling study
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Kemper, Johann, Kohaupt, Lena, Witzler, Jette, Tuzhikov, Michael, Roth, Sebastian, Stroda, Alexandra, M’Pembele, René, Tenge, Theresa, Schultze, Cornelia, Verbarg, Nele, Gehrke, Christian, Klemann, Anna Katharina, Hagebölling, Friederike, Albrecht, Svenja, Stroeder, Jakob, Schubert, Ann-Kristin, Espeter, Florian, Russe, Benedikt, Weigand, Markus A., Bergmann, Lars, Unterberg, Matthias, Bischoff, Petra, Pirzer, Raphael, Rach, Patric Rene, Ott, Klaus, Zarbock, Alexander, Kowark, Ana, Neumann, Claudia, Marchand, Bahareh, Sponholz, Christoph, Rueffert, Henrik, Kramer, Mira, Zacharowski, Kai, Meybohm, Patrick, Lindau, Simone, Carollo, Melissa, Novazzi, Cecilia, Toso, Fiorenza, Bacuzzi, Alessandro, Ragazzi, Riccardo, Volta, Carlo Alberto, De Giorgi, Francesco, Bacer, Barbara, Federico, Antonio, Chiumello, Davide, Vetrugno, Luigi, Castella, Alberto, Tesoro, Simonetta, Cotoia, Antonella, Bignami, Elena, Bellissima, Agrippino, Cortegiani, Andrea, Crisman, Marco, Toninelli, Arturo, Piazza, Ornella, Mirabella, Lucia, Bossolasco, Matteo, Bona, Francesco, Perdomo, Juan Manuel, Coca-Martinez, Miquel, Carramiñana, Albert, Servén, Marta Giné, González, Astrid Batalla, Gil Sánchez, José Maria, Becerra-Bolaños, Ángel, Rodríguez-Pérez, Aurelio, Soler, Anna Artigas, Basso, Morena, Font, Anna Peig, Vernetta, Diana, Santos, Julia Hernando, Muñoz, Enrique Alday, Olivares, Mercedes Cabellos, Marco, Gregorio, Lopez, Maria Bermudez, Barrio, Javier, Forés, María Isabel, Boix, Estefanía, Ayuso, Mercedes, Petre, Bogdan Sorel, Oprea, Ioana Sorina, Latiș, Mihai Dan, Margarit, Simona, Vasian, Horatiu, Tomescu, Dana, Cîndea, Iulia, Dirzu, Dan Sebastian, Copotoiu, Sanda-Maria, Moise, Alida, Bubenek-Turconi, Serban, Valeanu, Liana, Wanner, Patrick Mark, Djurdjevic, Mirjana, Nuth, Sandra, Seeberger, Esther, Goettel, Nicolai, Kamber, Firmin, Ganter, Michael Thomas, Gerber, Thomas Jan, Schneebeli, Daniela, Pregernig, Andreas, Grape, Sina, Tomala, Simon, Pinto, Bernardo Bollen, Żukowski, Maciej, Zegan-Barańska, Małgorzata, Karolak, Igor, Krzych, Lukasz, Czajka, Szymon, Studzińska, Dorota, Kluzik, Anna, Koszel, Tomasz, Pabjańczyk, Izabela, Gajdosz, Anna, Erkoc, Suheyla Karadag, Meco, Basak Ceyda, Koltka, Ahmet Kemalettin, Dincer, Muserref Beril, Ekmekçi, Perihan, Saracoglu, Kemal Tolga, Solmaz, Filiz Alkaya, Ozcelik, Menekse, Arun, Oguzhan, Dilmen, Ozlem Korkmaz, Preckel, Benedikt, Hollmann, Markus W., Hazen, Yannick, Donald de Boer, Hans, Epema, Anne, Koopman, Seppe, Van Lier, Felix, Pinto, Rita, Carrão, André, Ribeiro, Daniel, Mourão, Joana, Coelho, Miguel, Losa, Nuno, Santos, Nuno, Cabral, Luis, Afonso, Diana, Zenha, Sérgio, Ramos, Cristina, Hipólito, Carla, Vasilaki, Maria, Andreeva, Antonia, Zaimi, Donika, Chalkias, Athanasios, Spyraki, Maria, Rekatsina, Martina, Tsaousi, Georgia, Short, Anthony, Meier, Sonja, Madhuri, Thumuluru Kavitha, Latham, Scott, Knock, James, Drummond, Andrew, Ramsden, Fiona, Kubisz-Pudelko, Agnieszka, Walker, James, Moppett, Iain, White, Louise, Jackson, Matthew, Reschreiter, Henrik, Innes, Richard, Chew, Michelle, Kalman, Sigridur, Wallden, Jakob, Schening, Anna, Jonikaite, Lina, Enlund, Anna, De Baerdemaeker, Luc, Morrison, Stuart, Rex, Steffen, Alexis, Alexandros, Khoronenko, Viktoria E., Ovezov, Alexey, Belskii, Vladislav, Kaznacheeva, Kseniya, Gritsan, Alexey, Kuzmanovska, Biljana, Malinovska-Nikolovska, Liljana, Barisin, Stjepan, Poredos, Peter, Arabadzhieva, Daniela, Unic-Stojanovic, Dragana, Golubović, Mladjan, Fleischmann, Edith, Kotzinger, Oskar, Des Deserts, Marc Danguy, Ducrocq, Nicolas, Buggy, Donal J., Bonnet, Jean François, Cusack, Barbara, Calleja, Paul, Hasani, Antigona, Nallbani, Rajmonda, Mauermann, Eckhard, Ionescu, Daniela, Szczeklik, Wojciech, De Hert, Stefan, Filipovic, Miodrag, Beck Schimmer, Beatrice, Spadaro, Savino, Matute, Purificación, Ganter, Michael T., Turhan, Sanem C., van Waes, Judith, Lagarto, Filipa, Theodoraki, Kassiani, Gupta, Anil, Gillmann, Hans-Jörg, Guzzetti, Luca, Kotfis, Katarzyna, Larmann, Jan, Corneci, Dan, Howell, Simon J., and Lurati Buse, Giovanna
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- 2024
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5. Postoperative high-sensitivity troponin T predicts 1-year mortality and days alive and out of hospital after orthotopic heart transplantation
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M’Pembele, René, Roth, Sebastian, Nucaro, Anthony, Stroda, Alexandra, Tenge, Theresa, Lurati Buse, Giovanna, Bönner, Florian, Scheiber, Daniel, Ballázs, Christina, Tudorache, Igor, Aubin, Hug, Lichtenberg, Artur, Huhn, Ragnar, and Boeken, Udo
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- 2023
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6. Association between hypotension and myocardial injury in patients with severe trauma
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Stroda, Alexandra, Thelen, Simon, M’Pembele, René, Khademlou, Nick, Jaekel, Carina, Schiffner, Erik, Bieler, Dan, Bernhard, Michael, Huhn, Ragnar, Lurati Buse, Giovanna, and Roth, Sebastian
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- 2023
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7. Risk assessment for major adverse cardiovascular events after noncardiac surgery using self-reported functional capacity: international prospective cohort study
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Lurati, Giovanna, Spadaro, Savino, Matute, Purificación, Ionescu, Daniela, Bolliger, Daniel, Szczeklik, Wojciech, Turhan, Sanem Cakar, van Waes, Judith, Lagarto, Filipa, Theodoraki, Kassiani, Howell, Simon J., Gupta, Anil, De Hert, Stefan, Ovezov, Alexey, Tollinche, Luis E., Kuzmanovska, Biljana, Barisin, Stjepan, Poredos, Peter, Arabadzhieva, Daniela, Unic-Stojanovic, Dragana, Fleischmann, Edith, Meistelman, Claude, Buggy, Donal J., Calleja, Paul, Hasani, Antigona, Kemper, Johann, Kohaupt, Lena, Witzler, Jette, Tuzhikov, Michael, Roth, Sebastian, Stroda, Alexandra, Schultze, Cornelia, Verbarg, Nele, Gehrke, Christian, Klemann, Anna Katharina, Hagebölling, Friederike, Albrecht, Svenja, Stroeder, Jakob, Schubert, Ann-Kristin, Espeter, Florian, Russe, Benedikt, Weigand, Markus A., Bergmann, Lars, Unterberg, Matthias, Bischoff, Petra, Pirzer, Raphael, Rach, Patric Rene, Ott, Klaus, Zarbock, Alexander, Kowark, Ana, Neumann, Claudia, Marchand, Bahareh, Sponholz, Christoph, Rueffert, Henrik, Kramer, Mira, Piekarski, Florian, Carollo, Melissa, Novazzi, Cecilia, Toso, Fiorenza, Bacuzzi, Alessandro, Ragazzi, Riccardo, Volta, Carlo Alberto, De Giorgi, Francesco, Bacer, Barbara, Federico, Antonio, Chiumello, Davide, Vetrugno, Luigi, Castella, Alberto, Tesoro, Simonetta, Cotoia, Antonella, Bignami, Elena, Bellissima, Agrippino, Cortegiani, Andrea, Crisman, Marco, Toninelli, Arturo, Piazza, Ornella, Mirabella, Lucia, Bossolasco, Matteo, Bona, Francesco, Perdomo, Juan Manuel, Coca-Martinez, Miquel, Carramiñana, Albert, Servén, Marta Giné, González, Astrid Batalla, Gil Sánchez, José Maria, Becerra-Bolaños, Ángel, Rodríguez-Pérez, Aurelio, Soler, Anna Artigas, Basso, Morena, Font, Anna Peig, Vernetta, Diana, Santos, Julia Hernando, Muñoz, Enrique Alday, Olivares, Mercedes Cabellos, Marco, Gregorio, Lopez, Maria Bermudez, Barrio, Javier, Forés, María Isabel, Boix, Estefanía, Ayuso, Mercedes, Petre, Bogdan Sorel, Oprea, Ioana Sorina, Latiș, Mihai Dan, Margarit, Simona, Vasian, Horatiu, Tomescu, Dana, Cîndea, Iulia, Dirzu, Dan Sebastian, Copotoiu, Sanda-Maria, Moise, Alida, Bubenek-Turconi, Serban, Valeanu, Liana, Wanner, Patrick Mark, Djurdjevic, Mirjana, Nuth, Sandra, Seeberger, Esther, Goettel, Nicolai, Kamber, Firmin, Ganter, Michael Thomas, Gerber, Thomas Jan, Schneebeli, Daniela, Pregernig, Andreas, Grape, Sina, Tomala, Simon, Pinto, Bernardo Bollen, Żukowski, Maciej, Zegan-Barańska, Małgorzata, Karolak, Igor, Krzych, Lukasz, Czajka, Szymon, Studzińska, Dorota, Kluzik, Anna, Koszel, Tomasz, Pabjańczyk, Izabela, Gajdosz, Anna, Erkoc, Suheyla Karadag, Meco, Basak Ceyda, Koltka, Ahmet Kemalettin, Dincer, Muserref Beril, Ekmekçi, Perihan, Saracoglu, Kemal Tolga, Solmaz, Filiz Alkaya, Ozcelik, Menekse, Arun, Oguzhan, Dilmen, Ozlem