1. Optimal euploid embryo transfer strategy, fresh versus frozen, after preimplantation genetic screening with next generation sequencing: a randomized controlled trial.
- Author
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Coates, Alison, Kung, Allen, Mounts, Emily, Hesla, John, Bankowski, Brandon, Barbieri, Elizabeth, Ata, Baris, Cohen, Jacques, and Munné, Santiago
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EMBRYO transfer , *PREIMPLANTATION genetic diagnosis , *CHILDBIRTH , *BLASTOCYST , *RANDOMIZED controlled trials , *INFERTILITY treatment , *BIOPSY , *BIRTH rate , *COMPARATIVE studies , *CRYOPRESERVATION of organs, tissues, etc. , *FERTILITY , *FERTILIZATION in vitro , *GENES , *INFERTILITY , *RESEARCH methodology , *EVALUATION of medical care , *MEDICAL cooperation , *PREGNANCY , *RESEARCH , *GENETIC testing , *EVALUATION research , *FETAL development , *TREATMENT effectiveness , *PREDICTIVE tests , *SEQUENCE analysis , *DIAGNOSIS , *PHYSIOLOGY - Abstract
Objective: To compare two commonly used protocols (fresh vs. vitrified) used to transfer euploid blastocysts after IVF with preimplantation genetic screening.Design: Randomized controlled trial.Setting: Private assisted reproduction center.Patient(s): A total of 179 patients undergoing IVF treatment using preimplantation genetic screening.Intervention(s): Patients were randomized at the time of hCG administration to either a freeze-all cycle or a fresh day 6 ET during the stimulated cycle.Main Outcome Measure(s): Implantation rates (sac/embryo transferred), ongoing pregnancy rates (PRs) (beyond 8 weeks), and live birth rate per ET in the primary transfer cycle.Result(s): Implantation rate per embryo transferred showed an improvement in the frozen group compared with the fresh group, but not significantly (75% vs. 67%). The ongoing PR (80% vs. 61%) and live birth rates (77% vs. 59%) were significantly higher in the frozen group compared with the fresh group.Conclusion(s): Either treatment protocol investigated in the present study can be a reasonable option for patients. Freezing all embryos allows for inclusion of all blastocysts in the cohort of embryos available for transfer, which also results in a higher proportion of patients reaching ET. These findings suggest a trend toward favoring the freeze-all option as a preferred transfer strategy when using known euploid embryos.Clinical Trial Registration Number: NCT02000349. [ABSTRACT FROM AUTHOR]- Published
- 2017
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