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2. Fractional carbon dioxide laser monotherapy and its combination with topical platelet-rich plasma in the management of striae distensae.

Author

El-Domyati, Moetaz, Moawad, Osama, Abdel-Wahab, Hossam, Behairy, Ezzeldin F., and Rezk, Ahmed F.

Subjects
CUTANEOUS therapeutics, BIOPSY, PATIENT safety, QUALITATIVE research, CUTANEOUS manifestations of general diseases, BLIND experiment, STATISTICAL sampling, PLATELET-rich plasma, TREATMENT effectiveness, RANDOMIZED controlled trials, DESCRIPTIVE statistics, QUANTITATIVE research, CHI-squared test, MANN Whitney U Test, LASER therapy, LONGITUDINAL method, IMMUNOHISTOCHEMISTRY, COMBINED modality therapy, CARBON dioxide, COMPARATIVE studies, COLLAGEN, STAINS & staining (Microscopy), PATIENT satisfaction, DERMATOLOGISTS, DATA analysis software
Abstract

Background: A variety of therapeutic approaches have been introduced for striae distensae (SD) with modest outcomes. Fractional carbon dioxide laser (FCL) and platelet-rich plasma (PRP) are effective separately in improving SD. Objective: To assess the safety and efficacy of topically applied PRP combined with FCL in the management of SD. Patients and methods: In this prospective, single-blinded, randomized, comparative intrapatient study, 24 patients with bilateral SD lesions were subjected to FCL on both sides and followed by topical application of PRP on one side only allocated by simple randomization. The sessions were performed biweekly for a total of six sessions. Overall clinical improvement was graded using the Quartile Grading Scale. Biopsies, before and after treatment, were stained with H and E, Masson's trichrome, and Orcein stains. In addition, collagen I and elastin immunohistochemical staining were performed. Results: In this study of 24 SD patients (19 females, 5 males; aged 19–39 years), topical PRP with FCL achieved moderate to excellent outcomes 3 months after the last session. Early striae rubra improved after the initial session, reaching marked excellent outcomes within a month after the second session. Manageable side effects were reported. Histological examination showed improved epidermal and dermal thickness, collagen, and elastic fiber quality after treatment, with the combined PRP and FCL side exhibiting more significant outcomes than the FCL-treated side. Conclusion: Topical PRP application post-FCL proves to be a highly effective therapeutic approach for SD, expressing superior treatment outcomes, and heightened patient satisfaction compared with the use of FCL alone. In additio, topical application is preferred over intradermal injection, offering practicality, effectiveness, and noninvasiveness. [ABSTRACT FROM AUTHOR]

Published
2024
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3. Melanocyte-keratinocyte cross-talk in vitiligo

Author

Touni, Ahmed Ahmed, primary, Shivde, Rohan S., additional, Echuri, Harika, additional, Abdel-Aziz, Rasha T. A., additional, Abdel-Wahab, Hossam, additional, Kundu, Roopal V., additional, and Le Poole, I. Caroline, additional

Published
2023
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4. Clinical characteristics of pediatric hidradenitis suppurativa:a cross-sectional multicenter study of 140 patients

Author

Riis, Peter Theut, Saunte, Ditte Marie, Sigsgaard, Viktoria, Villani, Axel Patrice, Guillem, Philippe, Pascual, José C., Kappe, Naomi N., Vanlaerhoven, Annika M.J.D., van der Zee, Hessel H., Prens, Errol P., El-Domyati, Moetaz, Abdel-Wahab, Hossam, Moftah, Nayera, Abdelghani, Rania, Agut-Busquet, Eugenia, Romaní, Jorge, Hlela, Carol, van den Worm, Lerinza, Bettoli, Vincenzo, Calamo, Giada, Gürer, Mehmet Ali, Beksaç, Burcu, Matusiak, Lukasz, Glowaczewska, Amelia, Szepietowski, Jacek C., Emtestam, Lennart, Lapins, Jan, Kottb, Hassan Riad, Fatani, Mohammad, Weibel, Lisa, Theiler, Martin, Delage-Toriel, Maïa, Lam, Thi Thanh Hong, Nassif, Aude, Becherel, Pierre Andre, Dolenc-Voljc, Mateja, Doss, Nejib, Bouazzi, Dorra, Benhadou, Farida, del Marmol, Veronique, Jemec, Gregor B.E., Riis, Peter Theut, Saunte, Ditte Marie, Sigsgaard, Viktoria, Villani, Axel Patrice, Guillem, Philippe, Pascual, José C., Kappe, Naomi N., Vanlaerhoven, Annika M.J.D., van der Zee, Hessel H., Prens, Errol P., El-Domyati, Moetaz, Abdel-Wahab, Hossam, Moftah, Nayera, Abdelghani, Rania, Agut-Busquet, Eugenia, Romaní, Jorge, Hlela, Carol, van den Worm, Lerinza, Bettoli, Vincenzo, Calamo, Giada, Gürer, Mehmet Ali, Beksaç, Burcu, Matusiak, Lukasz, Glowaczewska, Amelia, Szepietowski, Jacek C., Emtestam, Lennart, Lapins, Jan, Kottb, Hassan Riad, Fatani, Mohammad, Weibel, Lisa, Theiler, Martin, Delage-Toriel, Maïa, Lam, Thi Thanh Hong, Nassif, Aude, Becherel, Pierre Andre, Dolenc-Voljc, Mateja, Doss, Nejib, Bouazzi, Dorra, Benhadou, Farida, del Marmol, Veronique, and Jemec, Gregor B.E.

