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1. Feasibility and Acceptability of a Healthy Nordic Diet Intervention for the Treatment of Depression : A Randomized Controlled Pilot Trial

Author

Sabet, Julia A., Ekman, Moa S., Lundvall, A. Sofia, Risérus, Ulf, Johansson, Ulrica, Öström, Åsa, Adamsson, Viola, Cao, Yang, Msghina, Mussie, Brummer, Robert J., Sabet, Julia A., Ekman, Moa S., Lundvall, A. Sofia, Risérus, Ulf, Johansson, Ulrica, Öström, Åsa, Adamsson, Viola, Cao, Yang, Msghina, Mussie, and Brummer, Robert J.

Abstract

Healthy diet interventions have been shown to improve depressive symptoms, but there is a need for randomized controlled trials (RCTs) that are double blind and investigate biological mechanisms. The primary objectives of this randomized controlled pilot trial were to test the palatability of the meals and the acceptability of the intervention in preparation for an 8-week RCT in the future, which will investigate whether a healthy Nordic diet improves depressive symptoms in individuals with major depressive disorder, and associated biological mechanisms. Depressed (n = 10) and non-depressed (n = 6) women and men were randomized to receive either a healthy Nordic diet (ND) or a control diet (CD) for 8 days. Participants were blinded to their diet allocation and the study hypotheses. Health questionnaires were completed before and after the intervention and, throughout the study, questionnaires assessed participants' liking for the meals, their sensory properties, adherence, and open-ended feedback. In the ND group, 75% of participants consumed only the provided foods, as instructed, compared to 50% of CD participants. The meals of both diets, on average, received good ratings for liking and sensory properties, though the ND ratings were somewhat higher. Overall, results were positive and informative, indicating that the planned RCT will be feasible and well-accepted, with some proposed modifications.

Published
2021
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3. Diet as a moderator in the association of sedentary behaviors with inflammatory biomarkers among adolescents in the HELENA study

Author

Arouca, Aline B., Santaliestra-Pasías, Alba M., Moreno, Luis A., Marcos, Ascensión, Widhalm, Kurt, Molnár, Dénes, Manios, Yannis, Gottrand, Frederic, Kafatos, Anthony, Kersting, Mathilde, Sjöström, Michael, Sáinz, Ángel Gutiérrez, Ferrari, Marika, Huybrechts, Inge, González-Gross, Marcela, Forsner, Maria, de Henauw, Stefaan, Michels, Nathalie, Gottrand, Fréderic, Gilbert, Chantal, Libersa, Christian, Castelló, Sara, Sjöstrom, Michael, Dallongeville, Jean, Hall, Gunnar, Maes, Lea, Scalfi, Luca, Meléndez, Pilar, Casajús, José A., Fleta, Jesús, Rodríguez, Gerardo, Tomás, Concepción, Mesana, María I., Vicente-Rodríguez, Germán, Villarroya, Adoración, Gil, Carlos M., Ara, Ignacio, Alvira, Juan Fernández, Bueno, Gloria, Bueno, Olga, León, Juan F., Garagorri, Jesús Mª, Labayen, Idoia, Bel, Silvia, Gracia Marco, Luis A., Mouratidou, Theodora, Santaliestra-Pasías, Alba, Iglesia, Iris, González-Gil, Esther, de Miguel-Etayo, Pilar, Julián, Cristina, Miguel-Berges, Mary, Iguacel, Isabel, Rupérez, Azahara, Wärnberg, Julia, Nova, Esther, Gómez, Sonia, Díaz, Ligia Esperanza, Romeo, Javier, Veses, Ana, Zapatera, Belén, Pozo, Tamara, Martínez, David, Beghin, Laurent, Gottrand, Frédéric, Iliescu, Catalina, von Berlepsch, Juliana, Sichert-Hellert, Wolfgang, Koeppen, Ellen, Erhardt, Eva, Csernus, Katalin, Török, Katalin, Bokor, Szilvia, Angster, null, Nagy, Enikö, Kovács, Orsolya, Répasi, Judit, Codrington, Caroline, Plada, María, Papadaki, Angeliki, Sarri, Katerina, Viskadourou, Anna, Hatzis, Christos, Kiriakakis, Michael, Tsibinos, George, Vardavas, Constantine, Sbokos, Manolis, Protoyeraki, Eva, Fasoulaki, Maria, Stehle, Peter, Pietrzik, Klaus, Breidenassel, Christina, Spinneker, Andre, Al-Tahan, Jasmin, Segoviano, Miriam, Berchtold, Anke, Bierschbach, Christine, Blatzheim, Erika, Schuch, Adelheid, Pickert, Petra, Castillo, Manuel J., Gutiérrez, Ángel, Ortega, Francisco B, Ruiz, Jonatan R, Artero, Enrique G, España, Vanesa, Jiménez-Pavón, David, Chillón, Palma, Sánchez-Muñoz, Cristóbal, Cuenca, Magdalena, Arcella, Davide, Azzini, Elena, Barrison, Emma, Bevilacqua, Noemi, Buonocore, Pasquale, Catasta, Giovina, Censi, Laura, Ciarapica, Donatella, D’Acapito, Paola, Galfo, Myriam, Le Donne, Cinzia, Leclercq, Catherine, Maiani, Giuseppe, Mauro, Beatrice, Mistura, Lorenza, Pasquali, Antonella, Piccinelli, Raffaela, Polito, Angela, Roccaldo, Romana, Spada, Raffaella, Sette, Stefania, Zaccaria, Maria, Vitaglione, Paola, Montagnese, Concetta, de Bourdeaudhuij, Ilse, de Vriendt, Tineke, Matthys, Christophe, Vereecken, Carine, de Maeyer, Mieke, Ottevaere, Charlene, Phillipp, Katharina, Dietrich, Sabine, Boriss-Riedl, Birgit Kubelka Marion, Grammatikaki, Eva, Bouloubasi, Zoi, Cook, Tina Louisa, Eleutheriou, Sofia, Consta, Orsalia, Moschonis, George, Katsaroli, Ioanna, Kraniou, George, Papoutsou, Stalo, Keke, Despoina, Petraki, Ioanna, Bellou, Elena, Tanagra, Sofia, Kallianoti, Kostalenia, Argyropoulou, Dionysia, Tsikrika, Stamatoula, Karaiskos, Christos, Meirhaeghe, Aline, Hagströmer, María, Wennlöf, Anita Hurtig, Hallström, Lena, Patterson, Emma, Kwak, Lydia, Rizzo, Nico, Sánchez-Molero, Jackie, Picó, Elena, Navarro, Maite, Viadel, Blanca, Carreres, José Enrique, Merino, Gema, Sanjuán, Rosa, Lorente, María, Sánchez, María José, Thomas, Sarah, Allchurch, Elaine, Burgess, Peter, Astrom, Annika, Sverkén, Anna, Broberg, Agneta, Masson, Annick, Lehoux, Claire, Brabant, Pascal, Pate, Philippe, Fontaine, Laurence, Sebok, Andras, Kuti, Tunde, Hegyi, Adrienn, Maldonado, Cristina, Llorente, Ana, García, Emilio, von Fircks, Holger, Hallberg, Marianne Lilja, Messerer, Maria, Larsson, Mats, Fredriksson, Helena, Adamsson, Viola, Börjesson, Ingmar, Fernández, Laura, Smillie, Laura, Wills, Josephine, Pedrero-Chamizo, Raquel, Meléndez, Agustín, Valtueña, Jara, Albers, Ulrike, Benito, Pedro J., Lorente, Juan José Gómez, Cañada, David, Urzanqui, Alejandro, Torres, Rosa María, Navarro, Paloma, Arouca, Aline B., Santaliestra-Pasías, Alba M., Moreno, Luis A., Marcos, Ascensión, Widhalm, Kurt, Molnár, Déne, Manios, Yanni, Gottrand, Frederic, Kafatos, Anthony, Kersting, Mathilde, Sjöström, Michael, Sáinz, Ángel Gutiérrez, Ferrari, Marika, Huybrechts, Inge, González-Gross, Marcela, Forsner, Maria, de Henauw, Stefaan, Michels, Nathalie, Gottrand, Fréderic, Gilbert, Chantal, Libersa, Christian, Castelló, Sara, Sjöstrom, Michael, Dallongeville, Jean, Hall, Gunnar, Maes, Lea, Scalfi, Luca, Meléndez, Pilar, Casajús, José A., Fleta, Jesú, Rodríguez, Gerardo, Tomás, Concepción, Mesana, María I., Vicente-Rodríguez, Germán, Villarroya, Adoración, Gil, Carlos M., Ara, Ignacio, Alvira, Juan Fernández, Bueno, Gloria, Bueno, Olga, León, Juan F., Garagorri, Jesús Mª, Labayen, Idoia, Bel, Silvia, Gracia Marco, Luis A., Mouratidou, Theodora, Santaliestra-Pasías, Alba, Iglesia, Iri, González-Gil, Esther, de Miguel-Etayo, Pilar, Julián, Cristina, Miguel-Berges, Mary, Iguacel, Isabel, Rupérez, Azahara, Wärnberg, Julia, Nova, Esther, Gómez, Sonia, Díaz, Ligia Esperanza, Romeo, Javier, Veses, Ana, Zapatera, Belén, Pozo, Tamara, Martínez, David, Beghin, Laurent, Gottrand, Frédéric, Iliescu, Catalina, von Berlepsch, Juliana, Sichert-Hellert, Wolfgang, Koeppen, Ellen, Erhardt, Eva, Csernus, Katalin, Török, Katalin, Bokor, Szilvia, Angster, Null, Nagy, Enikö, Kovács, Orsolya, Répasi, Judit, Codrington, Caroline, Plada, María, Papadaki, Angeliki, Sarri, Katerina, Viskadourou, Anna, Hatzis, Christo, Kiriakakis, Michael, Tsibinos, George, Vardavas, Constantine, Sbokos, Manoli, Protoyeraki, Eva, Fasoulaki, Maria, Stehle, Peter, Pietrzik, Klau, Breidenassel, Christina, Spinneker, Andre, Al-Tahan, Jasmin, Segoviano, Miriam, Berchtold, Anke, Bierschbach, Christine, Blatzheim, Erika, Schuch, Adelheid, Pickert, Petra, Castillo, Manuel J., Gutiérrez, Ángel, Ortega, Francisco B, Ruiz, Jonatan R, Artero, Enrique G, España, Vanesa, Jiménez-Pavón, David, Chillón, Palma, Sánchez-Muñoz, Cristóbal, Cuenca, Magdalena, Arcella, Davide, Azzini, Elena, Barrison, Emma, Bevilacqua, Noemi, Buonocore, Pasquale, Catasta, Giovina, Censi, Laura, Ciarapica, Donatella, D’Acapito, Paola, Galfo, Myriam, Le Donne, Cinzia, Leclercq, Catherine, Maiani, Giuseppe, Mauro, Beatrice, Mistura, Lorenza, Pasquali, Antonella, Piccinelli, Raffaela, Polito, Angela, Roccaldo, Romana, Spada, Raffaella, Sette, Stefania, Zaccaria, Maria, Vitaglione, Paola, Montagnese, Concetta, de Bourdeaudhuij, Ilse, de Vriendt, Tineke, Matthys, Christophe, Vereecken, Carine, de Maeyer, Mieke, Ottevaere, Charlene, Phillipp, Katharina, Dietrich, Sabine, Boriss-Riedl, Birgit Kubelka Marion, Grammatikaki, Eva, Bouloubasi, Zoi, Cook, Tina Louisa, Eleutheriou, Sofia, Consta, Orsalia, Moschonis, George, Katsaroli, Ioanna, Kraniou, George, Papoutsou, Stalo, Keke, Despoina, Petraki, Ioanna, Bellou, Elena, Tanagra, Sofia, Kallianoti, Kostalenia, Argyropoulou, Dionysia, Tsikrika, Stamatoula, Karaiskos, Christo, Meirhaeghe, Aline, Hagströmer, María, Wennlöf, Anita Hurtig, Hallström, Lena, Patterson, Emma, Kwak, Lydia, Rizzo, Nico, Sánchez-Molero, Jackie, Picó, Elena, Navarro, Maite, Viadel, Blanca, Carreres, José Enrique, Merino, Gema, Sanjuán, Rosa, Lorente, María, Sánchez, María José, Thomas, Sarah, Allchurch, Elaine, Burgess, Peter, Astrom, Annika, Sverkén, Anna, Broberg, Agneta, Masson, Annick, Lehoux, Claire, Brabant, Pascal, Pate, Philippe, Fontaine, Laurence, Sebok, Andra, Kuti, Tunde, Hegyi, Adrienn, Maldonado, Cristina, Llorente, Ana, García, Emilio, von Fircks, Holger, Hallberg, Marianne Lilja, Messerer, Maria, Larsson, Mat, Fredriksson, Helena, Adamsson, Viola, Börjesson, Ingmar, Fernández, Laura, Smillie, Laura, Wills, Josephine, Pedrero-Chamizo, Raquel, Meléndez, Agustín, Valtueña, Jara, Albers, Ulrike, Benito, Pedro J., Lorente, Juan José Gómez, Cañada, David, Urzanqui, Alejandro, Torres, Rosa María, Navarro, Paloma, and European Commission

