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1. Systematic review: economic evaluations of HCV screening in the direct-acting antivirals era

Author

Cortesi, P, Barca, R, Giudicatti, G, Mossini, S, Ciaccio, A, Iannazzo, S, Micale, M, Cesana, G, Mantovani, L, Cortesi, Paolo Angelo, BARCA, ROBERTA, GIUDICATTI, GIULIA, MOSSINI, SERGIO, Ciaccio, Antonio, Iannazzo, Sergio, Micale, Mariangela, Cesana, Giancarlo, Mantovani, Lorenzo Giovanni, Cortesi, P, Barca, R, Giudicatti, G, Mossini, S, Ciaccio, A, Iannazzo, S, Micale, M, Cesana, G, Mantovani, L, Cortesi, Paolo Angelo, BARCA, ROBERTA, GIUDICATTI, GIULIA, MOSSINI, SERGIO, Ciaccio, Antonio, Iannazzo, Sergio, Micale, Mariangela, Cesana, Giancarlo, and Mantovani, Lorenzo Giovanni

Abstract

Background: The World Health Organization estimated that 90% of the infected people need to be diagnosed and 80% need to be treated to reach the aim of hepatitis C virus (HCV) elimination by 2030. For this reason, all possible strategies to detect and treat HCV-infected people need to be carefully evaluated to implement the best one. Aim: To review and synthesise the economic evaluations of HCV screening programs conducted in the era of direct-acting antiviral agents regimens. Methods: A systematic literature review was conducted until April 2018 to provide information on the costs and effectiveness of HCV screenings in direct-acting antiviral agents era. A critical assessment of the quality of economic evaluations retrieved was conducted. Results: The literature search identified 716 references; 17 of them assessed cost and effectiveness of screening programs and antiviral treatments in different populations: general population (n = 7), drug users (n = 5), high-risk populations (n = 4) and other populations (n = 3). The HCV screening and direct-acting antiviral agents treatment appear to be good value for money, both in general and high-risk populations, if a cost per quality adjusted life years of $50 000 is set as willingness to pay threshold. Some studies showed the value of including lower stage of fibrosis in the treatment selection criteria. Conclusions: Several HCV screening strategies plus direct-acting antiviral agents treatments resulted cost-effectiveness in different populations. However, there is still need of country and population-specific evaluations within the different HCV screening and treatment strategies available, in order to assess their cost-effectiveness and sustainability and fully support an evidence-informed policy for HCV elimination

