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Background and purpose: With the increasing sensitivity of axillary imaging and ultrasound guided biopsy, some clinically axillary negative patients were upstaged to axillary positive (cN1) and received axillary lymph node dissection (ALND). This study aimed to assess the feasibility of sentinel lymph node (SLN) biopsy (SLNB) in patients with axilla negative evaluation by physical examination but suspicious lymph nodes finding on preoperative imaging and metastasis confirmed with a fine-needle aspiration cytology/core-needle biopsy pathology (FNAC/CNBP). Methods: This retrospective cohort study included patients with early breast cancer who had axilla negative evaluation by physical examination but suspicious lymph nodes finding on preoperative imaging and metastasis confirmed with a FNAC/CNBP from October 2015 to December 2022 in the Breast Cancer Centre of Shandong Cancer Hospital and Institute. All patients received ALND. The data were analyzed by using SPSS version 27.0 statistical software, and P

Precise regulation of the active site structure is an important means to enhance the activity and selectivity of catalysts in CO2 electroreduction. Here, we creatively introduce anionic groups, which can not only stabilize metal sites with strong coordination ability but also have rich interactions with protons at active sites to modify the electronic structure and proton transfer process of catalysts. This strategy helps to convert CO2 into fuel chemicals at low overpotentials. As a typical example, a composite catalyst, CuO/Cu−NSO4/CN, with highly dispersed Cu(II)−SO4 sites has been reported, in which CO2 electroreduction to formate occurs at a low overpotential with a high Faradaic efficiency (−0.5 V vs. RHE, FEformate=87.4 %). Pure HCOOH is produced with an energy conversion efficiency of 44.3 % at a cell voltage of 2.8 V. Theoretical modeling demonstrates that sulfate promotes CO2 transformation into a carboxyl intermediate followed by HCOOH generation, whose mechanism is significantly different from that of the traditional process via a formate intermediate for HCOOH production. [ABSTRACT FROM AUTHOR]

Graphyne has recently attracted much attention since it is an important derivative of graphene with unique topological properties. Although graphyne is not a conventional topological insulator because of its weak spin–orbit coupling, it is a real Chern topological insulator with the higher-order topology. However, it lacks a realistic model. Here, we propose a schedule to realize acoustic graphyne. By introducing negative coupling to simulate the carbon–carbon triple bond, we realize the transition from trivial to higher-order topological phases, characterized by real Chern numbers. These topologically protected corner states are achieved in a finite-size sample, and the condition for their existence is discussed. Our research extends the concept of real Chern insulators and provides a platform for studying the topological properties of graphene-like structural compounds. [ABSTRACT FROM AUTHOR]

Moblie platform is an online store for distributing mobile apps and designed to connect mobile app developers and users. Mobile platform launches in-app advertisement for their advertisers to monetize the mobile app market. Unlike traditional advertising, the profitability of in-app advertising is not only affected by the decision of the platform, but also by the decision of the app developer, and they will share the advertising revenue. We develop an app advertising revenue sharing model with two competitive app developers and one mobile platform. The mobile platform is the leader, and the two app developers are the follower. Our analysis shows that the two app developers may choose to publish or not publish adds. If publishing, app developers may choose to offer a free app with in-app ads, or choose to offer a paid app with in-app ads. These results can be categorized into seven ranges for the platform's given revenue share of advertisement. In addition, we find the platform's optimal choice of ad revenue share is affected by the quality of advertisement. With the improvement of advertising quality, the revenue sharing ratio will first remain unchanged, then decrease, and finally increase. This is caused by the platform's subsidization strategy for app developers. [ABSTRACT FROM AUTHOR]

