48,532 results
Search Results
2. Mapping the landscape of Y90 radioembolisation research: a citation analysis of the top 100 papers
- Author
-
Mahmood, Hassan, Deshwal, Avinash, Khalid, Aleena, and Mc Manus, Ethel
- Published
- 2024
- Full Text
- View/download PDF
3. Hypothesis paper: GDF15 demonstrated promising potential in Cancer diagnosis and correlated with cardiac biomarkers
- Author
-
Hao, Xiaohe, Zhang, Zhenyu, Kong, Jing, Ma, Rufei, Mao, Cuiping, Peng, Xun, Ru, Kun, Liu, Lisheng, Zhao, Chuanxi, Mo, Xinkai, Cai, Meijuan, Yu, Xiangguo, and Lin, Qinghai
- Published
- 2024
- Full Text
- View/download PDF
4. Hypothesis paper: GDF15 demonstrated promising potential in Cancer diagnosis and correlated with cardiac biomarkers
- Author
-
Xiaohe Hao, Zhenyu Zhang, Jing Kong, Rufei Ma, Cuiping Mao, Xun Peng, Kun Ru, Lisheng Liu, Chuanxi Zhao, Xinkai Mo, Meijuan Cai, Xiangguo Yu, and Qinghai Lin
- Subjects
GDF15 ,Cancer ,Cardiovascular toxicity ,CTRCD ,Biomarker ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Background Cardiovascular toxicity represents a significant adverse consequence of cancer therapies, yet there remains a paucity of effective biomarkers for its timely monitoring and diagnosis. To give a first evidence able to elucidate the role of Growth Differentiation Factor 15 (GDF15) in the context of cancer diagnosis and its specific association with cardiac indicators in cancer patients, thereby testing its potential in predicting the risk of CTRCD (cancer therapy related cardiac dysfunction). Methods Analysis of differentially expressed genes (DEGs), including GDF15, was performed by utilizing data from the public repositories of the Cancer Genome Atlas (TCGA) and the Gene Expression Omnibus (GEO). Cardiomyopathy is the most common heart disease and its main clinical manifestations, such as heart failure and arrhythmia, are similar to those of CTRCD. Examination of GDF15 expression was conducted in various normal and cancerous tissues or sera, using available database and serum samples. The study further explored the correlation between GDF15 expression and the combined detection of cardiac troponin-T (c-TnT) and N-terminal prohormone of brain natriuretic peptide (NT-proBNP), assessing the combined diagnostic utility of these markers in predicting risk of CTRCD through longitudinal electrocardiograms (ECG). Results GDF15 emerged as a significant DEG in both cancer and cardiomyopathy disease models, demonstrating good diagnostic efficacy across multiple cancer types compared to healthy controls. GDF15 levels in cancer patients correlated with the established cardiac biomarkers c-TnT and NT-proBNP. Moreover, higher GDF15 levels correlated with an increased risk of ECG changes in the cancer cohort. Conclusion GDF15 demonstrated promising diagnostic potential in cancer identification; higher GDF15, combined with elevated cardiac markers, may play a role in the monitoring and prediction of CTRCD risk.
- Published
- 2024
- Full Text
- View/download PDF
5. Mapping the landscape of Y90 radioembolisation research: a citation analysis of the top 100 papers
- Author
-
Hassan Mahmood, Avinash Deshwal, Aleena Khalid, and Ethel Mc Manus
- Subjects
Y90 radioembolisation ,Cancer ,Radiation therapy ,Citation analysis ,Bibliometrics ,Medical physics. Medical radiology. Nuclear medicine ,R895-920 - Abstract
Abstract Background This study aims to identify trends, research gaps, leading journals, institutions, countries, and authors by examining the top 100 cited Yttrium-90 Radioembolization (Y90) research articles. The insights gained will assist funding and collaboration efforts in Y90 research. The team analyzed 981 articles from 36 peer-reviewed journals, gathering data on authors, publication year, journal, citations, affiliations, keywords, and references. Author affiliations were scrutinized to pinpoint institutions and countries. p values 3, n = 31/35) and SCImago Q1 journals (86/100), with Northwestern University, Clínica Universidad de Navarra, and Ludwig Maximilian University of Munich being the leading institutions. The most prolific authors were Salem, R., Lewandowski, R.J., and Mulcahy, M.F., with Salem, R. as the most influential. A statistically significant positive correlation between collaborative links and published articles was also discovered. Short conclusion The top 100 cited articles were primarily published in high-impact journals, and Northwestern University and the USA showed greater productivity and collaboration. These findings have crucial implications for researchers, policymakers, and institutions, aiding in the improvement of Y90 application and understanding in clinical practice.
- Published
- 2024
- Full Text
- View/download PDF
6. Position Paper: Should the Scottish National Party Support Scotland to Legalize, Decriminalize, or Prohibit Cannabis?
- Author
-
Jhaveri, Sujata
- Abstract
The UK has the highest rate of cannabis use among young people worldwide. Dr. Alan Leshner, Director of the National Institute of Drug Abuse reports, "Every year more than 100,000 people, most of them adolescents, seek treatment for their inability to control their marijuana use." According to the Scottish Drug Misuse Statistics in Scotland 2002, 51% of individuals under 20 years have used cannabis. Cannabis use is not limited to youth; it is also the single-most used illicit drug among adults. Because of their widespread negative impact, illicit drugs have become a focus of the agenda of the English Parliament and there is ongoing debate on how to combat this problem. As the research assistant of Michael Matheson (MSP), the author compiled this report to gather information on cannabis and to assess approaches that would form the most effective cannabis policy. This research explores whether or not the recent change toward decriminalization is adequate, or if it needs further revising.
- Published
- 2005
7. Cancer Mortality in Workers Exposed to Organochlorine Compounds in the Pulp and Paper Industry: An International Collaborative Study
- Author
-
McLean, David, Pearce, Neil, Langseth, Hilde, Jäppinen, Paavo, Szadkowska-Stanczyk, Irena, Persson, Bodil, Wild, Pascal, Kishi, Reiko, Lynge, Elsebeth, Henneberger, Paul, Sala, Maria, Teschke, Kay, Kauppinen, Timo, Colin, Didier, Kogevinas, Manolis, and Boffetta, Paolo
- Published
- 2006
8. Incidental findings of gallbladder and bile ducts – Management strategies: Normal findings, anomalies, 'silent gallstones' and bile duct dilatation - A World Federation of Ultrasound in Medicine and Biology (WFUMB) position paper
- Author
-
Christian Jenssen, Christian P. Nolsøe, Torben Lorentzen, Jae Young Lee, Nitin Chaubal, Kathleen Möller, Caroline Ewertsen, Xin Wu Cui, Edda Leonor Chaves, Alina Popescu, Yi Dong, and Christoph F. Dietrich
- Subjects
Incidental findings ,Bile duct ,Gall bladder ,Cancer ,Anomalies ,Gallstones ,Medical technology ,R855-855.5 - Abstract
The World Federation of Ultrasound in Medicine and Biology (WFUMB) has started a series of position papers highlighting the role of ultrasound techniques for diagnosis, risk assessment and follow-up of incidental imaging findings. Gallbladder and biliary tree are among the most frequent anatomical localizations of incidental findings. A first part of the position paper on incidental findings of gallbladder and bile ducts was related to gallbladder polyps and other incidental findings of the gallbladder wall. Based on a description of normal findings, this second part addresses congenital anomalies and variations of the gallbladder and the biliary tree, asymptomatic bile duct dilatation and “silent” gallstones. Based on evidence on prevalence and outcome and with a special focus on ultrasound techniques, the position paper makes recommendations regarding diagnostic work-up, follow-up and treatment of these incidental findings.
- Published
- 2024
- Full Text
- View/download PDF
9. RESET: Information Services Trends in 2012. Selected Papers from PIALA Conference 2012, Pacific Islands Association of Libraries, Archives, and Museums Annual Conference (22nd, Tumon, U.S. Territory of Guam, Nov 13-16, 2012)
- Author
-
Pacific Islands Association of Libraries, Archives and Museums and Drake, Paul B.