Abstract

Hidradenitis suppurativa (HS) rarely affects pediatric patients. The literature on pediatric HS patients is scarce. This is a cross-sectional study based on case note review or interviews and clinical examination of 140 pediatric patients undergoing secondary or tertiary level care. Patients were predominantly female (75.5%, n = 105) with a median age of 16. 39% reported 1st-degree relative with HS. Median BMI percentile was 88, and 11% were smokers (n = 15). Median modified Sartorius score was 8.5. Notable comorbidities found were acne (32.8%, n = 45), hirsutism (19.3%, n = 27), and pilonidal cysts (16.4%, n = 23). Resorcinol (n = 27) and clindamycin (n = 25) were the most frequently used topical treatments. Patients were treated with tetracycline (n = 32), or oral clindamycin and rifampicin in combination (n = 29). Surgical excision was performed in 18 patients, deroofing in five and incision in seven patients. Obesity seemed to be prominent in the pediatric population and correlated to parent BMI, suggesting a potential for preventive measures for the family. Disease management appeared to be similar to that of adult HS, bearing in mind that the younger the patient, the milder the disease in majority of cases.

Published
2020

5. Clinical characteristics of pediatric hidradenitis suppurativa: a cross-sectional multicenter study of 140 patients.

Author

Riis, Peter Theut, Saunte, Ditte Marie Lindhardt D.M., Sigsgaard, Viktoria, Villani, Axel Patrice, Guillem, Philippe, Pascual, José Carlos, Kappe, Naomi NN, Vanlaerhoven, Annika AMJD, van der Zee, Hessel H, Prens, Errol E.P., El-Domyati, Moetaz, Abdel-Wahab, Hossam, Moftah, Nayera, Abdelghani, Rania, Agut-Busquet, Eugenia, Romaní, Jorge, Hlela, Carol, van den Worm, Lerinza, Bettoli, Vincenzo, Calamo, Giada, Gürer, Mehmet Ali, Beksaç, Burcu, Matusiak, Łukasz L., Glowaczewska, Amelia, Szepietowski, Jacek C, Emtestam, Lennart, Lapins, Jan, Kottb, Hassan Riad, Fatani, Mohammad, Weibel, Lisa, Theiler, Martin, Delage-Toriel, Maïa, Lam, Thi Thanh Hong, Nassif, Aude, Becherel, Pierre-Andre, Dolenc-Voljc, Mateja, Doss, Néjib, Bouazzi, Dorra, Benhadou, Farida, Del Marmol, Véronique, Jemec, Gregor B E, Riis, Peter Theut, Saunte, Ditte Marie Lindhardt D.M., Sigsgaard, Viktoria, Villani, Axel Patrice, Guillem, Philippe, Pascual, José Carlos, Kappe, Naomi NN, Vanlaerhoven, Annika AMJD, van der Zee, Hessel H, Prens, Errol E.P., El-Domyati, Moetaz, Abdel-Wahab, Hossam, Moftah, Nayera, Abdelghani, Rania, Agut-Busquet, Eugenia, Romaní, Jorge, Hlela, Carol, van den Worm, Lerinza, Bettoli, Vincenzo, Calamo, Giada, Gürer, Mehmet Ali, Beksaç, Burcu, Matusiak, Łukasz L., Glowaczewska, Amelia, Szepietowski, Jacek C, Emtestam, Lennart, Lapins, Jan, Kottb, Hassan Riad, Fatani, Mohammad, Weibel, Lisa, Theiler, Martin, Delage-Toriel, Maïa, Lam, Thi Thanh Hong, Nassif, Aude, Becherel, Pierre-Andre, Dolenc-Voljc, Mateja, Doss, Néjib, Bouazzi, Dorra, Benhadou, Farida, Del Marmol, Véronique, and Jemec, Gregor B E