Coronavirus Disease 2019 (COVID-19) infected by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) has been declared a public health emergency of international concerns. Cytokine storm syndrome (CSS) is a critical clinical symptom of severe COVID-19 patients, and the macrophage is recognized as the direct host cell of SARS-CoV-2 and potential drivers of CSS. In the present study, peramivir was identified to reduce TNF-α by partly intervention of NF-κB activity in LPS-induced macrophage model. In vivo , peramivir reduced the multi-cytokines in serum and bronchoalveolar lavage fluid (BALF), alleviated the acute lung injury and prolonged the survival time in mice. In human peripheral blood mononuclear cells (hPBMCs), peramivir could also inhibit the release of TNF-α. Collectively, we proposed that peramivir might be a candidate for the treatment of COVID-19 and other infections related CSS. [ABSTRACT FROM AUTHOR]

To attain the general form of stable coalition structure, this paper addressed the problem of retailers’ coalition stability in a two-stage supply chain consisting of one supplier and multiple retailers. A profit gain function was established via introducing market gain coefficient and coalition cost coefficient for different coalition structures. Based on the function, the profit of each retailer in all kinds of coalition structures was analysed, and the general feature of a stable coalition structure was attained by the largest consistent set method and the stable set method. Furthermore, some insights were obtained. For example, stable coalition structures are equidistributed or approximate equidistributed; with supplier’s cost increasing, the size of the retailers’ coalition increases. Finally, the above conclusions are verified by numerical simulation. The results of this paper provide a reference for retailers’ coalition in a supply chain, such as automobile or Information Technology supply chain. [ABSTRACT FROM PUBLISHER]

Exploring earth‐abundant materials for low concentration CO2 photoreduction is the key in the energy related field. Here, we demonstrated biphasic titania (anatase and rutile) derived from Ti‐based metal‐organic framework (MOF) nanoplates exhibited excellent performance in CO2 photoreduction without any co‐catalysts and sacrificial agents under ambient condition, the maximum CH4 production rate was up to 65.39 μmol g−1 h−1 with near 100 % electron selectivity as well as great stability. The activity of the optimal derivative was maintained well even in 1 % CO2 (CH4: 45.59 μmol g−1 h−1) and much better than that of commercial P25. The upgraded performance originated from the synergism between local anatase/rutile interface and numerous defective sites (Ti3+ and Ov), by promoting the separation and migration of photogenerated carriers, CO2 adsorption and activation, and H2O dissociation. Besides, a possible fast hydrodeoxygenation mechanism for methane formation was proposed according to in situ DRIFTS characterization. [ABSTRACT FROM AUTHOR]

Waveguides and resonators are core components in the large-scale integration of electronics, photonics and phononics, both in existing and future scenarios. In certain situations, there is critical coupling of the two components; i.e. no energy passes through the waveguide after the incoming wave couples into the resonator. The transmission spectral characteristics resulting from this phenomenon are highly advantageous for signal filtering, switching, multiplexing and sensing. In the present study, adopting an elastic-wave platform, we introduce topological insulator (TI), a remarkable achievement in condensed matter physics over the past decade, into a classical waveguide-ring-resonator configuration. Along with basic similarities with classical systems, a TI system has important differences and advantages, mostly owing to the spin-momentum locked transmission states at the TI boundaries. As an example, a two-port TI waveguide resonator can fundamentally eliminate upstream reflections while completely retaining useful transmission spectral characteristics, and maximize the energy in the resonator, with possible applications being novel signal processing, gyro/sensing, lasering, energy harvesting and intense wave–matter interactions, using phonons, photons or even electrons. The present work further enhances confidence in using topological protection for practical device performance and functionalities, especially considering the crucial advantage of introducing (pseudo)spins to existing conventional configurations. More in-depth research on advancing phononics/photonics, especially on-chip, is foreseen. [ABSTRACT FROM AUTHOR]

This paper considers a stochastic multi-period inventory and acquisition effort decisions problem in a hybrid manufacturing/remanufacturing system. Different from past papers, two factors are introduced into the dynamic decision problem. One is the dependency between sales and returns, the other is the dual impacts of acquisition effort on the return of used products and the demand. Few past papers consider them, but they are important and unavoidable for many practical cases. These factors make the problem a high-dimensional decision-making problem, which is difficult to analyze and solve the optimal policy by stochastic dynamic programming, so we employ the robust optimization method. Based on the duality theory, an equivalent robust optimization model is given, which is a convex programming problem. By numerical analyses, we analyze the effects of system parameters on the related decisions and profits, which can provide insights for producers to manage their hybrid manufacturing/remanufacturing systems. [ABSTRACT FROM AUTHOR]

