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4. Neuropsychological function in psychosis of epilepsy

Author

Allebone, James, Kanaan, Richard A., Rayner, Genevieve, Maller, Jerome, O’Brien, Terence J., Mullen, Saul A., Cook, Mark, Adams, Sophia J., Vogrin, Simon, Vaughan, David N., Kwan, Patrick, Berkovic, Samuel F., D’Souza, Wendyl J., Jackson, Graeme, Velakoulis, Dennis, and Wilson, Sarah J.

Published
2023
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16. In Vivo 7-Tesla MRI Investigation of Brain Iron and Its Metabolic Correlates in Chronic Schizophrenia

Author

Ravanfar, Parsa, Syeda, Warda T., Jayaram, Mahesh, Rushmore, R. Jarrett, Moffat, Bradford, Lin, Alexander P., Lyall, Amanda E., Merritt, Antonia H., Yaghmaie, Negin, Laskaris, Liliana, Luza, Sandra, Opazo, Carlos M., Liberg, Benny, Chakravarty, M. Mallar, Devenyi, Gabriel A., Desmond, Patricia, Cropley, Vanessa L., Makris, Nikos, Shenton, Martha E., Bush, Ashley I., Velakoulis, Dennis, and Pantelis, Christos

Published
2022
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17. Cortico-cognition coupling in treatment resistant schizophrenia

Author

Syeda, Warda T., Wannan, Cassandra M.J., Merritt, Antonia H., Raghava, Jayachandra M., Jayaram, Mahesh, Velakoulis, Dennis, Kristensen, Tina D., Soldatos, Rigas Filippos, Tonissen, Shane, Thomas, Naveen, Ambrosen, Karen S., Sørensen, Mikkel E., Fagerlund, Birgitte, Rostrup, Egill, Glenthøj, Birte Y., Skafidas, Efstratios, Bousman, Chad A., Johnston, Leigh A., Everall, Ian, Ebdrup, Bjørn H., and Pantelis, Christos

Published
2022
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18. Referral reasons to a Victorian mental health triage service for individuals living with young-onset dementia.

Author

Loi, Samantha M. and Velakoulis, Dennis

Subjects
*HOME care services, *MENTAL health services, *BEHAVIOR modification, *SUICIDAL ideation, *PARANOIA, *RETROSPECTIVE studies, *AGITATION (Psychology), *ANXIETY, *DESCRIPTIVE statistics, *CHI-squared test, *AGE factors in disease, *AGGRESSION (Psychology), *DEMENTIA, *DATA analysis software, *MEDICAL referrals, *MEDICAL triage, *MENTAL depression, *RESIDENTIAL care
Abstract

Objectives: Mental health triage services are the first contact for people wanting support for their mental health and provide access to public mental health services in Victoria, Australia. People living with young-onset dementia and their families may contact triage services seeking assistance for behaviour changes and pathways to care as there are few alternative services available. Methods: The authors reviewed the minimum triage dataset from one of the largest mental health services in Victoria, Australia from 2018 to 2021 investigating reasons for referral for people with young-onset dementia. Results: Of the 1766 referrals for 'dementia', 145 were for young-onset dementia. Of these, 69% were referred for behaviour changes. About half of the referrals for behaviour changes were triaged as 'advice only'. One-third of referrals were from general practitioners. Conclusions: The availability of dementia-specific support services that could provide advice on dementia as well as advice for behaviour changes related to the disease could potentially ease the burden of phone calls received by mental health triage services. What is known about the topic? Young-onset dementia refers to a dementia with onset at less than 65 years of age. People with young-onset dementia may contact mental health services for support but the reasons for contact are unknown. What does this paper add? The reasons for contacting one Victorian mental health service included behaviour changes such as agitation or aggression and psychotic symptoms (74%) and general advice, including about dementia pathways (14%). General practitioners made up one-third of referral sources. What are the implications for practitioners? Victorian mental health services are generally overloaded and complex. There is a need to promote alternative dementia support organisations in order to provide an alternative contact for people affected by young-onset dementia. [ABSTRACT FROM AUTHOR]

Published
2024
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19. Younger people with dementia registered to public mental health services in Victoria, Australia.

