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Your search keyword '"Zhou, Zong-Guang"' showing total 198 results
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198 results on '"Zhou, Zong-Guang"'

7. Mismatch repair protein deficiency and its implications on distant metastasis in colorectal cancer: A comprehensive analysis.

Author

Fan, Chuanwen, Fang, Chao, Wang, Wei, Lv, Zhaoying, Zhang, Xueli, Long, Feiwu, Jiang, Zongze, Li, Yuan, Zhang, Hong, Zhou, Zong‐Guang, Wang, Cun, and Sun, Xiao‐Feng

Subjects
PROTEIN deficiency, COLORECTAL cancer, GENE regulatory networks, METASTASIS, GENE expression
Abstract

Background: While previous studies have indicated variability in distant metastatic potential among different mismatch repair (MMR) states in colorectal cancer (CRC), their findings remain inconclusive, especially considering potential differences across various ethnic backgrounds. Furthermore, the gene regulatory networks and the underlying mechanisms responsible for these variances in metastatic potential across MMR states have yet to be elucidated. Methods: We collected 2058 consecutive primary CRC samples from the South West of China and assessed the expression of MMR proteins (MLH1, MSH2, MSH6, and PMS2) using immunohistochemistry. To explore the inconsistencies between different MMR statuses and recurrence, we performed a meta‐analysis. To delve deeper, we employed Weighted Gene Co‐expression Network Analysis (WGCNA), ClueGo, and iRegulon, pinpointing gene expression networks and key regulatory molecules linked to metastasis and recurrence in CRC. Lastly, both univariate and multivariate Cox regression analyses were applied to determine the impact of core regulatory molecules on metastasis. Results: Of the samples, 8.2% displayed deficient MMR (dMMR), with losses of MLH1 and PSM2 observed in 40.8% and 63.9%, respectively. A unique 24.3% isolated loss of PMS2 without concurrent metastasis was identified, a result that diverges from established literature. Additionally, our meta‐analysis further solidifies the reduced recurrence likelihood in dMMR CRC samples compared to proficient MMR (pMMR). Two gene expression networks tied to distant metastasis and recurrence were identified, with a majority of metastasis‐related genes located on chromosomes 8 and 18. An IRF1 positive feedback loop was discerned in the metastasis‐related network, and IRF1 was identified as a predictive marker for both recurrence‐free and distant metastasis‐free survival across multiple datasets. Conclusion: Geographical and ethnic factors might influence peculiarities in MMR protein loss. Our findings also highlight new gene expression networks and crucial regulatory molecules in CRC metastasis, enhancing our comprehension of the mechanisms driving distant metastasis. [ABSTRACT FROM AUTHOR]

Published
2024
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12. Is Preoperative Fibrinogen Associated with the Survival Prognosis of Gastric Cancer Patients? A Multi-centered, Propensity Score-Matched Retrospective Study

Author

Zhao, Lin-Yong, Zhao, Yong-Liang, Wang, Jun-Jiang, Zhao, Qi-Di, Yi, Wen-Qi, Yuan, Qing, Chen, Xin-Zu, Li, Yong, Yang, Kun, Chen, Xiao-Long, Zhang, Wei-Han, Liu, Kai, Pang, Hua-Yang, Galiullin, Danil, Wang, Hui, Sun, Li-Fei, Song, Xiao-Hai, Zheng, Jia-Bin, Yao, Xue-Qing, Zhou, Zong-Guang, Yu, Pei-Wu, and Hu, Jian-Kun

Published
2020
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24. Colorectal cancer liver metastasis: genomic evolution and crosstalk with the liver microenvironment.

Author

Liu, Qiu-Luo, Zhou, Huijie, Zhou, Zong-Guang, and Chen, Hai-Ning

Abstract

Colorectal cancer (CRC) patients frequently develop liver metastases, which are the major cause of cancer-related mortality. The molecular basis and management of colorectal liver metastases (CRLMs) remain a challenging clinical issue. Recent genomic evidence has demonstrated the liver tropism of CRC and the presence of a stricter evolutionary bottleneck in the liver as a target organ compared to lymph nodes. This bottleneck challenging CRC cells in the liver is organ-specific and requires adaptation not only at the genetic level, but also at the phenotypic level to crosstalk with the hepatic microenvironment. Here, we highlight the emerging evidence on the clonal evolution of CRLM and review recent insights into the molecular mechanisms orchestrating the bidirectional interactions between metastatic CRC cells and the unique liver microenvironment. [ABSTRACT FROM AUTHOR]

Published
2023
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50. Application of Gross Tissue Response System in Gastric Cancer After Neoadjuvant Chemotherapy: A Primary Report of a Prospective Cohort Study.

Author

Yang, Hua, Zhang, Wei-Han, Ge, Rui, Peng, Bo-Qiang, Chen, Xin-Zu, Yang, Kun, Liu, Kai, Chen, Xiao-Long, He, Du, Liu, Jian-Ping, Zhang, Wei-Wei, Qin, Yun, Zhou, Zong-Guang, and Hu, Jian-Kun

Subjects
NEOADJUVANT chemotherapy, STOMACH cancer, SURGICAL blood loss, PREOPERATIVE risk factors, CANCER chemotherapy
Abstract

Objective: We previously established a gross tissue response (GTR) system to evaluate the intraoperative response of perigastric tissue in patients with gastric cancers to neoadjuvant chemotherapy. This prospective cohort study aims to confirm the relationship between gross tissue response and clinicopathological characteristics and explore the possibility of using the GTR system to predict the difficulty of surgery and the occurrence of postoperative complications within 30 days. Methods: A total of 102 patients with gastric cancer from January 2019 to April 2020 were enrolled in this study. The degrees of fibrosis, edema, and effusion in the perigastric tissues were assessed intraoperatively according to the GTR system. We systematically analyzed the relations between GTR and clinicopathological characteristics, and then a prediction model that includes GTR was established to predict the difficulty of surgery and the occurrence of postoperative complications within 30 days. Results: Finally, the study included 71 male patients and 31 female patients. The patients had an average age of 58.79 ± 1.03 years, BMI of 22.89 ± 0.29, and tumor diameter of 4.50 ± 0.27 cm. Among these patients, 17 underwent laparoscopic gastrectomy, 85 underwent open gastrectomy, the average operation time was 294.63 ± 4.84 minutes, and the mean volume of intraoperative blood loss was 94.65 ± 5.30 ml. The overall 30-day postoperative complication rate was 19.6% (20/102). The total GTR was significantly related to the primary tumor stage, operation time and 30-day postoperative complication rate (p<0.05). Edema and effusion were significantly related to intraoperative blood loss (p<0.05). The logistic regression analysis identified that the total GTR score (score: 4-9, OR 2.888, 95% CI: 1.035-8.062, p = 0.043) was an independent risk factor for postoperative complications within 30 days, and the total GTR score (score 4-9, OR 3.32, 95% CI 1.219-9.045, p=0.019) was also an independent risk factor for operation time. The AUC of the total GTR score for predicting postoperative complications within 30 days was 0.681. Conclusion: According to the results of the present study, the gross tissue response (GTR) system is an effective tool that may be used to predict the risk of a difficult operation after neoadjuvant chemotherapy and postoperative complications. Although neoadjuvant chemotherapy improves the therapeutic effect, it also increases the risk of surgical trauma and postoperative complications. Clinical Trial Registration: ClinicalTrials.gov , identifier NCT03791268. [ABSTRACT FROM AUTHOR]

Published
2021
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