Published
2019

2. Notulae to the Italian alien vascular flora: 8

Author

Galasso, G, Domina, G, Andreatta, S, Angiolini, C, Ardenghi, N, Aristarchi, C, Arnoul, M, Azzella, M, Bacchetta, G, Bartolucci, F, Bodino, S, Bommartini, G, Bonari, G, Buono, S, Buono, V, Caldarella, O, Calvia, G, Corti, E, D'Antraccoli, M, De Luca, R, De Mattia, F, Di Natale, S, Di Turi, A, Esposito, A, Ferretti, G, Fiaschi, T, Fogu, M, Forte, L, Frigerio, J, Gubellini, L, Guzzetti, L, Hofmann, N, Laface, V, Laghetti, G, Lallai, A, La Rosa, A, Lazzaro, L, Lodetti, S, Lonati, M, Luchino, F, Magrini, S, Mainetti, A, Marignani, M, Maruca, G, Medagli, P, Mei, G, Menini, F, Mezzasalma, V, Misuri, A, Mossini, S, Mugnai, M, Musarella, C, Nota, G, Olivieri, N, Padula, A, Pascale, M, Pasquini, F, Peruzzi, L, Picella, G, Pinzani, L, Pirani, S, Pittarello, M, Podda, L, Enri, S, Rifici, C, Roma-Marzio, F, Romano, R, Rosati, L, Scafidi, F, Scarici, E, Scarici, M, Spampinato, G, Stinca, A, Wagensommer, R, Zanoni, G, Nepi, C, Galasso, Gabriele, Domina, Gianniantonio, Andreatta, Sebastiano, Angiolini, Claudia, Ardenghi, Nicola M. G., Aristarchi, Claudio, Arnoul, Matteo, Azzella, Mattia M., Bacchetta, Gianluigi, Bartolucci, Fabrizio, Bodino, Silvia, Bommartini, Giacomo, Bonari, Gianmaria, Buono, Sergio, Buono, Vito, Caldarella, Orazio, Calvia, Giacomo, Corti, Emilio, D'Antraccoli, Marco, De Luca, Rocco, De Mattia, Fabrizio, Di Natale, Stefano, Di Turi, Alessandra, Esposito, Assunta, Ferretti, Giulio, Fiaschi, Tiberio, Fogu, Maria C., Forte, Luigi, Frigerio, Jessica, Gubellini, Leonardo, Guzzetti, Lorenzo, Hofmann, Nicole, Laface, Valentina L. A., Laghetti, Gaetano, Lallai, Andrea, La Rosa, Alfonso, Lazzaro, Lorenzo, Lodetti, Silvano, Lonati, Michele, Luchino, Fabio, Magrini, Sara, Mainetti, Andrea, Marignani, Michela, Maruca, Gina, Medagli, Pietro, Mei, Giacomo, Menini, Flavio, Mezzasalma, Valerio, Misuri, Alice, Mossini, Sara, Mugnai, Michele, Musarella, Carmelo M., Nota, Ginevra, Olivieri, Nicola, Padula, Alessia, Pascale, Marziano, Pasquini, Federico, Peruzzi, Lorenzo, Picella, Gianni, Pinzani, Lorenzo, Pirani, Silvia, Pittarello, Marco, Podda, Lina, Enri, Simone Ravetto, Rifici, Carmelo D., Roma-Marzio, Francesco, Romano, Rosario, Rosati, Leonardo, Scafidi, Filippo, Scarici, Enrico, Scarici, Marco, Spampinato, Giovanni, Stinca, Adriano, Wagensommer, Robert