The hybrid numbers were introduced by Ozdemir [9] as a new generalization of complex, dual, and hyperbolic numbers. A hybrid number is defined by $k=a+bi+c\epsilon +dh$, where $a,b,c,d$ are real numbers and $% i,\epsilon ,h$ are operators such that $i^{2}=-1,\epsilon ^{2}=0,h^{2}=1$ and $ih=-hi=\epsilon +i$. This work is intended as an attempt to introduce the bi-periodic Horadam hybrid numbers which generalize the classical Horadam hybrid numbers. We give the generating function, the Binet formula, and some basic properties of these new hybrid numbers. Also, we investigate some relationships between generalized bi-periodic Fibonacci hybrid numbers and generalized bi-periodic\ Lucas hybrid numbers.