213 results on '"Minucci, Saverio"'
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2. Caloric restriction leads to druggable LSD1-dependent cancer stem cells expansion
3. Endogenous PP2A inhibitor CIP2A degradation by chaperone-mediated autophagy contributes to the antitumor effect of mitochondrial complex I inhibition
4. Co-targeting leukemia-initiating cells and leukemia bulk leads to disease eradication
5. Longitudinal single-cell transcriptomics reveals distinct patterns of recurrence in acute myeloid leukemia
6. SMARCA5 interacts with NUP98-NSD1 oncofusion protein and sustains hematopoietic cells transformation
7. Single cell-derived spheroids capture the self-renewing subpopulations of metastatic ovarian cancer
8. Pharmacological inhibition of LSD1 triggers myeloid differentiation by targeting GSE1 oncogenic functions in AML
9. Insights into the design of inhibitors of the EGFR family with anticancer activity overcoming resistance: A case of optimizing thieno[2,3-d]pyrimidine-based EGFR inhibitors
10. Novel non-covalent LSD1 inhibitors endowed with anticancer effects in leukemia and solid tumor cellular models
11. Discovery of a benzimidazole-based dual FLT3/TrKA inhibitor targeting acute myeloid leukemia
12. Biocompatible cellulose nanocrystal-based Trojan horse enables targeted delivery of nano-Au radiosensitizers to triple negative breast cancer cells.
13. Indolin-2-one derivatives as selective Aurora B kinase inhibitors targeting breast cancer
14. Endosomal trafficking and DNA damage checkpoint kinases dictate survival to replication stress by regulating amino acid uptake and protein synthesis
15. Anticancer innovative therapy congress: Highlights from the 10th anniversary edition
16. Rad51/BRCA2 disruptors inhibit homologous recombination and synergize with olaparib in pancreatic cancer cells
17. Cabozantinib in neuroendocrine tumors: tackling drug activity and resistance mechanisms.
18. Surmounting the resistance against EGFR inhibitors through the development of thieno[2,3-d]pyrimidine-based dual EGFR/HER2 inhibitors
19. Targeting Protein Inactivation through an Oligomerization Chain Reaction
20. Methyltransferase Recruitment and DNA Hypermethylation of Target Promoters by an Oncogenic Transcription Factor
21. A Histone Deacetylase Inhibitor Potentiates Retinoid Receptor Action in Embryonal Carcinoma Cells
22. Retinoid X Receptor-Selective Ligands Produce Malformations in Xenopus Embryos
23. Synthesis, biological characterization and molecular modeling insights of spirochromanes as potent HDAC inhibitors
24. Functional-genetic dissection of HDAC dependencies in mouse lymphoid and myeloid malignancies
25. A Refined Single Cell Landscape of Haematopoiesis in the Mouse Foetal Liver.
26. Epigenomic profiling of archived FFPE tissues by enhanced PAT-ChIP (EPAT-ChIP) technology
27. Pure enantiomers of benzoylamino-tranylcypromine: LSD1 inhibition, gene modulation in human leukemia cells and effects on clonogenic potential of murine promyelocytic blasts
28. Dual modulation of MCL-1 and mTOR determines the response to sunitinib
29. Synthesis, biological activity and mechanistic insights of 1-substituted cyclopropylamine derivatives: A novel class of irreversible inhibitors of histone demethylase KDM1A
30. Synthesis and biological characterization of spiro[2H-(1,3)-benzoxazine-2,4′-piperidine] based histone deacetylase inhibitors
31. A dual role for Hdac1: oncosuppressor in tumorigenesis, oncogene in tumor maintenance
32. Chromatin accessibility, p300, and histone acetylation define PML-RARα and AML1-ETO binding sites in acute myeloid leukemia
33. Pathology tissue—chromatin immunoprecipitation, coupled with high-throughput sequencing, allows the epigenetic profiling of patient samples
34. Protein Kinase C β and Prolyl Isomerase 1 Regulate Mitochondrial Effects of the Life-Span Determinant $\text{p}66^{\text{Shc}}$
35. The Methyl-CpG Binding Protein MBD1 Is Required for PML-RARα Function
36. Activation of a promyelocytic leukemia-tumor protein 53 axis underlies acute promyelocytic leukemia cure
37. Epigenetic alterations in acute myeloid leukemias
38. Histone deacetylase inhibitors as a new weapon in the arsenal of differentiation therapies of cancer
39. HDAC Inhibition as Potential Therapeutic Strategy to Restore the Deregulated Immune Response in Severe COVID-19.
40. SILAC-based proteomic analysis to dissect the “histone modification signature” of human breast cancer cells
41. HDACs link the DNA damage response, processing of double-strand breaks and autophagy
42. Functional characterization of a novel FGFR1OP-RET rearrangement in hematopoietic malignancies
43. Cell-cycle restriction limits DNA damage and maintains self-renewal of leukaemia stem cells
44. Tackling Oxidative Stress by a Direct Route: A New Job for HDAC Inhibitors?
45. Overexpression of sPRDM16 coupled with loss of p53 induces myeloid leukemias in mice
46. Protein kinase C[beta] and prolyl isomerase 1 regulate mitochondrial effects of the life-span determinant [p66.sup.Shc]
47. Determinants of Oncogenic Transformation in Acute Promyelocytic Leukemia: The Hetero-Union Makes the Force
48. Role of the Polycomb Repressive Complex 2 in Acute Promyelocytic Leukemia
49. Differentiation response of acute promyelocytic leukemia cells and PML/RARα leukemogenic activity studies by real-time RT-PCR
50. Electron transfer between cytochrome c and p66(super Shc) generates reactive oxygen species that trigger mitochondrial apoptosis
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