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Background: Coronavirus disease 2019 (COVID-19) is frequntly accompanied by venous thromboembolism (VTE), and its mechanism may be related to the abnormal inflammation and immune status of COVID-19 patients. It has been proved that interleukin-6 (IL-6), ferritin and lactate dehydrogenase (LDH) may play an important role in the occurrence of VTE in COVID-19 infection. But whether they can server as predictors for VTE in COVID-19 is still unclear. In this study, we performed a systematic review and meta-analysis to compare IL-6, ferritin and LDH in VTE and non-VTE COVID-19 patients in order to shed light on the prevention and treatment of VTE. Methods: Related literatures were searched in PubMed, Embase, Web of Science, Google Scholar, China National Knowledge Infrastructure (CNKI), WANGFANG. COVID-19 patients were divided into VTE group and non-VTE group. Meta-analysis was then conducted to compare levels of IL-6, ferritin and LDH between the two groups. Results: We finally included and analyzed 17 literatures from January 2019 to October 2022. There was a total of 7,035 COVID-19 patients, with a weighted mean age of 60.01 years. Males accounted for 62.64% and 61.34% patients were in intensive care unit (ICU). Weighted mean difference (WMD) of IL-6, ferritin and LDH was 31.15 (95% CI: 9.82, 52.49), 257.02 (95% CI: 51.70, 462.33) and 41.79 (95% CI: -19.38, 102.96), respectively. The above results indicated that than compared with non-VTE group, VTE group had significantly higher levels of IL-6 and ferritin but similar LDH. Conclusion: This systematic review and meta-analysis pointed out that elevated levels of IL-6 and ferritin were significantly possitive associated with VTE, thus could be used as biological predictive indicators of VTE among COVID-19 patients. However, no association was found between level of LDH and VTE. Therefore, close monitoring of changes in IL-6 and ferritin concentrations is of great value in assisting clinicans to rapidly identify thrombotic complications among COVID-19 patients, hence facilitating the timely effective managment. Further studies are required in terms of the clinical role of cytokines in the occurrence of VTE among COVID-19 infection, with more reliable systematic controls and interventional trials. [ABSTRACT FROM AUTHOR]

Background: The prevalence of pain comorbid and anxiety/depression in clinical observations has been high, and the number of related publications has increased in recent years. Nevertheless, few studies have used bibliometric methods to analyze the scientific research on comorbid pain and depression/anxiety. The aim of this study was to systematically examine the trends in global scientific research on comorbid pain and depression/anxiety from 2012 to 2022.Methods: Papers published between 2012 and 2022 were identified in the Web of Science database. Publications that examined comorbid pain and depression/anxiety were included. The language was limited to English. CiteSpace, Excel and VOSviewer were used to analyze the volume of publications, countries, institutions, authors, cocited authors, and keywords.Results: A total of 30,290 papers met the inclusion criteria of the study. Using CiteSpace, VOSviewer and Excel, the results showed that the United States (10,614 publications), Harvard University (1195 publications), and Jensen, Mark P. (77 publications) were the most productive country, institution, and author, respectively. The hotspots and frontiers were "relationship between depression and pain", "gender differences in pain and depression/anxiety domains", "study of specific pain types with depression/anxiety", "treatment of pain combined with anxiety/depression", and "effects of COVID-19 on patients with pain combined with depression/anxiety".Conclusion: These findings indicate a growing interest in the field of comorbid pain and depression/anxiety. The research has been broad and deep, but there is still much room for growth. Furthermore, there is a need for more mature global collaborative networks as well as more high-quality research results in the future. [ABSTRACT FROM AUTHOR]

Ridge slopes often occur in highway or railway engineering. The initial stress distribution of a ridge slope is important for the original slope and an excavation slope. In this paper, a wire-frame model of ridge slope was established. Numerical simulations on the 3D stability analysis were performed using the strength reduction method based on unified strength theory. The influences of ridgeline dip angle α, flank slope angle β, and slope height H on the deformation and failure mode of ridgeline slopes were analyzed. When α was small, cracking failure easily occurred at the front edge of the ridge slope and the area near the ridge line. When α was large, shear failure was prone to occur at the trailing edge of the ridge slope. Under the same reduction coefficient, the larger the flank slope angle β, the larger the slope displacement of the ridge. The plastic zone gradually concentrated near the ridge. When H was small, the displacement mainly occurred at the trailing edge of the slope, and the slopes were generally prone to cracking damage at the trailing edge. The front edge of the slope experienced a large displacement when the height of the ridge slope increased. The bottom of the flank slope was also displaced, and a plastic zone was observed at the foot of the slope. When the excavation slope ratio of the ridge slope was small, the plastic zone was mainly located on the side slope. When the excavation rate increased, the plastic zone appeared on the excavation slope surface, and its stability decreased significantly. [ABSTRACT FROM AUTHOR]

Objective: Uterine carcinosarcomas (UCSs) are aggressive rare tumors recognized as malignancies composed of metaplastic transformation of epithelial elements. Nay no comprehensive molecular classification has been applied to UCS to guide targeted therapies so far, which motivated us to subtyping UCS by aggregating multiple genomic platform data. Methods: We classified UCS into three distinct subtypes with different clinicopathologic and molecular characterization by using similarity network fusion under consensus clustering framework (SNFCC+) to aggregate four genomic data platforms of 55 UCS patients. Differences across subtypes were extracted by functional enrichment, gene mutations and clinical features. Subtypes were further distinguished by putative biomarkers. We also determined associations between individual oncogenes and chemotherapeutics to discuss subtype-specific drug sensitivity. Results: Functional enrichment analysis of the subtype-specific differential expression genes endowed three subtypes new designation: Myo, Cell and Hormone. Mutations in PTEN, PIK3CA, ARID1A and PPP2R1A altered across subtypes. The epithelial-to-mesenchymal transition (EMT) score distinguished Myo from another two subtypes whereby a high EMT scores prevalently existed and each case was judged as M (mesenchymal) phenotype in Myo subtype. Through the drug sensitivity analysis, we found that the response to - tinib drugs is quite different across subtypes according to expression level. Additionally, different subtypes' response to broad-spectrum anti-cancer drug paclitaxel may be also different. Conclusions: In this study, we identified three distinct molecular subtypes of UCS with different features. Subtypes were also revealed to have different sensitivity to existing chemotherapy drugs, which may support in-depth study of subtype-specific dosing regimens. [ABSTRACT FROM AUTHOR]

After the victory of the New Democracy Revolution, especially, the accompanishment of the socialist transform in the early 1950s, Mao Zedong summed up the experience of Soviet and Chinese socialist construction, initiated and led the Party and all the peoples to make the second integration of Marxism with Chinese realities, and further created a road of China's socialist construction, which was quite different from the Soviet Socialist Construction Model in the respects of economics, politics and culture. The great course of Chinese reform & open has been carried out on the foundation of the successful experience in the search for the socialist construction law by the first Party leadership collective at the core of Mao Zedong. Mao Zedong's exploration into the second integration of Marxism with Chinese realities has not only improved the development of Marxist Sinilization, but also deepened the theory of Marxist Nationality Reshaping. [ABSTRACT FROM AUTHOR]