P., Zanoni, Giovanni, Nepi, Chiara, Galasso, G, Domina, G, Andreatta, S, Angiolini, C, Ardenghi, N, Aristarchi, C, Arnoul, M, Azzella, M, Bacchetta, G, Bartolucci, F, Bodino, S, Bommartini, G, Bonari, G, Buono, S, Buono, V, Caldarella, O, Calvia, G, Corti, E, D'Antraccoli, M, De Luca, R, De Mattia, F, Di Natale, S, Di Turi, A, Esposito, A, Ferretti, G, Fiaschi, T, Fogu, M, Forte, L, Frigerio, J, Gubellini, L, Guzzetti, L, Hofmann, N, Laface, V, Laghetti, G, Lallai, A, La Rosa, A, Lazzaro, L, Lodetti, S, Lonati, M, Luchino, F, Magrini, S, Mainetti, A, Marignani, M, Maruca, G, Medagli, P, Mei, G, Menini, F, Mezzasalma, V, Misuri, A, Mossini, S, Mugnai, M, Musarella, C, Nota, G, Olivieri, N, Padula, A, Pascale, M, Pasquini, F, Peruzzi, L, Picella, G, Pinzani, L, Pirani, S, Pittarello, M, Podda, L, Enri, S, Rifici, C, Roma-Marzio, F, Romano, R, Rosati, L, Scafidi, F, Scarici, E, Scarici, M, Spampinato, G, Stinca, A, Wagensommer, R, Zanoni, G, Nepi, C, Galasso, Gabriele, Domina, Gianniantonio, Andreatta, Sebastiano, Angiolini, Claudia, Ardenghi, Nicola M. G., Aristarchi, Claudio, Arnoul, Matteo, Azzella, Mattia M., Bacchetta, Gianluigi, Bartolucci, Fabrizio, Bodino, Silvia, Bommartini, Giacomo, Bonari, Gianmaria, Buono, Sergio, Buono, Vito, Caldarella, Orazio, Calvia, Giacomo, Corti, Emilio, D'Antraccoli, Marco, De Luca, Rocco, De Mattia, Fabrizio, Di Natale, Stefano, Di Turi, Alessandra, Esposito, Assunta, Ferretti, Giulio, Fiaschi, Tiberio, Fogu, Maria C., Forte, Luigi, Frigerio, Jessica, Gubellini, Leonardo, Guzzetti, Lorenzo, Hofmann, Nicole, Laface, Valentina L. A., Laghetti, Gaetano, Lallai, Andrea, La Rosa, Alfonso, Lazzaro, Lorenzo, Lodetti, Silvano, Lonati, Michele, Luchino, Fabio, Magrini, Sara, Mainetti, Andrea, Marignani, Michela, Maruca, Gina, Medagli, Pietro, Mei, Giacomo, Menini, Flavio, Mezzasalma, Valerio, Misuri, Alice, Mossini, Sara, Mugnai, Michele, Musarella, Carmelo M., Nota, Ginevra, Olivieri, Nicola, Padula, Alessia, Pascale, Marziano, Pasquini, Federico, Peruzzi, Lorenzo, Picella, Gianni, Pinzani, Lorenzo, Pirani, Silvia, Pittarello, Marco, Podda, Lina, Enri, Simone Ravetto, Rifici, Carmelo D., Roma-Marzio, Francesco, Romano, Rosario, Rosati, Leonardo, Scafidi, Filippo, Scarici, Enrico, Scarici, Marco, Spampinato, Giovanni, Stinca, Adriano, Wagensommer, Robert P., Zanoni, Giovanni, and Nepi, Chiara