- Abstract
This publication follows the tradition of publishing selected papers from Pacific Islands Association of Libraries, Archives and Museums (PIALA) annual conferences. This 22th annual conference was held in Tumon, Territory of Guam USA, November 13-16, 2012. The volume begins with a listing of the members of the PIALA 2012 Planning Committee and PIALA Officers and Executive Board, Acknowledgements, and the Conference program schedule. John Fernandez, Superintendent of the Guam Department of Education, provided the keynote address. James Lonergan, U.S. Institute of Museum and Library Services provided opening remarks. Presentations include: (1) Pathways to Excellence And Achievement in Research and Learning (PEARL): Training K-12 School Teams to Support Student Research (Violet H. Harada and Michael-Brian Ogawa); (2) 21st Century Skills and Web Tools for the Library (Sudi Q. Napalan); (3) Guam And Chamorro Educational Facility (Ken Baki); (4) Web 2.0 Technology Tools for the School Library (Alicia Diego and Rose Unpingco); (5) Localizing History for Community Relevance author talk (Judy Flores); (6) "Let Go and Let God" author talk (Genevieve Leon Guerrero); (7) Data Mining Techniques Using a Spreadsheet (Manny Hechanova); (8) Highlights from the IFLA International Leaders Programme (Atarino A. Helieisar); (9) The Instrument of the Book, the Instrument of the Internet: "Thinking" "Information" in the Pacific (Nicholas J. Goetzfridt); (10) Creating Quality Services: Palau Bookmobile Panel Discussion (Joycelene Moses, Mary Arius, Grace Merong, and Pasquana Tirso) and (11) Guam Public Library Bookmobile Outreach Services (Terry Kennimer, Doris A Francisco, and Victor Palomo). Presentations contain individual references. Appended are: (1) PIALA Executive Board Meeting Agenda; (2) American Pacific Territories' "Librarians Say Books Are Here to Stay". "Radio Australia "Pacific Beat" interview : November 15, 2012; (3) Program from Welcome Dinner; (4) Guam Public Library System Bookmobile Brochure; (5) Guam Public Library System Bookmobile Cutout; (6) Guam Public Library System Bookmobile Library Card Group Form; (7) Guam Public Library System Bookmobile Tour Request Form; (8) Guam Public Library System Bookmobile schedule November, 2012; (9) Chronology of PIALA Conferences; and (10) Conference Registration Form.
- Published
- 2013
10. Engineering the Signal Resolution of a Paper-Based Cell-Free Glutamine Biosensor with Genetic Engineering, Metabolic Engineering, and Process Optimization
- Author
-
Tyler J. Free, Joseph P. Talley, Chad D. Hyer, Catherine J. Miller, Joel S. Griffitts, and Bradley C. Bundy
- Subjects
biosensor ,glutamine ,cell-free protein synthesis (CFPS) ,cancer ,Chemical technology ,TP1-1185 - Abstract
Specialized cancer treatments have the potential to exploit glutamine dependence to increase patient survival rates. Glutamine diagnostics capable of tracking a patient’s response to treatment would enable a personalized treatment dosage to optimize the tradeoff between treatment success and dangerous side effects. Current clinical glutamine testing requires sophisticated and expensive lab-based tests, which are not broadly available on a frequent, individualized basis. To address the need for a low-cost, portable glutamine diagnostic, this work engineers a cell-free glutamine biosensor to overcome assay background and signal-to-noise limitations evident in previously reported studies. The findings from this work culminate in the development of a shelf-stable, paper-based, colorimetric glutamine test with a high signal strength and a high signal-to-background ratio for dramatically improved signal resolution. While the engineered glutamine test is important progress towards improving the management of cancer and other health conditions, this work also expands the assay development field of the promising cell-free biosensing platform, which can facilitate the low-cost detection of a broad variety of target molecules with high clinical value.
- Published
- 2024
- Full Text
- View/download PDF
11. THE ROLE OF PHYSIOTHERAPY IN CANCER CARE IN THE EUROPE REGION: A POSITION PAPER OF THE CANCER WORKING GROUP OF EUROPE REGION WORLD PHYSIOTHERAPY
- Author
-
Nele Adriaenssens, Kristin Lyudmilova, Nikolaos Strimpakos, Nirit Rotem, Gráinne Sheill, Michele Cannone, Loredana Gigli, Līva Tiesnese, Aline Descloux, Alex MacKenzie, Miguel Pérez Navarro, Aitor Carpio García, and Carmen Suarez-Serrano
- Subjects
cancer ,oncology ,physiotherapy ,exercise-oncology ,rehabilita- tion ,prehabilitation ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Background Physiotherapists have strong knowledge and skills to deal with many of the functional problems that result from cancer treatment. The role of physiotherapy spans from cancer prevention to palliative and end of life care. Physiotherapeutic interventions offer a solution for many of the impairments experienced by patients living with and beyond cancer such as declines in physical function and quality of life. Specialized physiotherapeutic interventions can manage complex cancer-related side effects. The aim of this position paper is to outline the role of physiotherapy in the cancer journey. Material and methods The research was performed by eleven physiotherapy experts in oncology between May and October 2021 by using PubMed, PeDro and clinical guidelines databases. The search was divided according to the phases of the cancer journey: primary and secondary prevention, prehabilitation, during cancer treatment, post-treatment cancer rehabilitation, long-term rehabilitation of people living after cancer and advanced cancer. The role of physiotherapy is described and statements for each phase are developed. The final text was reviewed by three external reviewers, who provided feedback to improve the final version. Results Ten statements were developed by the authors, including general statements and statements for the different phases of the cancer journey. An infographic compiles all the statements providing a general and graphic vision of the role of physiotherapy in cancer care, based on the evidence. Conclusions Physiotherapists play an increasingly important role in the multidisciplinary care of cancer survivors. Many oncology physiotherapists have skills that can help to manage cancer-related impairments such as lymphedema, functional decline and cancer-related fatigue. Physiotherapists have strong knowledge and skills to deal with many of the functional problems that result from cancer treatment. Rehabilitation services, including physiotherapy, should be integrated at the point of diagnosis to assess an individual's baseline functional performance status and inform about the cancer care plan.
- Published
- 2023
- Full Text
- View/download PDF
12. Position paper of the Italian association of medical oncology on health disparities among transgender and gender-diverse people: the Assisi recommendations
- Author
-
Alberto Giovanni Leone, Raffaella Casolino, Dario Trapani, Rosalba Miceli, Massimo Massagrande, Federica Morano, Nicla La Verde, Davide Dalu, Rossana Berardi, Silvia Marsoni, Matteo Lambertini, Bianca Iula, Eva Carieri, Manlio Converti, Massimo Di Maio, Giordano Domenico Beretta, Francesco Perrone, Filippo Pietrantonio, and Saverio Cinieri
- Subjects
Transgender ,Gender-diverse ,Gender ,Cancer ,Disparities ,Medicine (General) ,R5-920 - Abstract
Summary: Transgender and gender-diverse individuals experience substantial health disparities across the cancer care continuum. Despite well recognized unique healthcare needs, there are barriers in accessing cancer prevention and treatment services, influenced by disadvantages in key social-economic determinants of health which result in worse clinical outcomes, as compared to the general population. The Italian Association of Medical Oncology (AIOM) acknowledges the critical relevance of this issue. The “Assisi Recommendations” here summarize the outcomes of the “AIOM Oncology Ethics Day” dedicated to gender differences in oncology and cancer care of transgender and gender-diverse people. The recommendations generated during a 2-day multidisciplinary discussion address the various aspects of cancer care experience of transgender and gender-diverse people. The promotion of research in this field, through the generation of new evidence and the collection of prospective data, has been identified as a priority action to mitigate these disparities. By acknowledging the challenges of cancer care in transgender and gender-diverse people and recognizing the need for dedicated policy and clinical recommendations, AIOM demonstrates its commitment to improving the health and well-being of all patients with cancer, regardless of their gender identity or any other personal or social circumstances, as part of health-for-all societal vision.
- Published
- 2023
- Full Text
- View/download PDF
13. Engineering the Signal Resolution of a Paper-Based Cell-Free Glutamine Biosensor with Genetic Engineering, Metabolic Engineering, and Process Optimization.
