7,604 results on '"Marquardt, A."'
Search Results
2. Pan-cancer profiling of tumor-infiltrating natural killer cells through transcriptional reference mapping
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Netskar, Herman, Pfefferle, Aline, Goodridge, Jodie P., Sohlberg, Ebba, Dufva, Olli, Teichmann, Sarah A., Brownlie, Demi, Michaëlsson, Jakob, Marquardt, Nicole, Clancy, Trevor, Horowitz, Amir, and Malmberg, Karl-Johan
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- 2024
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3. Human factors in model-driven engineering: future research goals and initiatives for MDE
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Liebel, Grischa, Klünder, Jil, Hebig, Regina, Lazik, Christopher, Nunes, Inês, Graßl, Isabella, Steghöfer, Jan-Philipp, Exelmans, Joeri, Oertel, Julian, Marquardt, Kai, Juhnke, Katharina, Schneider, Kurt, Gren, Lucas, Happe, Lucia, Herrmann, Marc, Wyrich, Marvin, Tichy, Matthias, Goulão, Miguel, Wohlrab, Rebekka, Kalantari, Reyhaneh, Heinrich, Robert, Greiner, Sandra, Rukmono, Satrio Adi, Chakraborty, Shalini, Abrahão, Silvia, and Amaral, Vasco
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- 2024
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4. Ultrasound segmentation analysis via distinct and completed anatomical borders
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Duque, Vanessa Gonzalez, Marquardt, Alexandra, Velikova, Yordanka, Lacourpaille, Lilian, Nordez, Antoine, Crouzier, Marion, Lee, Hong Joo, Mateus, Diana, and Navab, Nassir
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- 2024
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5. Preparing to Serve: Sensemaking, Sensegiving, and Diversity Learning in an Alternative Break Program and Connected Honors Course
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Chelsea Redger-Marquardt and Jean A. Patterson
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Atypical in Alternative Break (AB) practice, an intentionally connected course was examined to understand students' perceptions of their semester-long experience. Using qualitative narrative analysis, authors analyze data from 20 AB participants to evaluate student perceptions and experiential outcomes before, during, and after their service trips (one involving the social issue of human environment impact and the other, hunger and homelessness). Pre- and post-trip instruction on the causes and issues related to privilege, oppression, dominant narratives, and potential pitfalls related to immersive service is presented. Reflective blogs are measured against two theoretical frameworks: diversity learning and sensemaking. Results indicate powerful sensemaking when service and learning combine in a synergistic relationship, with students articulating the importance of class learning coupled with informal interactional learning and hands-on experience for gaining knowledge of an issue and understanding for those involved. Authors suggest that AB practitioners/faculty be diligent in preparing students to serve; thoughtful in selecting strong on-trip service experiences and community partners; mindful of the importance of reflection; and dedicated to furthering post-trip learning through sensegiving.
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- 2023
6. A novel particle decomposition scheme to improve parallel performance of fully resolved particulate flow simulations
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Marquardt, J. E., Hafen, N., and Krause, M. J.
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Physics - Fluid Dynamics ,Physics - Computational Physics - Abstract
This study addresses the challenge of simulating realistic particle systems by proposing a novel particle decomposition scheme that improves the parallel performance of surface resolved particle simulations. Realistic particle systems often involve large numbers of particles and complex particle shapes. The resulting need to account for shape factors requires the inclusion of even more particles to obtain statistically meaningful results. However, the computational cost increases with the number of particles, making efficient parallelization crucial. Therefore, the proposed scheme aims to improve the scalability by optimizing the communication and data management between processors. Through hindered settling experiments, the applicability and performance of the novel particle decomposition scheme are thoroughly investigated using the homogenized lattice Boltzmann method. The results show that the proposed method significantly improves the performance, especially in scenarios with a large number of particles, by reducing communication constraints and improving scalability. This research contributes to the advancement of computational methods for efficient study of complex particle systems and provides valuable insights for future developments in this field.
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- 2023
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7. Deterministic or Probabilistic: U.S. Children's Beliefs about Genetic Inheritance
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David Menendez, Andrea Marquardt Donovan, Olympia N. Mathiaparanam, Vienne Seitz, Nour F. Sabbagh, Rebecca E. Klapper, Charles W. Kalish, Karl S. Rosengren, and Martha W. Alibali
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Do children think of genetic inheritance as deterministic or probabilistic? In two novel tasks, children viewed the eye colors of animal parents and judged and selected possible phenotypes of offspring. Across three studies (N = 353, 162 girls, 172 boys, 2 non-binary; 17 did not report gender) with predominantly White U.S. participants collected in 2019-2021, 4- to 12-year-old children showed a probabilistic understanding of genetic inheritance, and they accepted and expected variability in the genetic inheritance of eye color. Children did not show a mother bias but they did show two novel biases: perceptual similarity and sex-matching. These results held for unfamiliar animals and several physical traits (e.g., eye color, ear size, and fin type), and persisted after a lesson.
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- 2024
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8. Mindsets of Experienced Action Learning Coaches and Their Impact on the Practice of Coaching Action Learning Groups
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Michael Marquardt
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Team coaching has become more utilized in organizations as they realize the importance of developing highly effective teams. There has been some research done on the skills needed by those who coach teams. However, very little has been done on the mindset needed for effectively coaching teams, and no research on the mindset for coaching action learning teams. This qualitative research is the study of 19 highly experienced master action learning coaches who have been certified by the World Institute for Action Learning (WIAL) and have over 500 h of action learning coaching experiences over a 10-year-plus time period. The Master Action Learning Coaches (MALCs) were asked to: (a) confirm if the 5 key mindsets identified by the researcher for coaching action learning teams were valid and (b) provide examples and questions that accrued from incorporating these mindsets in their coaching of action learning teams. The MALCs concurred on the 5 mindsets, and also provided a rich array of examples of how these mindsets affected their coaching. Two additional mindsets were offered as well. Implications for research and as well as the practice of action learning coaching are presented.
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- 2024
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9. Time-of-day effects of cancer drugs revealed by high-throughput deep phenotyping
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Carolin Ector, Christoph Schmal, Jeff Didier, Sébastien De Landtsheer, Anna-Marie Finger, Francesca Müller-Marquardt, Johannes H. Schulte, Thomas Sauter, Ulrich Keilholz, Hanspeter Herzel, Achim Kramer, and Adrián E. Granada
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Science - Abstract
Abstract The circadian clock, a fundamental biological regulator, governs essential cellular processes in health and disease. Circadian-based therapeutic strategies are increasingly gaining recognition as promising avenues. Aligning drug administration with the circadian rhythm can enhance treatment efficacy and minimize side effects. Yet, uncovering the optimal treatment timings remains challenging, limiting their widespread adoption. In this work, we introduce a high-throughput approach integrating live-imaging and data analysis techniques to deep-phenotype cancer cell models, evaluating their circadian rhythms, growth, and drug responses. We devise a streamlined process for profiling drug sensitivities across different times of the day, identifying optimal treatment windows and responsive cell types and drug combinations. Finally, we implement multiple computational tools to uncover cellular and genetic factors shaping time-of-day drug sensitivity. Our versatile approach is adaptable to various biological models, facilitating its broad application and relevance. Ultimately, this research leverages circadian rhythms to optimize anti-cancer drug treatments, promising improved outcomes and transformative treatment strategies.