Korkmaz, Preckel, Benedikt, Hollmann, Markus W., Hazen, Yannick, Donald de Boer, Hans, Epema, Anne, Koopman, Seppe, Van Lier, Felix, Pinto, Rita, Carrão, André, Ribeiro, Daniel, Mourão, Joana, Coelho, Miguel, Losa, Nuno, Santos, Nuno, Cabral, Luis, Afonso, Diana, Zenha, Sérgio, Ramos, Cristina, Hipólito, Carla, Vasilaki, Maria, Andreeva, Antonia, Zaimi, Donika, Chalkias, Athanasios, Spyraki, Maria, Rekatsina, Martina, Tsaousi, Georgia, Short, Anthony, Meier, Sonja, Madhuri, Thumuluru Kavitha, Latham, Scott, Knock, James, Drummond, Andrew, Ramsden, Fiona, Kubisz-Pudelko, Agnieszka, Walker, James, Moppett, Iain, White, Louise, Jackson, Matthew, Reschreiter, Henrik, Innes, Richard, Chew, Michelle, Kalman, Sigridur, Wallden, Jakob, Schening, Anna, Jonikaite, Lina, Enlund, Anna, De Baerdemaeker, Luc, Morrison, Stuart, Rex, Steffen, Alexis, Alexandros, Khoronenko, Viktoria E., Belskii, Vladislav, Kaznacheeva, Kseniya, Gritsan, Alexey, Yeoh, Cindy B., Malinovska-Nikolovska, Liljana, Golubović, Mladjan, Kotzinger, Oskar, Des Deserts, Marc Danguy, Ducrocq, Nicolas, Bonnet, Jean François, Cusack, Barbara, Nallbani, Rajmonda, Daamen, Sylvia, Plichon, Benoit, Harlet, Pierre, Farsi, Slama, Sepehr, Saman Homayun, Espinosa, David, Lurati Buse, Giovanna A., Mauermann, Eckhard, Filipovic, Miodrag, Beck-Schimmer, Beatrice, Gillmann, Hans-Jörg, Guzzetti, Luca, Kotfis, Katarzyna, Wulf, Hinnerk, Larmann, Jan, Corneci, Dan, and Chammartin-Basnet, Frederique
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- 2023
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8. Perioperative troponin surveillance in major noncardiac surgery: a narrative review
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Chew, Michelle S., Saugel, Bernd, and Lurati-Buse, Giovanna
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- 2023
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9. Incidence and prognosis of myocardial injury in patients with severe trauma
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Stroda, Alexandra, Thelen, Simon, M’Pembele, René, Adelowo, Antony, Jaekel, Carina, Schiffner, Erik, Bieler, Dan, Bernhard, Michael, Huhn, Ragnar, Lurati Buse, Giovanna, and Roth, Sebastian
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- 2022
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10. Patient- and procedure-related factors in the pathophysiology of perioperative myocardial infarction/injury
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Badertscher, Patrick, Boeddinghaus, Jasper, Buser, Andreas, Freese, Michael, Hammerer-Lercher, Angelika, Koechlin, Luca, Lopez-Ayala, Pedro, Mehrkens, Arne, Mujagic, Edin, Nestelberger, Thomas, Prepoudis, Alexandra, Mitrovic, Sandra, Rentsch, Katharina, Seeberger, Esther, Vogt, Ronja, Walter, Joan, Wildi, Karin, Wolff, Thomas, Wussler, Desiree, Gueckel, Johanna, Puelacher, Christian, Glarner, Noemi, Gualandro, Danielle M., Strebel, Ivo, Zimmermann, Tobias, Arslani, Ketina, Hidvegi, Reka, Liffert, Marcel, Genini, Alessandro, Marbot, Stella, Schlaepfer, Maria, Steiner, Luzius A., Bolliger, Daniel, Lampart, Andreas, Gürke, Lorenz, Kindler, Christoph, Schären, Stefan, Osswald, Stefan, Clauss, Martin, Rikli, Daniel, Lurati Buse, Giovanna, and Mueller, Christian
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- 2022
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11. Cardiovascular imaging following perioperative myocardial infarction/injury
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Arslani, Ketina, Gualandro, Danielle M., Puelacher, Christian, Lurati Buse, Giovanna, Lampart, Andreas, Bolliger, Daniel, Schulthess, David, Glarner, Noemi, Hidvegi, Reka, Kindler, Christoph, Blum, Steffen, Cardozo, Francisco A. M., Caramelli, Bruno, Gürke, Lorenz, Wolff, Thomas, Mujagic, Edin, Schaeren, Stefan, Rikli, Daniel, Campos, Carlos A., Fahrni, Gregor, Kaufmann, Beat A., Haaf, Philip, Zellweger, Michael J., Kaiser, Christoph, Osswald, Stefan, Steiner, Luzius A., and Mueller, Christian
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- 2022
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12. Validation of days alive and out of hospital as a new patient-centered outcome to quantify life impact after heart transplantation
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M’Pembele, René, Roth, Sebastian, Stroda, Alexandra, Reier, Tilman, Lurati Buse, Giovanna, Sixt, Stephan U., Westenfeld, Ralf, Rellecke, Philipp, Tudorache, Igor, Hollmann, Markus W., Aubin, Hug, Akhyari, Payam, Lichtenberg, Artur, Huhn, Ragnar, and Boeken, Udo
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- 2022
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13. Evaluation of clinical outcomes in patients treated with heparin or direct thrombin inhibitors during extracorporeal membrane oxygenation: a systematic review and meta-analysis
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M’Pembele, René, Roth, Sebastian, Metzger, Aljoscha, Nucaro, Anthony, Stroda, Alexandra, Polzin, Amin, Hollmann, Markus W., Lurati Buse, Giovanna, and Huhn, Ragnar
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- 2022
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14. Neutrophil-lymphoycyte-ratio, platelet-lymphocyte-ratio and procalcitonin for early assessment of prognosis in patients undergoing VA-ECMO
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Roth, Sebastian, M’Pembele, René, Stroda, Alexandra, Jansen, Catrin, Lurati Buse, Giovanna, Boeken, Udo, Akhyari, Payam, Lichtenberg, Artur, Hollmann, Markus W., Huhn, Ragnar, and Aubin, Hug
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- 2022
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15. Adherence to the European Society of Cardiology/European Society of Anaesthesiology recommendations on preoperative cardiac testing and association with positive results and cardiac events: a cohort study
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Gueckel, Johanna, Strebel, Ivo, Liffert, Marcel, du Fay de Lavallaz, Jeanne, Pouly, Jeanne, Hammerer-Lercher, Angelika, Rentsch, Katharina, Lopez Ayala, Pedro, Osswald, Stefan, Seeberger, Esther, Koechlin, Luca, Buser, Andreas, Rikli, Daniel, Schaeren, Stefan, Lardinois, Didier, Caramelli, Bruno, Lurati Buse, Giovanna A.L., Puelacher, Christian, Gualandro, Danielle Menosi, Kilinc, Derya, Glarner, Noemi, Hidvegi, Reka, Bolliger, Daniel, Arslani, Ketina, Lampart, Andreas, Steiner, Luzius A., Kindler, Christoph, Wolff, Thomas, Mujagic, Edin, Guerke, Lorenz, and Mueller, Christian
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- 2021
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16. Association between self-reported functional capacity and major adverse cardiac events in patients at elevated risk undergoing noncardiac surgery: a prospective diagnostic cohort study
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Gueckel, Johanna, Strebel, Ivo, Liffert, Marcel, Wolff, Thomas, EdinMujagic, Guerke, Lorenz, Hammerer-Lercher, Angelika, Rentsch, Katharina, Boeddinghaus, Jasper, Nestelberger, Thomas, Wildi, Karin, Zimmermann, Tobias, Prepoudis, Alexandra, Lampart, Andreas, Osswald, Stefan, Seeberger, Esther, Koechlin, Luca, Buser, Andreas, Rikli, Daniel, Lurati Buse, Giovanna A.L., Puelacher, Christian, Gualandro, Danielle Menosi, Genini, Alessandro S., Hidvegi, Reka, Bolliger, Daniel, Arslani, Ketina, Steiner, Luzius A., Kindler, Christoph, and Mueller, Christian
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- 2021
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17. Fibrinogen–Albumin-Ratio is an independent predictor of thromboembolic complications in patients undergoing VA-ECMO
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Roth, Sebastian, Jansen, Catrin, M’Pembele, René, Stroda, Alexandra, Boeken, Udo, Akhyari, Payam, Lichtenberg, Artur, Hollmann, Markus W., Huhn, Ragnar, Lurati Buse, Giovanna, and Aubin, Hug
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- 2021
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18. Die Rolle von kardialen Biomarkern in der perioperativen Risikoevaluation von nichtkardiochirurgischen Patienten – eine Zusammenfassung der ESAIC-Leitlinie 2023.
