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Background: Phototherapy is effective in treating psoriasis and other skin conditions. However, clinic-based phototherapy can be time-consuming, expensive, and inconvenient. Conventional home phototherapy addresses many hurdles, but has other limitations.Objective: Assess the treatment efficacy, adherence, and satisfaction of a novel ultraviolet B home phototherapy system.Methods: Eight patients with stable plaque psoriasis completed a multicenter, prospective, open label, interventional study using a home phototherapy device designed to improve treatment control and adherence. Matched control and study lesions were assessed on each subject. A dosing protocol based on American Academy of Dermatology guidelines for narrowband UVB phototherapy was managed by the phototherapy system. Responsiveness to the treatment was measured using the Psoriasis Severity Index (PSI) at 10 weeks versus control. Patient satisfaction was graded on a five-star Likert scale.Results: At 10 weeks, all patients experienced improvement in the treated lesions, with a mean improvement of 57% in PSI (P

The original article was published on February 15, 2019 and corrected on April 15, 2019. The third pair of panes of Figure 2 were reversed, such that the pane previously depicted on the left was after phototherapy. The corrected sequence is now before phototherapy, on the left, and after, on the right. This change appears in the revised online PDF copy of this article.

But if men suffer worse from fragility fractures and more is needed to prevent them, then there may be issues regarding the current diagnosis of osteoporosis and/or the approaches toward preventing fragility fractures in men. Keywords: aging; diet and nutrition; global public health; hip fracture; osteoporosis; physical fitness; prevention EN aging diet and nutrition global public health hip fracture osteoporosis physical fitness prevention 1 4 4 10/10/23 20231005 NES 231005 Osteoporosis is a skeletal disease of reduced bone mass that greatly increases the risk of fractures, and while the disease is most commonly thought of as an issue for older women, it is a growing concern for older men. Comparing older men and women, women perceive that they are more susceptible to osteoporosis and have higher self-efficacy to undergo osteoporosis screening than men ([9]), which may explain why osteoporosis screenings are generally utilized by women but widely neglected by men. [Extracted from the article]

Background: Osteoporosis prevention education interventions have been found to be ineffective. Purpose: To determine the effectiveness of a developed intervention based on the health belief model, which emphasized its visible severity and proximal time of onset. Method: A sample of 109 college women were randomly assigned to either a treatment or control group to receive an osteoporosis prevention education intervention or stress management intervention, respectively. After pretest, interventions were administered, followed by posttest two weeks later. Results: Both groups showed a significant increase in perceived benefits of exercise to prevent osteoporosis, perceived barriers to exercise, perceived barriers to calcium and health motivation; however, there were no group differences. Perceived susceptibility to osteoporosis differed significantly before and after intervention; however, there was no group difference post intervention after controlling for difference before intervention. Discussion: Likely due to the distal time of onset of osteoporosis, young individuals are not concerned with preventing the disease. Promoted health behaviors should be desirable and manageable. Translation to Health Education Practice: Promoted health behaviors should emphasize benefits that are motivating with more proximal, rather than distal, time of onset. They should also be promoted for their enjoyment in order to help initiate, and ultimately sustain, them. (Contains 3 tables.)

Introduction: Colorectal cancer (CRC) remains a significant cause of cancer related mortality. Fat mass and obesity-associated protein (FTO) is a m6A mRNA demethylase that plays an oncogenic role in various malignancies. In this study we evaluated the role of FTO in CRC tumorigenesis. Methods: Cell proliferation assays were conducted in 6 CRC cell lines with the FTO inhibitor CS1 (50-3200 nM) (± 5-FU 5-80 mM) and after lentivirus mediated FTO knockdown. Cell cycle and apoptosis assays were conducted in HCT116 cells (24 h and 48 h, 290 nM CS1). Western blot and m6A dot plot assays were performed to assess CS1 inhibition of cell cycle proteins and FTO demethylase activity. Migration and invasion assays of shFTO cells and CS1 treated cells were performed. An in vivo heterotopic model of HCT116 cells treated with CS1 or with FTO knockdown cells was performed. RNA-seq was performed on shFTO cells to assess which molecular and metabolic pathways were impacted. RT-PCR was conducted on select genes downregulated by FTO knockdown. Results: We found that the FTO inhibitor, CS1 suppressed CRC cell proliferation in 6 colorectal cancer cell lines and in the 5-Fluorouracil resistant cell line (HCT116-5FUR). CS1 induced cell cycle arrest in the G2/M phase by down regulation of CDC25C and promoted apoptosis of HCT116 cells. CS1 suppressed in vivo tumor growth in the HCT116 heterotopic model (p< 0.05). Lentivirus knockdown of FTO in HCT116 cells (shFTO) mitigated in vivo tumor proliferation and in vitro demethylase activity, cell growth, migration and invasion compared to shScr controls (p< 0.01). RNA-seq of shFTO cells compared to shScr demonstrated down-regulation of pathways related to oxidative phosphorylation, MYC and Akt/ mTOR signaling pathways. Discussion: Further work exploring the targeted pathways will elucidate precise downstream mechanisms that can potentially translate these findings to clinical trials. [ABSTRACT FROM AUTHOR]