Subjects
0301 basic medicine, Male, Mediterranean diet, Adolescent, Physiology, Medicine (miscellaneous), 030209 endocrinology & metabolism, Low-grade inflammation, Diet, Mediterranean, Antioxidants, Low grade inflammation, Moderation, 03 medical and health sciences, 0302 clinical medicine, Insulin resistance, medicine, Humans, Inflammation, 030109 nutrition & dietetics, Nutrition and Dietetics, business.industry, medicine.disease, Healthy diet, Inflammatory biomarkers, Diet, Europe, Increased risk, Adolescent Behavior, HELENA study, Female, Sedentary Behavior, business, Biomarkers, Biomedical sciences
Abstract

HELENA study group., [Aim]: To assess if a healthy diet might attenuate the positive sedentary–inflammation relation, whereas an unhealthy diet may increase the effect of sedentary behaviors on inflammatory biomarkers., [Methods]: In 618 adolescents (13–17 years) of the European HELENA study, data were available on body composition, a set of inflammation markers, and food intake assessed by a self-administered computerized 24 h dietary recall for 2 days. A 9-point Mediterranean diet score and an antioxidant-rich diet z-score were used as dietary indices and tested as moderators. A set of low-grade inflammatory characteristics was used as outcome: several cytokines in an inflammatory ratio (IL-6, IL-10, TNF-α, TGFβ-1), C-reactive protein, three cell-adhesion molecules (sVCAM-1, sICAM-1, sE-selectin), three cardiovascular risk markers (GGT, ALT, homocysteine) and three immune cell types (white blood cells, lymphocytes, CD3). Sedentary behaviors were self-reported and analyzed as total screen time. Multiple linear regression analyses tested moderation by diet in the sedentary behaviors–inflammation association adjusted for age, sex, country, adiposity (sum of six skinfolds), parental education, and socio-economic status., [Results]: Both diet scores, Mediterranean and antioxidant-rich diet, were significant protective moderators in the effect of sedentary behaviors on alanine-transaminase enzyme (P = 0.014; P = 0.027), and on the pro/anti-inflammatory cytokine ratio (P = 0.001; P = 0.004), but not on other inflammatory parameters., [Conclusion]: A higher adherence to the Mediterranean diet or an antioxidant-rich diet may attenuate the onset of oxidative stress signs associated by sedentary behaviors, whereas a poor diet seems to increase inflammation., The HELENA Study was carried out with the financial support of the European Community Sixth RTD Framework Programme (Contract FOODCT-2005-007034).