The vacation queue models have been studied by many researchers. They usually assume that the server will take a vacation immediately at the end of a busy period. But in some cases, it is random that the server takes a vacation when the system is empty. Therefore, we study an M/G/1 queue model with random vacation policy in this paper. We derive the indexes such as the mean queue length, mean sojourn time of customers and the busy period of the server. Finally, numerical examples are provided for illustration. [ABSTRACT FROM AUTHOR]

The topological phase of matter, originally proposed and first demonstrated in fermionic electronic systems, has drawn considerable research attention in the past decades due to its robust transport of edge states and its potential with respect to future quantum information, communication, and computation. Recently, searching for such a unique material phase in bosonic systems has become a hot research topic worldwide. So far, many bosonic topological models and methods for realizing them have been discovered in photonic systems, acoustic systems, mechanical systems, etc. These discoveries have certainly yielded vast opportunities in designing material phases and related properties in the topological domain. In this review, we first focus on some of the representative photonic topological models and employ the underlying Dirac model to analyze the edge states and geometric phase. On the basis of these models, three common types of two-dimensional topological photonic systems are discussed: 1) photonic quantum Hall effect with broken time-reversal symmetry; 2) photonic topological insulator and the associated pseudo-time-reversal symmetry-protected mechanism; 3) time/space periodically modulated photonic Floquet topological insulator. Finally, we provide a summary and extension of this emerging field, including a brief introduction to the Weyl point in three-dimensional systems. [ABSTRACT FROM AUTHOR]

Di-(2-ethylhexyl)-phthalate (DEHP) is causing serious health hazard in wildlife animal and human through environment and food chain, including the effect of brain development and impacted neurobehavioral outcomes. However, DEHP exposure caused cerebellar toxicity in bird remains unclear. To evaluate DEHP-exerted potential neurotoxicity in cerebellum, male quails were exposed with 0, 250, 500 and 750 mg/kg BW/day DEHP by gavage treatment for 45 days. Neurobehavioral abnormality and cerebellar histopathological alternation were observed in DEHP-induced quails. DEHP exposure increased the contents of total Cytochrome P450s (CYPs) and Cytochrome b5 (Cyt b5) and the activities of NADPH-cytochrome c reductase (NCR) and aniline-4-hydeoxylase (AH) in quail cerebellum. The expression of nuclear xenobiotic receptors (NXRs) and the transcriptions of CYP enzyme isoforms were also influenced in cerebellum by DEHP exposure. These results suggested that DEHP exposure caused the toxic effects of quail cerebellum. DEHP exposure disrupted the cerebellar CYP enzyme system homeostasis via affecting the transcription of CYP enzyme isoforms. The cerebellar P450arom and CYP3A4 might be biomarkers in evaluating the neurotoxicity of DEHP in bird. Finally, this study provided new evidence that DEHP-induced toxic effect of quail cerebellum was associated with activating the NXRs responses and disrupting the CYP enzyme system homeostasis. [ABSTRACT FROM AUTHOR]

