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287 results on '"Takahashi, Michiko"'

1. The combination of doxazosin and metyrosine as a preoperative treatment for pheochromocytomas and paragangliomas

Author

Ohmachi, Yuka, Yamamoto, Masaaki, Inaba, Yuiko, Makino, Shohei, Urai, Shin, Matsumoto, Risa, Bando, Hironori, Kanie, Keitaro, Tsujimoto, Yasutaka, Motomura, Yuma, Sasaki, Yuriko, Oi-Yo, Yuka, Yamamoto, Naoki, Suzuki, Masaki, Takahashi, Michiko, Iguchi, Genzo, Kanzawa, Maki, Furukawa, Junya, Shigemura, Katsumi, Mizobuchi, Satoshi, Ogawa, Wataru, and Fukuoka, Hidenori

Published
2024
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9. Antibodies to Crohn’s disease peptide 353 as a diagnostic marker for pediatric Crohn’s disease: a prospective multicenter study in Japan

Author

Mizuochi, Tatsuki, Arai, Katsuhiro, Kudo, Takahiro, Nambu, Ryusuke, Tajiri, Hitoshi, Aomatsu, Tomoki, Abe, Naoki, Kakiuchi, Toshihiko, Hashimoto, Kunio, Sogo, Tsuyoshi, Takahashi, Michiko, Etani, Yuri, Takaki, Yugo, Konishi, Ken-ichiro, Ishihara, Jun, Obara, Hitoshi, Kakuma, Tatsuyuki, Kurei, Shunsuke, Yamashita, Yushiro, and Mitsuyama, Keiichi

Published
2020
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10. Isolation of viruses, including mollivirus, with the potential to infect Acanthamoeba from a Japanese warm temperate zone.

Author

Morimoto, Daichi, Tateishi, Naohisa, Takahashi, Michiko, and Nagasaki, Keizo

Subjects
VIRUS isolation, ACANTHAMOEBA, ACANTHAMOEBA castellanii, VIRAL genomes, MARINE sediments, JAPANESE encephalitis viruses
Abstract

Acanthamoeba castellanii is infected with diverse nucleocytoplasmic large DNA viruses. Here, we report the co-isolation of 12 viral strains from marine sediments in Uranouchi Inlet, Kochi, Japan. Based on the morphological features revealed by electron microscopy, these isolates were classified into four viral groups including Megamimiviridae, Molliviridae, Pandoraviridae, and Pithoviridae. Genomic analyses indicated that these isolates showed high similarities to the known viral genomes with which they are taxonomically clustered, and their phylogenetic relationships were also supported by core gene similarities. It is noteworthy that Molliviridae was isolated from the marine sediments in the Japanese warm temperate zone because other strains have only been found in the subarctic region. Furthermore, this strain has 19 and 4 strain-specific genes found in Mollivirus sibericum and Mollivirus kamchatka, respectively. This study extends our knowledge about the habitat and genomic diversity of Molliviridae. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Awareness of children's developmental problems and sharing of concerns with parents by preschool teachers and childcare workers: The Japanese context.

Author

Honda, Hideo, Sasayama, Daimei, Niimi, Taemi, Shimizu, Ayako, Toibana, Yuki, Kuge, Rie, Takagi, Hidetoshi, Nakajima, Aya, Sakatsume, Reiko, Takahashi, Michiko, Heda, Takuma, Nitto, Yukari, Tsukada, Shota, and Nishigaki, Akiko

Subjects
CHILD care, PROFESSIONS, CHILD care workers, PSYCHOLOGY of teachers, MEDICAL personnel, PATIENTS' families, HEALTH literacy, SURVEYS, ATTENTION-deficit hyperactivity disorder, COMMUNICATION, PRESCHOOLS, HEALTH, INFORMATION resources, RESEARCH funding, AUTISM, CHILD development deviations, PARENTS, EARLY diagnosis
Abstract

