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The original version of this Article contained an error in Affiliation 25, which was incorrectly given as ‘Faculty of Medicine ArqFuturo INSPER, University of São Paulo, São Paulo, Brazil’. The correct affiliation is listed below. Faculty of Medicine, University of São Paulo, São Paulo, Brazil The original Article has been corrected. © The Author(s) 2022.

Background: Increased mortality risk is associated with short-term temperature variability. However, to our knowledge, there has been no comprehensive assessment of the temperature variability-related mortality burden worldwide. In this study, using data from the MCC Collaborative Research Network, we first explored the association between temperature variability and mortality across 43 countries or regions. Then, to provide a more comprehensive picture of the global burden of mortality associated with temperature variability, global gridded temperature data with a resolution of 0·5° × 0·5° were used to assess the temperature variability-related mortality burden at the global, regional, and national levels. Furthermore, temporal trends in temperature variability-related mortality burden were also explored from 2000–19. Methods: In this modelling study, we applied a three-stage meta-analytical approach to assess the global temperature variability-related mortality burden at a spatial resolution of 0·5° × 0·5° from 2000–19. Temperature variability was calculated as the SD of the average of the same and previous days’ minimum and maximum temperatures. We first obtained location-specific temperature variability related-mortality associations based on a daily time series of 750 locations from the Multi-country Multi-city Collaborative Research Network. We subsequently constructed a multivariable meta-regression model with five predictors to estimate grid-specific temperature variability related-mortality associations across the globe. Finally, percentage excess in mortality and excess mortality rate were calculated to quantify the temperature variability-related mortality burden and to further explore its temporal trend over two decades. Findings: An increasing trend in temperature variability was identified at the global level from 2000 to 2019. Globally, 1 753 392 deaths (95% CI 1 159 901–2 357 718) were associated with temperature variability per year, accounting for

Studies have investigated the effects of heat and temperature variability (TV) on mortality. However, few assessed whether TV modifies the heat-mortality association. Data on daily temperature and mortality in the warm season were collected from 717 locations across 36 countries. TV was calculated as the standard deviation of the average of the same and previous days’ minimum and maximum temperatures. We used location-specific quasi-Poisson regression models with an interaction term between the cross-basis term for mean temperature and quartiles of TV to obtain heat-mortality associations under each quartile of TV, and then pooled estimates at the country, regional, and global levels. Results show the increased risk in heat-related mortality with increments in TV, accounting for 0.70% (95% confidence interval [CI]: −0.33 to 1.69), 1.34% (95% CI: −0.14 to 2.73), 1.99% (95% CI: 0.29–3.57), and 2.73% (95% CI: 0.76–4.50) of total deaths for Q1–Q4 (first quartile–fourth quartile) of TV. The modification effects of TV varied geographically. Central Europe had the highest attributable fractions (AFs), corresponding to 7.68% (95% CI: 5.25–9.89) of total deaths for Q4 of TV, while the lowest AFs were observed in North America, with the values for Q4 of 1.74% (95% CI: −0.09 to 3.39). TV had a significant modification effect on the heat-mortality association, causing a higher heat-related mortality burden with increments of TV. Implementing targeted strategies against heat exposure and fluctuant temperatures simultaneously would benefit public health. © 2022 The Author(s)

Background: Increased mortality risk is associated with short-term temperature variability: However, to our knowledge, there has been no comprehensive assessment of the temperature variability-related mortality burden worldwide. In this study, using data from the MCC Collaborative Research Network, we first explored the association between temperature variability and mortality across 43 countries or regions. Then, to provide a more comprehensive picture of the global burden of mortality associated with temperature variability, global gridded temperature data with a resolution of 0·5° × 0·5° were used to assess the temperature variability-related mortality burden at the global, regional, and national levels. Furthermore, temporal trends in temperature variability-related mortality burden were also explored from 2000–19. Methods: In this modelling study, we applied a three-stage meta-analytical approach to assess the global temperature variability-related mortality burden at a spatial resolution of 0·5° × 0·5° degrees from 2000–19. Temperature variability was calculated as the SD of the average of the same and previous days’ minimum and maximum temperatures. We first obtained location-specific temperature variability related-mortality associations based on a daily time series of 750 locations from the Multi-country Multi-city Collaborative Research Network. We subsequently constructed a multivariable meta-regression model with five predictors to estimate grid-specific temperature variability related-mortality associations across the globe. Finally, percentage excess in mortality and excess mortality rate were calculated to quantify the temperature variability-related mortality burden and to further explore its temporal trend over two decades. Findings: An increasing trend in temperature variability was identified at the global level from 2000 to 2019. Globally, 1753392 deaths (95% CI 1159 901–2357 718) were associated with temperature variability per year, ac