Abstract

In this contribution, new data concerning the distribution of vascular flora alien to Italy are presented. It includes new records, confirmations, exclusions, and status changes for Italy or for Italian administrative regions of taxa in the genera Bunias, Calocedrus, Calycanthus, Celosia, Clerodendrum, Convolvulus, Crassula, Cyclamen, Datura, Dicliptera, Eragrostis, Erigeron, Gamochaeta, Gazania, Impatiens, Kolkwitzia, Leucaena, Ludwigia, Medicago, Muscari, Nigella, Oenothera, Opuntia, Paulownia, Petroselinum, Phyllostachys, Physalis, Pseudosasa, Quercus, Reynoutria, Roldana, Saccharum, Sedum, Semiarundinaria, Senecio, Sisyrinchium, Solanum, Sporobolus, Tulipa, Vachellia, Verbena, and Youngia. Nomenclatural and distribution updates published elsewhere are provided as Suppl. material 1.

Published
2019

5. Notulae to the Italian native vascular flora: 8

Author

Gianluigi Bacchetta, Goffredo Filibeck, Bruno Petriglia, L. Gubellini, Corrado Tietto, Giovanni Maiorca, Francesco Roma-Marzio, Sara Magrini, Federica Bonini, Vito Buono, Daniele Viciani, G. Gestri, Pier Luigi Nimis, Giovanni Spampinato, Lina Podda, Serafino Cannavò, Fabrizio Bartolucci, Claudia Turcato, Simonetta Peccenini, Livia Lunardi, Nicole Hofmann, Sara Mossini, Gianmaria Bonari, Assunta Esposito, Sergio Buono, Robert P. Wagensommer, Daniela Gigante, Leonardo Beccarisi, Andrea Mainetti, Liliana Bernardo, Richard Lorenz, Günter Gottschlich, Luigi Forte, G. Barberis, Giacomo Calvia, Valeria Tomaselli, Chiara Nepi, Gianniantonio Domina, Rita T. Messa Ballarin, Giuliano Mereu, Salvatore Brullo, Simone Ravetto Enri, Luigi Minuto, Nicodemo G. Passalacqua, Manuel Tiburtini, Graziana Fiorini, Enrico Banfi, Michele Lonati, Franco Ballarin, Giovanni Bacaro, Lorenzo Lastrucci, Nicola M. G. Ardenghi, Leonardo Rosati, Franco Caldararo, Gabriele Galasso, Alessandro Ruggero, Mario Calbi, Adriano Stinca, Simonetta Fascetti, Laura Cancellieri, Giovanna Potenza, Davide Dagnino, Carmelo Maria Musarella, Bartolucci F., Domina G., Ardenghi N.M.G., Bacaro G., Bacchetta G., Ballarin F., Banfi E., Barberis G., Beccarisi L., Bernardo L., Bonari G., Bonini F., Brullo S., Buono S., Buono V., Calbi M., Caldararo F., Calvia G., Cancellieri L., Cannavo S., Dagnino D., Esposito A., Fascetti S., Filibeck G., Fiorini G., Forte L., Galasso G., Gestri G., Gigante D., Gottschlich G., Gubellini L., Hofmann N., Lastrucci L., Lonati M., Lorenz R., Lunardi L., Magrini S., Mainetti A., Maiorca G., Mereu G., Ballarin R.T.M., Minuto L., Mossini S., Musarella C.M., Nimis P.L., Passalacqua N.G., Peccenini S., Petriglia B., Podda L., Potenza G., Enri S.R., Roma-Marzio F., Rosati L., Ruggero A., Spampinato G., Stinca A., Tiburtini M., Tietto C., Tomaselli V., Turcato C., Viciani D., Wagensommer R.P., Nepi C., Bartolucci, F., Domina, G., Ardenghi, N. M. G., Bacaro, G., Bacchetta, G., Ballarin, F., Banfi, E., Barberis, G., Beccarisi, L., Bernardo, L., Bonari, G., Bonini, F., Brullo, S., Buono, S., Buono, V., Calbi, M., Caldararo, F., Calvia, G., Cancellieri, L., Cannavo, S., Dagnino, D., Esposito, A., Fascetti, S., Filibeck, G., Fiorini, G., Forte, L., Galasso, G., Gestri, G., Gigante, D., Gottschlich, G., Gubellini, L., Hofmann, N., Lastrucci, L., Lonati, M., Lorenz, R., Lunardi, L., Magrini, S., Mainetti, A., Maiorca, G., Mereu, G., Ballarin, R. T. M., Minuto, L., Mossini, S., Musarella, C. M., Nimis, P. L., Passalacqua, N. G., Peccenini, S., Petriglia, B., Podda, L., Potenza, G., Enri, S. R., Roma-Marzio, F., Rosati, L., Ruggero, A., Spampinato, G., Stinca, A., Tiburtini, M., Tietto, C., Tomaselli, V., Turcato, C., Viciani, D., Wagensommer, R. P., Nepi, C., Bartolucci, F, Domina, G, Ardenghi, Nmg, Bacaro, G, Bacchetta, G, Ballarin, F, Banfi, E, Barberis, G, Beccarisi, L, Bernardo, L, Bonari, G, Bonini, F, Brullo, S, Buono, S, Buono, V, Calbi, M, Caldararo, F, Calvia, G, Cancellieri, L, Cannavò, S, Dagnino, D, Esposito, A, Fascetti, S, Filibeck, G, Fiorini, G, Forte, L, Galasso, G, Gestri, G, Gigante, D, Gottschlich, G, Gubellini, L, Hofmann, N, Lastrucci, L, Lonati, M, Lorenz, R, Lunardi, L, Magrini, S, Mainetti, A, Maiorca, G, Mereu, G, Messa Ballarin, Rt, Minuto, L, Mossini, S, Musarella, Cm, Nimis, Pl, Passalacqua, Ng, Peccenini, S, Petriglia, B, Podda, L, Potenza, G, Ravetto Enri, S, Roma-Marzio, F, Rosati, L, Ruggero, A, Spampinato, G, Stinca, A, Tiburtini, M, Tietto, C, Tomaselli, V, Turcato, C, Viciani, D, Wagensommer, Rp, and Nepi, C