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M'Pembele, René, Roth, Sebastian, and Lurati Buse, Giovanna
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BIOMARKERS ,PERIOPERATIVE care ,TROPONIN ,SURGICAL complications ,MYOCARDIAL injury ,MEDICAL protocols ,PEPTIDE hormones - Abstract
Copyright of Die Anaesthesiologie is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2024
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19. Prediction of perioperative myocardial infarction/injury in high-risk patients after noncardiac surgery.
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Meister, Rebecca, Puelacher, Christian, Glarner, Noemi, Gualandro, Danielle Menosi, Andersson, Henrik A, Pargger, Mirjam, Huré, Gabrielle, Virant, Georgiana, Bolliger, Daniel, Lampart, Andreas, Steiner, Luzius, Hidvegi, Reka, Lurati Buse, Giovanna, Kindler, Christoph, Gürke, Lorenz, Mujagic, Edin, Schaeren, Stefan, Clauss, Martin, Lardinois, Didier, and Hammerer-Lercher, Angelika
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- 2023
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20. Cardiac Biomarkers for the Prediction and Detection of Adverse Cardiac Events After Noncardiac Surgery: A Narrative Review
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De Hert, Stefan G. and Lurati Buse, Giovanna A.
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- 2020
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21. B-type natriuretic peptide secretion without change in intra-cardiac pressure
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Puelacher, Christian, Rudez, Jasna, Twerenbold, Raphael, Moreno Weidmann, Zoraida, Osswald, Stefan, Eckstein, Friedrich, Lurati-Buse, Giovanna, Pargger, Hans, and Mueller, Christian
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- 2015
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22. Perioperative Myocardial Injury After Noncardiac Surgery: Incidence, Mortality, and Characterization
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Puelacher, Christian, Lurati Buse, Giovanna, Seeberger, Daniela, Sazgary, Lorraine, Marbot, Stella, Lampart, Andreas, Espinola, Jaqueline, Kindler, Christoph, Hammerer, Angelika, Seeberger, Esther, Strebel, Ivo, Wildi, Karin, Twerenbold, Raphael, du Fay de Lavallaz, Jeanne, Steiner, Luzius, Gurke, Lorenz, Breidthardt, Tobias, Rentsch, Katharina, Buser, Andreas, Gualandro, Danielle M., Osswald, Stefan, Mueller, Christian, Seeberger, Manfred, Christ-Crain, Mirjam, Cuculi, Florim, Badertscher, Patrick, Nestelberger, Thomas, Wussler, Desiree, Flores, Dayana, Boeddinghaus, Jasper, Sabti, Zaid, Giménez, Maria Rubini, Kozhuharov, Nikola, Shrestha, Samyut, Kloos, Wanda, Lohrmann, Jens, Reichlin, Tobias, Freese, Michael, Meissner, Kathrin, Kaiser, Christoph, and Buser, Andreas
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- 2018
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23. Postoperative High-Sensitivity Troponin and Its Association With 30-Day and 12-Month, All-Cause Mortality in Patients Undergoing On-Pump Cardiac Surgery
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Mauermann, Eckhard, Bolliger, Daniel, Fassl, Jens, Grapow, Martin, Seeberger, Esther E., Seeberger, Manfred D., Filipovic, Miodrag, and Lurati Buse, Giovanna A. L.
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- 2017
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24. Absolute Postoperative B-Type Natriuretic Peptide Concentrations, but Not Their General Trend, Are Associated With 12-Month, All-Cause Mortality After On-Pump Cardiac Surgery
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Mauermann, Eckhard, Bolliger, Daniel, Fassl, Jens, Grapow, Martin, Seeberger, Esther E., Seeberger, Manfred D., Filipovic, Miodrag, and Lurati Buse, Giovanna A. L.
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- 2017
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25. Acute heart failure after non‐cardiac surgery: incidence, phenotypes, determinants and outcomes.
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Gualandro, Danielle M., Puelacher, Christian, Chew, Michelle S., Andersson, Henrik, Lurati Buse, Giovanna, Glarner, Noemi, Mueller, Daria, Cardozo, Francisco A.M., Burri‐Winkler, Katrin, Mork, Constantin, Wussler, Desiree, Shrestha, Samyut, Heidelberger, Isabelle, Fält, Mikael, Hidvegi, Reka, Bolliger, Daniel, Lampart, Andreas, Steiner, Luzius A., Schären, Stefan, and Kindler, Christoph
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HEART failure ,CHRONIC obstructive pulmonary disease ,HEART failure patients ,PERIPHERAL vascular diseases ,ANKLE brachial index ,CORONARY artery disease - Abstract
Aims: Primary acute heart failure (AHF) is a common cause of hospitalization. AHF may also develop postoperatively (pAHF). The aim of this study was to assess the incidence, phenotypes, determinants and outcomes of pAHF following non‐cardiac surgery. Methods and results: A total of 9164 consecutive high‐risk patients undergoing 11 262 non‐cardiac inpatient surgeries were prospectively included. The incidence, phenotypes, determinants and outcome of pAHF, centrally adjudicated by independent cardiologists, were determined. The incidence of pAHF was 2.5% (95% confidence interval [CI] 2.2–2.8%); 51% of pAHF occurred in patients without known heart failure (de novo pAHF), and 49% in patients with chronic heart failure. Among patients with chronic heart failure, 10% developed pAHF, and among patients without a history of heart failure, 1.5% developed pAHF. Chronic heart failure, diabetes, urgent/emergent surgery, atrial fibrillation, cardiac troponin elevations above the 99th percentile, chronic obstructive pulmonary disease, anaemia, peripheral artery disease, coronary artery disease, and age, were independent predictors of pAHF in the logistic regression model. Patients with pAHF had significantly higher all‐cause mortality (44% vs. 11%, p < 0.001) and AHF readmission (15% vs. 2%, p < 0.001) within 1 year than patients without pAHF. After Cox regression analysis, pAHF was an independent predictor of all‐cause mortality (adjusted hazard ratio [aHR] 1.7 [95% CI 1.3–2.2]; p < 0.001) and AHF readmission (aHR 2.3 [95% CI 1.5–3.7]; p < 0.001). Findings were confirmed in an external validation cohort using a prospective multicentre cohort of 1250 patients (incidence of pAHF 2.4% [95% CI 1.6–3.3%]). Conclusions: Postoperative AHF frequently developed following non‐cardiac surgery, being de novo in half of cases, and associated with a very high mortality. [ABSTRACT FROM AUTHOR]
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- 2023
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26. Myocardial Injury Is Associated with the Incidence of Major Adverse Cardiac Events in Patients with Severe Trauma.
