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Your search keyword '"Sun, Yonggan"' showing total 25 results
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25 results on '"Sun, Yonggan"'

12. Gut firmicutes: Relationship with dietary fiber and role in host homeostasis.

Author

Sun, Yonggan, Zhang, Shanshan, Nie, Qixing, He, Huijun, Tan, Huizi, Geng, Fang, Ji, Haihua, Hu, Jielun, and Nie, Shaoping

Subjects
*DIETARY fiber, *PROBIOTICS, *HOMEOSTASIS, *INTESTINAL mucosa, *FOOD production, *BACTEROIDES, *LACTOBACILLUS
Abstract

Firmicutes and Bacteroidetes are the predominant bacterial phyla colonizing the healthy human gut. Accumulating evidence suggests that dietary fiber plays a crucial role in host health, yet most studies have focused on how the dietary fiber affects health through gut Bacteroides. More recently, gut Firmicutes have been found to possess many genes responsible for fermenting dietary fiber, and could also interact with the intestinal mucosa and thereby contribute to homeostasis. Consequently, the relationship between dietary fiber and Firmicutes is of interest, as well as the role of Firmicutes in host health. In this review, we summarize the current knowledge regarding the molecular mechanism of dietary fiber degradation by gut Firmicutes and explain the communication pathway of the dietary fiber-Firmicutes-host axis, and the beneficial effects of dietary fiber-induced Firmicutes and their metabolites on health. A better understanding of the dialogue sustained by the dietary fiber-Firmicutes axis and the host could provide new insights into probiotic therapy and novel dietary interventions aimed at increasing the abundance of Firmicutes (such as Faecalibacterium, Lactobacillus, and Roseburia) to promote health. Dietary fiber-induced gut Firmicutes and their metabolites exhibit relevant health-promoting functions. Most of dietary fiber have a great effect on gut Firmicutes. Mechanisms of dietary fiber uptake by gut Firmicutes are outlined. Mechanisms of dietary fiber- gut Firmicutes-host interactions require more investigation for the development of dietary fiber in food production and host health. [ABSTRACT FROM AUTHOR]

Published
2023
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23. Not all dietary fibers alleviate type 2 diabetes

Author

Nie, Qixing, primary, Gao, He, additional, Li, Mingzhi, additional, Sun, Yonggan, additional, Chen, Haihong, additional, Zuo, Sheng, additional, Fang, Qingying, additional, Huang, Xiaojun, additional, Yin, Junyi, additional, Hu, Jielun, additional, and Nie, Shaoping, additional

Published
2020
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25. Arabinoxylan Alleviates Obesity by Regulating Gut Microbiota and Bile Acid Metabolism

Author

Lin, Jun, Liu, Huiying, Sun, Yonggan, Zou, Jianqiao, Nie, Qixing, and Nie, Shaoping

Abstract

Overweight and obesity are major and increasingly global public health concern. High intake of dietary fiber is negatively correlated with obesity and obesity-related metabolic diseases. Here, we investigated the impact of arabinoxylan on obesity based on the modification of gut microecology. Arabionxylan reduced body weight and improved glucose metabolism, as well as intestinal barrier function and metabolic endotoxemia in obese mice. Supplementation with arabinoxylan increased the relative abundance of Prevotellaceae_UCG_001, Lachnospiraceae_NK4A136_group, Clostridia_UCG_014, Alistipes, Bacteroides, and Ruminococcus,which was associated with the upregulated 7α-dehydroxylation function and production of secondary bile acids (deoxycholic acid and lithocholic acid). The modification of gut microbiota by arabinoxylan also influenced the production of SCFAs, genistein, daidzein, indolelactic acid, and indoleacetic acid, contributing to the amelioration of obesity. Our study highlights the antiobesity effects of arabinoxylan through the modification of gut microbiota and the production of bioactive metabolites.

Published
2024
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