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- 2024
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10. Microstructural investigation of Au ion-irradiated Eu-doped LaPO4 ceramics and single crystals
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Sara E. Gilson, Volodymyr Svitlyk, Andrey A. Bukaemskiy, Jonas Niessen, Theresa Lender, Gabriel L. Murphy, Maximilian Henkes, Holger Lippold, Julien Marquardt, Shavkat Akhmadaliev, Christoph Hennig, Bjoern Winkler, Thorsten Tonnesen, Lars Peters, Cornelius Fischer, and Nina Huittinen
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Materials of engineering and construction. Mechanics of materials ,TA401-492 - Abstract
Abstract Ceramics and single crystals of LaPO4 monazite doped with Eu(III) were irradiated with 14 MeV Au5+ ions at three different fluences. Changes to crystallinity, local coordination environments, and topography were probed using grazing-incidence X-ray diffraction (GIXRD), vertical scanning interferometry (VSI), scanning electron microscopy (SEM), Raman, and luminescence spectroscopy. GIXRD data of the ceramics revealed fluence dependent amorphization. A similar level of amorphization was detected for samples irradiated with 5 × 1013 ions/cm2 and 1 × 1014 ions/cm2, whereas the sample irradiated with the highest fluence of 1 × 1015 ions/cm2 appeared slightly less amorphous. VSI showed clear swelling of entire grains at the highest ion fluence, while more localized damage to grain boundaries was detected for ceramic samples irradiated at the lowest fluence. Single crystal specimens showed no pronounced topography changes following irradiation. SEM images of the ceramic irradiated at the highest fluence showed topological features indicative of grain surface melting. Raman and luminescence data showed a different degree of disorder in polycrystalline vs. single crystal samples. While changes to PO4 vibrational modes were observed in the ceramics, changes were more subtle or not present in the single crystals. The opposite was observed when probing the local Ln-O environment using Eu(III) luminescence, where the larger changes in terms of an elongation of the Eu-O (or La-O) bond and an increasing relative disorder with increasing fluence were observed only for the single crystals. The dissimilar trends observed in irradiated single crystals and ceramics indicate that grain boundary chemistry likely plays a significant role in the radiation response.
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- 2024
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11. Sociodemographic influences on private and professional contact behaviour during the COVID-19 pandemic in Germany: cross-sectional analysis based on a Regional Blood Donor Cohort
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Robert Pohl, Christoph Stallmann, Pauline Marquardt, Ute Bank, Jacqueline Färber, Lotte Scheibler, Hans-Gert Heuft, Achim J. Kaasch, and Christian Apfelbacher
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COVID-19 ,Contact reduction ,Blood donors ,SeMaCo study ,Medicine ,Biology (General) ,QH301-705.5 ,Science (General) ,Q1-390 - Abstract
Abstract Objective The COVID-19 pandemic has had significant health and socioeconomic impacts worldwide. Extensive measures, including contact restrictions, were implemented to control the spread of the virus. This study aims to examine the factors that influenced private and professional contact behaviour during the COVID-19 pandemic. Results We used baseline data (January–April 2021) from the SeMaCo study (Serologische Untersuchungen bei Blutspendern des Großraums Magdeburg auf Antikörper gegen SARS-CoV-2), a longitudinal, regional cohort study assessing COVID-19 seroprevalence in blood donors from Magdeburg and surrounding areas in Germany. In the blood donor cohort (n = 2,195), there was a general reduction in private contacts (by 78.9%) and professional contacts (by 54.4%) after March 18, 2020. Individuals with higher education reduced both private (by 84.1%) and professional (by 70.1%) contacts more than those with lower education levels (private contacts 59.5%; professional contacts 37%). Younger age groups (18–30 years) reduced private contacts more frequently (by 85.4%) than older individuals (61–83 years, by 68.6%) and demonstrated a higher likelihood of private contact reduction compared to older age groups (51–60 years: odds ratio (OR) 0.45 [95% [CI] 0.32–0.65]; 61–83 years: OR 0.33 [95% [CI] 0.22–0.48]).
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- 2024
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12. Biology and ecology of Zercon hamaricus Kaczmarek et al. 2021 (Parasitiformes: Zerconidae) with morphological study of all instars
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T. Marquardt, S. Kaczmarek, A. Seniczak, and M. Chudaś
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Mites ,Mesostigmata ,ontogeny ,ecological parameters scanning electron microscopy ,Zoology ,QL1-991 - Abstract
We provide data on the biology of Zercon hamaricus Kaczmarek et al. 2021 with regard to duration of egg and juvenile stages, analysis of change of body size during ontogeny, population parameters and morphological analysis of egg and all postembryonic stages using scanning electron microscopy. We confirmed the effectiveness of using hexamethyldisilazane in drying of Z. hamaricus individuals for SEM (Scanning Electron Microscopy) analysis. The overall egg duration was 3.7 ± 1.8 days on average. Duration of postembryonic stages ranged from 4.1 to 4.9 days and was the longest in deutonymphs. Change in length was statistically insignificant in larvae and significant in nymphs. At the species’ type locality juveniles (protonymphs) predominated, females were more abundant than males and juveniles were more abundant than adults. The exochorion of eggs of Z. hamaricus consists of dense areola with long processes and a fine polygonal pattern. We report on the presence and arrangement of metapodal plates in protonymphs and deutonymphs, and illustrate the post-coxal cuticular spines in adults. The influence of preparation method on the shape of the peritreme, position of seta r1 and shield and body size are discussed.
