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Simple Summary: In radiotherapy treatment, organs at risk and target volumes are contoured by the clinicians to prepare a dosimetry plan. In retrospective data, these structures are not often standardised to universal names across the patients plans, which is required to enable data mining and analysis. In this paper, a new method was proposed and evaluated to automatically standardise radiotherapy structures names using machine learning algorithms. The proposed approach was deployed over a dataset with 1613 patients collected from Liverpool & Macarthur Cancer Therapy Centres, New South Wales, Australia. It was concluded that machine learning techniques can standardise the dosimetry plan structures, taking into consideration the integration of multiple modalities representing each structure during the training process. In progressing the use of big data in health systems, standardised nomenclature is required to enable data pooling and analyses. In many radiotherapy planning systems and their data archives, target volumes (TV) and organ-at-risk (OAR) structure nomenclature has not been standardised. Machine learning (ML) has been utilised to standardise volumes nomenclature in retrospective datasets. However, only subsets of the structures have been targeted. Within this paper, we proposed a new approach for standardising all the structures nomenclature by using multi-modal artificial neural networks. A cohort consisting of 1613 breast cancer patients treated with radiotherapy was identified from Liverpool & Macarthur Cancer Therapy Centres, NSW, Australia. Four types of volume characteristics were generated to represent each target and OAR volume: textual features, geometric features, dosimetry features, and imaging data. Five datasets were created from the original cohort, the first four represented different subsets of volumes and the last one represented the whole list of volumes. For each dataset, 15 sets of combinations of features were generated to investigate the effect of using different characteristics on the standardisation performance. The best model reported 99.416% classification accuracy over the hold-out sample when used to standardise all the nomenclatures in a breast cancer radiotherapy plan into 21 classes. Our results showed that ML based automation methods can be used for standardising naming conventions in a radiotherapy plan taking into consideration the inclusion of multiple modalities to better represent each volume. [ABSTRACT FROM AUTHOR]

The national health insurance system in Australia records details on medical services and claims provided to its population. An effective method to the discovery of temporal behavioral patterns in the data set is proposed in this paper. The method consists of a two-step approach which is applied recursively to the data set. First, a clustering algorithm is used to segment the data into classes. Then, hidden Markov models are employed to find the underlying temporal behavioral patterns. These steps are applied recursively to features extracted from the data set until convergence. The main objective is to minimize the misclassification of patient profiles into various classes. This results in a hierarchical tree model consisting of a number of classes; each class groups similar patient temporal behavioral patterns together. The capabilities of the proposed method are demonstrated through the application to a subset of the Australian national health insurance data set. It is shown that the proposed method not only clusters data into various categories of interest, but it also automatically marks the periods in which similar temporal behavioral patterns occurred. [ABSTRACT FROM AUTHOR]