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Your search keyword '"Yao, Jian-Zhong"' showing total 11 results
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11 results on '"Yao, Jian-Zhong"'

7. Antitumor Activities and Structure-Activity Relationship of Phosphotriester Derivatives of Homocamptothecin Based on a Semisynthetic Route.

Author

Zhang, Yong-Qiang, Zhang, Huo-Jun, Zhang, Jing, Wang, Juan, Yao, Jian-Zhong, Zhu, Lin-Jian, Zhuang, Chun-Lin, Wang, Sheng-Zheng, Dong, Guo-Qiang, Sheng, Chun-Quan, Miao, Zhen-Yuan, and Zhang, Wan-Nian

Abstract

Based on a new semisynthetic route, a series of phosphotriester 7-alkyl-homocamptothecin derivatives are designed and synthesized. Cytotoxic activity assays show that compounds 12a and 14c with a methyl in position C7 of the homocamptothecin are more potent than the other derivatives and the positive drug irinotecan against A-549, MCF-7, and LOVO cell lines. Moreover, compound 14c shows potent tumour inhibitory activity in a Colo205 xenograft model. [ABSTRACT FROM AUTHOR]

Published
2011
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10. Inversion of secondary chiral alcohols in toluene with the tunable complex of R3NCOOH

Author

Shi, Xiao-Xin, Shen, Chun-Li, Yao, Jian-Zhong, Nie, Liang-Deng, and Quan, Na

Subjects
*CHIRALITY, *ALCOHOLS (Chemical class), *TOLUENE, *ENANTIOMERS, *SULFONATES, *CARBOXYLIC acids, *COMPLEX compounds, *NUCLEOPHILIC reactions
Abstract

Abstract: The SN2 reaction of enantiomerically pure sulfonates with the tunable complex of R3N–R′COOH in toluene has been extensively studied. It was revealed that the molar ratio of the tertiary amines and carboxylic acids in the complex of R3NR′COOH is crucial for the SN2 reaction, and should be tuned for each sulfonate to give the best yield. Fifteen sulfonates 1 and 3–13 (Scheme 2) were prepared and transformed into 22 corresponding inverted esters 2 and 14–24 (Scheme 2) in good to high yields. [Copyright &y& Elsevier]

Published
2010
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