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- 2024
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13. Neurological outcome in long‐chain hydroxy fatty acid oxidation disorders
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Ulrike Mütze, Alina Ottenberger, Florian Gleich, Esther M. Maier, Martin Lindner, Ralf A. Husain, Katja Palm, Skadi Beblo, Peter Freisinger, René Santer, Eva Thimm, Stephan vom Dahl, Natalie Weinhold, Karina Grohmann‐Held, Claudia Haase, Julia B. Hennermann, Alexandra Hörbe‐Blindt, Clemens Kamrath, Iris Marquardt, Thorsten Marquardt, Robert Behne, Dorothea Haas, Ute Spiekerkoetter, Georg F. Hoffmann, Sven F. Garbade, Sarah C. Grünert, and Stefan Kölker
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Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Abstract Objective This study aims to elucidate the long‐term benefit of newborn screening (NBS) for individuals with long‐chain 3‐hydroxy‐acyl‐CoA dehydrogenase (LCHAD) and mitochondrial trifunctional protein (MTP) deficiency, inherited metabolic diseases included in NBS programs worldwide. Methods German national multicenter study of individuals with confirmed LCHAD/MTP deficiency identified by NBS between 1999 and 2020 or selective metabolic screening. Analyses focused on NBS results, confirmatory diagnostics, and long‐term clinical outcomes. Results Sixty‐seven individuals with LCHAD/MTP deficiency were included in the study, thereof 54 identified by NBS. All screened individuals with LCHAD deficiency survived, but four with MTP deficiency (14.8%) died during the study period. Despite NBS and early treatment neonatal decompensations (28%), symptomatic disease course (94%), later metabolic decompensations (80%), cardiomyopathy (28%), myopathy (82%), hepatopathy (32%), retinopathy (17%), and/or neuropathy (22%) occurred. Hospitalization rates were high (up to a mean of 2.4 times/year). Disease courses in screened individuals with LCHAD and MTP deficiency were similar except for neuropathy, occurring earlier in individuals with MTP deficiency (median 3.9 vs. 11.4 years; p = 0.0447). Achievement of dietary goals decreased with age, from 75% in the first year of life to 12% at age 10, and consensus group recommendations on dietary management were often not achieved. Interpretation While NBS and early treatment result in improved (neonatal) survival, they cannot reliably prevent long‐term morbidity in screened individuals with LCHAD/MTP deficiency, highlighting the urgent need of better therapeutic strategies and the development of disease course‐altering treatment.
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- 2024
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14. Some Must Watch While Some Must Sleep : An Impromptu Text Thread
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Marquardt, Tanya and Stephenson, Jenn
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- 2024
15. The Politics of Youth Representation at Climate Change Conferences: Who Speaks, Who Is Spoken of, and Who Listens?
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Marquardt, Jens, Lövbrand, Eva, and Buhre, Frida
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- 2024
16. A Cautionary Tale for Polycentric Climate Governance: Sweden’s Roles in Orchestrating Decarbonization
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Widerberg, Oscar, Bäckstrand, Karin, Lövbrand, Eva, Marquardt, Jens, and Nasiritousi, Naghmeh
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- 2024
17. Time-of-day effects of cancer drugs revealed by high-throughput deep phenotyping
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Ector, Carolin, Schmal, Christoph, Didier, Jeff, De Landtsheer, Sébastien, Finger, Anna-Marie, Müller-Marquardt, Francesca, Schulte, Johannes H., Sauter, Thomas, Keilholz, Ulrich, Herzel, Hanspeter, Kramer, Achim, and Granada, Adrián E.
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- 2024
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18. Microstructural investigation of Au ion-irradiated Eu-doped LaPO4 ceramics and single crystals
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Gilson, Sara E., Svitlyk, Volodymyr, Bukaemskiy, Andrey A., Niessen, Jonas, Lender, Theresa, Murphy, Gabriel L., Henkes, Maximilian, Lippold, Holger, Marquardt, Julien, Akhmadaliev, Shavkat, Hennig, Christoph, Winkler, Bjoern, Tonnesen, Thorsten, Peters, Lars, Fischer, Cornelius, and Huittinen, Nina
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- 2024
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19. Intraoperative pelvic neuromonitoring based on bioimpedance signals: a new method analyzed on 30 patients
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Kalev, Georgi, Schuler, Ramona, Langer, Andreas, Goos, Matthias, Konschake, Marko, Schiedeck, Thomas, and Marquardt, Christoph
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- 2024
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20. Exploring CT pixel and voxel size effect on anatomic modeling in mandibular reconstruction
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Ahmed, Maariyah, Garzanich, Myra, Melaragno, Luigi E., Nyirjesy, Sarah, Windheim, Natalia Von, Marquardt, Matthew, Luttrull, Michael, Quails, Nathan, and VanKoevering, Kyle K.
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- 2024
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21. Understanding referral of patients with cancer in rural Ethiopia: a qualitative study
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Trabitzsch, Josephin, Marquardt, Morena, Negash, Sarah, Belay, Winini, Abebe, Yonas, Seife, Edom, Abdella, Kunuz, Gizaw, Muluken, Getachew, Sefonias, Addissie, Adamu, Kantelhardt, Eva Johanna, and Wondimagegnehu, Abigiya
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- 2024
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22. Turnover intention of foreign trained physicians in German rehabilitation facilities—a quantitative study
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Jansen, Eva, Schmidt, Johanna, and Marquardt, Manuela
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- 2024
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23. Overcoming resolution attenuation during tilted cryo-EM data collection
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Aiyer, Sriram, Baldwin, Philip R., Tan, Shi Min, Shan, Zelin, Oh, Juntaek, Mehrani, Atousa, Bowman, Marianne E., Louie, Gordon, Passos, Dario Oliveira, Đorđević-Marquardt, Selena, Mietzsch, Mario, Hull, Joshua A., Hoshika, Shuichi, Barad, Benjamin A., Grotjahn, Danielle A., McKenna, Robert, Agbandje-McKenna, Mavis, Benner, Steven A., Noel, Joseph A. P., Wang, Dong, Tan, Yong Zi, and Lyumkis, Dmitry
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- 2024
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24. Automatic muscle impedance and nerve analyzer (AMINA) as a novel approach for classifying bioimpedance signals in intraoperative pelvic neuromonitoring
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Schuler, Ramona, Langer, Andreas, Marquardt, Christoph, Kalev, Georgi, Meisinger, Maximilian, Bandura, Julia, Schiedeck, Thomas, Goos, Matthias, Vette, Albert, and Konschake, Marko
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- 2024
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25. Distinguishing the impact of distinct obstructive sleep apnea syndrome (OSAS) and obesity related factors on human monocyte subsets
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Pries, Ralph, Kosyna, Friederike Katharina, Depping, Reinhard, Plötze-Martin, Kirstin, Lange, Christian, Meyhöfer, Svenja, Meyhöfer, Sebastian M., Marquardt, Jens U., Bruchhage, Karl-Ludwig, and Steffen, Armin