- Author
-
Free, Tyler J., Talley, Joseph P., Hyer, Chad D., Miller, Catherine J., Griffitts, Joel S., and Bundy, Bradley C.
- Subjects
- *
GLUTAMINE , *PROCESS optimization , *BIOSENSORS , *OVERALL survival , *SURVIVAL rate , *ENGINEERS , *GENETIC engineering - Abstract
Specialized cancer treatments have the potential to exploit glutamine dependence to increase patient survival rates. Glutamine diagnostics capable of tracking a patient's response to treatment would enable a personalized treatment dosage to optimize the tradeoff between treatment success and dangerous side effects. Current clinical glutamine testing requires sophisticated and expensive lab-based tests, which are not broadly available on a frequent, individualized basis. To address the need for a low-cost, portable glutamine diagnostic, this work engineers a cell-free glutamine biosensor to overcome assay background and signal-to-noise limitations evident in previously reported studies. The findings from this work culminate in the development of a shelf-stable, paper-based, colorimetric glutamine test with a high signal strength and a high signal-to-background ratio for dramatically improved signal resolution. While the engineered glutamine test is important progress towards improving the management of cancer and other health conditions, this work also expands the assay development field of the promising cell-free biosensing platform, which can facilitate the low-cost detection of a broad variety of target molecules with high clinical value. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
14. Comparison between web-based and paper versions of a self-administered anthropometrie questionnaire
- Author
-
Touvier, Mathilde, Méjean, Caroline, Kesse-Guyot, Emmanuelle, Pollet, Clothilde, Malón, Aurelie, Castetbon, Katia, and Hercberg, Serge
- Published
- 2010
15. Ovarian cancer and occupational exposure among pulp and paper employees in Norway
- Author
-
Langseth, Hilde and Kjærheim, Kristina
- Published
- 2004
16. The North American Neuroendocrine Tumor Society Consensus Paper on the Surgical Management of Pancreatic Neuroendocrine Tumors.
- Author
-
Howe, James R, Merchant, Nipun B, Conrad, Claudius, Keutgen, Xavier M, Hallet, Julie, Drebin, Jeffrey A, Minter, Rebecca M, Lairmore, Terry C, Tseng, Jennifer F, Zeh, Herbert J, Libutti, Steven K, Singh, Gagandeep, Lee, Jeffrey E, Hope, Thomas A, Kim, Michelle K, Menda, Yusuf, Halfdanarson, Thorvardur R, Chan, Jennifer A, and Pommier, Rodney F
- Subjects
Humans ,Neuroendocrine Tumors ,Pancreatic Neoplasms ,Societies ,Medical ,North America ,Consensus Development Conferences as Topic ,Review Literature as Topic ,Practice Guidelines as Topic ,Surgeons ,Rare Diseases ,Cancer ,Neurosciences ,Pancreatic Cancer ,Digestive Diseases ,pancreas ,neuroendocrine ,pancreatic neuroendocrine tumor ,metastases ,neuroendocrine tumor liver metastases ,pancreatectomy ,Clinical Sciences ,Gastroenterology & Hepatology - Abstract
This manuscript is the result of the North American Neuroendocrine Tumor Society consensus conference on the surgical management of pancreatic neuroendocrine tumors from July 19 to 20, 2018. The group reviewed a series of questions of specific interest to surgeons taking care of patients with pancreatic neuroendocrine tumors, and for each, the available literature was reviewed. What follows are these reviews for each question followed by recommendations of the panel.
- Published
- 2020
17. Gliomas among men employed in the Swedish pulp and paper industry
- Author
-
Andersson, Eva, Nilsson, Ralph, and Torén, Kjell
- Published
- 2002
18. Cohort cancer incidence among pulp and paper mill workers in British Columbia
- Author
-
Band, Pierre R, D Le, Nhu, Fang, Raymond, Astrakianakis, George, Bert, Joel, Keefe, Anya, and Krewski, Daniel
- Published
- 2001
19. Cancer incidence among male pulp and paper workers in Norway
- Author
-
Langseth, Hilde and Andersen, Aage
- Published
- 2000
20. Proceedings of the International Association for Development of the Information Society (IADIS) International Conferences on e-Society (ES 2024, 22nd) and Mobile Learning (ML 2024, 20th) (Porto, Portugal, March 9-11, 2024)
- Author
-
International Association for Development of the Information Society (IADIS), Piet Kommers, Inmaculada Arnedillo Sánchez, Pedro Isaías, Piet Kommers, Inmaculada Arnedillo Sánchez, Pedro Isaías, and International Association for Development of the Information Society (IADIS)
- Abstract
These proceedings contain the papers and posters of the 22nd International Conference on e-Society (ES 2024) and 20th International Conference on Mobile Learning (ML 2024), organised by the International Association for Development of the Information Society (IADIS) in Porto, Portugal, during March 9-11, 2024. The e-Society 2024 conference aims to address the main issues of concern within the Information Society. This conference covers both the technical as well as the non-technical aspects of the Information Society. The Mobile Learning 2024 Conference seeks to provide a forum for the presentation and discussion of mobile learning research which illustrate developments in the field. These events received 185 submissions from more than 25 countries. In addition to the papers' presentations, the conferences also feature two keynote presentations. [Individual papers are indexed in ERIC.]
- Published
- 2024
21. AACR White Paper: Shaping the Future of Cancer Prevention – A Roadmap for Advancing Science and Public Health
- Author
-
Lippman, Scott M, Abate-Shen, Cory, Colbert Maresso, Karen L, Colditz, Graham A, Dannenberg, Andrew J, Davidson, Nancy E, Disis, Mary L, DuBois, Raymond N, Szabo, Eva, Giuliano, Anna R, Hait, William N, Lee, J Jack, Kensler, Thomas W, Kramer, Barnett S, Limburg, Paul, Maitra, Anirban, Martinez, Maria Elena, Rebbeck, Timothy R, Schmitz, Kathryn H, Vilar, Eduardo, and Hawk, Ernest T
- Subjects
Genetics ,Prevention ,Cancer ,Digestive Diseases ,Human Genome ,Good Health and Well Being ,Biomedical Research ,Congresses as Topic ,Health Plan Implementation ,Health Status Disparities ,Humans ,Neoplasms ,Obesity ,Primary Prevention ,Public Health ,Societies ,Medical ,Societies ,Scientific ,United States ,Clinical Sciences ,Oncology and Carcinogenesis ,Oncology & Carcinogenesis - Abstract
The recent pace, extent, and impact of paradigm-changing cancer prevention science has been remarkable. The American Association for Cancer Research (AACR) convened a 3-day summit, aligned with five research priorities: (i) Precancer Atlas (PCA). (ii) Cancer interception. (iii) Obesity-cancer linkage, a global epidemic of chronic low-grade inflammation. (iv) Implementation science. (v) Cancer disparities. Aligned with these priorities, AACR co-led the Lancet Commission to formally endorse and accelerate the NCI Cancer Moonshot program, facilitating new global collaborative efforts in cancer control. The expanding scope of creative impact is perhaps most startling-from NCI-funded built environments to AACR Team Science Awarded studies of Asian cancer genomes informing global primary prevention policies; cell-free epigenetic marks identifying incipient neoplastic site; practice-changing genomic subclasses in myeloproliferative neoplasia (including germline variant tightly linked to JAK2 V617F haplotype); universal germline genetic testing for pancreatic cancer; and repurposing drugs targeting immune- and stem-cell signals (e.g., IL-1β, PD-1, RANK-L) to cancer interception. Microbiota-driven IL-17 can induce stemness and transformation in pancreatic precursors (identifying another repurposing opportunity). Notable progress also includes hosting an obesity special conference (connecting epidemiologic and molecular perspectives to inform cancer research and prevention strategies), co-leading concerted national implementation efforts in HPV vaccination, and charting the future elimination of cancer disparities by integrating new science tools, discoveries and perspectives into community-engaged research, including targeted counter attacks on e-cigarette ad exploitation of children, Hispanics and Blacks. Following this summit, two unprecedented funding initiatives were catalyzed to drive cancer prevention research: the NCI Cancer Moonshot (e.g., PCA and disparities); and the AACR-Stand Up To Cancer bold "Cancer Interception" initiative.
