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The article focuses on the establishment of the Implementing GeNomics In praTticE (IGNITE) network or Pharmacogenetics Working Group which aim to support the investigation and development of genomic medicine practice models. Topics discussed include the use of pharmacogenetic testing in assisting prescribing decisions, CYP2C19 genotyping for prediction of clopidogrel response, and guide antiplatelet therapy for percutaneous coronary intervention (PCI).

Hospital systems increasingly utilize pharmacogenomic testing to inform clinical prescribing. Successful implementation efforts have been modeled at many academic centers. In contrast, this report provides insights into the formation of a pharmacogenomics consultation service at a safety-net hospital, which predominantly serves low-income, uninsured, and vulnerable populations. The report describes the INdiana GENomics Implementation: an Opportunity for the UnderServed (INGENIOUS) trial and addresses concerns of adjudication, credentialing, and funding. [ABSTRACT FROM AUTHOR]