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- 2024
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26. Development of Smart Jute Composite with a Thermochromic Agent
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Hiller, Ana Paula, Marquardt, André Luiz, Bierhalz, Andrea Cristiane Krause, and Steffens, Fernanda
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- 2024
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27. Exploring CT pixel and voxel size effect on anatomic modeling in mandibular reconstruction
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Maariyah Ahmed, Myra Garzanich, Luigi E. Melaragno, Sarah Nyirjesy, Natalia Von Windheim, Matthew Marquardt, Michael Luttrull, Nathan Quails, and Kyle K. VanKoevering
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Anatomic modeling ,CT scan resolution ,Head and neck surgery ,Mandibular reconstruction ,Pixel size ,Slice thickness ,Medical physics. Medical radiology. Nuclear medicine ,R895-920 - Abstract
Abstract Background Computer-aided modeling and design (CAM/CAD) of patient anatomy from computed tomography (CT) imaging and 3D printing technology enable the creation of tangible, patient-specific anatomic models that can be used for surgical guidance. These models have been associated with better patient outcomes; however, a lack of CT imaging guidelines risks the capture of unsuitable imaging for patient-specific modeling. This study aims to investigate how CT image pixel size (X-Y) and slice thickness (Z) impact the accuracy of mandibular models. Methods Six cadaver heads were CT scanned at varying slice thicknesses and pixel sizes and turned into CAD models of the mandible for each scan. The cadaveric mandibles were then dissected and surface scanned, producing a CAD model of the true anatomy to be used as the gold standard for digital comparison. The root mean square (RMS) value of these comparisons, and the percentage of points that deviated from the true cadaveric anatomy by over 2.00 mm were used to evaluate accuracy. Two-way ANOVA and Tukey-Kramer post-hoc tests were used to determine significant differences in accuracy. Results Two-way ANOVA demonstrated significant difference in RMS for slice thickness but not pixel size while post-hoc testing showed a significant difference in pixel size only between pixels of 0.32 mm and 1.32 mm. For slice thickness, post-hoc testing revealed significantly smaller RMS values for scans with slice thicknesses of 0.67 mm, 1.25 mm, and 3.00 mm compared to those with a slice thickness of 5.00 mm. No significant differences were found between 0.67 mm, 1.25 mm, and 3.00 mm slice thicknesses. Results for the percentage of points deviating from cadaveric anatomy greater than 2.00 mm agreed with those for RMS except when comparing pixel sizes of 0.75 mm and 0.818 mm against 1.32 mm in post-hoc testing, which showed a significant difference as well. Conclusion This study suggests that slice thickness has a more significant impact on 3D model accuracy than pixel size, providing objective validation for guidelines favoring rigorous standards for slice thickness while recommending isotropic voxels. Additionally, our results indicate that CT scans up to 3.00 mm in slice thickness may provide an adequate 3D model for facial bony anatomy, such as the mandible, depending on the clinical indication.
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- 2024
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28. Understanding referral of patients with cancer in rural Ethiopia: a qualitative study
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Josephin Trabitzsch, Morena Marquardt, Sarah Negash, Winini Belay, Yonas Abebe, Edom Seife, Kunuz Abdella, Muluken Gizaw, Sefonias Getachew, Adamu Addissie, Eva Johanna Kantelhardt, and Abigiya Wondimagegnehu
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Cancer ,Healthcare system ,Sub-Saharan Africa ,Patient pathways ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Background Cancer incidence is increasing in Ethiopia mainly due to increased life expectancy, while oncological capacities remain limited. Strong referral linkages between different levels of the healthcare system are key to provide timely access to cancer care. In this qualitative study, we assessed limitations and potential of cancer patient referral in the rural Southwest of Ethiopia. Methods We held four focus group discussions (FGD) with health professionals at one primary and three secondary hospitals and conducted eight in-depth interviews (IDI) with the hospitals´ medical executives and local health bureau representatives. Data was analysed inductively using thematic analysis and emerging themes were categorized within the revised concept of access by Penchansky and Saurman. Results The inevitable referral of patients with cancer in the rural Southwest of Ethiopia is characterized by the absence of clear communication protocols and the lack of formal referral linkages. The newly implemented hub-system has improved emergency referrals and could be expanded to non-emergency referrals, sensitive to the needs of advanced oncological care. Liaison officers can pave the way but need to be trained and equipped adequately. Referred patients struggle with inadequate transportation systems, the lack of accommodation close to specialized facilities as well as the inability to navigate at those sites due to language barriers, illiteracy, and stigmatization. Few Non-Governmental Organizations (NGOs) help but cannot compensate the limited governmental support. The shortage of medications at public hospitals leads to patients being directed to costly private pharmacies. In the light of those challenges, cancer remains to be perceived as a “death sentence” within the rural communities. Conclusions Standardized referral linkages and a multi-faceted support network throughout the cancer care continuum are necessary to make oncology care accessible to Ethiopia´s large rural population.
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- 2024
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29. Lessons Learned from Cross-Systems Approach to COVID-19 Pandemic Response in Juvenile Justice System, Colorado, USA
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Ashley M. Tunstall, Shannon C. O’Brien, Deborah M. Monaghan, Alexis Burakoff, and Renée K. Marquardt
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juvenile justice system ,COVID-19 ,respiratory infections ,severe acute respiratory syndrome coronavirus 2 ,SARS-CoV-2 ,SARS ,Medicine ,Infectious and parasitic diseases ,RC109-216 - Abstract
The global COVID-19 pandemic illustrates the importance of a close partnership between public health and juvenile justice systems when responding to communicable diseases. Many setting-specific obstacles must be navigated to respond effectively to limit disease transmission and negative health outcomes while maintaining necessary services for youth in confinement facilities. The response requires multidisciplinary expertise and collaboration to address unique considerations. Public health mitigation strategies must balance the risk for disease against the negative effects of restrictions. Key aspects of the COVID-19 response in the juvenile justice system of Colorado, USA, involved establishing robust communication and data reporting infrastructures, building a multidisciplinary response team, adapting existing infection prevention guidelines, and focusing on a whole-person health approach to infection prevention. We examine lessons learned and offer recommendations on pandemic emergency response planning and managing a statewide public health emergency in youth confinement settings that ensure ongoing readiness.
