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218 results on '"Toth, A. G."'

3. Design and Rationale of the BIOFLOW-DAPT Trial: a Prospective, Randomized, Multicenter Study to Assess the Safety of the Orsiro Mission Stent Compared to the Resolute Onyx Stent in Subjects at High Risk for Bleeding in Combination with 1-Month Dual Antiplatelet Therapy

Author

Landi, Antonio, Wlodarczak, Adrian, Tölg, Ralph, Kelbæk, Henning, Legutko, Jacek, Galli, Stefano, Godin, Matthieu, Toth, Gabor G., Lhermusier, Thibault, Honton, Benjamin, Dietrich, Peter Laurenz, Stammen, Francis, Ferdinande, Bert, Silvain, Johanne, Capodanno, Davide, Cayla, Guillaume, and Valgimigli, Marco

Published
2023
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4. In-hospital Outcomes of Rotational Atherectomy in ST-Elevation Myocardial Infarction: Results From the Multicentre ROTA-STEMI Network

Author

Hemetsberger, Rayyan, Mankerious, Nader, Muntané-Carol, Guillem, Temporal, Justin, Sulimov, Dmitriy, Gaede, Luise, Woitek, Felix, Grau, Edgar Fadeuilhe, Scalamogna, Maria, Olschewski, Maximilian, Mitsis, Andreas, Ruzsa, Zoltán, Toth, Gabor G., Heyer, Hajo, Toelg, Ralph, Gómez-Hospital, Joan A., Mügge, Andreas, Hengstenberg, Christian, Mangner, Norman, Gori, Tommaso, Cassese, Salvatore, Suárez, Xavier Carrillo, Abdel-Wahab, Mohamed, Johnson, Thomas, Richardt, Gert, and Allali, Abdelhakim

Published
2024
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6. Differential Impact of Fractional Flow Reserve Measured After Coronary Stent Implantation by Left Ventricular Dysfunction

Author

Choi, Ki Hong, Kwon, Woochan, Shin, Doosup, Lee, Seung-Hun, Hwang, Doyeon, Zhang, Jinlong, Nam, Chang-Wook, Shin, Eun-Seok, Doh, Joon-Hyung, Chen, Shao-Liang, Kakuta, Tsunekazu, Toth, Gabor G., Piroth, Zsolt, Hakeem, Abdul, Uretsky, Barry F., Hokama, Yohei, Tanaka, Nobuhiro, Lim, Hong-Seok, Ito, Tsuyoshi, Matsuo, Akiko, Azzalini, Lorenzo, Leesar, Massoud A., Daemen, Joost, Collison, Damien, Collet, Carlos, De Bruyne, Bernard, Koo, Bon-Kwon, Park, Taek Kyu, Yang, Jeong Hoon, Song, Young Bin, Hahn, Joo-Yong, Choi, Seung-Hyuk, Gwon, Hyeon-Cheol, and Lee, Joo Myung

Published
2024
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7. Two-year results from Onyx ONE clear in patients with high bleeding risk on one-month DAPT with and without intracoronary imaging

Author

Toth, Gabor G., Kandzari, David E., Kirtane, Ajay J., Windecker, Stephan, Latib, Azeem, Kedhi, Elvin, Mehran, Roxana, Price, Matthew J., Choi, James W., Caputo, Ronald, Troquay, Roel, Diderholm, Erik, Singh, Sunil, Brar, Somjot S., Loussararian, Arthur, Chetcuti, Stanley, Tulli, Mark, Stone, Gregg W., Lung, Te-Hsin, and Mylotte, Darren

Published
2024
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8. Efficacy, drug sustainability, and safety of ustekinumab treatment in Crohn’s disease patients over three years

Author

Barkai, Laszlo J., Gonczi, Lorant, Balogh, Fruzsina, Angyal, Dorottya, Farkas, Klaudia, Farkas, Bernadett, Molnar, Tamas, Szamosi, Tamas, Schafer, Eszter, Golovics, Petra A., Juhasz, Mark, Patai, Arpad, Vincze, Aron, Sarlos, Patricia, Farkas, Alexandra, Dubravcsik, Zsolt, Toth, Tamas G., Szekely, Hajnal, Miheller, Pal, Lakatos, Peter L., and Ilias, Akos