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Stroda, Alexandra, Jaekel, Carina, M'Pembele, René, Guenther, Alexander, Tenge, Theresa, Thielmann, Carl Maximilian, Thelen, Simon, Schiffner, Erik, Bieler, Dan, Bernhard, Michael, Huhn, Ragnar, Lurati Buse, Giovanna, and Roth, Sebastian
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MAJOR adverse cardiovascular events ,MYOCARDIAL injury ,CARDIAC patients ,RECEIVER operating characteristic curves ,LOGISTIC regression analysis - Abstract
Background: Severe trauma potentially results in end-organ damage such as myocardial injury. Data suggest that myocardial injury is associated with increased mortality in this cohort, but the association with the incidence of in-hospital major adverse cardiac events (MACE) remains undetermined. Methods: Retrospective cohort study including adult patients with severe trauma treated at the University Hospital Duesseldorf between January 2016 and December 2019. The main exposure was myocardial injury at presentation. Endpoints were in-hospital incidence of MACE and incidence of acute kidney injury (AKI) within 72 h. Discrimination of hsTnT for MACE and AKI was examined by the receiver operating characteristic curve (ROC) and the area under the curve (AUC). We conducted multivariate logistic regression analysis. Results: We included 353 patients in our final analysis (72.5% male (256/353), age: 55 ± 21 years). The AUC for hsTnT and MACE was 0.68 [95% confidence interval (CI): 0.59–0.78]. The AUC for hsTnT and AKI was 0.64 [95% (CI): 0.55–0.72]. The adjusted odds ratio (OR) for myocardial injury and MACE was 2.97 [95% (CI): 1.31–6.72], and it was 2.14 [95% (CI): 1.03–4.46] for myocardial injury and AKI. Conclusion: Myocardial injury at presentation in patients with severe trauma is independently associated with the incidence of in-hospital MACE and AKI. [ABSTRACT FROM AUTHOR]
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- 2022
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27. Impact of Left Ventricular Assist Devices on Days Alive and Out of Hospital in Hemodynamically Stable Patients with End-Stage Heart Failure: A Propensity Score Matched Study.
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Tenge, Theresa, Roth, Sebastian, M'Pembele, René, Lurati Buse, Giovanna, Boenner, Florian, Ballázs, Christina, Tudorache, Igor, Boeken, Udo, Lichtenberg, Artur, Neukirchen, Martin, Huhn, Ragnar, and Aubin, Hug
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HEART assist devices ,PROPENSITY score matching ,HEART failure patients ,HEART transplantation - Abstract
The two main surgical options to treat end-stage heart failure are heart transplantation (HTx) or left ventricular assist device (LVAD) implantation. In hemodynamically stable patients, the decision for HTx listing with or without LVADs is challenging. We analyzed the impact of both options on days alive and out of hospital (DAOH) and survival. This retrospective study screened all patients with HTx or LVAD implantation between 2010 and 2020. The main inclusion criterion was hemodynamic stability defined as independence of intravenous inotropic/vasoactive support at decision. Propensity score matching (PSM) was performed. The primary endpoint was DAOH within one year after the decision. Secondary endpoints included survival, duration until HTx, and hospitalizations. In total, 187 patients received HTx and 227 patients underwent LVAD implantation. There were 21 bridge-to-transplant (BTT)-LVAD patients (implantation less than a month after HTx listing or listing after implantation) and 44 HTx-waiting patients included. PSM identified 17 matched pairs. Median DAOH at one year was not significantly different between the groups (BTT-LVAD: median 281, IQR 89; HTx waiting: median 329, IQR 74; p = 0.448). Secondary endpoints did not differ significantly. Our data suggest that BTT-LVAD implantation may not be favorable in terms of DAOH within one year for hemodynamically stable patients compared to waiting for HTx. Further investigations on quality of life and long-term outcomes are warranted. [ABSTRACT FROM AUTHOR]
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- 2022
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28. Influence of Short and Long Hyperglycemia on Cardioprotection by Remote Ischemic Preconditioning—A Translational Approach.
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Feige, Katharina, Roth, Sebastian, M'Pembele, René, Galow, Anna, Koenig, Sarah, Stroethoff, Martin, Raupach, Annika, Lurati Buse, Giovanna, Mathes, Alexander M., Hollmann, Markus W., Huhn, Ragnar, and Torregroza, Carolin
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HYPERGLYCEMIA ,ISCHEMIC preconditioning ,REPERFUSION injury ,BLOOD sugar ,MYOCARDIAL infarction ,LABORATORY rats - Abstract
The adverse impact of common diseases like diabetes mellitus and acute hyperglycemia on morbidity and mortality from myocardial infarction (MI) has been well documented over the past years of research. In the clinical setting, the relationship between blood glucose and mortality appears linear, with amplifying risk associated with increasing blood glucose levels. Further, this seems to be independent of a diagnosis of diabetes. In the experimental setting, various comorbidities seem to impact ischemic and pharmacological conditioning strategies, protecting the heart against ischemia and reperfusion injury. In this translational experimental approach from bedside to bench, we set out to determine whether acute and/or prolonged hyperglycemia have an influence on the protective effect of transferred human RIPC-plasma and, therefore, might obstruct translation into the clinical setting. Control and RIPC plasma of young healthy men were transferred to isolated hearts of young male Wistar rats in vitro. Plasma was administered before global ischemia under either short hyperglycemic (HGs Con, HGs RIPC) conditions, prolonged hyperglycemia (HGl Con, HGl RIPC), or under normoglycemia (Con, RIPC). Infarct sizes were determined by TTC staining. Control hearts showed an infarct size of 55 ± 7%. Preconditioning with transferred RIPC plasma under normoglycemia significantly reduced infarct size to 25 ± 4% (p < 0.05 vs. Con). Under acute hyperglycemia, control hearts showed an infarct size of 63 ± 5%. Applying RIPC plasma under short hyperglycemic conditions led to a significant infarct size reduction of 41 ± 4% (p < 0.05 vs. HGs Con). However, the cardioprotective effect of RIPC plasma under normoglycemia was significantly stronger compared with acute hyperglycemic conditions (RIPC vs. HGs RIPC; p < 0.05). Prolonged hyperglycemia (HGl RIPC) completely abolished the cardioprotective effect of RIPC plasma (infarct size 60 ± 7%; p < 0.05 vs. HGl Con; HGl Con 59 ± 5%). [ABSTRACT FROM AUTHOR]
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- 2022
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29. Validation of days alive and out of hospital as a new patient-centered outcome to quantify life impact after heart transplantation.
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M'Pembele, René, Roth, Sebastian, Stroda, Alexandra, Reier, Tilman, Lurati Buse, Giovanna, Sixt, Stephan U., Westenfeld, Ralf, Rellecke, Philipp, Tudorache, Igor, Hollmann, Markus W., Aubin, Hug, Akhyari, Payam, Lichtenberg, Artur, Huhn, Ragnar, and Boeken, Udo
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HEART transplantation ,HEART transplant recipients ,RENAL replacement therapy ,MORTALITY risk factors ,GLOMERULAR filtration rate - Abstract
The number of patients waiting for heart transplantation (HTX) is increasing. Thus, identification of outcome-relevant factors is crucial. This study aimed to identify perioperative factors associated with days alive and out of hospital (DAOH)—a patient-centered outcome to quantify life impact—after HTX. This retrospective cohort study screened 187 patients who underwent HTX at university hospital Duesseldorf, Germany from September 2010 to December 2020. The primary endpoint was DAOH at 1 year. Risk factors for mortality after HTX were assessed in univariate analysis. Variables with significant association were entered into multivariable quantile regression. In total, 175 patients were included into analysis. Median DAOH at 1 year was 295 (223–322) days. In univariate analysis the following variables were associated with reduced DAOH: recipient or donor diabetes pre-HTX, renal replacement therapy (RRT), VA-ECMO therapy, recipient body mass index, recipient estimated glomerular filtration rate (eGFR) and postoperative duration of mechanical ventilation. After adjustment, mechanical ventilation, RRT, eGFR and recipient diabetes showed significant independent association with DAOH. This study identified risk factors associated with reduced DAOH at 1-year after HTX. These findings might complement existing data for outcome of patients undergoing HTX. [ABSTRACT FROM AUTHOR]
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- 2022
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30. Noninvasive evaluation of the hemodynamic status in patients after heart transplantation or left ventricular assist device implantation.
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Roth, Sebastian, Fox, Henrik, M'Pembele, René, Morshuis, Michiel, Lurati Buse, Giovanna, Hollmann, Markus W., Huhn, Ragnar, and Bitter, Thomas
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HEART assist devices ,HEART transplant recipients ,TECHNOLOGICAL innovations ,HEMODYNAMICS ,CARDIAC output ,HEART transplantation - Abstract
Introduction: Hemodynamic assessment is crucial after heart transplantation (HTX) or left ventricular assist device (LVAD) implantation. Gold-standard is invasive assessment via thermodilution (TD). Noninvasive pulse contour analysis (NPCA) is a new technology that is supposed to determine hemodynamics completely noninvasive. We aimed to validate this technology in HTX and LVAD patients and conducted a prospective single-center cohort study. Methods: Patients after HTX or LVAD implantation underwent right heart catheterization including TD. NPCA using the CNAP Monitor (V.5.2.14; CNSystems Medizintechnik AG, Graz, Austria) was performed simultaneously. Three TD measurements were compared with simultaneous NPCA measurements for hemodynamic assessment. To describe the agreement between TD and NPCA, Bland–Altman analysis was done. Results: In total, 28 patients were prospectively enrolled (HTX: n = 10, LVAD: n = 18). Bland-Altman analysis revealed a mean bias of +1.05 l/min (limits of agreement ± 4.09 l/min, percentage error 62.1%) for cardiac output (CO). In LVAD patients, no adequate NPCA signal could be obtained. In 5 patients (27.8%), any NPCA signal could be detected, but was considered as low signal quality. Conclusion: In conclusion, according to our limited data in a small cohort of HTX and LVAD patients, NPCA using the CNAP Monitor seems not to be suitable for noninvasive evaluation of the hemodynamic status. [ABSTRACT FROM AUTHOR]
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- 2022
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31. 12-Month Outcome After Cardiac Surgery: Prediction by Troponin T in Combination With the European System for Cardiac Operative Risk Evaluation
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Lurati Buse, Giovanna A., Koller, Michael T., Grapow, Martin, Brüni, Céline M., Kasper, Jorge, Seeberger, Manfred D., and Filipovic, Miodrag
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- 2009
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32. Days alive and out of hospital after left ventricular assist device implantation.