Climate change affects human health; however, there have been no large-scale, systematic efforts to quantify the heat-related human health impacts that have already occurred due to climate change. Here, we use empirical data from 732 locations in 43 countries to estimate the mortality burdens associated with the additional heat exposure that has resulted from recent human-induced warming, during the period 1991–2018. Across all study countries, we find that 37.0% (range 20.5–76.3%) of warm-season heat-related deaths can be attributed to anthropogenic climate change and that increased mortality is evident on every continent. Burdens varied geographically but were of the order of dozens to hundreds of deaths per year in many locations. Our findings support the urgent need for more ambitious mitigation and adaptation strategies to minimize the public health impacts of climate change.

Climate change affects human health; however, there have been no large-scale, systematic efforts to quantify the heat-related human health impacts that have already occurred due to climate change. Here, we use empirical data from 732 locations in 43 countries to estimate the mortality burdens associated with the additional heat exposure that has resulted from recent human-induced warming, during the period 1991–2018. Across all study countries, we find that 37.0% (range 20.5–76.3%) of warm-season heat-related deaths can be attributed to anthropogenic climate change and that increased mortality is evident on every continent. Burdens varied geographically but were of the order of dozens to hundreds of deaths per year in many locations. Our findings support the urgent need for more ambitious mitigation and adaptation strategies to minimize the public health impacts of climate change.

Background: Exposure to cold or hot temperatures is associated with premature deaths. We aimed to evaluate the global, regional, and national mortality burden associated with non-optimal ambient temperatures. Methods: In this modelling study, we collected time-series data on mortality and ambient temperatures from 750 locations in 43 countries and five meta-predictors at a grid size of 0·5° × 0·5° across the globe. A three-stage analysis strategy was used. First, the temperature–mortality association was fitted for each location by use of a time-series regression. Second, a multivariate meta-regression model was built between location-specific estimates and meta-predictors. Finally, the grid-specific temperature–mortality association between 2000 and 2019 was predicted by use of the fitted meta-regression and the grid-specific meta-predictors. Excess deaths due to non-optimal temperatures, the ratio between annual excess deaths and all deaths of a year (the excess death ratio), and the death rate per 100 000 residents were then calculated for each grid across the world. Grids were divided according to regional groupings of the UN Statistics Division. Findings: Globally, 5 083 173 deaths (95% empirical CI [eCI] 4 087 967–5 965 520) were associated with non-optimal temperatures per year, accounting for 9·43% (95% eCI 7·58–11·07) of all deaths (8·52% [6·19–10·47] were cold-related and 0·91% [0·56–1·36] were heat-related). There were 74 temperature-related excess deaths per 100 000 residents (95% eCI 60–87). The mortality burden varied geographically. Of all excess deaths, 2 617 322 (51·49%) occurred in Asia. Eastern Europe had the highest heat-related excess death rate and Sub-Saharan Africa had the highest cold-related excess death rate. From 2000–03 to 2016–19, the global cold-related excess death ratio changed by −0·51 percentage points (95% eCI −0·61 to −0·42) and the global heat-related excess death ratio increased by 0·21 percentage points (0·13–0·31), l

