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7. 远端缺血预适应在脑梗死中的脑保护机制及临床应用研究进展 Current Research in the Mechanism and Clinical Application about Remote Ischemic Preconditioning in Cerebral Infarction

Author

LIU Xudong, LIU Meng, SU Ying, ZHOU Yanxia, REN Lijie

Subjects
脑梗死, 远端缺血预适应, 脑保护, 信号转导, cerebral infarction, remote ischemic preconditioning, cerebral protection, signal transduction, Neurology. Diseases of the nervous system, RC346-429
Abstract

脑梗死是全球范围内致残率和致死率较高的疾病之一，大量研究表明，远端缺血预适应（remote ischemic preconditioning，RIPC）能够显著提高靶器官对缺血的耐受程度，减小梗死面积，改善患者预后，但目前对其在脑梗死发生发展中的作用机制研究较少。本文将从神经、体液和免疫3个方面，结合相关信号通路对RIPC在脑梗死中的作用及作用机制进行总结，并综述RIPC目前在临床缺血性脑疾病中的应用进展，以期为后续研究提供参考依据。 Abstract: Cerebral infarction is one of the diseases with high rates of disability and death worldwide, but there is still a lack of more effective treatments. Many studies showed that remote ischemic preconditioning (RIPC) can significantly improve ischemic tolerance of target organs, reduce infarct size and improve prognosis. However, its role and mechanism in the development of cerebral infarction are still little studied. This paper will summarize the role and mechanism of RIPC in cerebral infarction from the following aspects: neural, humoral, immune and related signaling pathways, and review the current research progress of RIPC in clinical cerebral ischemic diseases to provide a reference for subsequent research.

Published
2024
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13. Dual Antiplatelet Therapies and Causes in Minor Stroke or Transient Ischemic Attack: A Prespecified Analysis in the CHANCE-2 Trial

Author

Xie, Xuewei, Jing, Jing, Meng, Xia, Claiborne Johnston, S., Bath, Philip M., Li, Zixiao, Zhao, Xingquan, Liu, Liping, Wang, Yilong, Xu, Qin, Wang, Anxin, Jiang, Yong, Li, Hao, Wang, Yongjun, Wang, Yongjun, Johnston, S. Claiborne, Xu, Anding, Bath, Philip M. W., Dong, Qiang, Wang, Yongjun, Li, Hao, Meng, Xia, Jing, Jing, Xie, Xuewei, Lin, Jinxi, Simon, Tabassome, Danchin, Nicolas, Zhi, Helen, Peng, Bin, Fan, Dongsheng, Wang, David, Youn, Teddy, Adams, Harold P., Jr., Meng, Xia, Xie, Xuewei, Jing, Jing, Lin, Jinxi, Niu, Siying, Li, Hao, Pan, Yuesong, Wang, Anxin, Jiang, Yong, Jin, Aoming, Wu, Haibo, Shi, Wei, Wu, Haibo, Li, Jianhua, Wang, Yanxia, Wei, Yan, Liu, Haichao, Zhao, Jianhua, Han, Xinshen, Sheng, Baoying, Yang, Xiaofan, Jing, Ping, Chen, Jiechun, Huang, Panbing, Chen, Guofang, Feng, Yefang, Wu, Lie, Zhu, Runxiu, Liu, Peiru, Chang, Liguo, Yang, Xiafeng, Wang, Xinqiang, Zhao, Jinguo, Zhang, Wei, Cui, Zhigang, Wu, Xuemei, Huang, Hua, Liu, Qiuwu, Zhao, Xingquan, Cheng, Dongli, Zhu, Yulan, Wang, Lihua, Li, Guozhong, Zhang, Xiaoxuan, Xue, Wenjun, Chen, Guohua, Li, Haipeng, Deng, Ke, Liu, Jingyao, Liu, Yansong, Wei, Xiu’e, Wang, Dunjing, Feng, Juan, Wang, Baojun, Chen, Yongming, Wu, Bing, Chai, Xiangting, Shi, Fudong, Cai, Xueli, Yang, Hongqin, Zhang, Yundong, Wang, Xia, Wang, Yumei, Shi, Zhimin, Chen, Shengli, Chen, Yangmei, Zhou, Lichun, Hong, Weimin, Yin, Lufeng, Ren, Lijie, Ma, Jianhua, Lei, Yongqian, Wu, Minghua, Zeng, Guoyong, Wu, Lingfeng, Cao, Mingha, Guo, Cunju, Man, Honghao, Bai, Yu, Wu, Aimei, Huang, Xuerong, Zhang, Chunhua, Jiang, Xiaoling, Shao, Peining, Luo, Dexin, Cai, Zhiyou, Jia, Yi, Ma, Aijun, Bai, Ying, Gong, Xuhai, Liu, Jirong, Zhang, Meng, Xu, Anding, Tan, Hong, An, Yi, Wang, Zhimin, Zhao, Weili, Wu, Xiangbin, Gao, Wenwei, Gao, Yueqiang, Li, Xinyi, Wu, Jin, Wang, Feng, Du, Ganqin, Wu, Kaiyi, Wan, Hebin, Chu, Lan, Hong, Daojun, Cao, Hui, Xu, Bing, Liu, Jie, Zhang, Hao, Yang, Jie, Zhang, Guiru, Chen, Hong, Zhang, Jianling, Li, Xuemei, Zou, Yu’an, Wang, Yan, Wei, Xia, Wang, Jianlin, Chen, Weifeng, Liu, Chunfeng, Sui, Changbai, Li, Hongyan, Zhong, Hua, Wu, Aisheng, Fan, Jinqi, Ji, Qiuhong, Lin, Jinshen, Shi, Xueying, Kang, Guangming, Xie, Haiyang, Ma, Dan, Wang, Hongliang, Chen, Wei, Shi, Peng, Shangguan, Wen, Gu, Jun, Feng, Xiaopeng, Zhan, Qunling, Han, Xianwen, Cao, Hongyuan, Wei, Liang, Lu, Weifeng, Zheng, Chunling, Yang, Chunjie, Zhao, Min, Wu, Heng, Dong, Chunhua, He, Yongli, Yao, Shufang, Zhu, Xiangyang, Zhao, Zhong, Ye, Min, Cai, Guodong, Peng, Guangyao, Li, Hongfei, Zhang, Lujun, Zhang, Shoucheng, Zhou, Wei, Liu, Hong, Fan, Xuewen, Tan, Wei, Zhu, Renxiang, He, Tianhui, Wang, Qizhang, Zhang, Lifang, Yang, Jinsuo, Liu, Yuqing, Su, Shaohua, He, Li, Yu, Yadong, Wei, Zhang, Zhankui, Lin, Rong Qiu, Xue, Bin Qi, Ying, Sheng, Lei, Zheng Wu, Shi, Di Wu, Song, Liang Wu, Sheng, Qin, Ding, Xiao, Bo, Wang, Kai, Ting Zhang, Xi, and Jing Pang, Jin