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Roth, Sebastian, M'Pembele, René, Stroda, Alexandra, Voit, Josephine, Lurati Buse, Giovanna, Sixt, Stephan U., Westenfeld, Ralf, Polzin, Amin, Rellecke, Philipp, Tudorache, Igor, Hollmann, Markus W., Boeken, Udo, Akhyari, Payam, Lichtenberg, Artur, Huhn, Ragnar, and Aubin, Hug
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HEART assist devices ,ARTIFICIAL blood circulation ,CHRONIC kidney failure ,QUANTILE regression ,TRACHEOTOMY ,UNIVARIATE analysis - Abstract
Aims: Implantation of left ventricular assist devices (LVADs) as a bridge to transplant or as destination therapy is increasing. The selection of suitable patients and outcome assessment belong to the key challenges. Mortality has traditionally been a focus of research in this field, but literature on quality of life is very limited. This study aimed to identify perioperative factors influencing patients' life as measured by days alive and out of hospital (DAOH) in the first year after LVAD implantation. Methods and results: This retrospective single‐centre cohort study screened 227 patients who underwent LVAD implantation at the University Hospital Duesseldorf, Germany, between 2010 and 2020. First, the influence of 10 prespecified variables on DAOH was investigated by univariate analysis. Second, multivariate quantile regression was conducted including all factors with significant influence on DAOH in the univariate model. Additionally, the impact of all variables on 1 year mortality was investigated using Kaplan–Meier curves to oppose DAOH and mortality. In total, 221 patients were included into analysis. As pre‐operative factors, chronic kidney disease (CKD), pre‐operative mechanical circulatory support (pMCS), and Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS) stadium < 3 were associated with lower DAOH at 1 year [CKD: 280 (155–322) vs. 230 (0–219), P = 0.0286; pMCS: 294 (155–325) vs. 243 (0–293), P = 0.0004; INTERMACS 1: 218 (0–293) vs. INTERMACS 2: 264 (6–320) vs. INTERMACS 3: 299 (228–325) vs. INTERMACS 4: 313 (247–332), P ≤ 0.0001]. Intra‐operative additional implantation of a right ventricular assist device (RVAD) was also associated with lower DAOH [RVAD: 290 (160–325) vs. 174 (0–277), P ≤ 0.0001]. As post‐operative values that were associated with lower DAOH, dialysis and tracheotomy could be identified [dialysis: 300 (252–326) vs. 186 (0–300), P ≤ 0.0001; tracheotomy: 292 (139–325) vs. 168 (0–269), P ≤ 0.0001]. Multivariate analysis revealed that all of these factors besides pMCS were independently associated with DAOH. According to Kaplan–Meier analysis, only post‐operative dialysis was significantly associated with increased mortality at 1 year (survival: no dialysis 89.4% vs. dialysis 70.1%, hazard ratio: 0.56, 95% confidence interval: 0.33–0.94; P = 0.031). Conclusions: The results of this study indicate that there can be a clear discrepancy between hard endpoints such as mortality and more patient‐centred outcomes reflecting life impact. DAOH may relevantly contribute to a more comprehensive selection process and outcome assessment in LVAD patients. [ABSTRACT FROM AUTHOR]
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- 2022
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33. Evaluation of clinical outcomes in patients treated with heparin or direct thrombin inhibitors during extracorporeal membrane oxygenation: a systematic review and meta-analysis.
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M'Pembele, René, Roth, Sebastian, Metzger, Aljoscha, Nucaro, Anthony, Stroda, Alexandra, Polzin, Amin, Hollmann, Markus W., Lurati Buse, Giovanna, and Huhn, Ragnar
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THERAPEUTIC use of proteins ,ONLINE information services ,MEDICAL databases ,CINAHL database ,META-analysis ,SYSTEMATIC reviews ,EXTRACORPOREAL membrane oxygenation ,TREATMENT effectiveness ,HEPARIN ,MEDLINE - Abstract
Background: The number of patients treated with extracorporeal membrane oxygenation (ECMO) devices is increasing. Anticoagulation therapy is crucial to prevent thrombosis during ECMO therapy. Predominantly, heparin has been used as primary anticoagulant but direct thrombin inhibitors (DTI) have been established as alternatives. The aim of this systematic review and meta-analysis was to evaluate clinical outcomes in patients treated with heparin compared to different DTI during ECMO. Methods: A systematic search was conducted. Full scientific articles were sought for inclusion if heparin anticoagulation was compared to DTI (argatroban/bivalirudin) in ECMO patients. Risk of bias was assessed by Newcastle Ottawa scale. Primary endpoint was in-hospital mortality. Bleeding events, thrombotic events, hours of ECMO support, days of hospital stay, percentage of time within therapeutic range and time to therapeutic range were extracted from full texts as secondary endpoints. Results were presented as Forrest-plots. GRADE was used for confidence assessment in outcomes. Results: Systematic search identified 4.385 records, thereof 18 retrospective studies for a total of 1942 patients, complied with the predefined eligibility criteria:15 studies investigated bivalirudin and 3 studies investigated argatroban versus heparin. Risk of bias was high for most studies. In-hospital mortality, major bleeding events and pump-related thrombosis were less frequent in DTI group as compared to heparin [mortality—OR 0.69, 95% CI 0.54–0.86; major bleeding—OR 0.48, 95% CI 0.29–0.81; pump thrombosis—OR 0.55, 95% CI 0.40–0.76]. Additionally, percentage of time within therapeutic range was higher for DTI [SMD 0.54, 95% CI 0.14–0.94]. GRADE approach revealed a very low level of certainty for each outcome. Conclusion: In this meta-analysis, DTI and especially bivalirudin showed beneficial effects on clinical outcomes in ECMO patients as compared to heparin. However, due to the lack of randomized trials, certainty of evidence is low. Trial Registration: This systematic review and meta-analysis was prospectively registered at PROSPERO data base (reference number CRD42021237252). [ABSTRACT FROM AUTHOR]
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- 2022
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34. Impact of Cardiopulmonary Resuscitation of Donors on Days Alive and Out of Hospital after Orthotopic Heart Transplantation.
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Roth, Sebastian, M'Pembele, René, Nucaro, Anthony, Stroda, Alexandra, Tenge, Theresa, Lurati Buse, Giovanna, Sixt, Stephan U., Westenfeld, Ralf, Rellecke, Philipp, Tudorache, Igor, Hollmann, Markus W., Aubin, Hug, Akhyari, Payam, Lichtenberg, Artur, Huhn, Ragnar, and Boeken, Udo
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CARDIOPULMONARY resuscitation ,HEART transplantation ,HEART transplant recipients ,CARDIAC patients ,HOSPITALS - Abstract
Background: The number of patients waiting for heart transplantation (HTX) is increasing. Optimizing the use of all available donor hearts is crucial. While mortality seems not to be affected by donor cardiopulmonary resuscitation (CPR), the impact of donor CPR on days alive and out of hospital (DAOH) is unclear. Methods: This retrospective study included adults who underwent HTX at the University Hospital Duesseldorf, Germany from 2010–2020. Main exposure was donor-CPR. Secondary exposure was the length of CPR. The primary endpoint was DAOH at one year. Results: A total of 187 patients were screened and 171 patients remained for statistical analysis. One-year mortality was 18.7%. The median DAOH at one year was 295 days (interquartile range 206–322 days). Forty-two patients (24.6%) received donor-CPR hearts. The median length of CPR was 15 (9–21) minutes. There was no significant difference in DAOH between patients with donor-CPR hearts versus patients with no-CPR hearts (CPR: 291 days (211–318 days) vs. no-CPR: 295 days (215–324 days); p = 0.619). Multivariate linear regression revealed that there was no association between length of CPR and DAOH (unstandardized coefficients B: −0.06, standard error: 0.81, 95% CI −1.65–1.53, p = 0.943). Conclusions: Donor CPR status and length of CPR are not associated with reduced DAOH at one year after HTX. [ABSTRACT FROM AUTHOR]
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- 2022
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35. Kardiale Biomarker im nichtkardiochirurgischen Setting: Eine Übersicht über kardiale Biomarker zur Risikostratifizierung und Früherkennung postoperativer kardialer Komplikationen.