- Published
- 2018
22. 'I have tried to step away from regrets. It has made dying easier'. When Simon Boas, 46, wrote to his local paper about his terminal cancer, his positive outlook struck a chord with readers. Now word has spread and his cheerful stoicism is touching people across the UK. Louise Carpenter reports
- Subjects
British Broadcasting Corp. ,Television broadcasting industry ,Cancer ,General interest - Abstract
Byline: Louise Carpenter A letter called 'A Beginner's Guide to Dying' by a 46-year-old Jersey-based man with terminal cancer has been dropping into inboxes all over Britain in the past [...]
- Published
- 2024
23. White paper of the Society of Abdominal Radiology hepatocellular carcinoma diagnosis disease-focused panel on LI-RADS v2018 for CT and MRI
- Author
-
Elsayes, Khaled M, Kielar, Ania Z, Elmohr, Mohab M, Chernyak, Victoria, Masch, William R, Furlan, Alessandro, Marks, Robert M, Cruite, Irene, Fowler, Kathryn J, Tang, An, Bashir, Mustafa R, Hecht, Elizabeth M, Kamaya, Aya, Jambhekar, Kedar, Kamath, Amita, Arora, Sandeep, Bijan, Bijan, Ash, Ryan, Kassam, Zahra, Chaudhry, Humaira, McGahan, John P, Yacoub, Joseph H, McInnes, Matthew, Fung, Alice W, Shanbhogue, Krishna, Lee, James, Deshmukh, Sandeep, Horvat, Natally, Mitchell, Donald G, Do, Richard KG, Surabhi, Venkateswar R, Szklaruk, Janio, and Sirlin, Claude B
- Subjects
Digestive Diseases ,Liver Cancer ,Cancer ,Biomedical Imaging ,Rare Diseases ,Liver Disease ,Good Health and Well Being ,Algorithms ,Carcinoma ,Hepatocellular ,Diagnosis ,Differential ,Humans ,Liver Neoplasms ,Magnetic Resonance Imaging ,Societies ,Medical ,Tomography ,X-Ray Computed ,United States ,LI-RADS ,v2018 ,CT ,MRI ,HCC - Abstract
The Liver Imaging and Reporting Data System (LI-RADS) is a comprehensive system for standardizing the terminology, technique, interpretation, reporting, and data collection of liver imaging with the overarching goal of improving communication, clinical care, education, and research relating to patients at risk for or diagnosed with hepatocellular carcinoma (HCC). In 2018, the American Association for the Study of Liver Diseases (AASLD) integrated LI-RADS into its clinical practice guidance for the imaging-based diagnosis of HCC. The harmonization between the AASLD and LI-RADS diagnostic imaging criteria required minor modifications to the recently released LI-RADS v2017 guidelines, necessitating a LI-RADS v2018 update. This article provides an overview of the key changes included in LI-RADS v2018 as well as a look at the LI-RADS v2018 diagnostic algorithm and criteria, technical recommendations, and management suggestions. Substantive changes in LI-RADS v2018 are the removal of the requirement for visibility on antecedent surveillance ultrasound for LI-RADS 5 (LR-5) categorization of 10-19 mm observations with nonrim arterial phase hyper-enhancement and nonperipheral "washout", and adoption of the Organ Procurement and Transplantation Network definition of threshold growth (≥ 50% size increase of a mass in ≤ 6 months). Nomenclatural changes in LI-RADS v2018 are the removal of -us and -g as LR-5 qualifiers.
- Published
- 2018
24. Overcoming the challenges in translational development of natural killer cell therapeutics: An opinion paper
- Author
-
Hong Qin, Changqiao You, Feng Yan, Kefang Tan, Changgen Xu, Rui Zhao, Marlene Davis Ekpo, and Songwen Tan
- Subjects
natural killer (NK) cells ,immunosenescence ,immunotherapy ,cancer ,chemotherapy ,biotherapeutics ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Published
- 2022
- Full Text
- View/download PDF
25. Improving World Health: A Least Cost Strategy. Worldwatch Paper 59.
- Author
-
Worldwatch Inst., Washington, DC. and Chandler, William U.
- Abstract
Least-cost health strategies designed to attack the world's leading causes of unnecessary death are explored. Section 1 emphasizes the value of primary health-care procedures--midwifery, maternal education on breastfeeding and weaning, vaccinations, oral rehydration of victims of diarrhea, and antibiotics against respiratory infections--in lowering infant and child mortality in developing countries. Part 2 links the availability of clean drinking water and human waste disposal to diarrheal, tropical, and parasitic diseases. Barriers preventing sanitation development in developing countries are outlined and cost figures are presented. Parts 3 and 4 suggest that the toll of heart disease and cancer in middle age can probably be halved with diet modification and the control of smoking. Educational campaigns for reducing fat and cholesterol consumption, coupled with taxes on tobacco and restrictions on public smoking, are recommended as a way of extending millions of lives into old age at favorable costs. Section 5 offers the best hope of low-cost cures to high-cost diseases such as malaria, sleeping sickness, and the cancers and diseases of the heart. The document concludes that the implementation of the above strategies deserves a high priority because they will effectively and cheaply save the largest number of lives. Eleven data tables supplement the document. (LH)
- Published
- 1984
26. Preventive Health Education Needs: A Survey of Adults in Elkland Borough, Tioga County, Pennsylvania, 1976. Rural Health Staff Papers - Paper Number 10.
- Author
-
Pennsylvania State Univ., University Park. Dept. of Agricultural Economics and Rural Sociology., Taranto, Angelo A., and Leadley, Samuel M.
- Abstract
From a population of 117 adult residents of Elkland Borough formerly interviewed in August 1974, 72 cases were chosen. Of these, 57 persons (43 women and 14 men) were reinterviewed in March 1976 as to their behaviors, beliefs, and attitudes related to preventing cancer and coronary heart disease. The age and sex of those interviewed were compared to those of the actual population as reported in the 1970 population census. The age ratio of the sample was found to be very similar to that of the actual population. Each respondent was asked 117 questions pertaining to: the seriousness and susceptibility of the disease, early detection, their knowledge about the disease, high blood pressure, dietary and weight control practices, regular health maintenance practices, and medical services. Each person rated five selected diseases regarding their seriousness and susceptibility. Findings included: 76% regarded cancer and 81% regarded heart disease as serious enough to require changes in their present life; 25% felt they were likely to have heart disease; 36% believed they were likely to have cancer; 21% of those interviewed in 1976 could name 1 or none of the 7 cancer signs as compared to 29% in 1974; 54% of the women and 14% of the men reported never or occasionally observing dietary rules; and 41 persons named exercise and/or dieting as preventive health measures that they practiced. (NQ)
- Published
- 1976
27. Health Education Needs: A Survey of Rural Adults in Armstrong County, Pennsylvania, 1975. An Interim Report. Rural Health Staff Papers - Paper Number 8.
- Author
-
Pennsylvania State Univ., University Park. Dept. of Agricultural Economics and Rural Sociology., Leadley, Samuel M., and Taranto, Angelo A.
- Abstract
In July and August 1975, 138 rural residents of Armstrong County, Pennsylvania were interviewed as to their behaviors, beliefs, and attitudes regarding the prevention of cancer and coronary heart disease. Respondents were selected by interviewing an adult living on a commercial farm (a farm that either sold $10,000 or more produce per year or the operator worked more than half time on the farm), and then interviewing an adult in the rural nonfarm residence closest to that commercial farm. Interviews were conducted with 71 farm residents and 67 nonfarm residents. Each respondent was asked 167 questions pertaining to: the seriousness and susceptibility of the disease, early detection, their knowledge about the disease, high blood pressure, diet and weight control practices, and medical services. Each person rated eight selected diseases as to their seriousness and susceptibility. Findings included: cancer was felt to be the most serious illness with heart disease ranking second; 29% felt they were likely to have heart disease; 27% perceived themselves as likely to have cancer; 35% could name either 1 or none of the 7 cancer signs; 87% had had their blood pressure checked within the past 18 months; and 66% felt that it was easy to get an appointment with a doctor for a complete physical examination. (NQ)
- Published
- 1975
28. Health Education Needs: A Survey of Rural Adults in Butler County, Pennsylvania, 1975. An Interim Report. Rural Health Staff Papers - Paper Number 7.