Published
2017

4. Antioxidant Vitamin Status (A, E, C, and Beta-Carotene) in European Adolescents - The HELENA Study

Author

Breidenassel, Christina, Valtueña, Jara, González Gross, Marcela, Benser, Jasmin, Spinneker, Andre, Moreno, Luis A., de Henauw, Stefaan, Widhalm, Kurt, Molnar, Denes, Maiani, Guiseppe, Stehle, Peter, Fleta, Jesús, Casajús, José A., Rodríguez, Gerardo, Tomás, Concepción, Mesana, María I., Vicente Rodríguez, Germán, Villarroya, Adoración, Gil, Carlos M., Ara, Ignacio, Revenga, Juan, Lachen, Carmen, Alvira, Juan Fernández, Bueno, Gloria, Lázaro, Aurora, Bueno, Olga, León, Juan F., Garagorri, Jesús M., Bueno, Manuel, López, Juan Pablo Rey, Iglesia, Iris, Velasco, Paula, Bel, Silvia, Marcos, Ascensión, Wärnberg, Julia, Nova, Esther, Gómez, Sonia, Díaz, Esperanza Ligia, Romeo, Javier, Veses, Ana, Puertollano, Mari Angeles, Zapatera, Belén, Pozo, Tamara, Beghin, Laurent, Libersa, Christian, Gottrand, Frédéric, Iliescu, Catalina, Von Berlepsch, Juliana, Kersting, Mathilde, Sichert Hellert, Wolfgang, Koeppen, Ellen, Erhardt, Eva, Csernus, Katalin, Török, Katalin, Bokor, Szilvia, Angster, M.r.s., Nagy, Enikö, Kovács, Orsolya, Repásy, Judit, Kafatos, Anthony, Codrington, Caroline, Plada, María, Papadaki, Angeliki, Sarri, Katerina, Viskadourou, Anna, Hatzis, Christos, Kiriakakis, Michael, Tsibinos, George, Sbokos, Constantine Vardavas Manolis, Protoyeraki, Eva, Fasoulaki, Maria, Pietrzik, Klaus, Al Tahan, Jasmin, Segoviano, Miriam, Berchtold, Anke, Bierschbach, Christine, Blatzheim, Erika, Schuch, Adelheid, Pickert, Petra, Castillo, Manuel J., Gutiérrez, Ángel, Ortega, Francisco B., Ruiz, Jonatan R., Artero, Enrique G., España Romero, Vanesa, Jiménez Pavón, David, Chillón, Palma, Arcella, Davide, Azzini, Elena, Barrison, Emma, Bevilacqua, Noemi, Buonocore, Pasquale, Catasta, Giovina, Censi, Laura, Ciarapica, Donatella, D'Acapito, Paola, Ferrari, Marika, Galfo, Myriam, Le Donne, Cinzia, Leclercq, Catherine, Mauro, Beatrice, Mistura, Lorenza, Pasquali, Antonella, Piccinelli, Raffaela, Polito, Angela, Spada, Raffaella, Sette, Stefania, Zaccaria, Maria, SCALFI, LUCA, Montagnese, Concetta, De Bourdeaudhuij, Ilse, De Vriendt, Tineke, Maes, Lea, Matthys, Christophe, Vereecken, Carine, de Maeyer, Mieke, Ottevaere, Charlene, Phillipp, Katharina, Dietrich, Sabine, Boriss Riedl, Birgit Kubelka Marion, Manios, Yannis, Grammatikaki, Eva, Bouloubasi, Zoi, Cook, Tina Louisa, Eleutheriou, Sofia, Consta, Orsalia, Moschonis, George, Katsaroli, Ioanna, Kraniou, George, Papoutsou, Stalo, Keke, Despoina, Petraki, Ioanna, Bellou, Elena, Tanagra, Sofia, Kallianoti, Kostalenia, Argyropoulou, Dionysia, Kondaki, Katerina, Tsikrika, Stamatoula, Karaiskos, Christos, Dallongeville, Jean, Meirhaeghe, Aline, Sjöstrom, Michael, Bergman, Patrick, Hagströmer, María, Hallström, Lena, Hallberg, Mårten, Poortvliet, Eric, Rizzo, Nico, Beckman, Linda, Wennlöf, Anita Hurtig, Patterson, Emma, Kwak, Lydia, Cernerud, Lars, Tillgren, Per, Sörensen, Stefaan, Sánchez Molero, Jackie, Picó, Elena, Navarro, Maite, Viadel, Blanca, Carreres, José Enrique, Merino, Gema, Sanjuán, Rosa, Lorente, María, Sánchez, María José, Castelló, Sara, Gilbert, Chantal, Thomas, Sarah, Allchurch, Elaine, Burguess, Peter, Hall, Gunnar, Astrom, Annika, Sverkén, Anna, Broberg, Agneta, Masson, Annick, Lehoux, Claire, Brabant, Pascal, Pate, Philippe, Fontaine, Laurence, Sebok, Andras, Kuti, Tunde, Hegyi, Adrienn, Maldonado, Cristina, Llorente, Ana, García, Emilio, von Fircks, Holger, Hallberg, Marianne Lilja, Messerer, Maria, Larsson, Mats, Fredriksson, Helena, Adamsson, Viola, Börjesson, Ingmar, Fernández, Laura, Smillie, Laura, Wills, Josephine, Albers, Ulrike, Pedrero, Raquel, Meléndez, Agustín, Benito, Pedro J., Cañada, David, Urzanqui, Alejandro, Ortiz, Juan Carlos, Fuentes, Francisco, Lorente, Juan José Gómez, Torres, Rosa María, Navarro, Paloma, VITAGLIONE, PAOLA, Breidenassel, Christina, Valtueña, Jara, González Gross, Marcela, Benser, Jasmin, Spinneker, Andre, Moreno, Luis A., de Henauw, Stefaan, Widhalm, Kurt, Molnar, Dene, Maiani, Guiseppe, Stehle, Peter, Fleta, Jesú, Casajús, José A., Rodríguez, Gerardo, Tomás, Concepción, Mesana, María I., Vicente Rodríguez, Germán, Villarroya, Adoración, Gil, Carlos M., Ara, Ignacio, Revenga, Juan, Lachen, Carmen, Alvira, Juan Fernández, Bueno, Gloria, Lázaro, Aurora, Bueno, Olga, León, Juan F., Garagorri, Jesús M., Bueno, Manuel, López, Juan Pablo Rey, Iglesia, Iri, Velasco, Paula, Bel, Silvia, Marcos, Ascensión, Wärnberg, Julia, Nova, Esther, Gómez, Sonia, Díaz, Esperanza Ligia, Romeo, Javier, Veses, Ana, Puertollano, Mari Angele, Zapatera, Belén, Pozo, Tamara, Beghin, Laurent, Libersa, Christian, Gottrand, Frédéric, Iliescu, Catalina, Von Berlepsch, Juliana, Kersting, Mathilde, Sichert Hellert, Wolfgang, Koeppen, Ellen, Erhardt, Eva, Csernus, Katalin, Török, Katalin, Bokor, Szilvia, Angster, M. r. s., Nagy, Enikö, Kovács, Orsolya, Repásy, Judit, Kafatos, Anthony, Codrington, Caroline, Plada, María, Papadaki, Angeliki, Sarri, Katerina, Viskadourou, Anna, Hatzis, Christo, Kiriakakis, Michael, Tsibinos, George, Sbokos, Constantine Vardavas Manoli, Protoyeraki, Eva, Fasoulaki, Maria, Pietrzik, Klau, Al Tahan, Jasmin, Segoviano, Miriam, Berchtold, Anke, Bierschbach, Christine, Blatzheim, Erika, Schuch, Adelheid, Pickert, Petra, Castillo, Manuel J., Gutiérrez, Ángel, Ortega, Francisco B., Ruiz, Jonatan R., Artero, Enrique G., España Romero, Vanesa, Jiménez Pavón, David, Chillón, Palma, Arcella, Davide, Azzini, Elena, Barrison, Emma, Bevilacqua, Noemi, Buonocore, Pasquale, Catasta, Giovina, Censi, Laura, Ciarapica, Donatella, D'Acapito, Paola, Ferrari, Marika, Galfo, Myriam, Le Donne, Cinzia, Leclercq, Catherine, Mauro, Beatrice, Mistura, Lorenza, Pasquali, Antonella, Piccinelli, Raffaela, Polito, Angela, Spada, Raffaella, Sette, Stefania, Zaccaria, Maria, Scalfi, Luca, Vitaglione, Paola, Montagnese, Concetta, De Bourdeaudhuij, Ilse, De Vriendt, Tineke, Maes, Lea, Matthys, Christophe, Vereecken, Carine, de Maeyer, Mieke, Ottevaere, Charlene, Phillipp, Katharina, Dietrich, Sabine, Boriss Riedl, Birgit Kubelka Marion, Manios, Yanni, Grammatikaki, Eva, Bouloubasi, Zoi, Cook, Tina Louisa, Eleutheriou, Sofia, Consta, Orsalia, Moschonis, George, Katsaroli, Ioanna, Kraniou, George, Papoutsou, Stalo, Keke, Despoina, Petraki, Ioanna, Bellou, Elena, Tanagra, Sofia, Kallianoti, Kostalenia, Argyropoulou, Dionysia, Kondaki, Katerina, Tsikrika, Stamatoula, Karaiskos, Christo, Dallongeville, Jean, Meirhaeghe, Aline, Sjöstrom, Michael, Bergman, Patrick, Hagströmer, María, Hallström, Lena, Hallberg, Mårten, Poortvliet, Eric, Rizzo, Nico, Beckman, Linda, Wennlöf, Anita Hurtig, Patterson, Emma, Kwak, Lydia, Cernerud, Lar, Tillgren, Per, Sörensen, Stefaan, Sánchez Molero, Jackie, Picó, Elena, Navarro, Maite, Viadel, Blanca, Carreres, José Enrique, Merino, Gema, Sanjuán, Rosa, Lorente, María, Sánchez, María José, Castelló, Sara, Gilbert, Chantal, Thomas, Sarah, Allchurch, Elaine, Burguess, Peter, Hall, Gunnar, Astrom, Annika, Sverkén, Anna, Broberg, Agneta, Masson, Annick, Lehoux, Claire, Brabant, Pascal, Pate, Philippe, Fontaine, Laurence, Sebok, Andra, Kuti, Tunde, Hegyi, Adrienn, Maldonado, Cristina, Llorente, Ana, García, Emilio, von Fircks, Holger, Hallberg, Marianne Lilja, Messerer, Maria, Larsson, Mat, Fredriksson, Helena, Adamsson, Viola, Börjesson, Ingmar, Fernández, Laura, Smillie, Laura, Wills, Josephine, Albers, Ulrike, Pedrero, Raquel, Meléndez, Agustín, Benito, Pedro J., Cañada, David, Urzanqui, Alejandro, Ortiz, Juan Carlo, Fuentes, Francisco, Lorente, Juan José Gómez, Torres, Rosa María, and Navarro, Paloma

