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Doped ceria is known for its high ionic conductivity which is limited by the creation of defect clusters. We investigate using Molecular Dynamics the evolution of the structure and oxygen diffusivity of the Ce 0.9 M 0.1 O 1.95 (M = Gd, Sm) doped and co-doped CeO 2 systems. Two configurations concerning the introduction of the doping ions and oxygen vacancies inside the structure are generated and compared, the random one (R) and the neighbor one (N). The pair potential parameter set is chosen among three sets by comparison with experimental data. The pair correlation function first peak is fitted by a lognormal function to take into account the asymmetry. The evolution of the coefficient of thermal expansion, the coordination number and the bond lengths of the different ion pairs with the temperature, is presented. The influence of the local C-type sesquioxide M 2 O 3 structure on those parameters is discussed. No significant positive co-doping effect on the oxygen diffusion process is revealed. The random configuration of the defects leads to the highest oxygen diffusivity and to the lower activation energy whatever the doping ion (Gd, Sm or Gd/Sm). [ABSTRACT FROM AUTHOR]

Abstract: Phosphatidylinositol 5-monophosphate (PtdIns5P), one of the latest phosphoinositides discovered, has been suggested to play important cellular functions. Here, we report the presence of higher levels of this lipid in cells expressing the oncogenic tyrosine kinase nucleophosmin anaplastic lymphoma kinase (NPM-ALK), a chimeric protein found in the large majority of anaplastic large cell lymphomas (ALCLs). In addition, we describe that a pool of PtdIns5P is located in the membrane extensions characteristic of NPM-ALK-transformed cells. Finally, we show that the increase of PtdIns5P is controlled by the kinase PIKfyve, which is known for its role in vesicular trafficking. These data suggest for the first time a role of PtdIns5P and PIKfyve in oncogenesis, potentially linking intracellular trafficking to cancer. [Copyright &y& Elsevier]