Subjects
0106 biological sciences, Endemic, Floristic data, Italy, Nomenclature, Flora, Nomenclature, Zoology, Floristic data, Plant Science, Biology, 010603 evolutionary biology, 01 natural sciences, lcsh:QK1-989, Endemic, Italy, lcsh:Botany, Settore BIO/03 - Botanica Ambientale E Applicata, Ecology, Evolution, Behavior and Systematics, 010606 plant biology & botany
Abstract

In this contribution, new data concerning the distribution of native vascular flora in Italy are presented. It includes new records, confirmations, exclusions, and status changes to the Italian administrative regions for taxa in the genera Ajuga, Chamaemelum, Clematis, Convolvulus, Cytisus, Deschampsia, Eleocharis, Epipactis, Euphorbia, Groenlandia, Hedera, Hieracium, Hydrocharis, Jacobaea, Juncus, Klasea, Lagurus, Leersia, Linum, Nerium, Onopordum, Persicaria, Phlomis, Polypogon, Potamogeton, Securigera, Sedum, Soleirolia, Stachys, Umbilicus, Valerianella, and Vinca. Nomenclatural and distribution updates, published elsewhere, and corrigenda are provided as Suppl. material 1.

Published
2019

6. Notulae to the Italian alien vascular flora: 8

Author

Andrea Mainetti, Nicola M. G. Ardenghi, Gianluigi Bacchetta, Lina Podda, Giulio Ferretti, Ginevra Nota, Lorenzo Peruzzi, Gina Maruca, Sara Magrini, Sergio Buono, Fabrizio Bartolucci, Enrico Scarici, Giovanni Zanoni, L. Gubellini, Michele Lonati, Francesco Roma-Marzio, Silvano Lodetti, Lorenzo Guzzetti, Rocco De Luca, Claudio Aristarchi, Valerio Mezzasalma, Filippo Scafidi, Leonardo Rosati, Stefano Di Natale, Fabrizio De Mattia, Gaetano Laghetti, Marco Pittarello, Giovanni Spampinato, Michela Marignani, Gabriele Galasso, Silvia Pirani, Orazio Caldarella, Assunta Esposito, Lorenzo Pinzani, Matteo Arnoul, Marco D'Antraccoli, Flavio Menini, Marziano Pascale, Fabio Luchino, Carmelo D. Rifici, Chiara Nepi, Sara Mossini, Gianniantonio Domina, Alessia Padula, Gianmaria Bonari, Adriano Stinca, Nicola Olivieri, Federico Pasquini, Robert P. Wagensommer, Giacomo Calvia, Sebastiano Andreatta, Rosario Romano, Maria Caterina Fogu, Pietro Medagli, Lorenzo Lazzaro, Vito Buono, Nicole Hofmann, Valentina Laface, Emilio Corti, Tiberio Fiaschi, Jessica Frigerio, Gianni Picella, Giacomo Mei, Michele Mugnai, Silvia Bodino, Alice Misuri, Simone Ravetto Enri, Claudia Angiolini, Mattia M. Azzella, Alessandra Di Turi, Luigi Forte, Andrea Lallai, Giacomo Bommartini, Marco Scarici, Carmelo Maria Musarella, Alfonso La Rosa, Galasso, G., Domina, G., Andreatta, S., Angiolini, C., Ardenghi, N. M. G., Aristarchi, C., Arnoul, M., Azzella, M. M., Bacchetta, G., Bartolucci, F., Bodino, S., Bommartini, G., Bonari, G., Buono, S., Buono, V., Caldarella, O., Calvia, G., Corti, E., D'Antraccoli, M., De Luca, R., De Mattia, F., Di Natale, S., Di Turi, A., Esposito, A., Ferretti, G., Fiaschi, T., Fogu, M. C., Forte, L., Frigerio, J., Gubellini, L., Guzzetti, L., Hofmann, N., Laface, V. L. A., Laghetti, G., Lallai, A., La Rosa, A., Lazzaro, L., Lodetti, S., Lonati, M., Luchino, F., Magrini, S., Mainetti, A., Marignani, M., Maruca, G., Medagli, P., Mei, G., Menini, F., Mezzasalma, V., Misuri, A., Mossini, S., Mugnai, M., Musarella, C. M., Nota, G., Olivieri, N., Padula, A., Pascale, M., Pasquini, F., Peruzzi, L., Picella, G., Pinzani, L., Pirani, S., Pittarello, M., Podda, L., Enri, S. R., Rifici, C. D., Roma-Marzio, F., Romano, R., Rosati, L., Scafidi, F., Scarici, E., Scarici, M., Spampinato, G., Stinca, A., Wagensommer, R. P., Zanoni, G., Nepi, C., Galasso G., Domina G., Andreatta S., Angiolini C., Ardenghi N.M.G., Aristarchi C., Arnoul M., Azzella M.M., Bacchetta G., Bartolucci F., Bodino S., Bommartini G., Bonari G., Buono S., Buono V., Caldarella O., Calvia G., Corti E., D'Antraccoli M., De Luca R., De Mattia F., Di Natale S., Di Turi A., Esposito A., Ferretti G., Fiaschi T., Fogu M.C., Forte L., Frigerio J., Gubellini L., Guzzetti L., Hofmann N., Laface V.L.A., Laghetti G., Lallai A., La Rosa A., Lazzaro L., Lodetti S., Lonati M., Luchino F., Magrini S., Mainetti A., Marignani M., Maruca G., Medagli P., Mei G., Menini F., Mezzasalma V., Misuri A., Mossini S., Mugnai M., Musarella C.M., Nota G., Olivieri N., Padula A., Pascale M., Pasquini F., Peruzzi L., Picella G., Pinzani L., Pirani S., Pittarello M., Podda L., Enri S.R., Rifici C.D., Roma-Marzio F., Romano R., Rosati L., Scafidi F., Scarici E., Scarici M., Spampinato G., Stinca A., Wagensommer R.P., Zanoni G., and Nepi C.