Published
2023
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14. A Cross-Lagged Regression Analysis of Loneliness and Depression: A Two-Year Trace

Author

Ren, Lijie, Mo, Bibo, Liu, Junsheng, and Li, Dan

Abstract

This article aims to explore the possible causal relationship between loneliness and depression in college students. Two hundred and fifty-nine college students had been investigated four times in 2 years with UCLA and CES-D, and cross-lagged regression analysis was used. (1) there was a significant positive correlation between loneliness and depression of college students; (2) cross-lagged regression analysis showed that after controlling the related variables and the stability of variables themselves, loneliness, and depression could positively predict each other at points-in-time T1 and T2; Depression could significantly positively predict loneliness at points-in-time T2, T3, and T4. There is a bidirectional relationship between loneliness and depression of college students, and the effect of depression on loneliness is stronger than that of loneliness on depression.

Published
2022
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15. Indobufen versus aspirin in patients with acute ischaemic stroke in China (INSURE): a randomised, double-blind, double-dummy, active control, non-inferiority trial

Author

Wang, Yongjun, Wang, Yanxia, Wang, Cunrui, Han, Yazhou, Yu, Ming, Yang, Hongqin, Zou, Guoping, Wu, Aisheng, Zhang, Guiru, Zhang, Ping, Yan, Mingzong, Zhang, Jia, Zhao, Jingyan, Zhang, Huitian, Qi, Qinde, Zhang, Jianling, Zhu, Zhishan, Zhao, Jinguo, Fan, Wenfeng, Li, Xueli, Chang, Liguo, Tan, Lan, Zhao, Liang, Xue, Yanzhong, Liu, Peiru, Ju, Xiaohua, Zhang, Zuowen, Li, Linwen, Wei, Feng, Yang, Lixia, Li, Xuemei, Zheng, Zhixiong, Liang, Hui, Wei, Yan, Zhang, Ming, Wang, Ting, Yang, Jianbo, Liu, Qing, Huang, Panbing, Tan, Guojun, Chen, Yongming, Zhou, Jin, An, Zhongping, Li, Chunlei, Chen, Guohua, Zhu, Runxiu, Sun, Xin, Liu, Yong, Zhang, Mei, Zhuo, Yanguang, Meng, Fanwen, Zhu, Hui, Li, Kebo, Zhang, Wei, Chai, Xiangting, Deng, Ke, Li, Jianhua, Cai, Zhiyou, Jin, Hailian, Li, Bo, Zhang, Xiaomei, Ge, Beihai, Hu, Wei, Jiao, Zhen, Zhong, Lianmei, Ren, Lijie, Li, Xinyi, Wu, Songdi, Wan, Yinguo, Zhang, Jinghua, Ma, Xiaoyan, Hu, Jizheng, Zhang, Ge, Zheng, Chunling, Xu, Jun, Zou, YuAn, Huang, Xuerong, Duan, Zhihui, Li, Changxin, Zhang, Qingxiu, Song, Xiaoming, Jia, Zhengchang, Wang, Chun, Shao, Peining, Teng, Jijun, Bao, Hua, Chen, Yangkun, Wei, Yunfei, Zhang, Xu, Meng, Xisi, Li, Guangning, Feng, Yefang, Pan, Pengke, Zhuang, Aixia, Dong, Qiang, Chen, Xiaofei, Zhou, Yanhua, Tang, Jun, An, Hongwei, You, Shihao, Tang, Yanyan, Zhang, Guilian, Li, Hongyan, Guo, Miao, Yu, Chunlei, Li, Ying, Liu, Haichao, Liang, Pengfei, Kang, Guangming, Sun, Huijie, Che, Yu, Tang, Juan, Li, Dandan, Feng, Xiaopeng, Geng, Yu, Liu, Bin, Wang, Huibing, Shen, Ping, Zhu, Huaiping, Li, Farong, Zhang, Lifang, Cao, Minghua, You, Yong, Cui, Guiyun, Gu, Jun, Li, Haitao, Zhang, Xiangfeng, Liu, Xiaojun, Chen, Houqin, Zhang, Yuehua, Zhao, Hongnian, Liang, Ke, Zhi, Rui, Ma, Ling, Wu, Yuanhua, Geng, Yalan, Sun, Ping, Zhong, Bing, Li, Dongxue, Jiao, Jingya, Hao, Yanlei, Li, Guozhong, Su, Shaohua, Ju, Weiping, Min, Lianqiu, Guo, Liyan, Shangguan, Yafei, Tai, Yingdong, Xing, Ying, Chang, Hongshan, Chen, Wenya, Tang, Hongtao, Huang, Shuchun, Fang, Jingxian, Yu, Donghui, Zhao, Hailong, Xu, Lei, Wu, Aimei, Wan, Hebin, Wang, Hongliang, Shen, Zhihui, Zhang, Qing, Wang, Qian, Pan, Yuesong, Meng, Xia, Yuan, Baoshi, Johnston, S Claiborne, Li, Hao, Bath, Philip M, Xu, Anding, Jing, Jing, Lin, Jinxi, Jiang, Yong, Xie, Xuewei, Jin, Aoming, Suo, Yue, Xiong, Yunyun, Li, Zixiao, Wang, Yilong, Zhao, Xingquan, and Liu, Liping

Published
2023
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22. The Association between Loneliness and Depression among Chinese College Students: Affinity for Aloneness and Gender as Moderators

Author

Ren, Lijie, Han, Xianguo, Li, Dan, Hu, Fangmin, Mo, Bibo, and Liu, Junsheng

Abstract

Objective: This study aims to explore the moderating role of affinity for aloneness and gender in the relationship between loneliness and depression. Methods: The University of California at Los Angeles (UCLA) loneliness scale, the Loneliness and Aloneness Scale for Children and Adolescents (LACA), and the Centre for Epidemiologic Studies Depression Scale (CES-D) were administered for 831 college students (317 males and 460 females). Results: (1) Males had higher scores than females for loneliness and depression; (2) Loneliness was positively associated with affinity for aloneness and depression, whereas affinity for aloneness was positively associated with depression; and (3) The moderating effects of affinity for aloneness in the correlation between loneliness and depression only existed in males, and affinity for aloneness can buffer the effect of loneliness on depression. Results: Affinity for aloneness may be a buffering factor that serves to protect individuals with high loneliness from developing psychological problems, especially among males.

Published
2021
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39. Corrigendum to “Sema7A protects against high-fat diet-induced obesity and hepatic steatosis by regulating adipo/lipogenesis” [Mol Metab. 70 (2023) 101698]∗

Author

Lu, Qiongyu, primary, Liu, Ziting, additional, Zhao, Luyao, additional, Xu, Linru, additional, Liu, Chu, additional, Li, Ling, additional, Cao, Yiren, additional, Li, Fengchan, additional, Wu, Lili, additional, Wang, Lei, additional, Chen, Ting, additional, You, Tao, additional, Ren, Lijie, additional, Wang, Guixue, additional, Tang, Chaojun, additional, and Zhu, Li, additional

Published
2023
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