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1. Effective Control of Crystal Size via an Integrated Crystallization, Wet Milling, and Annealing Recirculation System

Author

Aaron S. Cote, Lorenzo Codan, Jonathan P. McMullen, Wei Meng, Hanzhou Feng, and Eric B. Sirota

Subjects
Active ingredient, Imagination, Chemical substance, Materials science, 010405 organic chemistry, Annealing (metallurgy), Process analytical technology, media_common.quotation_subject, fungi, Organic Chemistry, food and beverages, 010402 general chemistry, 01 natural sciences, Wet-milling, 0104 chemical sciences, law.invention, Chemical engineering, law, Physical and Theoretical Chemistry, Crystallization, Science, technology and society, media_common
Abstract

For drug substance manufacturing, it is necessary to have a robust crystallization process that can isolate quality active pharmaceutical ingredients with the desired crystal size distribution (CSD...

Published
2020
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