Subjects
0106 biological sciences, Flora, Ecology, Alien species, Floristic data, Plant Science, Alien, Biology, 010603 evolutionary biology, 01 natural sciences, lcsh:QK1-989, Italy, Alien species, Floristic data, Italy, lcsh:Botany, Settore BIO/03 - Botanica Ambientale E Applicata, Ecology, Evolution, Behavior and Systematics, Alien specie, 010606 plant biology & botany
Abstract

In this contribution, new data concerning the distribution of vascular flora alien to Italy are presented. It includes new records, confirmations, exclusions, and status changes for Italy or for Italian administrative regions of taxa in the genera Bunias, Calocedrus, Calycanthus, Celosia, Clerodendrum, Convolvulus, Crassula, Cyclamen, Datura, Dicliptera, Eragrostis, Erigeron, Gamochaeta, Gazania, Impatiens, Kolkwitzia, Leucaena, Ludwigia, Medicago, Muscari, Nigella, Oenothera, Opuntia, Paulownia, Petroselinum, Phyllostachys, Physalis, Pseudosasa, Quercus, Reynoutria, Roldana, Saccharum, Sedum, Semiarundinaria, Senecio, Sisyrinchium, Solanum, Sporobolus, Tulipa, Vachellia, Verbena, and Youngia. Nomenclatural and distribution updates published elsewhere are provided as Suppl. material 1.

Published
2019

7. Systematic review: economic evaluations of HCV screening in the direct-acting antivirals era

Author

Sergio Mossini, Mariangela Micale, Paolo Cortesi, Giulia Giudicatti, Giancarlo Cesana, Lorenzo G. Mantovani, Roberta Barca, Sergio Iannazzo, A. Ciaccio, Cortesi, P, Barca, R, Giudicatti, G, Mossini, S, Ciaccio, A, Iannazzo, S, Micale, M, Cesana, G, and Mantovani, L

Subjects
medicine.medical_specialty, MED/42 - IGIENE GENERALE E APPLICATA, Cost-Benefit Analysis, Population, Hepacivirus, DIRECT ACTING ANTIVIRALS, Antiviral Agents, World health, Drug Costs, 03 medical and health sciences, 0302 clinical medicine, Willingness to pay, Risk Factors, medicine, Humans, Mass Screening, Pharmacology (medical), 030212 general & internal medicine, Intensive care medicine, education, education.field_of_study, Hepatology, business.industry, Gastroenterology, Hepatitis C, Chronic, Hepatitis C, Hcv elimination, Quality-adjusted life year, Systematic review, 030211 gastroenterology & hepatology, Critical assessment, Quality-Adjusted Life Years, business
Abstract

Background: The World Health Organization estimated that 90% of the infected people need to be diagnosed and 80% need to be treated to reach the aim of hepatitis C virus (HCV) elimination by 2030. For this reason, all possible strategies to detect and treat HCV-infected people need to be carefully evaluated to implement the best one. Aim: To review and synthesise the economic evaluations of HCV screening programs conducted in the era of direct-acting antiviral agents regimens. Methods: A systematic literature review was conducted until April 2018 to provide information on the costs and effectiveness of HCV screenings in direct-acting antiviral agents era. A critical assessment of the quality of economic evaluations retrieved was conducted. Results: The literature search identified 716 references; 17 of them assessed cost and effectiveness of screening programs and antiviral treatments in different populations: general population (n=7), drug users (n=5), high-risk populations (n=4) and other populations (n=3). The HCV screening and direct-acting antiviral agents treatment appear to be good value for money, both in general and high-risk populations, if a cost per quality adjusted life years of $50000 is set as willingness to pay threshold. Some studies showed the value of including lower stage of fibrosis in the treatment selection criteria. Conclusions: Several HCV screening strategies plus direct-acting antiviral agents treatments resulted cost-effectiveness in different populations. However, there is still need of country and population-specific evaluations within the different HCV screening and treatment strategies available, in order to assess their cost-effectiveness and sustainability and fully support an evidence-informed policy for HCV elimination