Published
2024
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9. Impact of Post-PCI FFR Stratified by Coronary Artery

Author

Collet, Carlos, Johnson, Nils P., Mizukami, Takuya, Fearon, William F., Berry, Colin, Sonck, Jeroen, Collison, Damien, Koo, Bon-Kwon, Meneveau, Nicolas, Agarwal, Shiv Kumar, Uretsky, Barry, Hakeem, Abdul, Doh, Joon-Hyung, Da Costa, Bruno R., Oldroyd, Keith G., Leipsic, Jonathon A., Morbiducci, Umberto, Taylor, Charles, Ko, Brian, Tonino, Pim A.L., Perera, Divaka, Shinke, Toshiro, Chiastra, Claudio, Sposito, Andrei C., Leone, Antonio Maria, Muller, Olivier, Fournier, Stephane, Matsuo, Hitoshi, Adjedj, Julien, Amabile, Nicolas, Piróth, Zsolt, Alfonso, Fernando, Rivero, Fernando, Ahn, Jung-Min, Toth, Gabor G., Ihdayhid, Abdul, West, Nick E.J., Amano, Tetsuya, Wyffels, Eric, Munhoz, Daniel, Belmonte, Marta, Ohashi, Hirofumi, Sakai, Koshiro, Gallinoro, Emanuele, Barbato, Emanuele, Engstrøm, Thomas, Escaned, Javier, Ali, Ziad A., Kern, Morton J., Pijls, Nico H.J., Jüni, Peter, and De Bruyne, Bernard

Published
2023
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11. Machine-learning-based prediction of fractional flow reserve after percutaneous coronary intervention

Author

Hamaya, Rikuta, Goto, Shinichi, Hwang, Doyeon, Zhang, Jinlong, Yang, Seokhun, Lee, Joo Myung, Hoshino, Masahiro, Nam, Chang-Wook, Shin, Eun-Seok, Doh, Joon-Hyung, Chen, Shao-Liang, Toth, Gabor G., Piroth, Zsolt, Hakeem, Abdul, Uretsky, Barry F., Hokama, Yohei, Tanaka, Nobuhiro, Lim, Hong-Seok, Ito, Tsuyoshi, Matsuo, Akiko, Azzalini, Lorenzo, Leesar, Massoud A., Collet, Carlos, Koo, Bon-Kwon, De Bruyne, Bernard, and Kakuta, Tsunekazu

Published
2023
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12. Clinical efficacy, drug sustainability and serum drug levels in Crohn's disease patients treated with ustekinumab – A prospective, multicenter cohort from Hungary

Author

Gonczi, Lorant, Szanto, Kata, Farkas, Klaudia, Molnar, Tamas, Szamosi, Tamas, Schafer, Eszter, Golovics, Petra A., Barkai, Laszlo, Lontai, Livia, Lovasz, Barbara, Juhasz, Mark, Patai, Arpad, Sarang, Krisztina, Vincze, Aron, Sarlos, Patricia, Farkas, Alexandra, Dubravcsik, Zsolt, Toth, Tamas G., Miheller, Pal, Ilias, Akos, and Lakatos, Peter L.

Published
2022
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14. Temporal changes in coronary plaque as assessed by an artificial intelligence–based optical coherence tomography: from the first-in-human trial on DREAMS 3G scaffold.