- Author
-
Pennsylvania State Univ., University Park. Dept. of Agricultural Economics and Rural Sociology., Leadley, Samuel M., and Taranto, Angelo A.
- Abstract
In July and August 1975, 17 men and 63 women living in rural areas in Butler County, Pennsylvania were interviewed as to their behaviors, beliefs, and attitudes related to preventing cancer and coronary heart disease. Respondents represented about 12% of all adults living on commercial farms and 5% of all rural nonfarm adults in the county. A commercial farm was one that "either sold $10,000 or more produce per year or the operator worked more than half time on the farm". During the interview, each respondent was asked 167 questions pertaining to: the seriousness and susceptibility of the disease, early detection, their knowledge about the disease, high blood pressure, dietary and weight control practices, and medical services. Each person rated eight selected diseases as to their seriousness and susceptibility. Findings included: cancer, heart disease, glaucoma, and emphysema were perceived to be serious, with cancer being the most serious; 27% felt they were likely to have heart disease; 30% believed themselves likely to have cancer; 3 out of 10 persons could name either 1 or none of the 7 cancer signs; 1/3 of the farm men and women reported never or only occasionally consciously observing dietary rules; and 92% indicated a willingness to consider treatment by allied health personnel. (NQ)
- Published
- 1975
29. Health Education Needs: A Survey of Rural Adults in Juniata County, Pennsylvania, 1975. An Interim Report. Rural Health Staff Papers - Paper Number 4.
- Author
-
Pennsylvania State Univ., University Park. Dept. of Agricultural Economics and Rural Sociology. and Leadley, Samuel M.
- Abstract
In June 1975, 62 men and 64 women living on commercial farms in Juniata County, Pennsylvania were interviewed regarding their behaviors, beliefs, and attitudes related to preventing cancer and coronary heart disease. Respondents represented about 22% of all adults living on commercial farms in the county. A commercial farm was defined as one that either sold $10,000 or more produce per year or the operator worked more than half time on the farm. During a face-to-face interview setting, each respondent was asked 137 questions pertaining to: the seriousness and susceptibility of the disease, early detection, their knowledge about the disease, high blood pressure, overweight, and medical services. Each person rated eight selected diseases as to their seriousness and susceptibility. Findings included: cancer was perceived to be the most serious of all eight illnesses with heart disease ranking second; 1/3 of the respondents perceived themselves as either likely or very likely to have heart disease; 30% believed themselves likely to have cancer; all but 5 of the respondents strongly agreed that many types of cancer detected in the early stages could be cured; and 99% of the respondents felt that high blood pressure could be reduced and were aware of 1 or more ways in which this could be accomplished. (NQ)
- Published
- 1975
30. Health Education Needs: A Survey of Rural Adults in Northumberland County, Pennsylvania, 1975. An Interim Report. Rural Health Staff Papers - Paper Number 6.
- Author
-
Pennsylvania State Univ., University Park. Dept. of Agricultural Economics and Rural Sociology. and Leadley, Samuel M.
- Abstract
In June 1975, 53 men and 56 women living on commercial farms in Northumberland County, Pennsylvania were interviewed regarding their behaviors, beliefs, and attitudes related to preventing cancer and coronary heart disease. Respondents represented about 23% of all adults living on commercial farms in the county. A commercial farm was defined as one that either sold $10,000 or more produce per year or the operator worked more than half time on the farm. During a face-to-face interview setting, each respondent was asked 137 questions pertaining to: the seriousness and susceptibility of the disease, early detection, their knowledge about the disease, high blood pressure, overweight, and medical services. Each person rated eight selected diseases as to their seriousness and susceptibility. Findings included: 92% felt that cancer and heart disease were serious or extremely serious; of the 109 persons, only 1 disagreed that many types of cancer detected in the early stages could be cured; 1 person out of 3 could name either 1 or none of the 7 cancer signs; associated with the frequency of occurrence of heart disease were factors such as high blood pressure, overweight, and lack of regular physical exercise; 84% had had their blood pressure checked while visiting a doctor; and 1 out of 4 persons felt that dietary regulation was difficult. (NQ)
- Published
- 1975
31. Health Education Needs: A Survey of Rural Adults in Fulton County, Pennsylvania, 1975. An Interim Report. Rural Health Staff Papers - Paper Number 5.
- Author
-
Pennsylvania State Univ., University Park. Dept. of Agricultural Economics and Rural Sociology. and Leadley, Samuel M.
- Abstract
In June 1975, 47 men and 43 women living on commercial farms in Fulton County, Pennsylvania were interviewed regarding their behaviors, beliefs, and attitudes related to preventing cancer and coronary heart disease. Respondents represented about 39% of all adults living on commercial farms in the county. A commercial farm was defined as one that either sold $10,000 or more produce per year or the operator worked more than half time on the farm. During a face-to-face interview setting, each respondent was asked 137 questions pertaining to: the seriousness and susceptibility of the disease, early detection, their knowledge about the disease, high blood pressure, overweight, and medical services. Each person rated eight selected diseases regarding their seriousness and susceptibility. Findings included: cancer was perceived to be the most serious of all eight illnesses with heart disease ranking second; 35% perceived themselves as either likely or very likely to have heart disease; 24% believed themselves likely to have cancer; all the respondents strongly agreed that many types of cancer detected in the early stages could be cured; 2 out of 5 persons could name either 2, 1 or none of the 7 cancer signs; and 99% felt that high blood pressure could be reduced and were aware of 1 or more ways in which this could be accomplished. (NQ)
- Published
- 1975
32. Banishing Tobacco. Worldwatch Paper 68.
- Author
-
Worldwatch Inst., Washington, DC. and Chandler, William U.
- Abstract
This report focuses on topics and issues related to the global use of tobacco. It consists of an introduction and six major sections. These sections deal with: (1) the epidemic rate at which smoking is spreading, indicating that the global rate has grown nearly 75 percent over the past two decades and is growing at 2.1 percent per year, faster than world population growth; (2) health factors, indicating that lung cancer is predominantly a disease of smoking and showing the international correlation between cigarette consumption and lung cancer deaths after 20 years of smoking; (3) sidestream smoke (which wafts from a smoker's cigarette to an involuntary smoker) and its effects on others, indicating that passive smoking has been correlated with lung cancer in nonsmoking spouses of smokers in more than 10 studies; (4) effects on children, indicating that in one United States survey, smokers gave birth to underweight babies twice as often as other women did; (5) antismoking efforts to date; and (6) stronger measures, such as banishing tobacco by prohibiting tobacco from workplaces and public buildings. Data tables are included when applicable, for example, on cigarette use in selected countries (1984), and smoking among United States males by educational level (1982). (JN)
- Published
- 1986
33. Point-of-care diagnostics for noncommunicable diseases using synthetic urinary biomarkers and paper microfluidics
- Author
-
Warren, Andrew D., Kwong, Gabriel A., Wood, David K., Lin, Kevin Y., and Bhatia, Sangeeta N.
- Published
- 2014
34. Multi-disciplinary summit on genetics services for women with gynecologic cancers: A Society of Gynecologic Oncology White Paper.