Subjects
Male, Vitamin, medicine.medical_specialty, Antioxidant, Adolescent, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, alpha-Tocopherol, Nutritional Status, Medicine (miscellaneous), Physiology, Ascorbic Acid, chemistry.chemical_compound, Reference Values, beta-Carotene, Internal medicine, Nutrition and Dietetic, medicine, Humans, Reference Value, Vitamin C, Child, Vitamin A, Cross-Sectional Studie, Sex Characteristics, α-tocopherol, Nutrition and Dietetics, Retinol, business.industry, Nutritional status, General Medicine, Sex Characteristic, beta Carotene, Antioxidant vitamins, Europe, Nutritional Statu, Cross-Sectional Studies, Endocrinology, Beta-carotene, chemistry, Female, business, Human
Abstract

Background: An adequate nutritional status of antioxidant vitamins (vitamins A, C, E) and β-carotene is essential especially during childhood and adolescence, because of their important roles in cell growth and development. Currently, there are no physiological reference values for blood concentration of these vitamins and β-carotene in apparently healthy European adolescents. The aim of the current study was to obtain reliable and comparable data of antioxidant vitamins and β-carotene in a cross-sectional study, within HELENA (Healthy Lifestyle in Europe by Nutrition in Adolescence), which was conducted in a representative sample of adolescents from ten European cities. Material and Methods: From a subsample of 1,054 adolescents (males= 501) of the HELENA Cross Sectional Study with an age range of 12.5 to 17.49 years, fasting blood samples were taken and analyzed for vitamins A, E, C, and β-carotene status. As specific reference values for adolescents are missing, percentile distribution by age and sex is given. Results: Mean concentrations were the following: Retinol: 356.4 ± 107.9 cm/mL; α-tocopherol: 9.9 ± 2.1 μg/mL; vitamin C: 10.3 ± 3.3 mg/L; and β-carotene: 245.6 ± 169.6 cm/mL. Females showed higher α-tocopherol and vitamin C values compared with males and 17-year-old boys had higher retinol levels than the same-aged girls (p = 0.018). Retinol serum concentrations increased significantly according to age in both gender, but girls had also significantly increasing β-carotene levels by age. Conclusions: For the first time, concentrations of antioxidant vitamins and pro-vitamin β-carotene have been obtained in a representative sample of apparently healthy European adolescents. These data can contribute to the establishment of reference ranges in adolescents. © 2011 Hans Huber Publishers, Hogrefe AG, Bern.

Published
2011
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5. Influence of parental socio-economic status on diet quality of European adolescents: Results from the HELENA study

