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643 results on '"Zhu, Nan"'

36. Low quality antibody responses in critically ill patients hospitalized with pandemic influenza A(H1N1)pdm09 virus infection

Author

Xiuhua Lu, Zhu Guo, Zhu-Nan Li, Crystal Holiday, Feng Liu, Stacie Jefferson, F. Liaini Gross, Wen-Ping Tzeng, Anand Kumar, Ian A. York, Timothy M. Uyeki, Terrence Tumpey, James Stevens, and Min Z. Levine

Subjects
Medicine, Science
Abstract

Abstract Although some adults infected with influenza 2009 A(H1N1)pdm09 viruses mounted high hemagglutination inhibition (HAI) antibody response, they still suffered from severe disease, or even death. Here, we analyzed antibody profiles in patients (n = 31, 17–65 years) admitted to intensive care units (ICUs) with lung failure and invasive mechanical ventilation use due to infection with A(H1N1)pdm09 viruses during 2009–2011. We performed a comprehensive analysis of the quality and quantity of antibody responses using HAI, virus neutralization, biolayer interferometry, enzyme-linked-lectin and enzyme-linked immunosorbent assays. At time of the ICU admission, 45% (14/31) of the patients had HAI antibody titers ≥ 80 in the first serum (S1), most (13/14) exhibited narrowly-focused HAI and/or anti-HA-head binding antibodies targeting single epitopes in or around the receptor binding site. In contrast, 42% (13/31) of the patients with HAI titers ≤ 10 in S1 had non-neutralizing anti-HA-stem antibodies against A(H1N1)pdm09 viruses. Only 19% (6/31) of the patients showed HA-specific IgG1-dominant antibody responses. Three of 5 fatal patients possessed highly focused cross-type HAI antibodies targeting the (K130 + Q223)-epitopes with extremely low avidity. Our findings suggest that narrowly-focused low-quality antibody responses targeting specific HA-epitopes may have contributed to severe infection of the lower respiratory tract.

Published
2022
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37. Linking autonomy support and health at work: The self-determination theory perspective

Author

Liu, Yuxin, Raza, Jamshed, Zhang, Jianwei, Zhu, Nan, and Gul, Habib

Subjects
Workers -- Health aspects, Employee motivation -- Evaluation, Psychology and mental health
Abstract

Based on self-determination theory, this paper formulated and confirmed a theoretical model linking autonomy support and employee health at work via several intervening variables. In total, 828 randomly selected professional employees were surveyed from six total companies in China: three from the manufacturing industry and three from the service industry. The questionnaire responses of these employees were collected and checked through structural equation model analyses. The results demonstrated that, as anticipated, autonomy support positively influenced basic psychological needs satisfaction, which, in turn, had a positive influence on the autonomous motivation of employees and negatively impacted controlled motivation. Correspondingly, autonomous motivation had a significantly positive effect and controlled motivation had a significantly negative effect on employee health at work. We also evaluated the impact of trait affect, i.e., the positive affect and negative affect experienced by employees at work, on the linkage between autonomy support and basic psychological needs satisfaction. Positive affect strengthened this relationship, while negative affected weakened it. This paper enables the progression of future theoretical research on understanding how autonomy support can influence employee health, which will add knowledge to the occupational health psychology literature. To conclude, theoretical contributions and managerial implications are highlighted., Author(s): Yuxin Liu [sup.1] , Jamshed Raza [sup.1] , Jianwei Zhang [sup.2] , Nan Zhu [sup.1] , Habib Gul [sup.1] Author Affiliations: (1) grid.443284.d, 0000 0004 0369 4765, Business School, [...]

Published
2022
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45. Professional Qualities of Special Education Itinerant Teachers: A Qualitative Study from China

Author

Zhu, Nan, Gao, Li, Wang, Jiaojiao, Wang, Yan, Huang, Zhonghe, Guo, Nannan, and Feng, Yajing

Abstract

In China, many special education schools are or have been rebuilt into resource centres. To support the national program of 'Learning in Regular Classroom' (LRC), these centres often recruit teachers in special education schools to serve as special education itinerant teachers (SEITs), who travel across regular schools to provide specialised professional support. However, most studies of professional qualities of SEITs have been conducted in western countries and the analysis was based on SEITs for students with visual or hearing impairment. Little is known about the professional qualities of SEITs in the Chinese LRC context. This study aims to make a contribution in this regard. Semi-structured interviews were carried out with seven SEITs. It was found that beliefs, knowledge, skills, professional identity and motivation, and self-awareness of professional development were recognised as the core professional competencies necessary for the implementation of itinerant service. Implications for practice and future research in SEITs' professional development are presented.

Published
2021
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