As exotic phenomena in optics, topological states in photonic crystals have drawn much attention due to their fundamental significance and great potential applications. Because of the broken time-reversal symmetry under the influence of an external magnetic field, the photonic crystals composed of magneto-optical materials will lead to the degeneracy lifting and show particular topological characters of energy bands. The upper and lower bulk bands have nonzero integer topological numbers. The gapless edge states can be realized to connect two bulk states. This topological photonic states originated from the topological property can be analogous to the integer quantum Hall effect in an electronic system. The gapless edge state only possesses a single sign of gradient in the whole Brillouin zone, and thus the group velocity is only in one direction leading to the one-way energy flow, which is robust to disorder and impurity due to the nontrivial topological nature of the corresponding electromagnetic states. Furthermore, this one-way edge state would cross the Brillouin center with nonzero group velocity, where the negative-zero-positive phase velocity can be used to realize some interesting phenomena such as tunneling and backward phase propagation. On the other hand, under the protection of time-reversal symmetry, a pair of gapless edge states can also be constructed by using magnetic-electric coupling meta-materials, exhibiting Fermion-like spin helix topological edge states, which can be regarded as an optical counterpart of topological insulator originating from the spin-orbit coupling. The aim of this article is to have a comprehensive review of recent research literatures published in this emerging field of photonic topological phenomena. Photonic topological states and their related phenomena are presented and analyzed, including the chiral edge states, polarization dependent transportation, unidirectional waveguide and nonreciprocal optical transmission, all of which might lead to novel applications such as one-way splitter, optical isolator and delay line. In addition, the possible prospect and development of related topics are also discussed. [ABSTRACT FROM AUTHOR]

This paper introduces a new method for the early detection of gastric cancer using a combination of feature extraction based on discrete wavelet transformation (DWT) for horizontal attenuated total reflectance-Fourier transform infrared spectroscopy (HATR-FT-IR) and classification using probability neural network (PNN). 344 FT-IR spectra were collected from 172 pairs of fresh normal and abnormal stomach tissue's samples. After preprocessing, 5 features were extracted with DWT analysis. Based on the PNN classification, all FT-IR spectra were classified into three categories. The accuracy of identifying normal gastric tissue, early gastric cancer tissue and gastric cancer tissue samples were 100.00, 97.56 and 100.00%, respectively. This result indicated that FT-IR with DWT and PNN could effectively and easily diagnose gastric cancer in its early stages. [ABSTRACT FROM AUTHOR]

Background: Cancer-testis antigens (CTAs) are suitable targets for cancer-specific immunotherapy. The aim of the study is to investigate the expression of CTAs in intrahepatic cholagiocarcinoma (IHCC) and evaluate their potential therapeutic values. Methods: Eighty-nine IHCC patients were retrospectively assessed for their expression of CTAs and HLA Class I by immunohistochemistry using the following antibodies: MA454 recognizing MAGE-A1, 57B recognizing multiple MAGE-A (MAGE-A3/A4), E978 recognizing NY-ESO-1, and EMR8-5 recognizing HLA class I. The clinicopathological and prognostic significance of individual CTA markers and their combination were further evaluated. Results: The expression rates of MAGE-A1, MAGE-A¾ and NY-ESO-1 were 29.2%, 27.0% and 22.5%, respectively. The concomitant expression of CTAs and HLA class I antigen was observed in 33.7% of the IHCC tumors. We found that positive MAGE-¾ expression correlated with larger tumor size (≥ 5 cm), tumor recurrence and poor prognosis. Moreover, we identified 52 cases (58.4%) of IHCC patients with at least one CTA marker expression, and this subgroup displayed a higher frequency of larger tumor size and a shorter survival than the other cases. Furthermore, expression of at least one CTA marker was also an independent prognostic factor in patients with IHCC. Conclusion: Our data suggest that specific immunotherapy targeted CTAs might be a novel treatment option for IHCC patients. [ABSTRACT FROM AUTHOR]

The recent discovery of anti‐chiral edge states in magnetic semimetals linking two unequal‐frequency bulk Dirac nodes manifests a paradoxical picture in contrast to the chiral behavior in Chern insulators, implying an untapped phase may exist. Here, a unique Chern metal, exhibiting a nontrivial Chern number but without a complete bandgap is proposed, and the complete topological phase diagram in the modified Haldane model is obtained. Subsequently, the Chern metal in a 2D honeycomb‐lattice gyromagnetic photonic crystal by simultaneously breaking parity and time‐reversal symmetries with opposite and unequal magnetic biases at different sublattices is realized. For the paired complementary‐shape boundaries, such as zigzag/bearded, it is experimentally revealed that either clockwise or counter‐clockwise chiral character is switchable in Chern metals relying on different boundary choices, a remarkable property deemed as bi‐chiral edge propagation. The topological Chern metal with hidden bulk‐boundary correspondence is articulated to bridge the chiral and anti‐chiral paradox gap between Chern insulators and magnetic semimetals. These results enrich the family of Chern materials and highlight the previously untapped on‐demand control of topological edge states. [ABSTRACT FROM AUTHOR]