Author

Garcia-Garcia, Hector M, Waksman, Ron, Melaku, Gebremedhin D, Garg, Mohil, Beyene, Solomon, Wlodarczak, Adrian, Kerai, Ajay, Levine, Molly B, Schaaf, René J van der, Torzewski, Jan, Ferdinande, Bert, Escaned, Javier, Iglesias, Juan F, Bennett, Johan, Toth, Gabor G, Joner, Michael, Toelg, Ralph, Wiemer, Marcus, Olivecrona, Göran, and Vermeersch, Paul

Subjects
WOUND healing, RESEARCH funding, ARTIFICIAL intelligence, OPTICAL coherence tomography, HEART assist devices, LIPIDS, DESCRIPTIVE statistics, PRE-tests & post-tests, CALCIUM, CORONARY arteries, COMPUTER-aided diagnosis, MESENCHYME tumors, PERCUTANEOUS coronary intervention, CORONARY artery disease, COMPARATIVE studies, DISEASE progression, PATIENT aftercare, DRUG-eluting stents
Abstract

Aims The aim of the study is to assess the impact of the baseline plaque composition on the DREAMS 3G luminal late loss and to compare the serial plaque changes between baseline and 6 and 12 months (M) follow-up. Methods and results A total of 116 patients were enrolled in the BIOMAG-I trial. Patients were imaged with optical coherence tomography (OCT) pre- and post-DREAMS 3G implantation and at 6 and 12 M. OCTPlus software uses artificial intelligence to assess composition (i.e. lipid, calcium, and fibrous tissue) of the plaque. The differences between the OCT-derived minimum lumen area (MLA) post-percutaneous coronary intervention and 12 M were grouped into three terciles. Patients with larger MLA differences at 12 M (P = 0.0003) had significantly larger content of fibrous tissue at baseline. There was a reduction of 24.8% and 20.9% in lipid area, both P < 0.001, between the pre-DREAMS 3G OCT and the 6 and 12 M follow-up. Conversely, the fibrous tissue increased by 48.4% and 36.0% at 6 and 12 M follow-up, both P < 0.001. Conclusion The larger the fibrous tissue in the lesion at baseline, the larger the luminal loss seen at 6 and 12 M. Following the implantation of DREAMS 3G, favourable healing of the vessel coronary wall occurs as shown by a decrease in the lipid area and an increase in fibrous tissue. [ABSTRACT FROM AUTHOR]

Published
2024
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15. Impact of the Timing of Mechanical Circulatory Support on the Outcomes in Myocardial Infarction-Related Cardiogenic Shock: Subanalysis of the PREPARE CS Registry.

Author

Prunea, Dan M., Bachl, Eva, Herold, Lukas, Kanoun Schnur, Sadeek S., Pätzold, Sascha, Altmanninger-Sock, Siegfried, Sommer, Gudrun A., Glantschnig, Theresa, Kolesnik, Ewald, Wallner, Markus, Ablasser, Klemens, Bugger, Heiko, Buschmann, Eva, Praschk, Andreas, Fruhwald, Friedrich M., Schmidt, Albrecht, von Lewinski, Dirk, and Toth, Gabor G.

Subjects
ARTIFICIAL blood circulation, CARDIOGENIC shock, INTRA-aortic balloon counterpulsation, EXTRACORPOREAL membrane oxygenation, IMPACT (Mechanics), MYOCARDIAL infarction, HOSPITAL mortality
Abstract

(1) Background: Mechanical circulatory support (MCS) in myocardial infarction-associated cardiogenic shock is subject to debate. This analysis aims to elucidate the impact of MCS's timing on patient outcomes, based on data from the PREPARE CS registry. (2) Methods: The PREPARE CS prospective registry includes patients who experienced cardiogenic shock (SCAI classes C–E) and were subsequently referred for cardiac catheterization. Our present analysis included a subset of this registry, in whom MCS was used and who underwent coronary intervention due to myocardial infarction. Patients were categorized into an Upfront group and a Procedural group, depending on the timing of MCS's introduction in relation to their PCI. The endpoint was in-hospital mortality. (3) Results: In total, 71 patients were included. MCS was begun prior to PCI in 33 (46%) patients (Upfront), whereas 38 (54%) received MCS during or after the initiation of PCI (Procedural). The groups' baseline characteristics and hemodynamic parameters were comparable. The Upfront group had a higher utilization of the Impella® device compared to extracorporeal membrane oxygenation (67% vs. 33%), while the Procedural group exhibited a balanced use of both (50% vs. 50%). Most patients suffered from multi-vessel disease in both groups (82% vs. 84%, respectively; p = 0.99), and most patients required a complex PCI procedure; the latter was more prevalent in the Upfront group (94% vs. 71%, respectively; p = 0.02). Their rates of complete revascularization were comparable (52% vs. 34%, respectively; p = 0.16). Procedural CPR was significantly more frequent in the Procedural group (45% vs. 79%, p < 0.05); however, in-hospital mortality was similar (61% vs. 79%, respectively; p = 0.12). (4) Conclusions: The upfront implantation of MCS in myocardial infarction-associated CS did not provide an in-hospital survival benefit. [ABSTRACT FROM AUTHOR]