Abstract

Hidradenitis suppurativa (HS) rarely affects pediatric patients. The literature on pediatric HS patients is scarce. This is a cross-sectional study based on case note review or interviews and clinical examination of 140 pediatric patients undergoing secondary or tertiary level care. Patients were predominantly female (75.5%, n = 105) with a median age of 16. 39% reported 1st-degree relative with HS. Median BMI percentile was 88, and 11% were smokers (n = 15). Median modified Sartorius score was 8.5. Notable comorbidities found were acne (32.8%, n = 45), hirsutism (19.3%, n = 27), and pilonidal cysts (16.4%, n = 23). Resorcinol (n = 27) and clindamycin (n = 25) were the most frequently used topical treatments. Patients were treated with tetracycline (n = 32), or oral clindamycin and rifampicin in combination (n = 29). Surgical excision was performed in 18 patients, deroofing in five and incision in seven patients. Obesity seemed to be prominent in the pediatric population and correlated to parent BMI, suggesting a potential for preventive measures for the family. Disease management appeared to be similar to that of adult HS, bearing in mind that the younger the patient, the milder the disease in majority of cases., SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2020

6. Expression of apoptosis regulatory markers in the skin of advanced hepatitis-C virus liver patients

Author

El-Domyati, Moetaz, Abo-Elenin, Mahmoud, El-Din, Wael, Abdel-Wahab, Hossam, Abdel-Raouf, Hamza, El-Amawy, Tarek, Barakat, Manal, and Hamdy, Mahmoud

Subjects
Health
Abstract

Byline: Moetaz. El-Domyati, Mahmoud. Abo-Elenin, Wael. El-Din, Hossam. Abdel-Wahab, Hamza. Abdel-Raouf, Tarek. El-Amawy, Manal. Barakat, Mahmoud. Hamdy Background: Hepatitis-C virus (HCV) infection is considered a major worldwide public health problem [...]

Published
2012

7. Low and high body mass index in hidradenitis suppurativa patients—different subtypes?

Author

Theut Riis, Peter, Saunte, Ditte Marie Lindhardt D.M., Benhadou, Farida, Del Marmol, Véronique, Guillem, Philippe, El-Domyati, Moetaz, Abdel-Wahab, Hossam, Antoniou, Christina, Dessinioti, Clio, Gürer, Mehmet Ali, Beksaç, B., Szepietowski, Jacek J.C., Matusiak, Łukasz L., Emtestam, Lennart, Lapins, Jan, Riad, Hassan, Doss, Néjib, Massa, A.F., Hamzavi, Iltefat, Nicholson, Cynthia, Dolenc-Voljc, Mateja, Kim, K.H., Ohn, Junghun, Zouboulis, Christos C.C., Karagiannidis, Ioannis, Mokos, Zrinka Bukvić, Durinec, Paola, Jemec, Gregor, Theut Riis, Peter, Saunte, Ditte Marie Lindhardt D.M., Benhadou, Farida, Del Marmol, Véronique, Guillem, Philippe, El-Domyati, Moetaz, Abdel-Wahab, Hossam, Antoniou, Christina, Dessinioti, Clio, Gürer, Mehmet Ali, Beksaç, B., Szepietowski, Jacek J.C., Matusiak, Łukasz L., Emtestam, Lennart, Lapins, Jan, Riad, Hassan, Doss, Néjib, Massa, A.F., Hamzavi, Iltefat, Nicholson, Cynthia, Dolenc-Voljc, Mateja, Kim, K.H., Ohn, Junghun, Zouboulis, Christos C.C., Karagiannidis, Ioannis, Mokos, Zrinka Bukvić, Durinec, Paola, and Jemec, Gregor