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- 2024
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30. Realizing a deep reinforcement learning agent discovering real-time feedback control strategies for a quantum system
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Reuer, Kevin, Landgraf, Jonas, Fösel, Thomas, O'Sullivan, James, Beltrán, Liberto, Akin, Abdulkadir, Norris, Graham J., Remm, Ants, Kerschbaum, Michael, Besse, Jean-Claude, Marquardt, Florian, Wallraff, Andreas, and Eichler, Christopher
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Quantum Physics - Abstract
To realize the full potential of quantum technologies, finding good strategies to control quantum information processing devices in real time becomes increasingly important. Usually these strategies require a precise understanding of the device itself, which is generally not available. Model-free reinforcement learning circumvents this need by discovering control strategies from scratch without relying on an accurate description of the quantum system. Furthermore, important tasks like state preparation, gate teleportation and error correction need feedback at time scales much shorter than the coherence time, which for superconducting circuits is in the microsecond range. Developing and training a deep reinforcement learning agent able to operate in this real-time feedback regime has been an open challenge. Here, we have implemented such an agent in the form of a latency-optimized deep neural network on a field-programmable gate array (FPGA). We demonstrate its use to efficiently initialize a superconducting qubit into a target state. To train the agent, we use model-free reinforcement learning that is based solely on measurement data. We study the agent's performance for strong and weak measurements, and for three-level readout, and compare with simple strategies based on thresholding. This demonstration motivates further research towards adoption of reinforcement learning for real-time feedback control of quantum devices and more generally any physical system requiring learnable low-latency feedback control., Comment: 14 pages, 10 figures
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- 2022
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31. Synthesis of B-site high-entropy BaTi0.2Hf0.2Zr0.2Y0.2Nb0.2O3 with water sensing properties
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Alexandra C. Austin, Amy J. Knorpp, Jon G. Bell, Huw Shiel, Luca Artiglia, Katharina Marquardt, and Michael Stuer
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Entropy-stabilized perovskite ,Spectroscopy ,Water sensor ,Clay industries. Ceramics. Glass ,TP785-869 - Abstract
A barium-based perovskite structured ceramic with five different B-site cations was prepared by a solid-state synthesis method. The phase and chemical homogeneity of the synthesised material was verified using x-ray diffraction and energy dispersive x-ray spectroscopy, showing the successful synthesis of a single-phase perovskite structure with Ba A-site and Ti, Hf, Zr, Y, Nb, B-site cations. Ultra-high vacuum x-ray photoelectron spectroscopy was used to reveal the valence states of the constituent elements. Conventional, two-step and spark plasma sintering were used to form dense pellets with limited grain growth. The room temperature electrical characteristics of the sintered pellets were investigated by electrochemical impedance spectroscopy where a conductivity increase of two orders of magnitude was observed in a water-bearing atmosphere. Synchrotron-based ambient-pressure x-ray photoelectron spectroscopy performed under water-bearing and dry conditions suggest that the conductivity increase is related to the incorporation of hydroxyl groups into the perovskite structure.
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- 2024
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32. Proton pump inhibitor use and risk of hepatic encephalopathy: A multicentre study
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Simon Johannes Gairing, Chiara Mangini, Lisa Zarantonello, Elise Jonasson, Henrike Dobbermann, Philippe Sultanik, Peter Robert Galle, Joachim Labenz, Dominique Thabut, Jens Uwe Marquardt, Patricia P. Bloom, Mette Munk Lauridsen, Sara Montagnese, and Christian Labenz
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Covert hepatic encephalopathy ,Decompensated cirrhosis ,Psychometric hepatic encephalopathy score ,Acid suppression ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Background & Aims: Data on the association between proton pump inhibitor (PPI) use and hepatic encephalopathy (HE) are conflicting, and data from multicentre studies are scarce. The aim of this study was to dissect the potential association between PPI use and minimal (MHE) and overt HE (OHE). Methods: Data from patients with cirrhosis recruited at seven centres across Europe and the US were analysed. MHE was defined by the psychometric hepatic encephalopathy score (PHES). PPI use was recorded on the day of testing with PHES. Patients were followed for OHE development and death/liver transplantation. Results: A total of 1,160 patients with a median MELD of 11 were included (Child-Pugh stages: A 49%/B 39%/C 11%). PPI use was noted in 58% of patients. Median follow-up time was 18.1 months, during which 230 (20%) developed an OHE episode, and 224 (19%) reached the composite endpoint of death/liver transplantation. In multivariable analyses, PPI use was neither associated with the presence of MHE at baseline nor OHE development during follow-up. These findings were consistent in subgroup analyses of patients with Child-Pugh A or B cirrhosis and after excluding patients with a history of OHE. PPI use was also not associated with a higher risk of OHE, neither in patients with an indication for treatment nor in patients without an indication. Conclusions: PPI use is not associated with a higher risk of HE in patients with cirrhosis. Based on these findings, at present, a prescription should not be prohibited in case of a generally accepted indication. Impact and implications: Data on the association between proton pump inhibitor (PPI) use and hepatic encephalopathy (HE) are conflicting. In this study, PPI use was not associated with a higher risk of minimal HE at baseline or overt HE during follow-up in patients with cirrhosis. Based on these findings, prescription of a PPI for a generally accepted indication should not be prohibited in patients with cirrhosis.
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- 2024
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33. The association between unemployment and treatment among adults with hemophilia
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Christian Qvigstad, Lars Q. Sørensen, Geir E. Tjønnfjord, Pål André Holme, Ingrid Pabinger, Cedric Hermans, Roseline d’Oiron, Robert Klamroth, Johannes Oldenburg, Natascha Marquardt, Peter Staritz, Olga Katsarou, Uri Martinowitz, Aharon Lubetsky, Gili Kenet, Annarita Tagliaferri, Maria Elisa Mancuso, Roger Schutgens, Pål André HolmE, Jerzy Windyga, Irena Zupan, Victor Jimenez Yuste, Ramiro Nunez, Philippe de Moerloose, Erik Berntorp, Jan Astermark, Campbell Tait, and Gerry Dolan
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hemophilia A ,hemophilia B ,treatment ,unemployment ,workforce ,Diseases of the blood and blood-forming organs ,RC633-647.5 - Abstract
Background: People with hemophilia often experience pain and suffer from comorbidities related to their bleeding disorder. Consequently, unemployment due to disability is prevalent among people with hemophilia. Objectives: To explore associations between unemployment due to disability and treatment while adjusting for known risk factors for unemployment. Methods: Collecting data from 20 hemophilia centers from 15 European countries, the Age-related DeVelopments ANd ComorbiditiEs in hemophilia study recruited 785 participants aged 40 years and over with hemophilia A or B. A comprehensive electronic case report form included items related to patient characteristics, demographic information, past and current treatment regimens, and medical history, including a lifelong history of comorbidities. Baseline data from the Age-related DeVelopments ANd ComorbiditiEs in hemophilia study was analyzed using descriptive statistics and logistic regression models. Results: Employment status was available for 756 of 785 participants aged 40 to 88 years (median, 53 years). We used regression analysis to compare people with hemophilia who were fully employed with those who were unemployed due to disability. This analysis included 424 participants. Using multivariable logistic regression, we found that age (odds ratio [OR], 1.07; P < .01), severe hemophilia (OR, 10.81; P < .01), current smoker (OR, 2.53; P < .01), and psychiatric disorder (OR, 4.18; P = .02) were associated with increased odds of unemployment due to disability. In contrast, prophylactic treatment (OR, 0.44; P = .01) was associated with decreased odds. Conclusion: Our analysis suggests that by maintaining factor levels above a critical threshold (3%-5%), prophylactic treatment for people with hemophilia could help avoid unemployment due to disability. While prophylaxis is more costly and can be burdensome, the benefits to material well-being and quality of life could be substantial.