Published
2018

8. Notulae to the Italian alien vascular flora: 2

Author

Francesco Roma-Marzio, Fabrizio Buldrini, Mirella Benedetta Campochiaro, Gino Palladino, Sergio Bangoni, Sergio Picollo, Alessandro Rosiello, F Mantino, Federico Selvi, Fabio Conti, Milena Villa, Carlo Argenti, Chiara Nepi, Gianniantonio Domina, C. Gangale, C. Santini, Alessandra Pepe, Lorenzo Peruzzi, Luigi Ghillani, Nicola Olivieri, Domenico Puntillo, Marziano Pascale, Carmen Novaro, Antonia Cristaudo, Giovanni Astuti, Lorenzo Cecchi, Mauro Mariotti, Günter Gottschlich, Luigi Forte, Fabrizio Bartolucci, Adriano Stinca, Francesco Saverio D’Amico, Filippo Scafidi, Anna Scoppola, Giovanni Russo, Franz-Georg Dunkel, M. Adorni, Enrico V. Perrino, Giuseppe D’Auria, Francesca Carruggio, Emilio Di Gristina, Galasso, Gabriele, Domina, Gianniantonio, Ardenghi, Nicola Maria Giuseppe, Arrigoni, Pierfranco, Banfi, Enrico, Bartolucci, Fabrizio, Bonari, Gianmaria, Buccomino, Giovanni, Ciaschetti, Giampiero, Conti, Fabio, Coppi, Andrea, Di Cecco, Valter, Di Martino, Luciano, Guiggi, Alessandro, Lastrucci, Lorenzo, Leporatti, Maria Lucia, López Tirado, Javier, Maiorca, Giovanni, Mossini, Sara, Olivieri, Nicola, Pennesi, Riccardo, Romiti, Bruno, Scoppola, Anna, Soldano, Adriano, Stinca, Adriano, Verloove, Filip, Villa, Milena, Nepi, Chiara, Bartolucci, F, Domina, G, Adorni, M, Argenti, C, Astuti, G, Bangoni, S, Buldrini, F, Campochiaro, MB, Carruggio, F, Cecchi, L, Conti, F, Cristaudo, A, D’Amico, FS, D'Auria, G, Di Gristina, E, Dunkel, F-G, Forte, L, Gangale, C, Ghillani, L, Gottschlich, G, Mantino, F, Mariotti, M, Novaro, C, Olivieri, N, Palladino, G, Pascale, M, Pepe, A, Perrino, EV, Peruzzi, L, Picollo, S, Puntillo, D, Roma-Marzio, F, Rosiello, A, Russo, G, Santini, C, Selvi, F, Scafidi, F, Scoppola, A, Stinca, A, Villa, M, Nepi, C, Fabrizio Bartolucci, Gianniantonio Domina, Michele Adorni, Carlo Argenti, Giovanni Astuti, Sergio Bangoni, Fabrizio Buldrini, Mirella Benedetta Campochiaro, Francesca Carruggio, Lorenzo Cecchi, Fabio Conti, Antonia Cristaudo, Francesco Saverio D’Amico, Giuseppe D’Auria, Emilio Di Gristina, Franz-Georg Dunkel, Luigi Forte, Carmen Gangale, Luigi Ghillani, Günter Gottschlich, Francesca Mantino, Mauro Mariotti, Carmen Novaro, Nicola Olivieri, Gino Palladino, Maurizio Pascale, Alessandra Pepe, Enrico Vito Perrino, Lorenzo Peruzzi, Sergio Picollo, Domenico Puntillo, Francesco Roma-Marzio, Alessandro Rosiello, Giovanni Russo, Claudio Santini, Federico Selvi, Filippo Scafidi, Anna Scoppola, Adriano Stinca, Milena Villa, Chiara Nepi, Galasso, G, Ardenghi, NMG, Arrigoni, P, Banfi, E, Bartolucci, F., Bonari, G., Buccomino, G, Ciaschetti, G, Coppi, A, Di Cecco, V, Di Martino, L, Guiggi, A, Lastrucci, L, Leporatti, M., López Tirado, J, Maiorca, G, Mossini, S, Pennesi, R, Romiti, B, Soldano, A, and Verloove, F

Subjects
0106 biological sciences, new combination, Clerodendrum, Ulmus, Lantana, Ligustrum, Ageratum, Aster, Buddleja, Cedrus, Centranthus, Cephalotaxus, Clerodendrum, Cotoneaster, Cyperus, Honorius, Lantana, Ligustrum, Morus, Muscari, Oenothera, Opuntia, Platycladus, Plumbago, Pseudotsuga, Sedum, Sporobolus, Stachys, Ulmus, Yucca, Zoology, Alien, Plant Science, Ageratum, Platycladus, Biology, Centranthus, 010603 evolutionary biology, 01 natural sciences, Sedum, Cephalotaxus, Sporobolus, lcsh:Botany, Yucca, Cyperus, Cedrus, Ecology, Evolution, Behavior and Systematics, Aster, Plumbago, Floristic data, Italy, Settore BIO/02 - Botanica Sistematica, Honorius, Opuntia, Floristic data, Cotoneaster, Muscari, Pseudotsuga, lcsh:QK1-989, Geography, Italy, Oenothera, Settore BIO/03 - Botanica Ambientale E Applicata, Italian Flora, Stachys, Morus, Buddleja, 010606 plant biology & botany
Abstract