Published
2024
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18. 2-Year Clinical Outcomes of an Abluminal Groove–Filled Biodegradable-Polymer Sirolimus-Eluting Stent Compared With a Durable-Polymer Everolimus-Eluting Stent

Author

Xu, Bo, Saito, Yuichi, Baumbach, Andreas, Kelbæk, Henning, van Royen, Niels, Zheng, Ming, Morel, Marie-Angèle, Knaapen, Paul, Slagboom, Ton, Johnson, Thomas W., Vlachojannis, Georgios, Arkenbout, Karin E., Holmvang, Lene, Janssens, Luc, Ochala, Andrzej, Brugaletta, Salvatore, Naber, Christoph K., Anderson, Richard, Rittger, Harald, Berti, Sergio, Barbato, Emanuele, Toth, Gabor G., Maillard, Luc, Valina, Christian, Buszman, Paweł, Thiele, Holge, Schächinger, Volker, Lansky, Alexandra, and Wijns, William

Published
2019
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26. Outcomes of ECLS-SHOCK Eligibility Criteria Applied to a Real-World Cohort.

Author

von Lewinski, Dirk, Herold, Lukas, Bachl, Eva, Bugger, Heiko, Glantschnig, Theresa, Kolesnik, Ewald, Verheyen, Nicolas, Benedikt, Martin, Wallner, Markus, von Lewinski, Friederike, Schmidt, Albrecht, Harb, Stefan, Ablasser, Klemens, Sacherer, Michael, Scherr, Daniel, Manninger-Wünscher, Martin, Pätzold, Sascha, Gollmer, Johannes, Zirlik, Andreas, and Toth, Gabor G.

Subjects
EXTRACORPOREAL membrane oxygenation, CARDIOGENIC shock, ARTIFICIAL blood circulation, HOSPITAL mortality, CARDIOPULMONARY resuscitation
Abstract

Background: Cardiogenic shock (CS) exhibits high (~50%) in-hospital mortality. The recently published Extracorporeal life Support in Cardiogenic Shock (ECLS-SHOCK) trial demonstrated the neutral effects of the use of veno-arterial extracorporeal membrane oxygenation (VA-ECMO) on all-cause death, as well as on all secondary outcomes in subjects presenting with myocardial-infarction (MI)-related CS. Here, we compared ECLS-SHOCK eligibility criteria with a real-world cohort of CS patients. Methods and Results: ECLS-SHOCK eligibility criteria were applied to a prospective single-center CS registry (the PREPARE CS registry) consisting of 557 patients who were consecutively admitted to the catheterization laboratory (cath lab) of the Medical University of Graz, Austria, due to CS (SCAI C-E). Overall use of mechanical circulatory support (MCS) in this cohort was 19%. Sixty-nine percent of the entire cohort had MI-related CS, 38% of whom would have met ECLS-SHOCK eligibility criteria, thus representing only 27% of the PREPARE CS registry. Exclusion from the ECLS-SHOCK trial was based on patients with initial lactate values below 3 mmol/L (n = 168; 43.6%), aged over 80 years (n = 65; 16.9%), and with a duration of cardiopulmonary resuscitation (CPR) exceeding 45 min (n = 22; 5.7%). The 30-day mortality of patients of the PREPARE CS registry who met the ECLS-SHOCK eligibility criteria was 57.0%, compared to 48.4% of patients in the ECLS-SHOCK trial. The patients' baseline characteristics, however, differed considerably with respect to type of infarction, age, and gender. Conclusions: In a real-world cohort of patients with MI-related CS, only 38% of patients met the eligibility criteria of the ECLS-SHOCK trial. Thus, the impact of the use of VA-ECMO on outcome parameters in MI-related CS, as observed in the ECLS-SHOCK trial, may differ in a more heterogeneous real-world CS population of the PREPARE CS registry. [ABSTRACT FROM AUTHOR]