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- 2024
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34. Indicators of technostress, their association with burnout and the moderating role of support offers among nurses in German hospitals: a cross-sectional study
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Stefanie Mache, Volker Harth, Tanja Wirth, Jessica Kräft, and Berit Marquardt
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Medicine - Abstract
Objectives To examine the level of indicators of technostress among nurses with and without a leadership position, the relationship between indicators of technostress and burnout and the moderating role of support offered by employers. The availability of support offers and further needs of nurses were also explored.Design Cross-sectional online survey.Setting Acute care hospitals in Germany.Participants 303 nurses (73.3% female) who have worked at the hospital for at least 1 year and a minimum of 10 hours per week.Primary and secondary outcome measures Indicators of technostress (complexity, overload, usefulness, lack of technical support and unreliability) served as predictors in multiple linear regression analyses to examine their association with the primary outcome burnout. Support of employers was included as a moderator variable. Validated subscales from the Digital Stressors Scale and Copenhagen Burnout Inventory as well as open-ended questions were applied.Results There were no differences in the level of indicators of technostress found between nurses with and without a leadership position. Techno-overload (β=0.259, p=0.004) and techno-complexity (β=0.161, p=0.043) were significantly associated with burnout. Support by the employer moderated the relationship between lack of technical support and burnout significantly (R² change=0.026, F(1,292)=7.41, p=0.007). Support offers such as training, IT service and contact persons on the ward helped nurses to be more confident in the use of information and communication technologies. However, they expressed further needs with regard to these and new offers.Conclusions There was an association between two indicators of technostress and burnout. Therefore, particular attention should be paid to supporting nurses in terms of techno-overload and techno-complexity. Furthermore, there is still a need for customised support and further offers from employers in the use of digital technologies.
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- 2024
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35. Tumour-specific activation of a tumour-blood transport improves the diagnostic accuracy of blood tumour markers in miceResearch in context
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Christian Schmithals, Bianca Kakoschky, Dominic Denk, Maike von Harten, Jan Henrik Klug, Edith Hintermann, Anne Dropmann, Eman Hamza, Anne Claire Jacomin, Jens U. Marquardt, Stefan Zeuzem, Peter Schirmacher, Eva Herrmann, Urs Christen, Thomas J. Vogl, Oliver Waidmann, Steven Dooley, Fabian Finkelmeier, and Albrecht Piiper
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HCC ,Tumour marker ,α fetoprotein ,iRGD ,CEND-1 ,Early cancer detection ,Medicine ,Medicine (General) ,R5-920 - Abstract
Summary: Background: The accuracy of blood-based early tumour recognition is compromised by signal production at non-tumoral sites, low amount of signal produced by small tumours, and variable tumour production. Here we examined whether tumour-specific enhancement of vascular permeability by the particular tumour homing peptide, iRGD, which carries dual function of binding to integrin receptors overexpressed in the tumour vasculature and is known to promote extravasation via neuropilin-1 receptor upon site-specific cleavage, might be useful to improve blood-based tumour detection by inducing a yet unrecognised vice versa tumour-to-blood transport. Methods: To detect an iRGD-induced tumour-to-blood transport, we examined the effect of intravenously injected iRGD on blood levels of α-fetoprotein (AFP) and autotaxin in several mouse models of hepatocellular carcinoma (HCC) or in mice with chronic liver injury without HCC, and on prostate-specific antigen (PSA) levels in mice with prostate cancer. Findings: Intravenously injected iRGD rapidly and robustly elevated the blood levels of AFP in several mouse models of HCC, but not in mice with chronic liver injury. The effect was primarily seen in mice with small tumours and normal basal blood AFP levels, was attenuated by an anti-neuropilin-1 antibody, and depended on the concentration gradient between tumour and blood. iRGD treatment was also able to increase blood levels of autotaxin in HCC mice, and of PSA in mice with prostate cancer. Interpretation: We conclude that iRGD induces a tumour-to-blood transport in a tumour-specific fashion that has potential of improving diagnosis of early stage cancer. Funding: Deutsche Krebshilfe, DKTK, LOEWE-Frankfurt Cancer Institute.
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- 2024
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36. Clinical Manifestations and Genomic Evaluation of Melioidosis Outbreak among Children after Sporting Event, Australia
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Smith, Simon, Marquardt, Tonia, Jennison, Amy V., D'Addona, Andrew, Stewart, James, Yarwood, Trent, Ho, Jennifer, Binotto, Enzo, Harris, Julian, Fahmy, Mark, Esmonde, Juliet, Richardson, Megan, Graham, Rikki M.A., Gair, Richard, Ariotti, Lawrence, Preston-Thomas, Annie, Rubenach, Sally, OSullivan, Siobhan, Allen, Darren, Ragh, Thomas, Grayson, Sachjuan, Manoy, Sophie, Warner, Jeffery M., Meumann, Ella M., Robson, Jennifer M., and Hanson, Josh
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Communicable diseases -- Complications and side effects -- Care and treatment ,Pseudomonas infections -- Care and treatment -- Complications and side effects ,Health - Abstract
Melioidosis, caused by the environmental gramnegative bacterium Burkholderia pseudomallei, is endemic in northern Australia (1). The most common clinical manifestation of the infection is pneumonia, with or without bacteremia, but [...]
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- 2023
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37. Primary hypothyroidism due to thyroid carcinoma in a feline /Hipotireoidismo primario devido a carcinoma de tireoide em um felino
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de Andrade Brum, Isabela, Mario, Fabiana Goes, Lucio, Bruna Marquardt, Mariga, Carollina, do Amaral, Anne Santos, and Filho, Saulo Tadeu Lemos Pinto
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- 2023
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38. Extreme thermodynamics in nanolitre volumes through stimulated Brillouin–Mandelstam scattering
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Geilen, Andreas, Popp, Alexandra, Das, Debayan, Junaid, Saher, Poulton, Christopher G., Chemnitz, Mario, Marquardt, Christoph, Schmidt, Markus A., and Stiller, Birgit
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- 2023
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39. Sink Strength During Sugarcane Culm Growth: Size Matters
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Botha, Frederik C., Scalia, Gerard, Marquardt, Annelie, and Wathen-Dunn, Kate
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- 2023
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40. Racial disparities in readmission rates following surgical treatment of pediatric developmental dysplasia of the hip
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Tarawneh, Omar H., Quan, Theodore, Liu, Ivan Z., Pizzarro, Jordan, Marquardt, Caillin, and Tabaie, Sean A.