Author

Béghin, L., Dauchet, L., De Vriendt, Tineke, Cuenca García, M., Manios, Y., Toti, E., Plada, M., Widhalm, K., Repasy, J., Huybrechts, I., Kersting, M., Moreno, L. A., Dallongeville, J., Gottrand, Frédéric, De Henauw, Stefaan, González Gross, Marcela, Gilbert, Chantal, Kafatos, Anthony, Libersa, Christian, Sánchez, Jackie, Sjöstrom, Michael, Molnár, Dénes, Hall, Gunnar, Maes, Lea, SCALFI, LUCA, Meléndez, Pilar, Fleta, Jesús, Casajús, J.o.s.é.a., Rodríguez, Gerardo, Tomás, Concepción, Mesana, María I., Vicente Rodríguez, Germán, Villarroya, Adoración, Gil, Carlos M., Ara, Ignacio, Revenga, Juan, Lachen, Carmen, Alvira, Juan Fernández, Bueno, Gloria, Lázaro, Aurora, Bueno, Olga, León, Juan F., Garagorri, Jesús Ma, Bueno, Manuel, López, Juan Pablo Rey, Iglesia, Iris, Velasco, Paula, Bel, Silvia, Marcos, Ascensión, Wärnberg, Julia, Nova, Esther, Gómez, Sonia, Díaz, Esperanza Ligia, Romeo, Javier, Veses, Ana, Puertollano, Mari Angeles, Zapatera, Belén, Pozo, Tamara, Iliescu, Catalina, Von Berlepsch, Juliana, Sichert Hellert, Wolfgang, Koeppen, Ellen, Erhardt, Eva, Csernus, Katalin, Török, Katalin, Bokor, Szilvia, Angster, M.r.s., Nagy, Enikö, Kovács, Orsolya, Répasi, Judit, Codrington, Caroline, Papadaki, Angeliki, Sarri, Katerina, Viskadourou, Anna, Hatzis, Christos, Kiriakakis, Michael, Tsibinos, George, Vardavas, Constantine, Sbokos, Manolis, Protoyeraki, Eva, Fasoulaki, Maria, Stehle, Peter, Pietrzik, Klaus, Breidenassel, Christina, Spinneker, Andre, Al Tahan, Jasmin, Segoviano, Miriam, Berchtold, Anke, Bierschbach, Christine, Blatzheim, Erika, Schuch, Adelheid, Pickert, Petra, Garzón, Manuel J. Castillo, Sáinz, Ángel Gutiérrez, Porcel, Francisco B. Ortega, Ruiz, Jonatan Ruiz, Artero, Enrique García, Romero, Vanesa España, Pavón, David Jiménez, Muñoz, Cristóbal Sánchez, Soto, Victor, Chillón, Palma, Heredia, Jose M., Aparicio, Virginia, Baena, Pedro, Cardia, Claudia M., Carbonell, Ana, Arcella, Davide, Catasta, Giovina, Censi, Laura, Ciarapica, Donatella, Ferrari, Marika, Le Donne, Cinzia, Leclerq, Catherine, Magrì, Luciana, Maiani, Giuseppe, Piccinelli, Rafaela, Polito, Angela, Spada, Raffaela, Montagnese, Concetta, De Bourdeaudhuij, Ilse, Matthys, Christophe, Vereecken, Carine, De Maeyer, Mieke, Ottevaere, Charlene, Phillipp, Katharina, Dietrich, Sabine, Grammatikaki, Eva, Bouloubasi, Zoi, Cook, Tina Louisa, Eleutheriou, Sofia, Consta, Orsalia, Moschonis, George, Katsaroli, Ioanna, Kraniou, George, Papoutsou, Stalo, Keke, Despoina, Petraki, Ioanna, Bellou, Elena, Tanagra, Sofia, Kallianoti, Kostalenia, Argyropoulou, Dionysia, Kondaki, Katerina, Tsikrika, Stamatoula, Karaiskos, Christos, Meirhaeghe, Aline, Bergman, Patrick, Hagströmer, María, Hallström, Lena, Hallberg, Mårten, Poortvliet, Eric, Rizzo, Nico, Beckman, Linda, Wennlöf, Anita Hurtig, Patterson, Emma, Kwak, Lydia, Cernerud, Lars, Tillgren, Per, Sörensen, Stefaan, Sánchez Molero, Jackie, Picó, Elena, Navarro, Maite, Viadel, Blanca, Carreres, José Enrique, Merino, Gema, Sanjuán, Rosa, Lorente, María, Sánchez, María José, Castelló, Sara, Thomas, Sarah, Allchurch, Elaine, Burguess, Peter, Astrom, Annika, Sverkén, Anna, Broberg, Agneta, Masson, Annick, Lehoux, Claire, Brabant, Pascal, Pate, Philippe, Fontaine, Laurence, Sebok, Andras, Kuti, Tunde, Hegyi, Adrienn, Maldonado, Cristina, Llorente, Ana, García, Emilio, Von Fircks, Holger, Hallberg, Marianne Lilja, Messerer, Maria, Larsson, Mats, Fredriksson, Helena, Adamsson, Viola, Börjesson, Ingmar, Fernández, Laura, Smillie, Laura, Wills, Josephine, Meléndez, Agustín, Benito, Pedro J., Calderón, Javier, Jiménez Pavón, David, Valtueña, Jara, Navarro, Paloma, Urzanqui, Alejandro, Albers, Ulrike, Pedrero, Raquel, Lorente, Juan José Gómez, VITAGLIONE, PAOLA, Béghin, L., Dauchet, L., De Vriendt, Tineke, Cuenca García, M., Manios, Y., Toti, E., Plada, M., Widhalm, K., Repasy, J., Huybrechts, I., Kersting, M., Moreno, L. A., Dallongeville, J., Gottrand, Frédéric, De Henauw, Stefaan, González Gross, Marcela, Gilbert, Chantal, Kafatos, Anthony, Libersa, Christian, Sánchez, Jackie, Sjöstrom, Michael, Molnár, Déne, Hall, Gunnar, Maes, Lea, Scalfi, Luca, Meléndez, Pilar, Fleta, Jesú, Casajús, J. o. s. é. a., Rodríguez, Gerardo, Tomás, Concepción, Mesana, María I., Vicente Rodríguez, Germán, Villarroya, Adoración, Gil, Carlos M., Ara, Ignacio, Revenga, Juan, Lachen, Carmen, Alvira, Juan Fernández, Bueno, Gloria, Lázaro, Aurora, Bueno, Olga, León, Juan F., Garagorri, Jesús Ma, Bueno, Manuel, López, Juan Pablo Rey, Iglesia, Iri, Velasco, Paula, Bel, Silvia, Marcos, Ascensión, Wärnberg, Julia, Nova, Esther, Gómez, Sonia, Díaz, Esperanza Ligia, Romeo, Javier, Veses, Ana, Puertollano, Mari Angele, Zapatera, Belén, Pozo, Tamara, Iliescu, Catalina, Von Berlepsch, Juliana, Sichert Hellert, Wolfgang, Koeppen, Ellen, Erhardt, Eva, Csernus, Katalin, Török, Katalin, Bokor, Szilvia, Angster, M. r. s., Nagy, Enikö, Kovács, Orsolya, Répasi, Judit, Codrington, Caroline, Papadaki, Angeliki, Sarri, Katerina, Viskadourou, Anna, Hatzis, Christo, Kiriakakis, Michael, Tsibinos, George, Vardavas, Constantine, Sbokos, Manoli, Protoyeraki, Eva, Fasoulaki, Maria, Stehle, Peter, Pietrzik, Klau, Breidenassel, Christina, Spinneker, Andre, Al Tahan, Jasmin, Segoviano, Miriam, Berchtold, Anke, Bierschbach, Christine, Blatzheim, Erika, Schuch, Adelheid, Pickert, Petra, Garzón, Manuel J. Castillo, Sáinz, Ángel Gutiérrez, Porcel, Francisco B. Ortega, Ruiz, Jonatan Ruiz, Artero, Enrique García, Romero, Vanesa España, Pavón, David Jiménez, Muñoz, Cristóbal Sánchez, Soto, Victor, Chillón, Palma, Heredia, Jose M., Aparicio, Virginia, Baena, Pedro, Cardia, Claudia M., Carbonell, Ana, Arcella, Davide, Catasta, Giovina, Censi, Laura, Ciarapica, Donatella, Ferrari, Marika, Le Donne, Cinzia, Leclerq, Catherine, Magrì, Luciana, Maiani, Giuseppe, Piccinelli, Rafaela, Polito, Angela, Spada, Raffaela, Vitaglione, Paola, Montagnese, Concetta, De Bourdeaudhuij, Ilse, Matthys, Christophe, Vereecken, Carine, De Maeyer, Mieke, Ottevaere, Charlene, Phillipp, Katharina, Dietrich, Sabine, Grammatikaki, Eva, Bouloubasi, Zoi, Cook, Tina Louisa, Eleutheriou, Sofia, Consta, Orsalia, Moschonis, George, Katsaroli, Ioanna, Kraniou, George, Papoutsou, Stalo, Keke, Despoina, Petraki, Ioanna, Bellou, Elena, Tanagra, Sofia, Kallianoti, Kostalenia, Argyropoulou, Dionysia, Kondaki, Katerina, Tsikrika, Stamatoula, Karaiskos, Christo, Meirhaeghe, Aline, Bergman, Patrick, Hagströmer, María, Hallström, Lena, Hallberg, Mårten, Poortvliet, Eric, Rizzo, Nico, Beckman, Linda, Wennlöf, Anita Hurtig, Patterson, Emma, Kwak, Lydia, Cernerud, Lar, Tillgren, Per, Sörensen, Stefaan, Sánchez Molero, Jackie, Picó, Elena, Navarro, Maite, Viadel, Blanca, Carreres, José Enrique, Merino, Gema, Sanjuán, Rosa, Lorente, María, Sánchez, María José, Castelló, Sara, Thomas, Sarah, Allchurch, Elaine, Burguess, Peter, Astrom, Annika, Sverkén, Anna, Broberg, Agneta, Masson, Annick, Lehoux, Claire, Brabant, Pascal, Pate, Philippe, Fontaine, Laurence, Sebok, Andra, Kuti, Tunde, Hegyi, Adrienn, Maldonado, Cristina, Llorente, Ana, García, Emilio, Von Fircks, Holger, Hallberg, Marianne Lilja, Messerer, Maria, Larsson, Mat, Fredriksson, Helena, Adamsson, Viola, Börjesson, Ingmar, Fernández, Laura, Smillie, Laura, Wills, Josephine, Meléndez, Agustín, Benito, Pedro J., Calderón, Javier, Jiménez Pavón, David, Valtueña, Jara, Navarro, Paloma, Urzanqui, Alejandro, Albers, Ulrike, Pedrero, Raquel, and Lorente, Juan José Gómez