In this contribution, new data concerning the Italian distribution of alien vascular flora are presented. It includes new records, exclusions and confirmations for Italy or for Italian administrative regions for taxa in the genera Ageratum, Aster, Buddleja, Cedrus, Centranthus, Cephalotaxus, Clerodendrum, Cotoneaster, Cyperus, Honorius, Lantana, Ligustrum, Morus, Muscari, Oenothera, Opuntia, Platycladus, Plumbago, Pseudotsuga, Sedum, Sporobolus, Stachys, Ulmus and Yucca. A nomen novum, Stachys talbotii, is proposed as a replacement name for Sideritis purpurea.

Published
2016

9. Systematic review: economic evaluations of HCV screening in the direct-acting antivirals era.

Author

Cortesi PA, Barca R, Giudicatti G, Mossini S, Ciaccio A, Iannazzo S, Micale M, Cesana G, and Mantovani LG

Subjects
Cost-Benefit Analysis, Drug Costs, Hepacivirus isolation & purification, Hepatitis C economics, Hepatitis C epidemiology, Hepatitis C, Chronic diagnosis, Hepatitis C, Chronic drug therapy, Hepatitis C, Chronic economics, Hepatitis C, Chronic epidemiology, Humans, Mass Screening methods, Mass Screening statistics & numerical data, Mass Screening trends, Quality-Adjusted Life Years, Risk Factors, Antiviral Agents economics, Antiviral Agents therapeutic use, Hepatitis C diagnosis, Hepatitis C drug therapy, Mass Screening economics
Abstract

Background: The World Health Organization estimated that 90% of the infected people need to be diagnosed and 80% need to be treated to reach the aim of hepatitis C virus (HCV) elimination by 2030. For this reason, all possible strategies to detect and treat HCV-infected people need to be carefully evaluated to implement the best one., Aim: To review and synthesise the economic evaluations of HCV screening programs conducted in the era of direct-acting antiviral agents regimens., Methods: A systematic literature review was conducted until April 2018 to provide information on the costs and effectiveness of HCV screenings in direct-acting antiviral agents era. A critical assessment of the quality of economic evaluations retrieved was conducted., Results: The literature search identified 716 references; 17 of them assessed cost and effectiveness of screening programs and antiviral treatments in different populations: general population (n = 7), drug users (n = 5), high-risk populations (n = 4) and other populations (n = 3). The HCV screening and direct-acting antiviral agents treatment appear to be good value for money, both in general and high-risk populations, if a cost per quality adjusted life years of $50 000 is set as willingness to pay threshold. Some studies showed the value of including lower stage of fibrosis in the treatment selection criteria., Conclusions: Several HCV screening strategies plus direct-acting antiviral agents treatments resulted cost-effectiveness in different populations. However, there is still need of country and population-specific evaluations within the different HCV screening and treatment strategies available, in order to assess their cost-effectiveness and sustainability and fully support an evidence-informed policy for HCV elimination., (© 2019 John Wiley & Sons Ltd.)

Published
2019
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10. Trace metal levels in serum and urine of a population in southern Brazil.

Author

Rocha GH, Steinbach C, Munhoz JR, Madia MA, Faria JK, Hoeltgebaum D, Barbosa F Jr, Batista BL, Souza VC, Nerilo SB, Bando E, Mossini SA, and Nishiyama P

Subjects
Adolescent, Adult, Aged, Brazil, Female, Humans, Male, Middle Aged, Reference Standards, Young Adult, Trace Elements blood, Trace Elements urine
Abstract

This study aimed to evaluate serum and urine concentrations of several trace metals of a non-directly exposed population in southern Brazil and establish reference values. Serum and urine samples were obtained from 240 volunteers (175 males and 65 females, age ranging from 18 to 74 years old). Levels of arsenic, chromium, cobalt, copper, lead, nickel, manganese and zinc were determined by means of dynamic reaction cell inductively coupled plasma mass spectrometry (DRC-ICP-MS). Comparison between genders resulted in no significant difference for all metals but serum copper, as concentrations are higher in females than males. For most metals assessed, a negative correlation between serum concentrations and age was found, but no significant correlation was found between urine concentrations and age., (Copyright © 2016. Published by Elsevier GmbH.)

Published
2016
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