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Roth, Sebastian, Huhn, Ragnar, Jung, Christian, Polzin, Amin, De Hert, Stefan, and Lurati Buse, Giovanna
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BRAIN natriuretic factor ,NATRIURETIC peptides ,TROPONIN ,BIOMARKERS ,MYOCARDIAL injury - Abstract
Copyright of Medizinische Klinik: Intensivmedizin & Notfallmedizin is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2022
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36. Myokardinfarkt in der Herzchirurgie: Neue kardiale Biomarker zur frühen Detektion.
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Roth, Sebastian and Lurati Buse, Giovanna
- Abstract
Copyright of Wiener Klinisches Magazin is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2022
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37. Revisiting Sample Size: Are Big Trials the Answer?
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Lurati Buse, Giovanna AL, Botto, Fernando, and Devereaux, P J
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- 2012
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38. Neue kardiale Biomarker zur frühen Detektion des Myokardinfarktes in der Herzchirurgie.
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Roth, Sebastian and Lurati Buse, Giovanna
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CARRIER proteins , *FATTY acids , *BIOMARKERS - Abstract
In-hospital mortality after cardiac surgery ranges from 2% to 8%. Many patients suffer from major adverse cardiovascular events, e.g. myocardial infarction, which in the long term can result in severe limitations in routine activities. Troponin plays the central role in identifying myocardial infarction; however, interpretation after cardiac surgery is difficult due to ischemia reperfusion injury and direct surgical trauma. Thus, the distinction between procedure-related myocardial injury and additional myocardial injury due to a new event is difficult. The fourth universal definition of type 5 myocardial infarction uses the 10 × upper limit of normal (ULN) as cut-off and notably > 90% of patients after on-pump procedures exceed this cut-off. Clinical consequences are mostly unclear. The dynamics of copeptin and heart-type fatty acid binding protein (H-FABP) concentrations start very early, i.e. several hours before troponin. The characteristics of copeptin and H‑FABP might help to overcome the limitations of troponin. This short narrative review gives a concise overview on this topic. Moreover, a brief view of future perspectives in this field is given. [ABSTRACT FROM AUTHOR]
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- 2021
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39. Adherence to the European Society of Cardiology/European Society of Anaesthesiology recommendations on preoperative cardiac testing and association with positive results and cardiac events: a cohort study.
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Lurati Buse, Giovanna A.L., Puelacher, Christian, Gualandro, Danielle Menosi, Kilinc, Derya, Glarner, Noemi, Hidvegi, Reka, Bolliger, Daniel, Arslani, Ketina, Lampart, Andreas, Steiner, Luzius A., Kindler, Christoph, Wolff, Thomas, Mujagic, Edin, Guerke, Lorenz, Mueller, Christian, and Incidence and Outcome of Perioperative Myocardial Injury After Non-cardiac Surgery (BASEL-PMI) Investigators
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STRESS echocardiography , *HEART failure , *ANESTHESIOLOGY , *CORONARY angiography , *COHORT analysis , *CARDIAC patients , *HEART disease diagnosis , *PREVENTION of heart diseases , *HEART disease related mortality , *PREOPERATIVE care , *RESEARCH , *PREDICTIVE tests , *OPERATIVE surgery , *RESEARCH methodology , *MEDICAL cooperation , *EVALUATION research , *MEDICAL protocols , *TREATMENT effectiveness , *RISK assessment , *COMPARATIVE studies , *DECISION making , *CARDIOVASCULAR disease diagnosis , *HEART diseases , *ALGORITHMS - Abstract
Background: European Society of Cardiology/European Society of Anaesthesiology (ESC/ESA) guidelines inform cardiac workup before noncardiac surgery based on an algorithm. Our primary hypotheses were that there would be associations between (i) the groups stratified according to the algorithms and major adverse cardiac events (MACE), and (ii) over- and underuse of cardiac testing and MACE.Methods: This is a secondary analysis of a multicentre prospective cohort. Major adverse cardiac events were a composite of cardiac death, myocardial infarction, acute heart failure, and life-threatening arrhythmia at 30 days. For each cardiac test, pathological findings were defined a priori. We used multivariable logistic regression to measure associations.Results: We registered 359 MACE at 30 days amongst 6976 patients; classification in a higher-risk group using the ESC/ESA algorithm was associated with 30-day MACE; however, discrimination of the ESC/ESA algorithms for 30-day MACE was modest; area under the curve 0.64 (95% confidence interval: 0.61-0.67). After adjustment for sex, age, and ASA physical status, discrimination was 0.72 (0.70-0.75). Overuse or underuse of cardiac tests were not consistently associated with MACE. There was no independent association between test recommendation class and pathological findings (P=0.14 for stress imaging; P=0.35 for transthoracic echocardiography; P=0.52 for coronary angiography).Conclusions: Discrimination for MACE using the ESC/ESA guidelines algorithms was limited. Overuse or underuse of cardiac tests was not consistently associated with cardiovascular events. The recommendation class of preoperative cardiac tests did not influence their yield.Clinical Trial Registration: NCT02573532. [ABSTRACT FROM AUTHOR]- Published
- 2021
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40. Incidence and outcomes of perioperative myocardial infarction/injury diagnosed by high-sensitivity cardiac troponin I.
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Gualandro, Danielle M., Puelacher, Christian, Lurati Buse, Giovanna, Glarner, Noemi, Cardozo, Francisco A., Vogt, Ronja, Hidvegi, Reka, Strunz, Celia, Bolliger, Daniel, Gueckel, Johanna, Yu, Pai C., Liffert, Marcel, Arslani, Ketina, Prepoudis, Alexandra, Calderaro, Daniela, Hammerer-Lercher, Angelika, Lampart, Andreas, Steiner, Luzius A., Schären, Stefan, and Kindler, Christoph
- Abstract
Background: Perioperative myocardial infarction/injury (PMI) diagnosed by high-sensitivity troponin (hs-cTn) T is frequent and a prognostically important complication of non-cardiac surgery. We aimed to evaluate the incidence and outcome of PMI diagnosed using hs-cTnI, and compare it to PMI diagnosed using hs-cTnT. Methods: We prospectively included 2455 patients at high cardiovascular risk undergoing 3111 non-cardiac surgeries, for whom hs-cTnI and hs-cTnT concentrations were measured before surgery and on postoperative days 1 and 2. PMI was defined as a composite of perioperative myocardial infarction (PMI
Infarct ) and perioperative myocardial injury (PMIInjury ), according to the Fourth Universal Definition of Myocardial Infarction. All-cause mortality was the primary endpoint. Results: Using hs-cTnI, the incidence of overall PMI was 9% (95% confidence interval [CI] 8–10%), including PMIInfarct 2.6% (95% CI 2.0–3.2) and PMIInjury 6.1% (95% CI 5.3–6.9%), which was lower versus using hs-cTnT: overall PMI 15% (95% CI 14–16%), PMIInfarct 3.7% (95% CI 3.0–4.4) and PMIInjury 11.3% (95% CI 10.2–12.4%). All-cause mortality occurred in 52 (2%) patients within 30 days and 217 (9%) within 1 year. Using hs-cTnI, both PMIInfarct and PMIInjury were independent predictors of 30-day all-cause mortality (adjusted hazard ratio [aHR] 2.5 [95% CI 1.1–6.0], and aHR 2.8 [95% CI 1.4–5.5], respectively) and, 1-year all-cause mortality (aHR 2.0 [95% CI 1.2–3.3], and aHR 1.8 [95% CI 1.2–2.7], respectively). Overall, the prognostic impact of PMI diagnosed by hs-cTnI was comparable to the prognostic impact of PMI using hs-cTnT. Conclusions: Using hs-cTnI, PMI is less common versus using hs-cTnT. Using hs-cTnI, both PMIInfarct and PMIInjury remain independent predictors of 30-day and 1-year mortality. [ABSTRACT FROM AUTHOR]- Published
- 2021
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41. Perioperative Kardioprotektion – „From bench to bedside“ : Aktuelle experimentelle Evidenz und mögliche Gründe für die limitierte Translation in die klinische Praxis.
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Torregroza, Carolin, Roth, Sebastian, Feige, Katharina, Lurati Buse, Giovanna, Hollmann, Markus W., and Huhn, Ragnar
- Abstract
Copyright of Anaesthesist is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2021
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- View/download PDF
42. Association between self-reported functional capacity and major adverse cardiac events in patients at elevated risk undergoing noncardiac surgery: a prospective diagnostic cohort study.
