Anne C. M. Cuijpers, Bart C. Bongers, Aniek F. J. M. Heldens, Martijn J. L. Bours, Nico L. U. Meeteren, Laurents P. S. Stassen, Tim Lubbers, Surgery, RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy, MUMC+: MA Heelkunde (9), Nutrition and Movement Sciences, RS: CAPHRI - R3 - Functioning, Participating and Rehabilitation, RS: NUTRIM - R3 - Respiratory & Age-related Health, RS: NUTRIM - R1 - Obesity, diabetes and cardiovascular health, Epidemiologie, MUMC+: TPZ Fysiotherapie (9), RS: GROW - R1 - Prevention, MUMC+: MA AIOS Heelkunde (9), RS: NUTRIM - R2 - Liver and digestive health, and Anesthesiology
Background and Objectives: To assess the association of preoperative aerobic fitness and body composition variables with a patient's resilience to the development and impact of postoperative complications after elective colorectal cancer (CRC) surgery. Methods: Preoperative aerobic fitness was assessed by steep ramp test performance. Preoperative body composition was assessed by muscle mass and density determined from preoperative computed tomography scan analysis at the L3-level. Complication development and severity was graded according to Clavien-Dindo. Complication impact was assessed by the time to recovery of physical functioning after complications. Multivariable logistic regression analyses adjusted for age, sex, comorbidities and tumour location was performed. Results: Of 238 included patients, 96 (40.3%) developed postoperative complications. Better preoperative aerobic fitness decreased the likelihood to develop complications, independent of muscle mass (odds ratio [OR]: 0.55, 95% confidence interval [CI]: 0.35−0.85) or muscle density (OR: 0.57, 95% CI: 0.36−0.89). A prolonged time to recovery following complications was associated with lower preoperative muscle density (OR: 4.14, 95% CI: 1.28−13.41), independent of aerobic fitness. Conclusions: Lower aerobic fitness increases the risk of complication development, while low muscle density seems associated with a prolonged recovery from complications. Aerobic fitness and muscle density could be valuable additives to preoperative risk assessment.