- Author
-
Randall, Leslie M, Pothuri, Bhavana, Swisher, Elizabeth M, Diaz, John P, Buchanan, Adam, Witkop, Catherine T, Bethan Powell, C, Smith, Ellen Blair, Robson, Mark E, Boyd, Jeff, Coleman, Robert L, and Lu, Karen
- Subjects
Humans ,Genital Neoplasms ,Female ,Genetic Services ,Genetic Counseling ,Gynecology ,Patient Selection ,Societies ,Medical ,Female ,Congresses as Topic ,Consensus Development Conferences as Topic ,Practice Guidelines as Topic ,Lynch Syndrome II ,Genetic Testing ,Hereditary Breast and Ovarian Cancer Syndrome ,Surgical Oncology ,Clinical Research ,Prevention ,Genetics ,Ovarian Cancer ,Cancer ,Health Services ,Rare Diseases ,Oncology and Carcinogenesis ,Paediatrics and Reproductive Medicine ,Oncology & Carcinogenesis - Abstract
ObjectiveTo assess current practice, advise minimum standards, and identify educational gaps relevant to genetic screening, counseling, and testing of women affected by gynecologic cancers.MethodsThe Society of Gynecologic Oncology (SGO) organized a multidisciplinary summit that included representatives from the American College of Obstetricians and Gynecologists (ACOG), the American Society Clinical Oncology (ASCO), the National Society of Genetic Counselors (NSGC), and patient advocacy groups, BrightPink and Facing our Risk of Cancer Empowered (FORCE). Three subject areas were discussed: care delivery models for genetic testing, barriers to genetic testing, and educational opportunities for providers of genetic testing.ResultsThe group endorsed current SGO, National Comprehensive Cancer Network (NCCN), and NSGC genetic testing guidelines for women affected with ovarian, tubal, peritoneal cancers, or DNA mismatch repair deficient endometrial cancer. Three main areas of unmet need were identified: timely and universal genetic testing for women with ovarian, fallopian tube, and peritoneal cancers; education regarding minimum standards for genetic counseling and testing; and barriers to implementation of testing of both affected individuals as well as cascade testing of family members. Consensus building among all stakeholders resulted in an action plan to address gaps in education of gynecologic oncology providers and delivery of cancer genetics care.
- Published
- 2017
35. SPECIAL ISSUE: THE 50th ANNIVERSARY OF THE NATIONAL CANCER ACT OF 1971 - OPINION PAPER - CANCER, A NEVER ENDING DISEASE?
- Author
-
Paolo Tralongo
- Subjects
cancer ,incurable ,cured ,social needs ,qol ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Advances in scientific research and the launch of cancer prevention programs have changed the natural history of cancer. Especially, many types of cancer initially considered incurable has gradually transformed into a "chronic" disease. More recently, several epidemiological data have con rmed that some cancer patients can be considered "cured" after a certain period of time, a period that varies from tumour to tumour. Perhaps it has come the time to use this word when appropriate. Its use could have signi cant repercussions, not only from a psychological but also from a social point of view, with an extraordinary impact on the Quality of Life of each patient.
- Published
- 2021
- Full Text
- View/download PDF
36. Cancer prevention – review paper
- Author
-
Anna Maria Lewandowska, Tomasz Lewandowski, Marcin Rudzki, Sławomir Rudzki, and Barbara Laskowska
- Subjects
cancer ,risk factors ,cancer prevention ,Agriculture ,Environmental sciences ,GE1-350 - Abstract
Introduction Every year there is an increase in the number of cases and deaths due to the majority of cancers. Currently, these diseases constitute the second cause of death in Poland and the USA. The number of cases of malignant neoplasms in Poland has more than doubled over the last three decades. According to the National Cancer Registry, in Poland about 95.5 people per thousand die every year from malignant neoplasms. Current epidemiological data on cancer is worrying because the World Health Organization predicts a significant increase in the incidence of cancer in the general population. This problem, which is significant on the global scale, demands the search for more effective prevention methods so that more and more attention is paid to both primary and secondary prevention. Prevention and early detection of cancer have become a priority for the national health policy of many European countries. Numerous studies around the world prove that reducing the risk of cancer is most effective through adopting a healthy lifestyle, avoiding exposure to carcinogens, combined with regular screening. Objective The aim of the study was to review knowledge on cancer prevention, including the latest research results. Conclusions Due to the systematic increase in the incidence of cancer, a strong emphasis should be placed on prevention. Preventive actions bring benefits not only to the individual, but are an important aspect of health policy. The importance of primary prevention in relation to healthy people has been demonstrated, including secondary prevention aimed at controlling risk factors in relation to persons exposed to them. The combination of these activities becomes an important element in maintaining the health of the individual, as well as society.
- Published
- 2021
- Full Text
- View/download PDF
37. AllergoOncology: ultra-low IgE, a potential novel biomarker in cancer—a Position Paper of the European Academy of Allergy and Clinical Immunology (EAACI)
- Author
-
Ferastraoaru, D., Bax, H. J., Bergmann, C., Capron, M., Castells, M., Dombrowicz, D., Fiebiger, E., Gould, H. J., Hartmann, K., Jappe, U., Jordakieva, G., Josephs, D. H., Levi-Schaffer, F., Mahler, V., Poli, A., Rosenstreich, D., Roth-Walter, F., Shamji, M., Steveling-Klein, E. H., Turner, M. C., Untersmayr, E., Karagiannis, S. N., and Jensen-Jarolim, E.
- Published
- 2020
- Full Text
- View/download PDF
38. Thermal ablation of colorectal liver metastases: a position paper by an international panel of ablation experts, the interventional oncology sans frontières meeting 2013
- Author
-
Gillams, Alice, Goldberg, Nahum, Ahmed, Muneeb, Bale, Reto, Breen, David, Callstrom, Matthew, Chen, Min Hua, Choi, Byung Ihn, de Baere, Thierry, Dupuy, Damian, Gangi, Afshin, Gervais, Debra, Helmberger, Thomas, Jung, Ernst-Michael, Lee, Fred, Lencioni, Riccardo, Liang, Ping, Livraghi, Tito, Lu, David, Meloni, Franca, Pereira, Philippe, Piscaglia, Fabio, Rhim, Hyunchul, Salem, Riad, Sofocleous, Constantinos, Solomon, Stephen B, Soulen, Michael, Tanaka, Masatoshi, Vogl, Thomas, Wood, Brad, and Solbiati, Luigi
- Subjects
Biomedical and Clinical Sciences ,Clinical Sciences ,Oncology and Carcinogenesis ,Liver Disease ,Biomedical Imaging ,Cancer ,Colo-Rectal Cancer ,Digestive Diseases ,Ablation Techniques ,Colorectal Neoplasms ,Humans ,Liver Neoplasms ,Survival Analysis ,Colorectal neoplasms ,Liver neoplasms ,Ablation techniques ,Consensus ,Clinical protocols ,Nuclear Medicine & Medical Imaging ,Clinical sciences - Abstract
ObjectivesPrevious attempts at meta-analysis and systematic review have not provided clear recommendations for the clinical application of thermal ablation in metastatic colorectal cancer. Many authors believe that the probability of gathering randomised controlled trial (RCT) data is low. Our aim is to provide a consensus document making recommendations on the appropriate application of thermal ablation in patients with colorectal liver metastases.MethodsThis consensus paper was discussed by an expert panel at The Interventional Oncology Sans Frontières 2013. A literature review was presented. Tumour characteristics, ablation technique and different clinical applications were considered and the level of consensus was documented.ResultsSpecific recommendations are made with regard to metastasis size, number, and location and ablation technique. Mean 31 % 5-year survival post-ablation in selected patients has resulted in acceptance of this therapy for those with technically inoperable but limited liver disease and those with limited liver reserve or co-morbidities that render them inoperable.ConclusionsIn the absence of RCT data, it is our aim that this consensus document will facilitate judicious selection of the patients most likely to benefit from thermal ablation and provide a unified interventional oncological perspective for the use of this technology.Key points• Best results require due consideration of tumour size, number, volume and location. • Ablation technology, imaging guidance and intra-procedural imaging assessment must be optimised. • Accepted applications include inoperable disease due to tumour distribution or inadequate liver reserve. • Other current indications include concurrent co-morbidity, patient choice and the test-of-time approach. • Future applications may include resectable disease, e.g. for small solitary tumours.