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Lurati Buse, Giovanna A.L., Puelacher, Christian, Menosi Gualandro, Danielle, Genini, Alessandro S., Hidvegi, Reka, Bolliger, Daniel, Arslani, Ketina, Steiner, Luzius A., Kindler, Christoph, Mueller, Christian, BASEL-PMI Investigators, and Gualandro, Danielle Menosi
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CARDIAC patients , *METABOLIC equivalent , *COHORT analysis , *RISK assessment , *STANDARD deviations , *RESEARCH , *EXERCISE tolerance , *SELF-evaluation , *RESEARCH methodology , *ACTIVITIES of daily living , *SURGICAL complications , *EVALUATION research , *MEDICAL cooperation , *COMPARATIVE studies , *HEART failure , *LONGITUDINAL method - Abstract
Background: Perioperative cardiovascular guidelines endorse functional capacity estimation, based on 'cut-off' daily activities for risk assessment and climbing two flights of stairs to approximate 4 metabolic equivalents. We assessed the association between self-reported functional capacity and postoperative cardiac events.Methods: Consecutive patients at elevated cardiovascular risk undergoing in-patient noncardiac surgery were included in this predefined secondary analysis. Self-reported ability to walk up two flights of stairs was extracted from electronic charts. The primary endpoint was a composite of cardiac death and cardiac events at 30 days. Secondary endpoints included the same composite at 1 yr, all-cause mortality, and myocardial injury.Results: Among the 4560 patients, mean (standard deviation) age 73 (SD 8 yr) yr, classified as American Society of Anesthesiologists physical status ≥3 in 61% (n=2786/4560), the 30-day and 1-yr incidences of major adverse cardiac events were 5.7% (258/4560) and 11.2% (509/4560), respectively. Functional capacity less than two flights of stairs was associated with the 30-day composite endpoint (adjusted hazard ratio 1.63, 95% confidence interval [CI] 1.23-2.15) and all other endpoints. The addition of functional capacity information to the revised cardiac risk index (RCRI) significantly improved risk classification (functional capacity plus RCRI vs RCRI: net reclassification improvement [NRI]Events 6.2 [95% CI 3.6-9.9], NRINonevents19.2 [95% CI 18.1-20.0]).Conclusions: In patients at high cardiovascular risk undergoing noncardiac surgery, self-reported functional capacity less than two flights of stairs was independently associated with major adverse cardiac events and all-cause mortality at 30 days and 1 yr. The addition of self-reported functional capacity to surgical and clinical risk improved risk classification.Clinical Trial Registration: INCT 02573532. [ABSTRACT FROM AUTHOR]- Published
- 2021
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43. Obesity paradox and perioperative myocardial infarction/injury in non-cardiac surgery.
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Hidvegi, Reka, Puelacher, Christian, Gualandro, Danielle M., Lampart, Andreas, Lurati Buse, Giovanna, Hammerer-Lerchner, Angelika, Walter, Joan, Liffert, Marcel, Bolliger, Daniel, Steiner, Luzius, Kindler, Christoph, Espinola, Jaqueline, Strebel, Ivo, Gueckel, Johanna, Marbot, Stella, Arslani, Ketina, Boeddinghaus, Jasper, Nestelberger, Thomas, Zimmermann, Tobias, and Freese, Michael
- Abstract
Background: The impact of obesity on the incidence of perioperative myocardial infarction/injury (PMI) and mortality following non-cardiac surgery is not well understood. Methods: We performed a prospective diagnostic study enrolling consecutive patients undergoing non-cardiac surgery, who were considered at increased cardiovascular risk. All patients were screened for PMI, defined as an absolute increase from preoperative to postoperative sensitive/high-sensitivity cardiac troponin T (hs-cTnT) concentrations. The body mass index (BMI) was classified according to the WHO classification (underweight< 18 kg/m
2 , normal weight 18–24.9 kg/m2 , overweight 25–29.9 kg/m2 , obesity class I 30–34.9 kg/m2 , obesity class II 35–39.9 kg/m2 , obesity class III > 40 kg/m2 ). The incidence of PMI and all-cause mortality at 365 days, both stratified according to BMI. Results: We enrolled 4277 patients who had undergone 5413 surgeries. The median BMI was 26 kg/m2 (interquartile range 23–30 kg/m2 ). Incidence of PMI showed a non-linear relationship with BMI and ranged from 12% (95% CI 9–14%) in obesity class I to 19% (95% CI 17–42%) in the underweight group. This was confirmed in multivariable analysis with obesity class I. showing the lowest risk (adjusted OR 0.64; 95% CI 0.49–0.83) for developing PMI. Mortality at 365 days was lower in all obesity groups compared to patients with normal body weight (e.g., unadjusted OR 0.54 (95% CI 0.39–0.73) and adjusted OR 0.52 (95% CI 0.38–0.71) in obesity class I). Conclusion: Obesity class I was associated with a lower incidence of PMI, and obesity in general was associated with a lower all-cause mortality at 365 days. [ABSTRACT FROM AUTHOR]- Published
- 2020
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44. NT-proBNP or Self-Reported Functional Capacity in Estimating Risk of Cardiovascular Events After Noncardiac Surgery.
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Lurati Buse, Giovanna, Larmann, Jan, Gillmann, Hans-Jörg, Kotfis, Katarzyna, Ganter, Michael T., Bolliger, Daniel, Filipovic, Miodrag, Guzzetti, Luca, Chammartin, Frédérique, Mauermann, Eckhard, Ionescu, Daniela, Szczeklik, Wojciech, De Hert, Stefan, Beck-Schimmer, Beatrice, and Howell, Simon J.
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- 2023
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45. Peri-operative copeptin concentrations and their association with myocardial injury after vascular surgery: A prospective observational cohort study.
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Kamber, Firmin, Mauermann, Eckhard, Seeberger, Esther, Guerke, Lorenz, Mueller, Christian, Bolliger, Daniel, Buse, Giovanna A. L. Lurati, and Lurati Buse, Giovanna A L
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MYOCARDIAL infarction diagnosis ,CARDIOVASCULAR surgery ,COMPARATIVE studies ,LONGITUDINAL method ,RESEARCH methodology ,MEDICAL cooperation ,MYOCARDIAL infarction ,PEPTIDES ,QUESTIONNAIRES ,RESEARCH ,SURGICAL complications ,EVALUATION research ,TROPONIN ,PERIOPERATIVE care - Abstract
Background: Copeptin levels in conjunction with cardiac troponin may be used to rule out early myocardial infarction in patients presenting with chest pain. Raised pre-operative copeptin has been shown to be associated with postoperative cardiac events. However, very little is known about the peri-operative time course of copeptin or the feasibility of very early postoperative copeptin measurement to diagnose or rule-out myocardial injury.Objectives: In this preparatory analysis for a larger trial, we sought to examine the time course of peri-operative copeptin and identify the time at which concentrations returned to pre-operative levels. Second, in an explorative analysis, we sought to examine the association of copeptin in general and at various time points with myocardial injury occurring within the first 48 h.Design: Preparatory analysis of a prospective, observational cohort study.Setting: Single university centre from February to July 2016.Patients: A total of 30 consecutive adults undergoing vascular surgery.Intervention: Serial peri-operative copeptin measurements.Main Outcome Measure: We measured copeptin concentrations before and immediately after surgery (0 h), then at 2, 4, 6 and 8 h after surgery and on the first and second postoperative day. Postoperative concentrations were compared with pre-operative levels with a Wilcoxon signed-rank test. Second, we explored an association between postoperative copeptin concentrations and myocardial injury by the second postoperative day. Myocardial injury was defined as a 5 ng l increase between pre-operative and postoperative high-sensitivity cardiac troponin T with an absolute peak of at least 20 ng l.Results: Immediate postoperative copeptin concentrations (median [interquartile range]) increased nearly eight-fold from pre-operative values (8.5 [3.6 to 13.8] to 64.75 pmol l [29.6 to 258.7]; P < 0.001). Copeptin concentrations remained elevated until returning to baseline on the second postoperative day. Postoperative copeptin was significantly higher in patients experiencing myocardial injury than in those who did not (P = 0.02). The earliest most promising single time point for diagnosis may be immediately after surgery (0 h). The receiver-operating characteristics curve for immediate postoperative copeptin and myocardial injury by the second postoperative day was 0.743 (95% confidence interval 0.560 to 0.926).Conclusion: Copeptin concentrations are greatly increased after vascular surgery and remain so until the 2nd postoperative day. Postoperative copeptin concentrations appear to be higher in patients who go on to exhibit myocardial injury. Immediate postoperative copeptin concentrations show promise for eliminating or identifying those at risk of myocardial injury.Trial Registration: ClinicalTrials.gov identifier: NCT02687776, Mauermann/Lurati Buse. [ABSTRACT FROM AUTHOR]- Published
- 2018
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46. Association of Troponin Trends and Cardiac Morbidity and Mortality After On-Pump Cardiac Surgery.
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Mauermann, Eckhard, Bolliger, Daniel, Fassl, Jens, Grapow, Martin, Seeberger, Esther E., Seeberger, Manfred D., Filipovic, Miodrag, and Lurati Buse, Giovanna A.L.