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- 2023
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41. Grazing-incidence synchrotron radiation diffraction studies on irradiated Ce-doped and pristine Y-stabilized ZrO2 at the Rossendorf beamline
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Volodymyr Svitlyk, Luiza Braga Ferreira dos Santos, Jonas Niessen, Sara Gilson, Julien Marquardt, Stefan Findeisen, Selina Richter, Shavkat Akhmadaliev, Nina Huittinen, and Christoph Hennig
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yttria-stabilized zirconia ,irradiation ,synchrotron radiation ,grazing incidence diffraction ,microstrain ,Nuclear and particle physics. Atomic energy. Radioactivity ,QC770-798 ,Crystallography ,QD901-999 - Abstract
In this work, Ce-doped yttria-stabilized zirconia (YSZ) and pure YSZ phases were subjected to irradiation with 14 MeV Au ions. Irradiation studies were performed to simulate long-term structural and microstructural damage due to self-irradiation in YSZ phases hosting alpha-active radioactive species. It was found that both the Ce-doped YSZ and the YSZ phases had a reasonable tolerance to irradiation at high ion fluences and the bulk crystallinity was well preserved. Nevertheless, local microstrain increased in all compounds under study after irradiation, with the Ce-doped phases being less affected than pure YSZ. Doping with cerium ions increased the microstructural stability of YSZ phases through a possible reduction in the mobility of oxygen atoms, which limits the formation of structural defects. Doping of YSZ with tetravalent actinide elements is expected to have a similar effect. Thus, YSZ phases are promising for the safe long-term storage of radioactive elements. Using synchrotron radiation diffraction, measurements of the thin irradiated layers of the Ce-YSZ and YSZ samples were performed in grazing incidence (GI) mode. A corresponding module for measurements in GI mode was developed at the Rossendorf Beamline and relevant technical details for sample alignment and data collection are also presented.
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- 2024
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42. Turnover intention of foreign trained physicians in German rehabilitation facilities—a quantitative study
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Eva Jansen, Johanna Schmidt, and Manuela Marquardt
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Retention ,Turnover intention ,Foreign trained Physicians ,Rehabilitation ,Health Workforce ,International Medical graduates ,Public aspects of medicine ,RA1-1270 - Abstract
Abstract Background Germany’s medical specialist shortage is an acute challenge, especially in the rehabilitation segment. One countermeasure is to recruit foreign trained physicians (FTP), but the high turnover of FTP is a burden on the departments that train them and integrate them professionally. Preliminary research showed that currently one in three physician positions in German Pension Insurance (DRV) contract facilities is filled by FTP.This paper examines factors related to turnover intention of FTP in German rehabilitative departments. Methodology In spring 2022, we surveyed FTP across all inpatient and outpatient rehabilitation departments under the German Pension Insurance, using a two-stage cross-sectional approach. We conducted an online survey of FTP and developed a specialized questionnaire that captured sociodemographic, occupation related and professional biographical data, turnover intention, satisfaction, difficulties with professional integration and departmental structural characteristics. To analyze retention within the rehabilitation field, we used a measure of turnover intention, taking into account the direction of potential turnover, residency requirements and considerations of returning to the rehabilitation field. The data was evaluated in a subgroup analysis comparing FTP with and without turnover intention using Fisher’s exact tests. Results The sample includes n = 145 FTP, 119 stating no turnover intention and 27 with turnover intention. More than half of FTP with turnover intention wished to move to an acute care hospital. FTP with turnover intention are comparatively younger and came to Germany and were employed in the rehabilitation departments more recently, indicating an earlier career stage. Besides, career-related and regional factors show the strongest relation to turnover intention. Discussion and conclusion The results reveal a group of “established FTP” whose professional integration has been successfully completed. FTP with turnover intention are comparatively younger, career-oriented physicians for whom work in a rehabilitative facility is a career springboard to gain a foothold in acute care clinics. A limitation is that FTP with turnover intention are difficult to reach and may be underrepresented in our sample.
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- 2024
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43. Distinguishing the impact of distinct obstructive sleep apnea syndrome (OSAS) and obesity related factors on human monocyte subsets
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Ralph Pries, Friederike Katharina Kosyna, Reinhard Depping, Kirstin Plötze-Martin, Christian Lange, Svenja Meyhöfer, Sebastian M. Meyhöfer, Jens U. Marquardt, Karl-Ludwig Bruchhage, and Armin Steffen
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Medicine ,Science - Abstract
Abstract Obstructive sleep apnea syndrome (OSAS) and obesity go hand in hand in the majority of patients and both are associated with a systemic inflammation, immune disturbance and comorbidities such as cardiovascular disease. However, the unambiguous impact of OSAS and obesity on the individual inflammatory microenvironment and the immunological consequences of human monocytes has not been distinguished yet. Therefore, aim of this study was to investigate the impact of OSAS and obesity related factors on the inflammatory microenvironment by performing flow cytometric whole blood measurements of CD14/CD16 monocyte subsets in normal weight OSAS patients, patients with obesity but without OSAS, and patients with OSAS and obesity, compared to healthy donors. Moreover, explicitly OSAS and obesity related plasma levels of inflammatory mediators adiponectin, leptin, lipocalin and metalloproteinase-9 were determined and the influence of different OSAS and obesity related factors on cytokine secretion and expression of different adhesion molecules by THP-1 monocytes was analysed. Our data revealed a significant redistribution of circulating classical and intermediate monocytes in all three patient cohorts, but differential effects in terms of monocytic adhesion molecules CD11a, CD11b, CD11c, CX3CR1, CD29, CD49d, and plasma cytokine levels. These data were reflected by differential effects of OSAS and obesity related factors leptin, TNFα and hypoxia on THP-1 cytokine secretion patterns and expression of adhesion molecules CD11b and CD49d. In summary, our data revealed differential effects of OSAS and obesity, which underlines the need for a customized therapeutic regimen with respect to the individual weighting of these overlapping diseases.
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- 2024
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44. Automatic muscle impedance and nerve analyzer (AMINA) as a novel approach for classifying bioimpedance signals in intraoperative pelvic neuromonitoring
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Ramona Schuler, Andreas Langer, Christoph Marquardt, Georgi Kalev, Maximilian Meisinger, Julia Bandura, Thomas Schiedeck, Matthias Goos, Albert Vette, and Marko Konschake
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Medicine ,Science - Abstract
Abstract Frequent complications arising from low anterior resections include urinary and fecal incontinence, as well as sexual disorders, which are commonly associated with damage to the pelvic autonomic nerves during surgery. To assist the surgeon in preserving pelvic autonomic nerves, a novel approach for intraoperative pelvic neuromonitoring was investigated that is based on impedance measurements of the innervated organs. The objective of this work was to develop an algorithm called AMINA to classify the bioimpedance signals, with the goal of facilitating signal interpretation for the surgeon. Thirty patients included in a clinical investigation underwent nerve-preserving robotic rectal surgery using intraoperative pelvic neuromonitoring. Contraction of the urinary bladder and/or rectum, triggered by direct stimulation of the innervating nerves, resulted in a change in tissue impedance signal, allowing the nerves to be identified and preserved. Impedance signal characteristics in the time domain and the time–frequency domain were calculated and classified to develop the AMINA. Stimulation-induced positive impedance changes were statistically significantly different from negative stimulation responses by the percent amplitude of impedance change Amax in the time domain. Positive impedance changes and artifacts were distinguished by classifying wavelet scales resulting from peak detection in the continuous wavelet transform scalogram, which allowed implementation of a decision tree underlying the AMINA. The sensitivity of the software-based signal evaluation by the AMINA was 96.3%, whereas its specificity was 91.2%. This approach streamlines and automates the interpretation of impedance signals during intraoperative pelvic neuromonitoring.