Subjects
Parents, Employment, Male, Pediatrics, medicine.medical_specialty, Adolescent, Cross-sectional study, Medicine (miscellaneous), Health Promotion, Socioeconomic Factor, Educational level, Diet Quality Index, Nutrition Policy, Feeding behavior, Parental Occupation, Surveys and Questionnaires, medicine, Nutrition and Dietetic, Humans, Surveys and Questionnaire, Socioeconomic status, Life Style, Cross-Sectional Studie, Nutrition and Dietetics, Dietary intake, Medicine (all), Feeding Behavior, Adolescent Development, Educational Statu, Adolescence, Diet, Europe, Geography, Cross-Sectional Studies, Multicenter study, Diet quality, Socioeconomic Factors, Parent, Adolescent Behavior, Food Habit, Educational Status, Patient Compliance, Female, Adolescent development, Nutritive Value, Demography, Human
Abstract

Diet quality is influenced by socio-economic and geographical factors. The present study sought to assess whether adolescents' diet quality is affected by their parents' socio-economic status and whether the relationship between these factors is similar in northern and southern Europe. Data collected in the Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) study in eight European countries were analysed. Dietary intake data were recorded via repeated 24 h recalls (using specifically developed HELENA Dietary Intake Assessment Tool software) and converted into an adolescent-specific Diet Quality Index (DQI-AM). Socio-economic status was estimated through parental educational level (Par-Educ-Lev) and parental occupation level (Par-Occ-Lev) as reported by the adolescents in a specific questionnaire. The DQI-AM data were then analysed as a function of Par-Educ-Lev and Par-Occ-Lev in northern European countries (Austria, Belgium, France, Germany and Sweden) and southern European countries (Greece, Italy and Spain). We studied a total of 1768 adolescents (age 14·7 (sd 1·3) years; percentage of girls: 52·8 %; 1135 and 633 subjects from northern and southern Europe, respectively). On average, the DQI-AM score was higher in southern Europe than in northern Europe (69·1 (sd 0·1) v. 60·4 (sd 2·8), respectively; PP interaction = 0·004 for the mother and 0·06 for the father). The DQI was also positively correlated with Par-Occ-Lev (all P trends P interaction = 0·51 for the mother and 0·50 for the father). In conclusion, Par-Educ-Lev and Par-Occ-Lev are associated with diet quality in adolescents in Europe. However, this association differs between northern Europe and southern Europe.

Published
2014

6. Role of a prudent breakfast in improving cardiometabolic risk factors in subjects with hypercholesterolemia : A randomized controlled trial

Author

Adamsson, Viola, Reumark, Anna, Marklund, Matti, Larsson, Anders, Risérus, Ulf, Adamsson, Viola, Reumark, Anna, Marklund, Matti, Larsson, Anders, and Risérus, Ulf

Abstract

BACKGROUND & AIMS: It is unclear whether advising a prudent breakfast alone is sufficient to improve blood lipids and cardiometabolic risk factors in overweight hypercholesterolemic subjects. The aim of this study was to investigate whether a prudent low-fat breakfast (PB) rich in dietary fiber lowers low-density lipoprotein cholesterol (LDL-C) and other cardiometabolic risk factors in subjects with elevated LDL-cholesterol levels. METHODS: In a parallel, controlled, 12-week study, 79 healthy overweight subjects (all regular breakfast eaters) were randomly allocated to a group that received a PB based on Nordic foods provided ad libitum or a control group that consumed their usual breakfast. The primary outcome was plasma LDL-C. Secondary outcomes were other blood lipids, body weight, sagittal abdominal diameter (SAD), glucose tolerance, insulin sensitivity and inflammation markers (C-reactive protein [CRP] and tumor necrosis factor receptor-2 [TNF-R2]), and blood pressure. The PB was in accordance with national and Nordic nutrition recommendations and included oat bran porridge with low-fat milk or yogurt, bilberry or lingonberry jam, whole grain bread, low-fat spread, poultry or fatty fish, and fruit. RESULTS: No differences were found in LDL-C, other blood lipids, body weight, or glucose metabolism, but SAD, plasma CRP, and TNF-R2 decreased more during PB compared with controls (p < 0.05). In the overall diet, PB increased dietary fiber and β-glucan compared with controls (p < 0.05). CONCLUSIONS: Advising a prudent breakfast for 3 months did not influence blood lipids, body weight, or glucose metabolism but reduced markers of visceral fat and inflammation. The trial was registered in the Current Controlled Trials database (http://www.controlled-trials.com); International Standard Randomized Controlled Trial Number (ISRCTN): 84550872.

Published
2015
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7. A Healthy Nordic Diet and Cardiometabolic Risk Factors : Intervention Studies with Special Emphasis on Plasma Lipoproteins

Author

Adamsson, Viola

Abstract

A healthy diet is important in the prevention of cardiovascular disease (CVD). Several risk factors, modifiable by diet, are involved in the development of CVD, e.g. hyperlipidaemia, hyperglycaemia, insulin resistance, obesity and hypertension. Little data however exist on diets composed of foods originating from the Nordic countries, and their potential to reduce CVD risk. This thesis aimed to investigate whether an ad libitum healthy Nordic diet (ND), either provided as a whole diet, or as a prudent breakfast (PB) alone, could influence CVD risk factors in healthy, mildly hypercholesterolemic men and women. Another aim was to describe the nutrient and food composition of the ND, both by using self-reported data and serum biomarkers of dietary fat quality. The primary clinical outcome measure was LDL-cholesterol, and other cardiometabolic risk factors were secondary outcomes. Two parallel, randomised, controlled intervention studies were conducted in free-living subjects. Clinical and dietary assessments were performed at baseline and at the end of dietary interventions. All foods were provided to subjects randomised to ND, whereas only breakfast items were supplied to subjects randomised to PB. Control groups followed their habitual diet/breakfast. Compared with controls, ND reduced body weight and improved several CVD risk factors including LDL-cholesterol, insulin sensitivity and blood pressure. Several, but not all effects were probably partly mediated by diet-induced weight loss. ND accorded with Nordic nutrition recommendations and was defined as “a plant-based diet, where animal products are used sparingly as side dishes”. Compared with average Swedish diet, ND was high in dietary fibre, but low in sodium, meat, high-fat dairy products, sweets and alcohol. A decreased intake of saturated fat and increased intake of n-3 PUFA during ND was partly reflected in serum lipids. Eating a PB without other dietary changes did not improve lipid or glucose metabolism, but decreased markers of visceral fat and inflammation, without influencing body weight. This thesis suggests that a whole ND, but not PB alone, promotes weight loss and improves multiple CVD risk factors in healthy subjects after 6 weeks. These results suggest that ND could have a potential role in the prevention of cardiometabolic diseases.

