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507 results on '"Park, Ji-Yeon"'

35. Effect of age and gender in rates of achieving minimal clinically important difference and patient‐acceptable symptom state 2 years after arthroscopic superior capsular reconstruction.

Author

Ben, Hui, Yeom, Ji Woong, Kholinne, Erica, Guo, Jia, Park, Ji Yeon, Ryu, Seung Min, Koh, Kyoung‐Hwan, and Jeon, In‐Ho

Subjects
OLDER patients, PATIENT reported outcome measures, GENDER, ROTATOR cuff, VISUAL analog scale, TOTAL shoulder replacement
Abstract

Purpose: This study aimed to evaluate patient‐reported outcome measures (PROMs) and the effects of gender and age on achieving clinically significant outcomes in patients undergoing arthroscopic superior capsular reconstruction (ASCR) with a minimum 2‐year follow‐up. Methods: Patients undergoing ASCR for irreparable rotator cuff tear between 2013 and 2020 were reviewed. Preoperative and minimum 2‐year postoperative PROMs were collected, including American Shoulder and Elbow Surgeons (ASES), Constant, single assessment numeric evaluation (SANE), and visual analog scale (VAS) scores. Minimal clinically important difference (MCID) and patient‐acceptable symptomatic state (PASS) were calculated for each functional score and analyzed according to age and gender. The percentages of patients achieving MCID and PASS were recorded. Results: The study included 83 patients, with a mean follow‐up of 3.5 ± 1.4 years. Significant improvements were found in ASES, Constant, SANE, and VAS for all groups based on gender and age. Based on receiver‐operating characteristic curves, all scores had acceptable areas under the curve for PASS. Values for PASS and MCID were 81.5 and 10.3 for ASES; 61.5 and 6.2 for Constant; 82.5 and 11.5 for SANE and 1.5 and 1.1 for VAS, respectively. Analysis of achieving MCID and PASS showed no difference between the groups in the majority of outcome measures. However, female patients achieved the SANE thresholds for PASS at significantly higher rates than male patients. Patients ≥65 years old achieved ASES and Constant thresholds for MCID at significantly higher rates than patients ˂65 years old. Conclusion: Most patients achieved MCID and PASS at a 2‐year follow‐up. Patients showed comparable rates of MCID and PASS achievement on most outcome tools based on age and gender. Female patients achieved PASS on SANE at significantly higher rates than male patients and older patients achieved MCID on ASES and Constant at higher rates than young patients. Thus, age is a stronger factor for achieving MCID than gender. Level of Evidence: Level II. [ABSTRACT FROM AUTHOR]

Published
2024
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37. Dynamic bidirectional regulation of NLRC3 and gammaherpesviruses during viral latency in B lymphocytes.

Author

Kang, Hye‐Ri, Han, Ji Ho, Ng, Yee Ching, Ryu, Seungbo, Park, Ji‐Yeon, Chung, Woo‐Chang, Song, Yoon‐Jae, Chen, Szu‐Ting, Brickey, W. June, Ting, Jenny P.‐Y., and Song, Moon Jung

Subjects
B cells, REGULATORY B cells, LATENT infection, MEMBRANE proteins, EPSTEIN-Barr virus
Abstract

While most NOD‐like receptors (NLRs) are predominately expressed by innate immune cells, NLRC3, an inhibitory NLR of immune signaling, exhibits the highest expression in lymphocytes. The role of NLRC3 or any NLRs in B lymphocytes is completely unknown. Gammaherpesviruses, including human Epstein–Barr virus (EBV) and murine gammaherpesvirus 68 (MHV‐68), establish latent infection in B lymphocytes, which requires elevated NF‐κB. This study shows that during latent EBV infection of human B cells, viral‐encoded latent membrane protein 1 (LMP1) decreases NLRC3 transcript. LMP1‐induced‐NF‐κB activation suppresses the promoter activity of NLRC3 via p65 binding to the promoter. Conversely, NLRC3 inhibits NF‐κB activation by promoting the degradation of LMP1 in a proteasome‐dependent manner. In vivo, MHV‐68 infection reduces Nlrc3 transcripts in splenocytes, and Nlrc3‐deficient mice show greater viral latency than controls. These results reveal a bidirectional regulatory circuit in B lymphocytes, where viral latent protein LMP1 reduces NLRC3 expression, while NLRC3 disrupts gammaherpesvirus latency, which is an important step for tumorigenesis. [ABSTRACT FROM AUTHOR]

Published
2024
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49. The semantic extension of Korean ideophones in newspapers headlines: Focusing on printed newspapers from 1990 to 2000.

Author

Park, Ji-Yeon

Abstract

This paper explores the semantic features of Korean ideophones in newspaper headlines. This paper argues that (i) there is a strong relationship between the language-specific sound symbolic meanings – dark and light vowel polarity and the meanings of ideophones in newspaper headlines and event descriptions; (ii) ideophones are much more common in articles about the financial issues; (iii) ideophones which exhibit vowel alternation go through different semantic extension routes to those of other ideophones. The findings of the paper suggest that Korean ideophones have been lexically highly conventionalized and integrated into the language system. [ABSTRACT FROM AUTHOR]

Published
2024
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