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- 2024
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45. Kiel 1969–2019: Die Zukunft der Geographie liegt auch in ihrer Vergangenheit
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B. Korf and N. Marquardt
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Human ecology. Anthropogeography ,GF1-900 ,Geography (General) ,G1-922 ,Cartography ,GA101-1776 - Published
- 2024
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46. Higher 2-Year Cumulative Incidence of Mental Health Disorders Following Irrigation and Debridement in Primary Lumbar Fusion
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Matthew J. Walker, Philip M. Parel, Alisa Malyavko, Amy Zhao, Theodore Quan, Caillin Marquardt, Addisu Mesfin, and Tushar C. Patel
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lumbar fusion ,mental health ,irrigation and debridement ,surgical site infection ,postoperative outcomes ,Surgery ,RD1-811 - Abstract
Introduction: Spinal fusion is an operation that is employed to treat spinal diseases. Surgical site infection (SSI) after lumbar fusion (LF) is a postoperative complication. SSI is treated with irrigation and debridement (I&D), which requires readmittance following discharge or prolonged hospital stays, which are deleterious to patients' mental health. The long-term relationship between treating SSI with I&D and patients' mental health is still understudied. Methods: Using the Mariner dataset from the PearlDiver Patient Records Database using Current Procedural Terminology and International Classification of Diseases procedure codes, retrospective cohort analysis was carried out. This study involved 445,480 patients who underwent LF with at least 2-year follow-up and were followed up for 2 years. Of the patients, 2,762 underwent I&D. Using univariate analysis employing Pearson Chi-square and Student t-test, where appropriate (), patient demographics between cohorts were gathered. 2-year cumulative incidence (CI) between LF and I&D cohorts was calculated using Kaplan-Meier analysis (). Cox proportional hazards were employed to observe significant differences in CI rates (). Results: For patients who received I&D, 2-year CI depression (HR: 1.72; 95% CI: 1.49-1.99; P
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- 2024
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47. Overcoming resolution attenuation during tilted cryo-EM data collection
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Sriram Aiyer, Philip R. Baldwin, Shi Min Tan, Zelin Shan, Juntaek Oh, Atousa Mehrani, Marianne E. Bowman, Gordon Louie, Dario Oliveira Passos, Selena Đorđević-Marquardt, Mario Mietzsch, Joshua A. Hull, Shuichi Hoshika, Benjamin A. Barad, Danielle A. Grotjahn, Robert McKenna, Mavis Agbandje-McKenna, Steven A. Benner, Joseph A. P. Noel, Dong Wang, Yong Zi Tan, and Dmitry Lyumkis
- Subjects
Science - Abstract
Abstract Structural biology efforts using cryogenic electron microscopy are frequently stifled by specimens adopting “preferred orientations” on grids, leading to anisotropic map resolution and impeding structure determination. Tilting the specimen stage during data collection is a generalizable solution but has historically led to substantial resolution attenuation. Here, we develop updated data collection and image processing workflows and demonstrate, using multiple specimens, that resolution attenuation is negligible or significantly reduced across tilt angles. Reconstructions with and without the stage tilted as high as 60° are virtually indistinguishable. These strategies allowed the reconstruction to 3 Å resolution of a bacterial RNA polymerase with preferred orientation, containing an unnatural nucleotide for studying novel base pair recognition. Furthermore, we present a quantitative framework that allows cryo-EM practitioners to define an optimal tilt angle during data acquisition. These results reinforce the utility of employing stage tilt for data collection and provide quantitative metrics to obtain isotropic maps.
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- 2024
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48. Impact of obesity on adult spinal deformity (ASD) long-segment spinal fusion radiographic and clinical outcomes
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Marquardt, Matthew D., Gibbs, David, Grossbach, Andrew, Keister, Alexander, Munjal, Vikas, Moranville, Robert, Mallory, Noah, Toop, Nathaniel, Dhaliwal, Joravar, Marquardt, Henry, Xu, David, and Viljoen, Stephanus
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- 2024
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49. Editorial: Expanding knowledge geographies
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H. Hilbrandt, J. Bluwstein, O. Cima, K. Duplan, N. Marquardt, L. Péaud, M. Pütz, R. Véron, and A. Vorbrugg
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Human ecology. Anthropogeography ,GF1-900 ,Geography (General) ,G1-922 ,Cartography ,GA101-1776 - Published
- 2024
50. A protocol for the safe recruitment of Indigenous and Black women experiencing intimate partner violence during the COVID-19 pandemic into a large mixed methods study: The Sisters by Choice Study
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Lucy Mkandawire-Valhmu, Jacqueline Callari-Robinson, Diane Schadewald, Hanan Abusbaitan, Anna Pirsch, Jeneile Luebke, Liz Marquardt, Erin Schubert, Jennifer Kibicho, Alexa Lopez, Kaboni Gondwe, Elizabeth Rice, Katie Bement, McKenzie Morgan, Rosalind McClain, Peninnah Kako, Faria Raghe, Cindy Figgins Hunter, Crystal Ayad, and Anne Dressel
- Subjects
Intimate partner violence ,COVID-19 ,help-seeking ,barriers ,Public aspects of medicine ,RA1-1270 - Abstract
ABSTRACTIntimate partner violence (IPV) is a complex and pervasive public health problem disproportionately affecting Indigenous and Black women. During the COVID-19 pandemic, IPV became more complicated for advocates because social distancing, quarantine, and isolation measures further endangered women experiencing IPV. This manuscript is based on an ongoing community-engaged study in an upper Midwestern state. Our primary goal for this study is to generate urgently needed knowledge on the impact of the COVID-19 pandemic on Indigenous and Black women’s help-seeking behaviours following IPV by systematically documenting barriers women faced during the pandemic. Engaging women in a large study that seeks to garner information about their experiences of violence is complex and challenging and requires significant planning, especially for ensuring participants’ safety. In this write-up, we detail the safety planning protocol developed for the purposes of recruiting and engaging women in rural and urban areas in an upper Midwestern state in the United States. Our goal is to provide scholars conducting research in the area of violence with practical considerations for safely conducting a study of this nature.
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- 2024
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