Published
2013

8. Influence of a healthy Nordic diet on serum fatty acid composition and associations with blood lipoproteins : results from the NORDIET study

Author

Adamsson, Viola, Cederholm, Tommy, Vessby, Bengt, Riserus, Ulf, Adamsson, Viola, Cederholm, Tommy, Vessby, Bengt, and Riserus, Ulf

Abstract

Background: The fatty acid (FA) composition of serum lipids is related to the quality of dietary fat. The aim of this study was to investigate the effects of a healthy Nordic diet (ND) on the FA composition of serum cholesterol esters (CE-FA) and assess the associations between changes in the serum CE-FA composition and blood lipoproteins during a controlled dietary intervention. Methods: The NORDIET trial was a six-week randomised, controlled, parallel-group dietary intervention study that included 86 adults (53±8 years) with elevated low-density lipoprotein cholesterol LDL-C. Serum CE-FA composition was measured using gas chromatography. Diet history interviews were conducted, and daily intake was assessed using checklists. Results: Food and nutrient intake data indicated that there was a reduction in the fat intake from dairy and meat products and an increase in the consumption of fatty fish with the ND, decreasing the levels of saturated fatty acids (SFA) in the diet, slightly decreasing the levels of monounsaturated fatty acids (MUFA) and moderately increasing the levels of polyunsaturated fatty acids (PUFA). Concomitantly, the levels of CE-SFA 14:0, 15:0 and 18:0, but not 16:0, decreased during the ND, and these changes differed from those observed in the control diet group (p<0.01). In contrast, serum 22:6n-3 increased during the ND compared with the control diet (p<0.01). The changes in CE-SFA 14:0, 15:0 and 18:0 during the intervention correlated positively with those in LDL-C, HDL-C, LDL-C/HDL-C, ApoA1 and ApoB (p<0.01), whereas the changes in CE-PUFA 22:6n-3 were negatively correlated with changes in the corresponding serum lipids. Conclusions: The decreased intake of saturated fat and increased intake of n-3 PUFA in a healthy Nordic diet are partly reflected by changes in the serum CE-FA composition, which are associated with an improved serum lipoprotein pattern.

Published
2014
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9. Influence of a prudent diet on circulating cathepsin S in humans

Author

Jobs, Elisabeth, Adamsson, Viola, Larsson, Anders, Jobs, Magnus, Nerpin, Elisabet, Ingelsson, Erik, Ärnlöv, Johan, Risérus, Ulf, Jobs, Elisabeth, Adamsson, Viola, Larsson, Anders, Jobs, Magnus, Nerpin, Elisabet, Ingelsson, Erik, Ärnlöv, Johan, and Risérus, Ulf

Abstract

Background: Increased circulating cathepsin S levels have been linked to increased risk of cardiometabolic diseases and cancer. However, whether cathepsin S is a modifiable risk factor is unclear. We aimed to investigate the effects of a prudent diet on plasma cathepsin S levels in healthy individuals. Findings: Explorative analyses of a randomized study were performed in 88 normal to slightly overweight and hyperlipidemic men and women (aged 25 to 65) that were randomly assigned to ad libitum prudent diet, i.e. healthy Nordic diet (ND) or a control group (habitual Western diet) for 6 weeks. Whereas all foods in the ND were provided, the control group was advised to consume their habitual diet throughout the study. The ND was in line with dietary recommendations, e. g. low in saturated fats, sugars and salt, but high in plant-based foods rich in fibre and unsaturated fats. The ND significantly decreased cathepsin S levels (from 20.1 (+/-4.0 SD) to 19.7 mu g/L (+/-4.3 SD)) compared with control group (from 18.2 (+/-2.9 SD) to 19.1 mu g/L (+/-3.8 SD)). This difference remained after adjusting for sex and change in insulin sensitivity (P = 0.03), and near significant after adjusting for baseline cathepsin S levels (P = 0.06), but not for change in weight or LDL-C. Changes in cathepsin S levels were directly correlated with change in LDL-C. Conclusions: Compared with a habitual control diet, a provided ad libitum healthy Nordic diet decreased cathepsin S levels in healthy individuals, possibly mediated by weight loss or lowered LDL-C. These differences between groups in cathepsin S were however not robust and therefore need further investigation.

Published
2014
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10. Inflammatory biomarker pentraxin 3 (PTX3) in relation to obesity, body fat depots, and weight loss

Author

Witasp, Anna, Carrero, Juan Jesús, Michaëlsson, Karl, Ahlström, Håkan, Kullberg, Joel, Adamsson, Viola, Risérus, Ulf, Larsson, Anders, Helmersson-Karlqvist, Johanna, Lind, Lars, Stenvinkel, Peter, Ärnlöv, Johan, Witasp, Anna, Carrero, Juan Jesús, Michaëlsson, Karl, Ahlström, Håkan, Kullberg, Joel, Adamsson, Viola, Risérus, Ulf, Larsson, Anders, Helmersson-Karlqvist, Johanna, Lind, Lars, Stenvinkel, Peter, and Ärnlöv, Johan

Abstract

OBJECTIVE: The relation between inflammatory markers, adiposity and disease is under extensive study. Here we tested the hypothesis that the immunomodulatory protein pentraxin 3 (PTX3) is associated with adiposity in the general population. DESIGN AND METHODS: Serum PTX3 concentrations, body mass index (BMI), waist circumference (WC) and fat depots, as quantified by dual-energy X-ray absorptiometry and magnetic resonance imaging, were assessed in three community-based cohorts: ULSAM, n = 790, mean age 78 years; PIVUS, n = 1003, mean age 70 years, women 50%; and the NORDIET-trial, n = 86, mean age 53 years, women 63%. Participants were re-examined after 5 years (PIVUS, n = 804) or following a 6-week randomized controlled dietary intervention (NORDIET). RESULTS: PTX3 levels were inversely associated with BMI and WC as well as with total and visceral fat (P < 0.05 for all; adjusted for age, inflammatory biomarkers and cardiovascular risk factors). The association between PTX3 and BMI appeared even stronger in nonobese individuals. A decrease in BMI over 5 years as well as weight loss following the NORDIET intervention were associated with increased serum PTX3 concentrations (P < 0.001). CONCLUSIONS: These consistent data support an inverse association between circulating PTX3 and anthropometrical measures, calling for further mechanistic studies of the link between PTX3 and fat.