Background: This study aims to determine the extent to which preschool teachers and childcare workers are aware of the presence of developmental problems among children and to what extent they share information with parents about their concerns regarding a child's development or diagnosis of neurodevelopmental disorders (NDDs). Methods: We wrote to all 924 preschools and childcare centres in Japan's Nagano and Yamanashi prefectures to request participants. We then sent survey forms to the preschools and childcare centres that agreed to cooperate for three grades comprising 3‐, 4‐ and 5‐year‐olds in the school year 2020. We asked the staff member in charge of each child to complete the survey. The survey included questions about the teacher's concerns regarding the possibility of an NDD and whether the matter had been shared with the children's parents. Results: We obtained data for 10 354 children from 206 preschools and childcare centres (response rate = 22.3%). Among these children, 457 (4.4%) had an NDD diagnosis that their parents shared with the teachers. However, the teachers of 1274 children (12.3%) had concerns regarding their development but were not informed by the parents about the diagnosis, if any. These 1274 children included 775 (60.8%) cases where the teachers failed to share their concerns with parents because (1) the teachers could not communicate with parents (n = 119), (2) the teachers were not sure if there was a neurodevelopmental problem (n = 360) and (3) the parents were not aware of the problem (n = 296). Conclusions: Preschool teachers and childcare workers had concerns about the development of a substantial proportion of children in their charge. However, teachers and childcare workers did not share their concerns regarding many children's developmental problems with their parents. The findings suggest that there are challenges in information‐sharing between teachers/childcare workers and parents. [ABSTRACT FROM AUTHOR]

Published
2024
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12. Clinical features of anti-pituitary-specific transcription factor-1 (PIT-1) hypophysitis: a new aspect of paraneoplastic autoimmune condition.

Author

Urai, Shin, Iguchi, Genzo, Kanie, Keitaro, Bando, Hironori, Yamamoto, Masaaki, Oi, Yuka, Kashitani, Yuya, Iida, Keiji, Kanzawa, Maki, Fukuoka, Hidenori, Takahashi, Michiko, Shintani, Yasushi, Ogawa, Wataru, and Takahashi, Yutaka

Subjects
ENDOCRINOLOGY, PATHOGENESIS, PARANEOPLASTIC syndromes, IMMUNE checkpoint inhibitors, CANCER immunotherapy, ANTINEOPLASTIC agents
Abstract

The pathogenesis of anti-pituitary-specific transcription factor-1 (PIT-1) hypophysitis was gradually revealed as cases emerged. Our comprehensive analysis, including all reported cases, identified a new instance of anti-PIT-1 hypophysitis postimmune checkpoint inhibitor therapy. All 9 patients exhibited extremely low growth hormone (GH), prolactin (PRL), and thyroid-stimulating hormone (TSH) levels; 2 had a slightly atrophic pituitary gland; 4 had thymoma, and 5 had malignant neoplasms of diffuse large B-cell lymphoma (DLBCL) and other origins. Patients with thymoma showed multiple autoimmune diseases. HLA-A*24:02 and/or A*02:06 were present in six and DR53 in 5 cases analyzed. High anti-PIT-1 antibody titers and ectopic PIT-1 expression in the cytosol and nucleus of the tumor tissues were observed in patients with thymoma or DLBCL, whereas it was exclusively observed in the nuclei of a bladder cancer patient. These findings provide new insights into the pathophysiology of paraneoplastic autoimmune hypophysitis. [ABSTRACT FROM AUTHOR]

Published
2024
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20. DsRNA sequencing revealed a previously missed terminal sequence of a +ssRNA virus that infects dinoflagellate Heterocapsa circularisquama.

Author

Takahashi, Michiko, Masuda, Yuichi, Chiba, Yuto, Urayama, Syun-ichi, and Nagasaki, Keizo

Abstract

Heterocapsa circularisquama RNA virus (HcRNAV) is the only dinoflagellate-infecting RNA virus cultured. However, only two strains of HcRNAV have been registered with complete genome sequences (strains 34 and 109 for UA and CY types, respectively). To extend the genomic information of HcRNAV, we performed full-genome sequencing of an unsequenced strain of HcRNAV (strain A8) using the fragmented and primer-ligated double-stranded RNA (dsRNA) sequencing (FLDS) method. The complete genome of HcRNAV A8 with 4457 nucleotides (nt) was successfully determined, and sequence alignment of the major capsid protein gene suggested that A8 was a UA-type strain, consistent with its intraspecific host specificity. The complete sequence was found to be 80 nt longer at the 5′ terminus than the registered sequences of HcRNAV strains (34 and 109), suggesting that FLDS is more reliable for determining the terminal sequence than conventional methods (5' Rapid Amplification of cDNA End). Our study contributes to a better understanding of dinoflagellate-infecting viruses with limited sequence data. [ABSTRACT FROM AUTHOR]

Published
2024
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22. Frailty and Colorectal Surgery: Review and Concept of Cancer Frailty.