Published
2023
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27. Management strategies for heavily calcified coronary stenoses: an EAPCI clinical consensus statement in collaboration with the EURO4C-PCR group.

Author

Barbato, Emanuele, Gallinoro, Emanuele, Abdel-Wahab, Mohamed, Andreini, Daniele, Carrié, Didier, Mario, Carlo Di, Dudek, Dariusz, Escaned, Javier, Fajadet, Jean, Guagliumi, Giulio, Hill, Jonathan, McEntegart, Margaret, Mashayekhi, Kambis, Mezilis, Nikolasos, Onuma, Yoshinobu, Reczuch, Krzyszstof, Shlofmitz, Richard, Stefanini, Giulio, Tarantini, Giuseppe, and Toth, Gabor G

Subjects
PERCUTANEOUS coronary intervention, ATHERECTOMY, STENOSIS, OLDER patients, CORONARY artery disease, MYOCARDIAL infarction
Abstract

Since the publication of the 2015 EAPCI consensus on rotational atherectomy, the number of percutaneous coronary interventions (PCI) performed in patients with severely calcified coronary artery disease has grown substantially. This has been prompted on one side by the clinical demand for the continuous increase in life expectancy, the sustained expansion of the primary PCI networks worldwide, and the routine performance of revascularization procedures in elderly patients; on the other side, the availability of new and dedicated technologies such as orbital atherectomy and intravascular lithotripsy, as well as the optimization of the rotational atherectomy system, has increased operators' confidence in attempting more challenging PCI. This current EAPCI clinical consensus statement prepared in collaboration with the EURO4C-PCR group describes the comprehensive management of patients with heavily calcified coronary stenoses, starting with how to use non-invasive and invasive imaging to assess calcium burden and inform procedural planning. Objective and practical guidance is provided on the selection of the optimal interventional tool and technique based on the specific calcium morphology and anatomic location. Finally, the specific clinical implications of treating these patients are considered, including the prevention and management of complications and the importance of adequate training and education. [ABSTRACT FROM AUTHOR]

Published
2023
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35. Special Issue "Coronary Artery Disease Interventions".

Author

Herold, Lukas, Toth, Gabor G., and von Lewinski, Dirk

Subjects
*CARDIOGENIC shock, *CORONARY artery disease, *ARTIFICIAL blood circulation, *MYOCARDIAL infarction
Abstract

This document is a special issue of the Journal of Clinical Medicine titled "Coronary Artery Disease Interventions." It aims to provide recent advances in the interventional and pharmacological strategies for patients with severe ischemic heart disease. The issue covers topics such as arterial access techniques, novel stents, optimal stenting techniques for bifurcation lesions, the impact of coronary calcification on outcomes, and the effect of complex percutaneous coronary interventions on ischemic and bleeding events. It also includes discussions on the use of extracorporeal membrane oxygenation in patients with cardiogenic shock and the long-term outcomes of ECMO survivors. The issue concludes with reviews on coronary microcirculation and coronary no-reflow after PCI. The authors express their gratitude to the reviewers, authors, and journal staff for their contributions. [Extracted from the article]

Published
2024
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38. Transesophageal echocardiography‐guided versus fluoroscopy‐guided patent foramen ovale closure: A single center registry.

