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Your search keyword '"Tománková, Kateřina"' showing total 21 results
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21 results on '"Tománková, Kateřina"'

11. Corrigendum to Carbon dots for in vivo fluorescence imaging of adipose tissue-derived mesenchymal stromal cells [Carbon 152 (2019) 434–443]

Author

Malina, Tomáš, primary, Poláková, Kateřina, additional, Skopalík, Josef, additional, Milotová, Věra, additional, Holá, Kateřina, additional, Havrdová, Markéta, additional, Tománková, Kateřina Bartoň, additional, Čmiel, Vratislav, additional, Šefc, Luděk, additional, and Zbořil, Radek, additional

Published
2021
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15. Water-insoluble thin films from palmitoyl hyaluronan with tunable properties

Author

Foglarová, Marcela, Chmelař, Josef, Huerta-Angeles, Gloria, Vágnerová, Hana, Kulhánek, Jaromír, Bartoň Tománková, Kateřina, Minařík, Antonín, Velebný, Vladimír, Foglarová, Marcela, Chmelař, Josef, Huerta-Angeles, Gloria, Vágnerová, Hana, Kulhánek, Jaromír, Bartoň Tománková, Kateřina, Minařík, Antonín, and Velebný, Vladimír

Abstract

Hyaluronan (HA) films exhibit properties suitable for various biomedical applications, but the solubility of HA limits their use in aqueous environments. Therefore, we developed water insoluble films based on palmitoyl esters of HA (pHA). Films were prepared from pHA samples with various degrees of substitution (DS) and molecular weights and their mechanical properties and swelling were characterized. Additionally, scanning electron microscopy and atomic force microscopy were used for visualization. Despite being prepared by solution casting, the films had a very smooth surface and were homogeneous in thickness. The film properties were in accordance with the polymer DS and molecular weight, enabling to tailor them for future applications by choosing a suitable pHA material. The behavior of the films toward cells was assessed in vitro. All films were non-cytotoxic and showed no adhesion of cells. These results show that the developed films are suitable candidates for various biomedical applications such as tissue engineering or wound healing. © 2016 Elsevier Ltd. All rights reserved.

Published
2016

21. Cartilage regeneration using peroral supplementation and artificial scaffolds

Author

Filová, Eva, Amler, Evžen, Jebavý, Lukáš, Otáhal, Stanislav, and Tománková, Kateřina

Abstract

Cartilage can regenerate only in a limited extend. The aim of the study was to enhance hyaline cartilage regeneration using peroral supplementation of glycosaminoglycans (GAGs) and antioxidants, or using artificial scaffolds seeded with autologous cells. Scaffolds seeded with chondrocytes or mesenchymal stem cells (MSCs) have a potential for treatment of cartilage defects. For the complex characterization of biomechanical properties of scaffold, we developed the novel shock dynamic method. Subsequently, the composite hyaluronate-type I collagen-fibrin scaffold with the viscoelastic properties and dynamic loading response similar to the native cartilage was developed. The composite scaffold was then used for osteochondral regeneration and physeal cartilage regeneration. The effect of peroral supplementation of GAGs and antioxidants (vitamin E/selenium) on the regeneration of osteochondral defects was investigated in rabbits. After introduction of defined osteochondral defects in the knee joint, groups of ten animals were given a GAG/vitamin E/selenium mixture or a placebo (milk sugar) for 6 weeks. The amount of sulfated GAGs in the osteochondral regenerates was significantly higher in the GAG group. In both groups, the GAG amount in the cartilage of the operated knee was significantly higher than in the...

Published
2009

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