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10 results on '"Posthuma, Ward"'

1. Proteomic markers with prognostic impact on outcome of chronic lymphocytic leukemia patients under chemo-immunotherapy: results from the HOVON 109 study

Author

Saberi Hosnijeh, Fatemeh, van der Straten, Lina, Kater, Arnon P., van Oers, Marinus H.J., Posthuma, Ward F.M., Chamuleau, Martine E.D., Bellido, Mar, Doorduijn, Jeanette K., van Gelder, Michel, Hoogendoorn, Mels, de Boer, Fransien, te Raa, G. Doreen, Kerst, J. Martijn, Marijt, Erik W.A., Raymakers, Reinier A.P., Koene, Harry R., Schaafsma, Martijn R., Dobber, Johan A., Tonino, Sanne H., Kersting, Sabina S., Langerak, Anton W., and Levin, Mark-David

Published
2020
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4. Hormone Replacement Therapy [with Reply]

Author

Duncan, Malcolm H., Stevenson, John C., Baum, Michael, Posthuma, Ward F. M., Westendorp, Rudi G. J., Vandenbroucke, Jan P., Air, Andrea, Lip, Gregory Y. H., and Beevers, D. Gareth

Published
1994

8. Integration of Mutational Signature Analysis with 3D Chromatin Data Unveils Differential AID-Related Mutagenesis in Indolent Lymphomas.

Author

Sepulveda-Yanez, Julieta H., Alvarez-Saravia, Diego, Fernandez-Goycoolea, Jose, Aldridge, Jacqueline, van Bergen, Cornelis A. M., Posthuma, Ward, Uribe-Paredes, Roberto, Veelken, Hendrik, and Navarrete, Marcelo A.

Subjects
DNA repair, LYMPHOMAS, MUTAGENESIS, DNA analysis, CHRONIC lymphocytic leukemia, FOLLICULAR lymphoma
Abstract

Activation-induced deaminase (AID) is required for somatic hypermutation in immunoglobulin genes, but also induces off-target mutations. Follicular lymphoma (FL) and chronic lymphocytic leukemia (CLL), the most frequent types of indolent B-cell tumors, are exposed to AID activity during lymphomagenesis. We designed a workflow integrating de novo mutational signatures extraction and fitting of COSMIC (Catalogue Of Somatic Mutations In Cancer) signatures, with tridimensional chromatin conformation data (Hi-C). We applied the workflow to exome sequencing data from lymphoma samples. In 33 FL and 30 CLL samples, 42% and 34% of the contextual mutations could be traced to a known AID motif. We demonstrate that both CLL and FL share mutational processes dominated by spontaneous deamination, failures in DNA repair, and AID activity. The processes had equiproportional distribution across active and nonactive chromatin compartments in CLL. In contrast, canonical AID activity and failures in DNA repair pathways in FL were significantly higher within the active chromatin compartment. Analysis of DNA repair genes revealed a higher prevalence of base excision repair gene mutations (p = 0.02) in FL than CLL. These data indicate that AID activity drives the genetic landscapes of FL and CLL. However, the final result of AID-induced mutagenesis differs between these lymphomas depending on chromatin compartmentalization and mutations in DNA repair pathways. [ABSTRACT FROM AUTHOR]

Published
2021
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10. Cardioprotective effect of hormone replacement therapy in postmenopausal women: is the evidence biased?

Author

Posthuma, Ward F.M., Westendorp, Rudi G.J., and Vandenbroucke, Jan P.

Subjects
*HORMONE therapy for menopause, *DISEASES in women
Abstract

Examines the cardioprotective effect of hormone replacement therapy in postmenopausal women. Comparison on relative risks between cardiovascular disease and cancer; Benefits of hormone replacement therapy; Implications on the administration of oestrogen replacement therapy.

Published
1994

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