Author

Loi, Samantha M., Eratne, Dhamidhu, and Velakoulis, Dennis

Subjects
PUBLIC hospitals, HEALTH services accessibility, MENTAL health services, CENSUS, SEX distribution, DESCRIPTIVE statistics, CHI-squared test, AGE factors in disease, DEMENTIA, COMPARATIVE studies, MEDICAL triage, NOSOLOGY
Abstract

Objectives: Individuals living with young-onset dementia fall through the gaps of adult and geriatric services. Given that non-cognitive symptoms of dementia in younger people are often psychiatric and behavioural in nature, these people may contact mental health services. There is sparse information investigating the frequency of people with young-onset dementia who contact mental health triage in Victoria. Methods: Triage data were obtained from the Victorian Agency for Health Information. The data contained demographics for people registered with Victorian mental health services. Consumers who had an International Classification for Diseases code for dementia and were aged less than 65 years were identified as people with young-onset dementia. Using information of the frequency of people with young-onset dementia who were registered with each area-based mental health service, population census statistics were used to make estimates of the frequency of young-onset dementia. Results: Of the 6172 people who had a dementia diagnosis, 1020 of them were aged less than 65 years and had young-onset dementia. There were proportionally more men who had young-onset dementia compared to women. There were more people with young-onset dementia registered to rural mental health services compared to metropolitan services. Conclusion: Findings provide important information for service planning in Victoria. Recommendations include upskilling and education for the assessment of dementia for those clinicians who work in mental health services, particularly in rural regions. What is known about the topic? Young-onset dementia refers to a dementia with onset at an age less than 65 years. Accessing age-appropriate services for these people is difficult as they fall through the gaps of adult and aged services due to their age. What does this paper add? Due to the behavioural and psychiatric manifestations related to young-onset dementia, data is provided about mental health service involvement for these people. What are the implications for practitioners? There is a need to upskill mental health clinicians, especially in rural areas, as younger people with dementia are accessing these services. [ABSTRACT FROM AUTHOR]

Published
2024
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20. Investigating Equivalence of In-Person and Telehealth-Based Neuropsychological Assessment Performance for Individuals Being Investigated for Younger Onset Dementia.

Author

Brown, Aimee D, Kelso, Wendy, Eratne, Dhamidhu, Loi, Samantha M, Farrand, Sarah, Summerell, Patrick, Neath, Joanna, Walterfang, Mark, Velakoulis, Dennis, and Stolwyk, Renerus J

Subjects
NEUROPSYCHOLOGICAL tests, WECHSLER Adult Intelligence Scale, DEMENTIA, INTRACLASS correlation
Abstract

Objective Given the rapid shift to in-home teleneuropsychology models, more research is needed to investigate the equivalence of non-facilitator models of teleneuropsychology delivery for people with younger onset dementia (YOD). This study aimed to determine whether equivalent performances were observed on neuropsychological measures administered in-person and via teleneuropsychology in a sample of people being investigated for YOD. Method Using a randomized counterbalanced cross-over design, 43 participants (M age = 60.26, SD age = 7.19) with a possible or probable YOD diagnosis completed 14 neuropsychological tests in-person and via teleneuropsychology, with a 2-week interval. Repeated measures t -tests, intraclass correlation coefficients (ICC), and Bland Altman analyses were used to investigate equivalence across the administration conditions. Results No statistical differences were found between in-person and teleneuropsychology conditions, except for the Hospital Anxiety and Depression Scale Anxiety subtest. Small to negligible effect sizes were observed (ranging from.01 to.20). ICC estimates ranged from.71 to.97 across the neuropsychological measures. Bland Altman analyses revealed that the Wechsler Adult Intelligence Scale—Fourth Edition Block Design subtest had slightly better overall performance in the in-person condition and participants reported higher levels of anxiety symptoms during the teleneuropsychology condition; however, average anxiety symptoms remained within the clinically normal range. Participants reported a high level of acceptability for teleneuropsychology assessments. Conclusions These results suggest that performances are comparable between in-person and teleneuropsychology assessment modalities. Our findings support teleneuropsychology as a feasible alternative to in-person neuropsychological services for people under investigation of YOD, who face significant barriers in accessing timely diagnoses and treatment options. [ABSTRACT FROM AUTHOR]

Published
2024
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28. Adverse events related to antiepileptic drugs

Author

Dang, Yew Li, Foster, Emma, Lloyd, Michael, Rayner, Genevieve, Rychkova, Maria, Ali, Rashida, Carney, Patrick W., Velakoulis, Dennis, Winton-Brown, Toby T., Kalincik, Tomas, Perucca, Piero, O'Brien, Terence J., Kwan, Patrick, and Malpas, Charles B.