- Published
- 2015
39. AllergoOncology: ultra-low IgE, a potential novel biomarker in cancer—a Position Paper of the European Academy of Allergy and Clinical Immunology (EAACI)
- Author
-
D. Ferastraoaru, H. J. Bax, C. Bergmann, M. Capron, M. Castells, D. Dombrowicz, E. Fiebiger, H. J. Gould, K. Hartmann, U. Jappe, G. Jordakieva, D. H. Josephs, F. Levi-Schaffer, V. Mahler, A. Poli, D. Rosenstreich, F. Roth-Walter, M. Shamji, E. H. Steveling-Klein, M. C. Turner, E. Untersmayr, S. N. Karagiannis, and E. Jensen-Jarolim
- Subjects
IgE ,Allergy diagnosis ,Atopy ,Cancer ,Malignancy ,Immunologic diseases. Allergy ,RC581-607 - Abstract
Abstract Elevated serum IgE levels are associated with allergic disorders, parasitosis and specific immunologic abnormalities. In addition, epidemiological and mechanistic evidence indicates an association between IgE-mediated immune surveillance and protection from tumour growth. Intriguingly, recent studies reveal a correlation between IgE deficiency and increased malignancy risk. This is the first review discussing IgE levels and links to pathological conditions, with special focus on the potential clinical significance of ultra-low serum IgE levels and risk of malignancy. In this Position Paper we discuss: (a) the utility of measuring total IgE levels in the management of allergies, parasitosis, and immunodeficiencies, (b) factors that may influence serum IgE levels, (c) IgE as a marker of different disorders, and d) the relationship between ultra-low IgE levels and malignancy susceptibility. While elevated serum IgE is generally associated with allergic/atopic conditions, very low or absent IgE may hamper anti-tumour surveillance, indicating the importance of a balanced IgE-mediated immune function. Ultra-low IgE may prove to be an unexpected biomarker for cancer risk. Nevertheless, given the early stage of investigations conducted mostly in patients with diseases that influence IgE levels, in-depth mechanistic studies and stratification of malignancy risk based on associated demographic, immunological and clinical co-factors are warranted.
- Published
- 2020
- Full Text
- View/download PDF
40. Randomized Controlled Trial of Paper-Based at a Hospital versus Continual Electronic Patient-Reported Outcomes at Home for Metastatic Cancer Patients: Does Electronic Measurement at Home Detect Patients' Health Status in Greater Detail?
- Author
-
Naruto Taira, Kojiro Shimozuma, Takashi Fukuda, Takuya Kawahara, Takeru Shiroiwa, Shinichi Noto, Yasuhiro Hagiwara, Tetsuya Iwamoto, and Keiko Konomura
- Subjects
medicine.medical_specialty ,business.industry ,Health Policy ,Health Status ,Cancer ,Paper based ,medicine.disease ,Outcome (game theory) ,Eortc qlq c 30 ,Hospitals ,law.invention ,Randomized controlled trial ,Quality of life ,law ,Neoplasms ,Surveys and Questionnaires ,Physical therapy ,Quality of Life ,Medicine ,Humans ,Patient-reported outcome ,Patient Reported Outcome Measures ,Electronics ,business - Abstract
Purpose This study aimed to determine whether continual electronic patient-reported outcome (ePRO) measurements at home can capture the fluctuations in health-related quality of life (HRQOL) scores between visits. Methods We performed a randomized controlled trial to compare the scores obtained by standard practice (paper-based measurements in the hospital) to scores by continuous measurement of ePRO at home. Metastatic cancer patients were randomly assigned to either the paper-based ( n = 50) or the ePRO group ( n = 52). EQ-5D-5L and EORTC QLQ C-30 scores were obtained on 3 different chemotherapy days in the paper-based group. Meanwhile, scores were obtained on the chemotherapy day and on days 3, 7, 10, and 14 in the ePRO group during 2 cycles. The first hypothesis of our study was that both scores at the same time points would be equivalent despite different measurement frequency, place, or mode of measurement. The second hypothesis was that PRO score–adjusted time would be different between the groups. For equivalence, the endpoint was the mean EQ-5D-5L index value on the chemotherapy day before the outpatient treatment. Only if equivalence was shown, quality-adjusted life-days (QALDs) were considered using all the data. Results The adjusted mean difference in the EQ-5D-5L index was determined to be −0.013 (95% confidence interval [CI]: −0.049 to 0.022); the 95% CI did not exceed the equivalence margin. Similarly, the mean difference in global health status (2.28 [95% CI: −2.55 to 7.11]) also showed equivalence. However, the QALD by EQ-5D-5L was significantly lower in the ePRO group by 1.36 per 30 d (95% CI: −2.22 to −0.51; P = 0.0021). Conclusions Continual measurements of the HRQOL at home by ePRO may yield more detailed profiles of the HRQOL.
- Published
- 2022
41. The palliative clinical specialist radiation therapist: A CAMRT White Paper
- Author
-
Nicole Harnett, Natalie Rozanec, and Carrie Lavergne
- Subjects
medicine.medical_specialty ,Radiological and Ultrasound Technology ,Palliative Radiation Therapy ,business.industry ,Radiation Therapist ,media_common.quotation_subject ,medicine.medical_treatment ,food and beverages ,Cancer ,medicine.disease ,Radiation therapy ,White paper ,Health care ,medicine ,Radiology, Nuclear Medicine and imaging ,Quality (business) ,Incurable cancer ,Intensive care medicine ,business ,media_common - Abstract
Palliative radiation therapy (pRT) is an effective tool for people with incurable cancer, in the treatment of many cancer-related symptoms such as pain, bleeding and dyspnea. As utilization rates for palliative radiation therapy increase, the demands on the healthcare system continue to grow. Radiation Therapists with advanced knowledge, skills and judgements began demonstrating their ability to practice autonomously in 2004, with the development of the Clinical Specialist Radiation Therapist (CSRT) role. Since this time, CSRTs with a specific focus in pRT (pCSRT) have been increasing in both numbers as well as their positive effects on the cancer care system. Integrating a pCSRT into the existing pRT system has resulted in increased access to and quality of pRT being delivered to palliative cancer patients. The benefits of the addition of pCSRTs to the cancer care system include increasing system capacity and increasing quality of care. This white paper provides information related to the improvements that can be realized in a RT program related to the care and treatment of its palliative patients by adding a pCSRT to the interprofessional healthcare team and suggest it as one of many strategies that can be undertaken to make improvements to access and quality of care.
- Published
- 2021
42. Navigator. Volume 45, Number 2, Winter 2009
- Author
-
National Science Education Leadership Association.
- Abstract
The National Science Education Leadership Association (NSELA) was formed in 1959 to meet a need to develop science education leadership for K-16 school systems. "Navigator" is published by NSELA to provide the latest NSELA events. This issue of "Navigator" contains the following reports: (1) A Message from the President: Creating Networks of Leading and Learning (Linda Atkinson); (2) Tech Support: RSS (Beth Snoke Harris); (3) Safe Science: Be Protected. Sun Safety in Science! (Ken Roy); (4) Regional News; (5) Informal Science Education: Getting More Science Into Out of School Time (OST) (Cheryl Lani Juarez); (6) Celebrating the Year of Science: Laissez Les Bons Temps Rouler! 2009 New Orleans NSTA Conference on Science Education Update; (7) Update on NSELA's Safety Position Papers; (8) Summary of Fall 2008 NSELA Board Meetings; and (9) ICASE News. Individual reports contain resources and figures.
- Published
- 2009
43. Indirect implications of COVID-19 prevention strategies on non-communicable diseases: An Opinion Paper of the European Society of Hypertension Working Group on Hypertension and Cardiovascular Risk Assessment in Subjects Living in or Emigrating from Low Resource Settings
- Author
-
Modesti, Pietro A., Wang, Jiguang, Damasceno, Albertino, Agyemang, Charles, Van Bortel, Luc, Persu, Alexandre, Zhao, Dong, Jarraya, Faical, Marzotti, Ilaria, Bamoshmoosh, Mohamed, Parati, Gianfranco, and Schutte, Aletta E.
