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Your search keyword '"Rose, Yannick"' showing total 8 results
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8 results on '"Rose, Yannick"'

1. A new class of small molecule RNA polymerase inhibitors with activity against Rifampicin-resistant Staphylococcus aureus

Author

Arhin, Francis, Bélanger, Odette, Ciblat, Stéphane, Dehbi, Mohammed, Delorme, Daniel, Dietrich, Evelyne, Dixit, Dilip, Lafontaine, Yanick, Lehoux, Dario, Liu, Jing, McKay, Geoffrey A., Moeck, Greg, Reddy, Ranga, Rose, Yannick, Srikumar, Ramakrishnan, Tanaka, Kelly S.E., Williams, Daniel M., Gros, Philippe, Pelletier, Jerry, Parr, Thomas R., Jr., and Far, Adel Rafai

Published
2006
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2. Novel non-nucleobase inhibitors of Staphylococcus aureus DNA polymerase IIIC

Author

Rose, Yannick, Ciblat, Stéphane, Reddy, Ranga, Belley, Adam C., Dietrich, Evelyne, Lehoux, Dario, McKay, Geoffrey A., Poirier, Hugo, Far, Adel Rafai, and Delorme, Daniel

Subjects
*DNA polymerases, *STAPHYLOCOCCUS aureus, *ANTI-infective agents, *STAPHYLOCOCCUS
Abstract

Abstract: The preparation and biological evaluation of 5-substituted-6-hydroxy-2-(anilino)pyrimidinones as a new class of DNA polymerase IIIC inhibitors, required for the replication of chromosomal DNA in Gram-positive bacteria, are described. These new dGTP competitive inhibitors displayed good levels of in vitro inhibition and antibacterial activity against Staphylococcus aureus. A new class of dATP competitive inhibitors, 6-substituted-2-amino-5-alkyl-pyrimidin-4-ones, whose antibacterial activity was unaffected by serum, were identified. [Copyright &y& Elsevier]

Published
2006
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