Published
2021
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30. The clinical utility of exome sequencing and extended bioinformatic analyses in adolescents and adults with a broad range of neurological phenotypes: an Australian perspective

Author

Eratne, Dhamidhu, Schneider, Amy, Lynch, Ella, Martyn, Melissa, Velakoulis, Dennis, Fahey, Michael, Kwan, Patrick, Leventer, Richard, Rafehi, Haloom, Chong, Belinda, Stark, Zornitza, Lunke, Sebastian, Phelan, Dean G., O'Keefe, Melanie, Siemering, Kirby, West, Kirsty, Sexton, Adrienne, Jarmolowicz, Anna, Taylor, Jessica A., Schultz, Joshua, Purvis, Rebecca, Uebergang, Eloise, Chalinor, Heather, Creighton, Belinda, Gelfand, Nikki, Saks, Tamar, Prawer, Yael, Smagarinsky, Yana, Pan, Tianxin, Goranitis, Ilias, Ademi, Zanfina, Gaff, Clara, Huq, Aamira, Walsh, Maie, James, Paul A., Krzesinski, Emma I., Wallis, Mathew, Stutterd, Chloe A., Bahlo, Melanie, Delatycki, Martin B., and Berkovic, Samuel F.

Published
2021
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33. Enlarged hippocampal fissure in psychosis of epilepsy

Author

Allebone, James, Kanaan, Richard A., Maller, Jerome J., O'Brien, Terrence, Mullen, Saul, Cook, Mark, Adams, Sophie, Vogrin, Simon, Vaughan, David, Connelly, Alan, Kwan, Patrick, Berkovic, Samuel F., D'Souza, Wendyl, Jackson, Graeme, Velakoulis, Dennis, and Wilson, Sarah J.

Published
2020
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47. Association Between Psychiatric Comorbidities and Mortality in Epilepsy

Author

Tao, Gerard, Auvrez, Clarissa, Nightscales, Russell, Barnard, Sarah, McCartney, Lara, Malpas, Charles B., Perucca, Piero, Chen, Zhibin, Adams, Sophia, McIntosh, Anne, Ignatiadis, Sophia, OʼBrien, Patrick, Cook, Mark J., Kwan, Patrick, Berkovic, Samuel F., DʼSouza, Wendyl, Velakoulis, Dennis, and OʼBrien, Terence J.

Published
2021
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48. Alzheimer's disease biomarker utilization at first referral enhances differential diagnostic precision with simultaneous exclusion of Creutzfeldt‐Jakob disease.

Author

Wang, Zitianyu, Lewis, Victoria, Stehmann, Christiane, Varghese, Shiji, Senesi, Matteo, McGlade, Amelia, Ellett, Laura J., Doecke, James D., Eratne, Dhamidhu, Velakoulis, Dennis, Masters, Colin L., Collins, Steven J., and Li, Qiao‐Xin

Subjects
ALZHEIMER'S disease, CREUTZFELDT-Jakob disease, TAU proteins, ENZYME-linked immunosorbent assay, BIOMARKERS
Abstract

Most suspected Creutzfeldt‐Jakob disease (CJD) cases are eventually diagnosed with other disorders. We assessed the utility of investigating Alzheimer's disease (AD) biomarkers and neurofilament light (NfL) in patients when CJD is suspected. The study cohort consisted of cerebrospinal fluid (CSF) samples referred for CJD biomarker screening wherein amyloid beta 1‐42 (Aβ1‐42), phosphorylated tau 181 (p‐tau181), and total tau (t‐tau) could be assessed via Elecsys immunoassays (n = 419) and NfL via enzyme‐linked immunosorbent assay (ELISA; n = 161). In the non‐CJD sub cohort (n = 371), 59% (219/371) had A+T– (abnormal Aβ1‐42 only) and 21% (79/371) returned A+T+ (abnormal Aβ1‐42 and p‐tau181). In the 48 CJD subjects, a similar AD biomarker profile distribution was observed. To partially address the prevalence of likely pre‐symptomatic AD, NfL was utilized to assess for neuronal damage. NfL was abnormal in 76% (25/33) of A+T– subjects 40 to 69 years of age, 80% (20/25) of whom had normal t‐tau. This study reinforces AD as an important differential diagnosis of suspected CJD, highlighting that incorporating AD biomarkers and NfL at initial testing is worthwhile. [ABSTRACT FROM AUTHOR]

Published
2024
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50. Supranutritional Sodium Selenate Supplementation Delivers Selenium to the Central Nervous System: Results from a Randomized Controlled Pilot Trial in Alzheimer’s Disease

Author

Cardoso, Barbara R., Roberts, Blaine R., Malpas, Charles B., Vivash, Lucy, Genc, Sila, Saling, Michael M., Desmond, Patricia, Steward, Christopher, Hicks, Rodney J., Callahan, Jason, Brodtmann, Amy, Collins, Steven, Macfarlane, Stephen, Corcoran, Niall M, Hovens, Christopher M., Velakoulis, Dennis, O’Brien, Terence J., Hare, Dominic J., and Bush, Ashley I.

Published
2019
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