- Published
- 2020
- Full Text
- View/download PDF
44. 'Lung cancer and tobacco consumption': technical evaluation of the 1943 paper by Schairer and Schoeniger published in Nazi Germany
- Author
-
Morabia, Alfredo
- Published
- 2013
45. Overview of virus and cancer relationships. Position paper
- Author
-
O Fernández-Capetillo, D Gracia, Joaquín Arribas, M Martín Jiménez, Rafael Bañares, M B Barragán, J.M. Eiros Bouza, J Tovar, Emilio Bouza, Luis Paz-Ares, A Torné, E Valencia, L Alemany, P Muñoz, Esteban Palomo, E Felip, J Bautista Mollar, and Rogelio López-Vélez
- Subjects
Microbiology (medical) ,HPV ,Oncolytic virus ,viruses ,Review ,Cancer mortality ,Hepatitis C. HBV ,Virus ,Tumours ,EBV ,Neoplasms ,Tumor Virus ,Humans ,Medicine ,Papillomaviridae ,HHV-8 ,Tropism ,Cancer ,Pharmacology ,Vaccines ,business.industry ,Human Papillomavirus ,HIV ,virus diseases ,Oncogenes ,General Medicine ,Hepatitis B ,medicine.disease ,Virology ,Cancer-prevention ,Human T Lymphotropic Virus I ,Virus Diseases ,HTLV-1 ,Human Herpes Virus 8 ,HCV ,Etiology ,Position paper ,Oncogenic Viruses ,Cancer-economy ,business ,Epstein-Barr Virus ,Human Immunodeficiency Virus ,Biomedical sciences - Abstract
The role of certain viruses in the etiology of some tumors is today indisputable, but there is a lack, however, of annoverview of the relationship between viruses and cancer with amultidisciplinary approach. For this reason, the Health Sciences Foundation has convened a group of professionals from different areas of knowledge to discuss the relationship between viruses and cancer, and the present document is the result of these deliberations. Although viruses cause only 10-15% of cancers, advances in oncology research are largely due to the work done during the last century on tumor viruses. The clearest cancer-inducing viruses are: HPV, HBV, HCV, EBV and, depending on the geographical area, HHV-8, HTLV-1 and HIV. HPVs, for example, are considered to be the causative agents of cervical carcinomas and, more recently, of a proportion of other cancers. Among the Herpes viruses, the association with the development of neoplasms is well established for EBV and HHV-8. Viruses can also be therapeutic agents in certain neoplasms and, thus, some oncolytic viruses with selective tropism for tumor cells have been approved for clinical use in humans. It is estimated that the prophylaxis or treatment of viral infections could prevent at least 1.5 million cancer deaths per year.
- Published
- 2021
46. Letter from Ralph J Cicerone regarding Edward Calabrese’s paper published online first on August 4th: “how the US national academy of sciences misled the world community on cancer risk assessment: new findings challenge historical foundations of the linear dose response.” [DOI 10.1007/s00204-013-1105-6, Review Article]
- Author
-
Cicerone, RJ and Crowley, KD
- Subjects
Cancer ,Humans ,National Academy of Sciences ,U.S. ,Neoplasms ,Risk Assessment ,Pharmacology and Pharmaceutical Sciences ,Toxicology - Published
- 2014
47. Printing And Supply Of Patients Investigation|Summary|Certificate - Reporting Forms In Branded A4 Size, 80 Gsm, White Paper For Regional Cancer Centre, Thiruvananthapuram, Kerala State
- Subjects
Cancer ,Business, international - Abstract
Tenders are invited for Printing and Supply of Patients investigation/ Summary/ Certificate - Reporting Forms in branded A4 Size, 80 GSM, white paper for Regional Cancer Centre, Thiruvananthapuram, Kerala state. [...]
- Published
- 2023
48. Environmental risk factors for cancer – review paper
- Author
-
Anna Maria Lewandowska, Marcin Rudzki, Sławomir Rudzki, Tomasz Lewandowski, and Barbara Laskowska
- Subjects
cancer ,risk factors ,environment ,biological factor ,Agriculture ,Environmental sciences ,GE1-350 - Abstract
The cancerous process is result of disturbed cell function. This is due to the accumulation of many genetic and epigenetic changes within the cell, expressed in the accumulation of chromosomal or molecular aberrations, which leads to genetic instability. It is difficult to assess the validity of individual aetiological factors, but it can be concluded that interaction of various risk factors has the largest contribution to the cancer development. Environmental, exogenous and endogenous factors as well as individual factors, including genetic predisposition contribute to the development of cancer. Epidemiological research on the development of malignant tumors has focused over the years on the determinants of environmental and genetic factors of cancer incidence and mortality rate. According to current state of knowledge, 80–90% of malignant tumors are caused by external environmental factors (carcinogens). Epidemiological studies have proved that the main factors responsible for the development of malignant neoplasia among humans are environmental factors arising from human behaviour. It has been confirmed that smoking, excessive alcohol consumption, diet, and reproductive behaviour are important for the development of malignant neoplasia in the human population. According to the World Health Organization, in 2020 we may expect about 10 million deaths, including 7–8 million in the developing countries, while this number in the developed countries will not change and will be 2–3 million. The aim this study was systematization of knowledge concerning the risk factors of malignant tumours and supplementing them with the latest research results.
- Published
- 2019
- Full Text
- View/download PDF
49. Impact of COVID-19 on the care of patients with liver disease: EASL-ESCMID position paper after 6 months of the pandemic
- Author
-
Tobias Boettler, Thomas Marjot, Philip N. Newsome, Mario U. Mondelli, Mojca Maticic, Elisa Cordero, Rajiv Jalan, Richard Moreau, Markus Cornberg, and Thomas Berg
- Subjects
Liver ,Cirrhosis ,Cancer ,COVID-19 ,NAFLD ,Telemedicine ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Summary: During the early stages of the coronavirus disease 2019 (COVID-19) pandemic, EASL and ESCMID published a position paper to provide guidance for physicians involved in the care of patients with chronic liver disease. While some healthcare systems are returning to a more normal routine, many countries and healthcare systems have been, or still are, overwhelmed by the pandemic, which is significantly impacting on the care of these patients. In addition, many studies have been published focusing on how COVID-19 may affect the liver and how pre-existing liver diseases might influence the clinical course of COVID-19. While many aspects remain poorly understood, it has become increasingly evident that pre-existing liver diseases and liver injury during the disease course must be kept in mind when caring for patients with COVID-19. This review should serve as an update on the previous position paper, summarising the evidence for liver disease involvement during COVID-19 and providing recommendations on how to return to routine care wherever possible.
- Published
- 2020
- Full Text
- View/download PDF
50. Cancer nanomedicines: So many papers and so few drugs!
- Author
-
Venditto, Vincent J and Szoka, Francis C
- Subjects
Medical Biotechnology ,Biomedical and Clinical Sciences ,Cancer ,Bioengineering ,Orphan Drug ,Nanotechnology ,Biotechnology ,Rare Diseases ,5.1 Pharmaceuticals ,Development of treatments and therapeutic interventions ,Antineoplastic Agents ,Drug Carriers ,Drug Delivery Systems ,Humans ,Nanomedicine ,Neoplasms ,Camptothecin ,Liposomes ,Monoclonal antibodies ,Platinum therapy ,Polymers ,Pharmacology and Pharmaceutical Sciences ,Pharmacology & Pharmacy ,Pharmacology and pharmaceutical sciences - Abstract
This review identifies a timeline to nanomedicine anticancer drug approval using the business model of inventors, innovators and imitators. By evaluating the publication record of nanomedicine cancer therapeutics we identified a trend of very few publications prior to FDA approval. We first enumerated the publications related to cancer involving polymers, liposomes or monoclonal antibodies and determined the number of citations per publication as well as the number of published clinical trials among the publications. Combining these data with the development of specific nanomedicines, we are able to identify an invention phase consisting of seminal papers in basic science necessary for the development of a specific nanomedicine. The innovation phase includes the first report, the development and the clinical trials involving that nanomedicine. Finally, the imitation phase begins after approval when others ride the wave of success by using the same formulation for new drugs or using the same drug to validate other nanomedicines. We then focused our analysis on nanomedicines containing camptothecin derivatives, which are not yet approved including two polymers considered innovations and one liposomal formulation in the imitation phase. The conclusion that may be drawn from the analysis of the camptothecins is that approved drugs reformulated in polymeric and liposomal cancer nanomedicines have a more difficult time navigating through the approval process than the parent molecule. This is probably due to the fact that for most currently approved drugs, reformulating them in a nanocarrier provides a small increase in performance that large pharmaceutical companies do not consider being worth the time, effort and expense of development. It also appears that drug carriers have a more difficult path through the clinic than monoclonal antibodies. The added complexity of nanocarriers also deters their use to deliver new molecular entities. Thus, the new drug candidates that might be most improved by drug delivery in nanocarriers are not formulated in this fashion.
- Published
- 2013
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.