1. Platelet [3H]imipramine and [3H]paroxetine binding in depressed patients
- Author
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Julio Vallejo, Pilar Rosel, Belén Arranz, Miguel Angel Navarro, P. Alvarez, F Lirón, and José M. Menchón
- Subjects
Adult ,Blood Platelets ,Male ,Imipramine ,medicine.medical_specialty ,Internal medicine ,medicine ,Humans ,Platelet ,Psychiatry ,Aged ,Depressive Disorder ,Binding Sites ,Chemistry ,Age Factors ,Middle Aged ,Control subjects ,Paroxetine ,Antidepressive Agents ,Dissociation constant ,Psychiatry and Mental health ,Clinical Psychology ,Endocrinology ,Endogenous depression ,Female ,3h imipramine ,Negative correlation ,medicine.drug - Abstract
[3H]Paroxetine and [3H]imipramine binding to blood platelet membranes was simultaneously measured in 63 control subjects and 18 patients with DSM-III-R criteria for major depression with melancholia. Both binding sites showed significantly different (p 0.001) maximum binding (Bmax) and equilibrium dissociation constant (Kd) values. Age was not correlated with either [3H]imipramine Bmax or Kd values, but a negative correlation was found between [3H]paroxetine Bmax and age in healthy controls. Furthermore, depressed patients showed significantly lower [3H]imipramine Bmax values (p 0.001) and higher Kd values (p 0.001) in comparison to the control group. No differences were observed in [3H]paroxetine Bmax and Kd values between the two groups.
- Published
- 1997