The study of the relationship between health and climate requires articulating various actors and disciplines. This paper presents the experience of the Latin American Seminar on Instruments and Methodologies for a climate and health observatory— held in Buenos Aires in 2019 and supported by the Latin American Center for Interdisciplinary Training (CELFI)—as a linking and training facility referencing the projects that are being carried out in this field throughout Latin American. This paper presents the design, contents, didactic approach and execution of the seminar, as well as its results regarding participation, products and evaluation. Likewise, the methodologies that could allow articulating different disciplines in a process of gainingknowledge about the climate-health relationship are reflected throughout this process. Finally, the main guidelines for this observatory, arising from an exchange with key actors, are set forth herein. The execution of the seminar, the projects presented as the products thereof, the discussions that arose during the exchange, and the need to continue with this work over the following months point out to the importance and necessity of building this observatory for Latin America and the Caribbean in an interdisciplinary way., El estudio de la relación entre clima y salud requiere la articulación de diversos actores y disciplinas. En este artículo se presenta la experiencia del Seminario Latinoamericano Instrumentos y Metodologías para un observatorio de clima y salud, realizado en Buenos Aires en 2019, apoyado por el Centro Latinoamericano de Formación Interdisciplinaria (CELFI), como un espacio de vinculación, capacitación y referencia a experiencias que se vienen desarrollando en este campo en América Latina. En este trabajo se presenta el diseño del seminario, su contenido, didáctica y desarrollo, así como los resultados en cuanto a participación, productos y evaluación. Asimismo, durante el proceso se reflexiona en torno a las metodologías que permitan articular diferentes disciplinas en un proceso de construcción de conocimiento sobre la relación clima-salud. Finalmente, se explicitan los principales lineamientos del observatorio, surgidos de una instancia de intercambio con actores clave. El desarrollo del seminario, los proyectos presentados como producto, las discusiones surgidas durante el intercambio y la continuidad de trabajo en los meses posteriores permiten dar cuenta de la importancia y necesidad de construir interdisciplinariamente este observatorio para América Latina y el Caribe., O estudo da relação entre o clima e a saúde requere a articulação de diversos atores e disciplinas. Neste artigo, apresenta-se a experiência do Seminário Latino-americano Instrumentos e Metodologias para um observatório de clima e saúde, realizado em Buenos Aires em 2019. Foi apoiado pelo Centro Latino-americano de Formação Interdisciplinar (CELFI), como espaço de vinculação, capacitação e referência das experiências que se estão a desenvolver neste campo na América Latina. Neste trabalho, apresenta- se a conceção do seminário, o seu conteúdo, dinâmica e desenvolvimento, bem como, os resultados em termos de participação, produtos e avaliação. Da mesma forma, durante o processo, é feita uma reflexão sobre as metodologias que permitem a articulação de diferentes disciplinas, num processo de construção do conhecimento sobre a relação clima-saúde. Por fim, explicitam-se as principais diretrizes do observatório, decorrentes de uma plataforma de intercâmbio dos atores chave. O desenvolvimento do seminário, os projetos apresentados como produto, as discussões ocorridas durante o intercâmbio e a continuidade de trabalho nos meses seguintes, permitem perceber a importância e a necessidade de construir este observatório interdisciplinar, para a América Latina e Caribe.

Background: Various retrospective studies have reported on the increase of mortality risk due to higher diurnal temperature range (DTR). This study projects the effect of DTR on future mortality across 445 communities in 20 countries and regions. Methods: DTR-related mortality risk was estimated on the basis of the historical daily time-series of mortality and weather factors from Jan 1, 1985, to Dec 31, 2015, with data for 445 communities across 20 countries and regions, from the Multi-Country Multi-City Collaborative Research Network. We obtained daily projected temperature series associated with four climate change scenarios, using the four representative concentration pathways (RCPs) described by the Intergovernmental Panel on Climate Change, from the lowest to the highest emission scenarios (RCP 2.6, RCP 4.5, RCP 6.0, and RCP 8.5). Excess deaths attributable to the DTR during the current (1985–2015) and future (2020–99) periods were projected using daily DTR series under the four scenarios. Future excess deaths were calculated on the basis of assumptions that warmer long-term average temperatures affect or do not affect the DTR-related mortality risk. Findings: The time-series analyses results showed that DTR was associated with excess mortality. Under the unmitigated climate change scenario (RCP 8.5), the future average DTR is projected to increase in most countries and regions (by −0·4 to 1·6°C), particularly in the USA, south-central Europe, Mexico, and South Africa. The excess deaths currently attributable to DTR were estimated to be 0·2–7·4%. Furthermore, the DTR-related mortality risk increased as the long-term average temperature increased; in the linear mixed model with the assumption of an interactive effect with long-term average temperature, we estimated 0·05% additional DTR mortality risk per 1°C increase in average temperature. Based on the interaction with long-term average temperature, the DTR-related excess deaths are projected to incre