Time-reversal symmetry (TRS) of electrons is associated with an anti-unitary operator with T 2 = − 1 , which induces Kramers degeneracy and plays an important role in realizing the quantum spin Hall effect (QSHE). By contrast, TRS of photons is described by T b 2 = 1 . We point out that due to this difference, TRS is not the necessary condition for the construction of the photonic analogue of the QSHE. Instead, by constructing an artificial pseudo TRS T p with T p 2 = − 1 in a photonic system, one can realize the photonic Kramers degeneracy and a pair of topological protected edge states, a photonic analogue of the QSHE. Specifically, by retrieving the optical parameters of materials with the pseudo TRS, we propose a photonic topological insulator (PTI) utilizing a pair of double-degenerate transverse electric (TE) and transverse magnetic (TM) polarizations to mimic the spin up and down states of the electron. We demonstrate that the unidirectional polarization-dependent transportation of TE and TM edge states can be realized in this system based on computer simulations. For all possible symmetry types, we check the robustness of these topological states by using a complete set of impurities, including three Pauli matrices and one complex conjugate operator. The results show that the PTI is protected by the pseudo TRS T p . In general, an arbitrary pair of optical polarizations on the Bloch sphere can be utilized to construct photonic pseudospin states and the PTI. Our findings confirm the physical meaning of the pseudo TRS and may provide guidance for future PTI designs. [ABSTRACT FROM AUTHOR]

The original version of this Article contained errors in the second sentence in the legend of Fig. 1, which incorrectly read 'These two elastic insulators are identical in lattice constant a (3a0), plate thickness (0.4a0), and radius of perforated holes r (0.18a0) but different hole-center distance characterized by b.' The correct version states 'plate thickness (√3 × 0.4a0)' in place of 'plate thickness (0.4a0)' and 'radius of perforated holes r (√3 × 0.18a0)' rather than 'radius of perforated holes r (0.18a0)'.The first sentence of the 'Sample preparation' section of the Methods originally incorrectly read 'Our samples are prepared exclusively on polished stainless-steel plates (Type 201, mass density 7803 kg m−3) with a fixed plate thickness 7.82 mm.' In the corrected version, 'mass density 7903 kg m−3' replaces 'mass density 7803 kg m−3'.The second sentence in the legend of Supplementary Fig. 3, originally incorrectly read 'The symmetry of the phononic crystal remains unchanged as C6ν, and thickness of the substrates H (equals to 0.4a0), lattice constant a (equals to 3a0) and radius of perforated holes r (equals to 0.18 a0) maintain constant.' The correct version states '√3 × 0.4a0' in place of '0.4a0' and '√3 × 0.18a0' rather than '0.18a0'.This has been corrected in both the PDF and HTML versions of the Article. [ABSTRACT FROM AUTHOR]

An acoustic asymmetric transmission device exhibiting unidirectional transmission property for acoustic waves is extremely desirable in many practical scenarios. Such a unique property may be realized in various configurations utilizing acoustic Zeeman effects in moving media as well as frequency-conversion in passive nonlinear acoustic systems and in active acoustic systems. Here we demonstrate a new acoustic frequency conversion process in a time-varying system, consisting of a rotating blade and the surrounding air. The scattered acoustic waves from this time-varying system experience frequency shifts, which are linearly dependent on the blade's rotating frequency. Such scattering mechanism can be well described theoretically by an acoustic linear time-varying perturbation theory. Combining such time-varying scattering effects with highly efficient acoustic filtering, we successfully develop a tunable acoustic unidirectional device with 20 dB power transmission contrast ratio between two counter propagation directions at audible frequencies. [ABSTRACT FROM AUTHOR]