Abstract

Introduction: Overweight is a well-established risk factor for hidradenitis suppurativa (HS). In this cross-sectional study, we compare HS patients with a high body mass index (BMI) with HS patients with a low BMI to investigate differences in disease characteristics. Materials and method: Patients were recruited from 17 dermatological centres from four continents. A total of 246 patients with a BMI below 25 were compared to 205 patients with a BMI of above 35. Results: Patients with a high BMI suffered more severe disease (Hurley, physician global assessment, number of areas affected and patient-reported severity (PRS), P < 0.001 for all). There was no difference in smoking (P = 0.783) nor in family history (P = 0.088). In both low and high BMI patients, early onset of HS was a predictor of positive family history (P < 0.001, for each). For low BMI patients, an increase in BMI significantly increased PRS (P < 0.001). For patients with a high BMI, number of pack-years significantly increased PRS (P = 0.001). Cluster analysis of eruption patterns was location specific for low BMI patients but severity specific for high BMI patients. Discussion: Patients with a low and high BMI could represent two clinically different subtypes. We suggest a non-linear relationship between BMI and impact of HS. As patients go from a low BMI patient to a high BMI patient (or from high to low), eruption patterns and risk factors may change., SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2018

8. Clinical characteristics of low and high BMI Hidradenitis suppurativa patients

Author

Theut Riis, Peter, Saunte, Ditte Marie Lindhardt D.M., Del Marmol, Véronique, Benhadou, Farida, Guillem, P, El-Domyati, Moetaz, Abdel-Wahab, Hossam, Antoniou, Christina, Dessinioti, Clio, Gürer, Mehmet Ali, Beksaç, B., Szepietowski, Jacek C, Matusiak, Łukasz L., Emtestam, Lennart, Lapins, Jan, Kottb, Hassan Riad, Doss, Néjib, Massa, A.F., Hamzavi, Iltefat, Nicholson, Cynthia, and Dolenc-Voljc, Mateja

Subjects
Dermatologie
Abstract

0, info:eu-repo/semantics/published

Published
2017

10. Diagnostic delay in hidradenitis suppurativa is a global problem.

Author

Saunte, Ditte Marie Lindhardt D.M., Boer, J, Stratigos, A, Szepietowski, Jacek C, Hamzavi, Iltefat, Kim, K H, Zarchi, K, Antoniou, Christina, Matusiak, Łukasz L., Lim, H W, Williams, M, Kwon, H H, Gürer, Mehmet Ali, Mammadova, F, Kaminsky, A, Prens, E, van der Zee, H H, Bettoli, Vincenzo, Zauli, S, Hafner, Jürg, Lauchli, S, French, L E, Riad, H, El-Domyati, Moetaz, Abdel-Wahab, Hossam, Kirby, B, Kelly, G, Calderon, P, Del Marmol, Véronique, Benhadou, Farida, Revuz, J, Zouboulis, Christos C.C., Karagiannidis, Ioannis, Sartorius, Karin, Hagströmer, L, McMeniman, E, Ong, N, Dolenc-Voljc, Mateja, Mokos, Zrinka Bukvić, Borradori, L, Hunger, Robert RE, Sladden, C, Scheinfeld, N, Moftah, Nayera, Emtestam, Lennart, Lapins, Jan, Doss, N, Kurokawa, I, Jemec, Gregor B E, Saunte, Ditte Marie Lindhardt D.M., Boer, J, Stratigos, A, Szepietowski, Jacek C, Hamzavi, Iltefat, Kim, K H, Zarchi, K, Antoniou, Christina, Matusiak, Łukasz L., Lim, H W, Williams, M, Kwon, H H, Gürer, Mehmet Ali, Mammadova, F, Kaminsky, A, Prens, E, van der Zee, H H, Bettoli, Vincenzo, Zauli, S, Hafner, Jürg, Lauchli, S, French, L E, Riad, H, El-Domyati, Moetaz, Abdel-Wahab, Hossam, Kirby, B, Kelly, G, Calderon, P, Del Marmol, Véronique, Benhadou, Farida, Revuz, J, Zouboulis, Christos C.C., Karagiannidis, Ioannis, Sartorius, Karin, Hagströmer, L, McMeniman, E, Ong, N, Dolenc-Voljc, Mateja, Mokos, Zrinka Bukvić, Borradori, L, Hunger, Robert RE, Sladden, C, Scheinfeld, N, Moftah, Nayera, Emtestam, Lennart, Lapins, Jan, Doss, N, Kurokawa, I, and Jemec, Gregor B E

Abstract

info:eu-repo/semantics/published

Published
2015

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