Author

Maeda, Hiromichi, Takahashi, Michiko, Seo, Satoru, and Hanazaki, Kazuhiro

Subjects
*PROCTOLOGY, *FRAILTY, *TREATMENT delay (Medicine), *SURGICAL complications, *PREHABILITATION
Abstract

Frailty is characterized by reduced physiological reserves across multiple systems. In patients with frailty, oncological surgery has been associated with a high rate of postoperative complications and worse overall survival. Further, given that cancer and frailty can co-exist in the same patient, cancer and cancer-related symptoms can rapidly accelerate the progression of baseline frailty, which we have termed "cancer frailty". This distinction is clinically meaningful because the prioritization of interventions and the treatment outcomes may differ based on health conditions. Specifically, in patients with cancer frailty, improvements in frailty may be achieved via surgical removal of tumors, while prehabilitation may be less effective, which may in turn result in delayed treatment and cancer progression. In this review, we focused on challenges in the surgical treatment of non-metastatic colorectal cancers in patients with frailty, including those related to decision making, prehabilitation, and surgery. Potential recommendations for treating patients with cancer frailty are also discussed. [ABSTRACT FROM AUTHOR]

Published
2023
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23. Serum leucine‐rich alpha‐2 glycoprotein and calprotectin in children with inflammatory bowel disease: A multicenter study in Japan.

Author

Yasuda, Ryosuke, Arai, Katsuhiro, Kudo, Takahiro, Nambu, Ryusuke, Aomatsu, Tomoki, Abe, Naoki, Kakiuchi, Toshihiko, Hashimoto, Kunio, Sogo, Tsuyoshi, Takahashi, Michiko, Etani, Yuri, Kato, Ken, Yamashita, Yushiro, Mitsuyama, Keiichi, and Mizuochi, Tatsuki

Subjects
INFLAMMATORY bowel diseases, CALPROTECTIN, CROHN'S disease, RECEIVER operating characteristic curves, IRRITABLE colon
Abstract

Background and Aim: Serum leucine‐rich alpha‐2 glycoprotein (LRG) and calprotectin have been studied as disease activity markers in adults with inflammatory bowel disease (IBD). We evaluated them in pediatric IBD patients. Methods: Subjects under 17 years old undergoing care at 11 Japanese pediatric centers were retrospectively assigned to 3 groups representing Crohn's disease (CD), ulcerative colitis (UC), and normal controls (NC) with irritable bowel syndrome or no illness. Serum LRG and calprotectin were measured using commercial enzyme‐linked immunosorbent assay kits. Results: We enrolled 173 subjects, including 74 with CD, 77 with UC, and 22 NC. Serum LRG concentrations in active CD (median, 200 μg/mL) were significantly greater than in remission (81 μg/mL; P < 0.001) or NC (69 μg/mL; P < 0.001). Serum calprotectin concentrations in active CD (2941 ng/mL) also were significantly greater than in remission (962 ng/mL; P < 0.05) or NC (872 ng/mL; P < 0.05). Serum LRG concentrations in active UC (134 μg/mL) were significantly greater than in remission (65 μg/mL; P < 0.01) but not significantly greater than in NC (69 μg/mL); serum calprotectin concentrations in active UC (1058 ng/mL) were not significantly different from those in remission (671 ng/mL) or NC (872 ng/mL). In receiver operating characteristic analyses of LRG, calprotectin, C‐reactive protein, and erythrocyte sedimentation rate for ability to distinguish active IBD from remission, CD and UC showed areas under receiver operating characteristic curves for LRG (0.77 and 0.70, respectively), exceeding those for calprotectin, C‐reactive protein, or erythrocyte sedimentation rate. Conclusions: In pediatric IBD, serum LRG may better reflect disease activity than serum calprotectin, particularly in CD. [ABSTRACT FROM AUTHOR]

Published
2023
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