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Psoriasis is an autoimmune disease, which has a significant impact on the quality of patient’s life. And, there is still no cure for psoriasis. The human dental pulp stem cell (hDPSC) possesses the properties of immunoregulation. In this study, we aimed to determine the effect of hDPSC on the imiquimod (IMQ)-induced psoriasis in mice. The psoriasis model was established by topical application of IMQ cream in mice for 7 days. We found that subcutaneous injection of hDPSC could reduce the symptoms of skin lesions in IMQ-induced psoriasis and suppress the expression of keratin 16, S100A8, S100A9, which are associated with abnormal epidermal proliferation. Subepithelial inflammatory cytokines, CD4+ T lymphocytes and CD11c+ dendritic cells infiltrations were significantly inhibited in by hDPSC. The TNF-α, IFN-γ expressions in serum were decreased, and splenomegaly induced by IMQ was improved after hDPSC treatment. In summary, our study demonstrated that hDPSC could reduce the symptoms of skin lesions and suppress local and systemic immune responses of IMQ-induced psoriasis in mice, which might provide a new sight for the treatment of psoriasis.

In this article, we calculate the value-at-risk (VaR) for large portfolios in intensity models, where the idiosyncratic and systematic risk exposures as well as the impact of past default losses are subsumed into the intensity processes. The adopted method is based on the theory of saddlepoint approximation for continuous-time Markov processes whose transition densities and distribution functions can be approximated in closed forms. A simple example with theoretical and numerical results is presented in the end. [ABSTRACT FROM AUTHOR]

Diabetic retinopathy (DR) is a very serious diabetes complication. Changes in the O-linked N-acetylglucosamine (O-GlcNAc) modification are associated with many diseases. However, its role in DR is not fully understood. In this research, we explored the effect of O-GlcNAc modification regulation by activating AMP-activated protein kinase (AMPK) in DR, providing some evidence for clinical DR treatment in the future. Bioinformatics was used to make predictions from the database, which were validated using the serum samples of diabetic patients. As an in vivo model, diabetic mice were induced using streptozotocin (STZ) injection with/without an AMPK agonist (metformin) or an AMPK inhibitor (compound C) treatment. Electroretinogram (ERG) and H&E staining were used to evaluate the retinal functional and morphological changes. In vitro, 661 w cells were exposed to high-glucose conditions, with or without metformin treatment. Apoptosis was evaluated using TUNEL staining. The protein expression was detected using Western blot and immunofluorescence staining. The angiogenesis ability was detected using a tube formation assay. The levels of O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA) in the serum changed in the DR patients in the clinic. In the diabetic mice, the ERG wave amplitude and retinal thickness decreased. In vitro, the apoptotic cell percentage and Bax expression were increased, and Bcl2 expression was decreased in the 661 w cells under high-glucose conditions. The O-GlcNAc modification was increased in DR. In addition, the expression of GFAT/TXNIP O-GlcNAc was also increased in the 661 w cells after the high-glucose treatment. Additionally, the Co-immunoprecipitation(CO-IP) results show that TXNIP interacted with the O-GlcNAc modification. However, AMPK activation ameliorated this effect. We also found that silencing the AMPKα1 subunit reversed this process. In addition, the conditioned medium of the 661 w cells may have affected the tube formation in vitro. Taken together, O-GlcNAc modification was increased in DR with photoreceptor cell degeneration and neovascularization; however, it was reversed after activating AMPK. The underlying mechanism is linked to the GFAT/TXNIP-O-GlcNAc modification signaling axis. Therefore, the AMPKα1 subunit plays a vital role in the process. [ABSTRACT FROM AUTHOR]

Simultaneous transmit and receive wireless communications have been highlighted for their potential to double the spectral efficiency. However, it is necessary to mitigate self-interference (SI). Considering both the SI channel and remote transmission (RT) channel need to be estimated before equalizing the received signal, we propose two adaptive algorithms for linear and nonlinear self-interference cancellation (SIC), based on a multi-layered joint channel estimator structure. The proposed algorithms estimate the RT channel while performing SIC, and the multi-layered structure ensures improved performance across various interference-to-signal ratios. The M-estimate function enhances the robustness of the algorithm, allowing it to converge even when affected by impulsive noise. For nonlinear SIC, this paper introduces an adaptive algorithm based on generalized Hammerstein polynomial basis functions. The simulation results indicate that this approach achieves a better convergence speed and normalized mean squared difference compared to existing SIC methods, leading to a lower system bit error rate. [ABSTRACT FROM AUTHOR]

In this paper, we employ correlated skew Brownian motions to describe the dynamics of the two assets underlying the spread option. In the pricing model, the two underlying assets are exposed to exogenous risks captured by the same Brownian motion, and their endogenous risks are also assumed to be correlated with each other. We obtain an approximate pricing formula of spread options and calibrate model parameters to real data. In addition, we compare the results obtained from the approximate formula with those derived from the exact closed-form formula and from the Monte Carlo method. Finally, we analyze the impact of the skewness parameter on option prices after checking the accuracy of the approximations numerically. [ABSTRACT FROM AUTHOR]

Due to factors such as a small amount of fertilizer application during rice topdressing and slow machine speed, the ordinary fertilizer discharge device fails to distribute the fertilizer uniformly and accurately as required, making it difficult to meet the needs of precise rice topdressing. This research focuses on the development of an offset spiral tooth fertilizer discharge device suitable for rice topdressing. The study analyzes the amount of fertilizer discharged in one cycle, the fertilizer force, and the motion of the fertilizer particles. In order to enhance the uniformity of the fertilizer discharge device at a low speed and small volume, the discrete element method is employed to conduct experimental research on the key structural parameters that affect the one-cycle amount of discharged fertilizer and the dynamics of the fertilizer discharge device. Through single-factor tests, it was found that the angle, height, number of spiral teeth, and diameter of the fertilizer discharge wheel are closely associated with the fertilizer discharge performance. To further investigate the impact of these four parameters on the fertilizer discharge performance, a regression combination test of the four factors is conducted based on the range optimized by the single-factor tests. A multi-objective mathematical model, considering the key parameters of fertilizer uniformity coefficient, one-cycle amount of fertilizer, and fertilizer discharge torque, is established at three speeds: 20, 55, and 90 rpm. The response surface method is utilized to analyze the influence of the interaction factors on the fertilizer discharge performance. The optimal combination of the key structural parameters was determined as follows: spiral tooth angle of 35.42°, tooth height of 9.02 mm, discharge wheel diameter of 57.43 mm, and tooth amount of 9.37. The bench test results of the device, using the optimal parameter combination and a fertilizer discharge speed of 0–90 rpm, were obtained for four commonly used rice fertilizers. The maximum variation coefficient of fertilizer discharge was found to be 10.42%. The one-cycle amount of fertilizer discharge was measured to be 19.82 ± 0.72 (A Kang), 17.20 ± 0.69 (Ba Tian), 20.34 ± 0.54 (Yaran), and 14.51 ± 0.44 (granular urea). The fertilizer discharge torque remained stable. These results indicate that the achieved optimization meets the precise fertilizer application requirements and can provide technical support for precise topdressing operations. [ABSTRACT FROM AUTHOR]