- Abstract
Background Elevated, single-measure, postoperative troponin is associated with adverse events after cardiac surgery. We hypothesized that increases in troponin from the first to the second postoperative day are also associated with all-cause, 12-month mortality and major adverse cardiac events (MACE). Methods This observational study included consecutive adults undergoing on-pump cardiac surgery with cardiac arrest. Troponin T was measured on the first and second postoperative day and was classified as “increasing” (>10%), “unchanged” (10% to –10%), or “decreasing” (<–10%). The primary endpoint was all-cause, 12-month mortality. Secondary endpoints were all-cause 12-month mortality or MACE and both outcomes at 30 days. The main analysis was by multivariable Cox regression. Results Of 1,417 included patients, 99 (7.0%) died and 162 (11.4%) died or suffered MACE at 12 months. A significant interaction ( p < 0.001) between first postoperative day troponin and the troponin trend from the first to the second postoperative day on 12-month, all-cause mortality precluded an analysis independent of first postoperative day troponin. Consequently, we stratified patients by their first postoperative day troponin (cutoff, 0.8 μg/L). Increasing troponin was associated with higher mortality in patients with first postoperative day troponin T ≥ 0.8 μg/L (hazard ratio, 1.98; 95% CI, 1.09 to 3.59; p = 0.025). Conclusions Troponin changes from the first to the second postoperative day should not be interpreted without consideration of the first postoperative day troponin concentration. For patients with a first postoperative day troponin ≥ 0.8 μg/L, an increase by more than 10% from the first to the second postoperative day was significantly associated with all-cause, 12-month mortality and other adverse events. [ABSTRACT FROM AUTHOR]
- Published
- 2017
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47. Time course of copeptin during a model of experimental pain and hyperalgesia: A randomised volunteer crossover trial.
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Mauermann, Eckhard, Blum, Claudine A., Buse, Giovanna Lurati, Bandschapp, Oliver, Ruppen, Wilhelm, and Lurati Buse, Giovanna
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Background: A reliable biomarker for quantifying pain or hyperalgesia has yet to be found. A surrogate marker of arginine vasopressin, copeptin, is elevated in a number of states of physiological and psychological stress and may have a role in quantifying pain and/or hyperalgesia.Objectives: To evaluate copeptin as a biomarker for pain or hyperalgesia developing after 120 min of sustained electrical stimulation.Design: Secondary analysis of a randomised, double-blinded, crossover trial.Setting: Single, tertiary university hospital from September 2014 to January 2015.Participants: A total of 16 healthy, opioid-naïve white men with no confounding medication or history of pain.Interventions: Copeptin and cortisol were measured five times during an established model of transdermal electrical stimulation designed to assess pain and hyperalgesia.Main Outcome Measures: The primary outcome was the change in copeptin concentration after 120 min of sustained electrical stimulation. Secondary outcomes were copeptin and cortisol concentrations after a subsequent period of rest and analyses of copeptin and cortisol concentrations were made in high-dose and low-dose fentanyl groups separately.Results: Total copeptin concentrations were not significantly elevated after 120 min [9.15 pmol l (interquartile ranges (IQR), 3.45 to 35.45 pmol l); P = 0.150] compared with baseline [6.15 pmol l (IQR, 3.60 to 10.62 pmol l)]. In the high-dose fentanyl group, there was a significant increase in copeptin within individuals [P = 0.001; median, 37.9 pmol l (IQR, 8.1 to 62 pmol l)] after 120 min, and in the low-dose fentanyl group a significant decrease in copeptin concentrations within individuals [P = 0.006; median, 4.7 pmol l (IQR, 3.13 to 9.35 pmol l)]. No correlation between copeptin concentration and either the area under the pain curve or area under the hyperalgesia curve could be found, indicating that the observed differences may be due to other fentanyl-mediated effects.Conclusion: Copeptin concentrations do not appear to be associated directly with pain and hyperalgesia. Instead, some fentanyl-mediated effect or effects appear to have greatly increased copeptin concentrations from baseline to 120 min.Trial Registration: Clinicaltrials.gov identifier: NCT02252458. [ABSTRACT FROM AUTHOR]- Published
- 2017
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48. Significance of new Q waves and their location in postoperative ECGs after elective on-pump cardiac surgery: An observational cohort study.
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Mauermann, Eckhard, Bolliger, Daniel, Fassl, Jens, Grapow, Martin, Seeberger, Esther E., Seeberger, Manfred D., Filipovic, Miodrag, Buse, Giovanna A. L. Lurati, Buse, Giovanna A L L, and Lurati Buse, Giovanna A L
- Abstract
Background: The clinical significance of new pathological Q waves after on-pump cardiac surgery is uncertain.Objectives: To determine whether or not either the occurrence per se or the location of new pathological Q waves after on-pump cardiac surgery is associated with 12-month, all-cause mortality and/or major adverse cardiac events (MACEs).Design: Observational cohort study.Setting: Single university hospital from January 2007 to October 2010.Patients: Consecutive adult patients undergoing elective on-pump cardiac surgery with MACE-free survival until at least the 7th postoperative day and available ECGs both preoperatively and on the 7th postoperative day (n = 1464). We conducted a subgroup analysis in patients undergoing isolated coronary artery bypass grafting (n = 740).Main Outcome Measure: Our primary endpoint was 12-month, all-cause mortality and/or MACE, defined as acute coronary syndrome, cardiac arrest, congestive heart failure or re-vascularisation at 12 months. Using logistic regression, we examined the prognostic value of new pathological Q waves according to the Minnesota ECG Code, adjusting for the EuroSCORE II, cardiopulmonary bypass time and peak postoperative troponin T concentrations.Results: We included 1464 patients (74% men; mean ± SD age 66 ± 10 years) and observed 103 (7.0%) all-cause deaths and/or MACEs at 12 months. A total of 236 patients (16.1%) had definite or probable new pathological Q waves according to the Minnesota ECG Code. The occurrence of new pathological Q waves per se was not associated with our primary endpoint [adjusted odds ratio, 0.970 (95% confidence interval, 0.540 to 1.648)]. However, the occurrence of a new pathological Q wave in V1 to V5 (anterior) was a strong independent predictor for poor outcome [adjusted odds ratio, 3.461 (95% confidence interval, 1.501 to 7.242)].Conclusion: The current analysis suggests that for patients undergoing elective on-pump cardiac surgery, only new pathological Q waves in V1 to V5 (anterior) in the 7th postoperative day ECG are associated with 12-month, all-cause mortality and/or MACE.Trial Registration: Clinicaltrials.gov identifier: NCT00468598. [ABSTRACT FROM AUTHOR]- Published
- 2017
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49. Reduced aspirin responsiveness as assessed by impedance aggregometry is not associated with adverse outcome after cardiac surgery in a small low-risk cohort.
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Bolliger, Daniel, Filipovic, Miodrag, Matt, Peter, Tanaka, Kenichi A., Gregor, Michael, Zenklusen, Urs, Seeberger, Manfred D., and Lurati Buse, Giovanna
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ASPIRIN ,NONSTEROIDAL anti-inflammatory agents ,CARDIAC surgery ,UNCERTAINTY ,REASONING - Abstract
Reduced aspirin responsiveness (i.e. persistent high platelet reactivity in platelet function testing) might be associated with increased risk of myocardial ischemia and cardiac mortality in patients with coronary disease. However, the impact in patients undergoing coronary artery bypass grafting (CABG) is unclear. The aim of this prospective cohort study was to evaluate the predictive value of reduced aspirin responsiveness on cardiac and thromboembolic events in patients undergoing elective isolated CABG surgery with aspirin intake until at least two days before surgery. We included 304 patients in this prospective single-center cohort study. Impedance platelet aggregometry (Multiplate®) was performed directly before and on the first day after surgery. Reduced aspirin responsiveness was defined as area under the curve in ASPItest (AUCASPI) ≥300 U. The primary outcome was a composite of all-cause mortality and/or major adverse cardiac or thromboembolic events within 1 year. Reduced aspirin responsiveness was found in 13 and 24% of patients pre and postoperatively, respectively. There was no difference in the outcomes between patients with normal and reduced aspirin responsiveness in the preoperative measurement (log-rank test,p = 0.540). Multivariate analysis including logistic EuroSCORE I and postoperative troponin T levels did not show any association of reduced aspirin responsiveness with adverse outcome (hazard ratio, 0.576; (95% CI 0.128–2.585;p = 0.471). Similarly, postoperative reduced aspirin responsiveness was not associated with adverse events. To conclude, reduced aspirin responsiveness as evaluated by Multiplate® platelet function analyzer was not associated with increased incidence of major adverse cardiac and thromboembolic events and mortality after CABG surgery. [ABSTRACT FROM PUBLISHER]
- Published
- 2016
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50. Predicting the occurrence of major adverse cardiac events within 30 days of a vascular surgery: an empirical comparison of the minimum p value method and ROC curve approach using individual patient data meta-analysis.
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Vanniyasingam, Thuva, Rodseth, Reitze, Lurati Buse, Giovanna, Bolliger, Daniel, Burkhart, Christoph, Cuthbertson, Brian, Gibson, Simon, Mahla, Elisabeth, Leibowitz, David, Biccard, Bruce, and Thabane, Lehana
- Published
- 2016
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