Author

Achim, Alexandru, Hochegger, Paul, Kanoun Schnur, Sadeek S., Moser, Lisa, Stark, Cosima, Pranevičius, Robertas, Prunea, Dan, Schmidt, Albrecht, Ablasser, Klemens, Verheyen, Nicolas, Kolesnik, Ewald, Maier, Robert, Luha, Olev, Ruzsa, Zoltan, Zirlik, Andreas, and Toth, Gabor G.

Subjects
ECHOCARDIOGRAPHY, LENGTH of stay in hospitals, TRANSESOPHAGEAL echocardiography, RETROSPECTIVE studies, FLUOROSCOPY, ATRIAL septal defects, TREATMENT effectiveness, DESCRIPTIVE statistics, RESEARCH funding, DISCHARGE planning
Abstract

Background: Percutaneous closure of patent foramen ovale (PFO) is conventionally performed under continuous transesophageal echocardiographic (TEE) guidance. We aimed to evaluate whether a simplified procedural approach, including pure fluoroscopy‐guidance and final TEE control, as well as an aimed 'next‐day‐discharge' is comparable with the conventional TEE‐guided procedure in terms of periprocedural and intermediate‐term outcomes. Methods: All patients who underwent a PFO closure at our center between 2010 and 2022 were retrospectively included. Prior to June 2019 cases were performed with continuous TEE guidance (TEE‐guided group). Since June 2019, only pure fluoroscopy‐guided PFO closures have been performed with TEE insertion and control just prior to device release (fluoroscopy‐guided group). We analyzed procedural aspects, as well as long term clinical and echocardiographic outcomes. Results: In total 291 patients were included in the analysis: 197 in the TEE‐guided group and 94 in the fluoroscopy‐guided group. Fluoroscopy‐guided procedures were markedly shorter (48 ± 20 min vs. 25 ± 9 min; p <.01). There was no difference in procedural complications, including death, major bleeding, device dislodgement, stroke or clinically relevant peripheral embolization between the two groups (.5% vs. 0%; p =.99). Hospital stay was also shorter with the simplified approach (2.5 ± 1.6 vs. 3.5 ± 1.2 days; p <.01), allowing 85% same‐day discharges during the last 12 months of observation period. At 6 ± 3 months echocardiographic follow‐up a residual leakage was described in 8% of the TEE‐guided cases and 2% of the fluoroscopy‐guided cases (p =.08). Conclusion: While a complete TEE‐free PFO closure might have potential procedural risks, our approach of pure fluoroscopy‐guided with a brisk final TEE check seems to be advantageous in terms of procedural aspects with no sign of any acute or intermediate‐term hazard and it could offer an equitable compromise between the two worlds: a complete TEE procedure and a procedure without any TEE. [ABSTRACT FROM AUTHOR]

Published
2023
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43. Prognostic Value of Fractional Flow Reserve: Linking Physiologic Severity to Clinical Outcomes

Author

Johnson, Nils P., Tóth, Gábor G., Lai, Dejian, Zhu, Hongjian, Açar, Göksel, Agostoni, Pierfrancesco, Appelman, Yolande, Arslan, Fatih, Barbato, Emanuele, Chen, Shao-Liang, Di Serafino, Luigi, Domínguez-Franco, Antonio J., Dupouy, Patrick, Esen, Ali M., Esen, Özlem B., Hamilos, Michalis, Iwasaki, Kohichiro, Jensen, Lisette O., Jiménez-Navarro, Manuel F., Katritsis, Demosthenes G., Kocaman, Sinan A., Koo, Bon-Kwon, López-Palop, Ramón, Lorin, Jeffrey D., Miller, Louis H., Muller, Olivier, Nam, Chang-Wook, Oud, Niels, Puymirat, Etienne, Rieber, Johannes, Rioufol, Gilles, Rodés-Cabau, Josep, Sedlis, Steven P., Takeishi, Yasuchika, Tonino, Pim A.L., Van Belle, Eric, Verna, Edoardo, Werner, Gerald S., Fearon, William F., Pijls, Nico H.J., De Bruyne, Bernard, and Gould, K. Lance

Published
2014
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