The study of the relationship between health and climate requires articulating various actors and disciplines. This paper presents the experience of the Latin American Seminar on Instruments and Methodologies for a climate and health observatory— held in Buenos Aires in 2019 and supported by the Latin American Center for Interdisciplinary Training (CELFI)—as a linking and training facility referencing the projects that are being carried out in this field throughout Latin American. This paper presents the design, contents, didactic approach and execution of the seminar, as well as its results regarding participation, products and evaluation. Likewise, the methodologies that could allow articulating different disciplines in a process of gainingknowledge about the climate-health relationship are reflected throughout this process. Finally, the main guidelines for this observatory, arising from an exchange with key actors, are set forth herein. The execution of the seminar, the projects presented as the products thereof, the discussions that arose during the exchange, and the need to continue with this work over the following months point out to the importance and necessity of building this observatory for Latin America and the Caribbean in an interdisciplinary way., El estudio de la relación entre clima y salud requiere la articulación de diversos actores y disciplinas. En este artículo se presenta la experiencia del Seminario Latinoamericano Instrumentos y Metodologías para un observatorio de clima y salud, realizado en Buenos Aires en 2019, apoyado por el Centro Latinoamericano de Formación Interdisciplinaria (CELFI), como un espacio de vinculación, capacitación y referencia a experiencias que se vienen desarrollando en este campo en América Latina. En este trabajo se presenta el diseño del seminario, su contenido, didáctica y desarrollo, así como los resultados en cuanto a participación, productos y evaluación. Asimismo, durante el proceso se reflexiona en torno a las metodologías que permitan articular diferentes disciplinas en un proceso de construcción de conocimiento sobre la relación clima-salud. Finalmente, se explicitan los principales lineamientos del observatorio, surgidos de una instancia de intercambio con actores clave. El desarrollo del seminario, los proyectos presentados como producto, las discusiones surgidas durante el intercambio y la continuidad de trabajo en los meses posteriores permiten dar cuenta de la importancia y necesidad de construir interdisciplinariamente este observatorio para América Latina y el Caribe., O estudo da relação entre o clima e a saúde requere a articulação de diversos atores e disciplinas. Neste artigo, apresenta-se a experiência do Seminário Latino-americano Instrumentos e Metodologias para um observatório de clima e saúde, realizado em Buenos Aires em 2019. Foi apoiado pelo Centro Latino-americano de Formação Interdisciplinar (CELFI), como espaço de vinculação, capacitação e referência das experiências que se estão a desenvolver neste campo na América Latina. Neste trabalho, apresenta- se a conceção do seminário, o seu conteúdo, dinâmica e desenvolvimento, bem como, os resultados em termos de participação, produtos e avaliação. Da mesma forma, durante o processo, é feita uma reflexão sobre as metodologias que permitem a articulação de diferentes disciplinas, num processo de construção do conhecimento sobre a relação clima-saúde. Por fim, explicitam-se as principais diretrizes do observatório, decorrentes de uma plataforma de intercâmbio dos atores chave. O desenvolvimento do seminário, os projetos apresentados como produto, as discussões ocorridas durante o intercâmbio e a continuidade de trabalho nos meses seguintes, permitem perceber a importância e a necessidade de construir este observatório interdisciplinar, para a América Latina e Caribe.

An increase in the global health burden of temperature was projected for 459 locations in 28 countries worldwide under four representative concentration pathway scenarios until 2099. We determined that the amount of temperature increase for each 100 ppm increase in global CO2 concentrations is nearly constant, regardless of climate scenarios. The overall average temperature increase during 2010–2099 is largest in Canada (1.16 °C/100 ppm) and Finland (1.14 °C/100 ppm), while it is smallest in Ireland (0.62 °C/100 ppm) and Argentina (0.63 °C/100 ppm). In addition, for each 1 °C temperature increase, the amount of excess mortality is increased largely in tropical countries such as Vietnam (10.34%p/°C) and the Philippines (8.18%p/°C), while it is decreased in Ireland (−0.92%p/°C) and Australia (−0.32%p/°C). To understand the regional variability in temperature increase and mortality, we performed a regression-based modeling. We observed that the projected temperature increase is highly correlated with daily temperature range at the location and vulnerability to temperature increase is affected by health expenditure, and proportions of obese and elderly population.