Published
2014
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12. Inflammatory biomarker pentraxin 3 (PTX3) in relation to obesity, body fat depots and weight loss

Author

Witasp, Anna, primary, Carrero, Juan Jesús, additional, Michaëlsson, Karl, additional, Ahlström, Håkan, additional, Kullberg, Joel, additional, Adamsson, Viola, additional, Risérus, Ulf, additional, Larsson, Anders, additional, Helmersson-Karlqvist, Johanna, additional, Lind, Lars, additional, Stenvinkel, Peter, additional, and Ärnlöv, Johan, additional

Published
2014
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14. What is a healthy Nordic diet? Foods and nutrients in the NORDIET study

Author

Adamsson, Viola, Reumark, Anna, Cederholm, Tommy, Vessby, Bengt, Risérus, Ulf, Johansson, Gunnar, Adamsson, Viola, Reumark, Anna, Cederholm, Tommy, Vessby, Bengt, Risérus, Ulf, and Johansson, Gunnar

Abstract

BACKGROUND: A healthy Nordic diet (ND), a diet based on foods originating from the Nordic countries, improves blood lipid profile and insulin sensitivity and lowers blood pressure and body weight in hypercholesterolemic subjects. OBJECTIVE: To describe and compare food and nutrient composition of the ND in relation to the intake of a Swedish reference population (SRP) and the recommended intake (RI) and average requirement (AR), as described by the Nordic nutrition recommendations (NNR). DESIGN: The analyses were based on an estimate of actual food and nutrient intake of 44 men and women (mean age 53±8 years, BMI 26±3), representing an intervention arm receiving ND for 6 weeks. RESULTS: The main difference between ND and SRP was the higher intake of plant foods, fish, egg and vegetable fat and a lower intake of meat products, dairy products, sweets and desserts and alcoholic beverages during ND (p<0.001 for all food groups). Intake of cereals and seeds was similar between ND and SRP (p>0.3). The relative intake of protein, fat and carbohydrates during ND was in accordance with RI. Intake of all vitamins and minerals was above AR, whereas sodium intake was below RI. CONCLUSIONS: When compared with the food intake of an SRP, ND is primarily a plant-based diet. ND represents a balanced food intake that meets the current RI and AR of NNR 2004 and has a dietary pattern that is associated with decreased morbidity and mortality. © 2012 Viola Adamsson et al.

Published
2012
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15. Effects of a healthy Nordic diet on cardiovascular risk factors in hypercholesterolaemic subjects : a randomized controlled trial (NORDIET)

Author

Adamsson, Viola, Reumark, A., Fredriksson, I. -B, Hammarström, E., Vessby, Bengt, Johansson, G., Risérus, Ulf, Adamsson, Viola, Reumark, A., Fredriksson, I. -B, Hammarström, E., Vessby, Bengt, Johansson, G., and Risérus, Ulf

Abstract

Objective. The aim of this study was to investigate the effects of a healthy Nordic diet (ND) on cardiovascular risk factors. Design and subjects. In a randomized controlled trial (NORDIET) conducted in Sweden, 88 mildly hypercholesterolaemic subjects were randomly assigned to an ad libitum ND or control diet (subjects' usual Western diet) for 6 weeks. Participants in the ND group were provided with all meals and foods. Primary outcome measurements were low-density lipoprotein (LDL) cholesterol, and secondary outcomes were blood pressure (BP) and insulin sensitivity (fasting insulin and homeostatic model assessment-insulin resistance). The ND was rich in high-fibre plant foods, fruits, berries, vegetables, whole grains, rapeseed oil, nuts, fish and low-fat milk products, but low in salt, added sugars and saturated fats. Results. The ND contained 27%, 52%, 19% and 2% of energy from fat, carbohydrate, protein and alcohol, respectively. In total, 86 of 88 subjects randomly assigned to diet completed the study. Compared with controls, there was a decrease in plasma cholesterol (-16%, P < 0.001), LDL cholesterol (-21%, P < 0.001), high-density lipoprotein (HDL) cholesterol (-5%, P < 0.01), LDL/HDL (-14%, P < 0.01) and apolipoprotein (apo)B/apoA1 (-1%, P < 0.05) in the ND group. The ND reduced insulin (-9%, P = 0.01) and systolic BP by -6.6 +/- 13.2 mmHg (-5%, P < 0.05) compared with the control diet. Despite the ad libitum nature of the ND, body weight decreased after 6 weeks in the ND compared with the control group (-4%, P < 0.001). After adjustment for weight change, the significant differences between groups remained for blood lipids, but not for insulin sensitivity or BP. There were no significant differences in diastolic BP or triglyceride or glucose concentrations. Conclusions. A healthy ND improves blood lipid profile and insulin sensitivity and lowers blood pressure at clinically relevant levels in hypercholesterolaemic subjects.

Published
2011
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16. Effects of a Nordic diet on cardiovascular and metabolic risk factors in hypercholesterolemic subjects: a randomized controlled study

Author

Adamsson, Viola, Reumark, Anna, Fredriksson, Ing-Britt, Hammarström, Eskil, Vessby, Bengt, Johansson, Gunnar, Riserus, Ulf, Adamsson, Viola, Reumark, Anna, Fredriksson, Ing-Britt, Hammarström, Eskil, Vessby, Bengt, Johansson, Gunnar, and Riserus, Ulf

Abstract

Background: Apart from lipid-lowering drugs, dietary changes can also reduce plasma LDL-C concentrations. No studies have been conducted to investigate the clinical effects of a diet with traditional foods originating from the Nordic countries. Method: In a randomised, controlled parallel-group intervention study 88 mildly hypercholesterolemic men and women were randomized to either an ad libitum Nordic diet (ND) or a control diet (CD) for 6 weeks. All meals and foods were provided to the participants in the ND group. Primary outcome measure was LDL-cholesterol, and secondary outcomes were blood pressure, plasma insulin and glucose concentrations. The ND was a high-fibre diet rich in plant foods (fruit, berries, vegetables, root vegetables, whole grain cereals and legumes), vegetable fats (rapeseed oil and nuts) and fatty fish, low-fat milk products, but low in salt, added sugars, saturated fats and red meats. Result: 86 subjects completed the study. Distribution of carbohydrates, fat and protein (E%) in ND was 54, 27, 19, respectively. ND lowered plasma total cholesterol 0.98±0.75 mmol/l (-16%), LDL-C by 0.83±0.67 mmol/l (-21%), HDL-C 0.08±0.23 mmol/l (-5%), including reduced LDL/HDL ratio by -0.42±0.57 (-14%) (all p<0.01 versus controls). Insulin concentrations decreased by 0.51± 2.25 (-9%, p=0.01) and systolic blood pressure by 7±13 mmHg (-5%, P<0.01) compared to controls. Despite diets were eaten ad libitum, body weight decreased by 3.0 kg in the ND (P<0.001). No significant differences were found for diastolic blood pressure, triglycerides or plasma glucose. Conclusion: A Nordic diet improves blood lipid profile, and insulin sensitivity as well as lowering blood pressure to a clinically significant extent in hypercholesterolemic subjects.

Published
2009

20. Role of a prudent breakfast in improving cardiometabolic risk factors in subjects with hypercholesterolemia : a randomized controlled trial

Author

Adamsson, Viola, Reumark, Anna, Larsson, Anders, Riserus, Ulf, Adamsson, Viola, Reumark, Anna, Larsson, Anders, and Riserus, Ulf

Abstract

Background & Aims: It is unclear whether advising a prudent breakfast alone is sufficient to improve blood lipids and cardiometabolic risk factors in overweight hypercholesterolemic subjects. Methods: The aim of the present study was to investigate whether a prudent low-fat breakfast (PB) rich in dietary fiber lowers low-density lipoprotein cholesterol (LDL-C) and other cardiometabolic risk factors in subjects with elevated LDL-cholesterol levels. In a parallel, controlled, 12-week study, 79 healthy overweight subjects (all regular breakfast eaters) were randomly allocated to a group that received a PB based on Nordic foods provided ad libitum or a control group that consumed their usual breakfast. The PB was in accordance with national and Nordic nutrition recommendations and included oat bran porridge with low-fat milk or yogurt, bilberry or lingonberry jam, whole grain bread, low-fat spread, poultry or fatty fish, and fruit. Results: No differences were found in LDL-C, blood lipids, body weight, or glucose metabolism, but SAD, plasma CRP, and TNF-R2 were lower during PB compared with controls (p<0.05). In the overall diet, PB increased dietary fiber and b-glucan compared with controls (p<0.05). Conclusions: Advising a prudent breakfast for 3 months did not influence blood lipids, body weight, or glucose metabolism but reduced markers of visceral fat and inflammation.

21. Do dietary patterns determine levels of vitamin B6, folate, and vitamin B12 intake and corresponding biomarkers in European adolescents? The Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) study

Author

Iris Iglesia, Inge Huybrechts, Theodora Mouratidou, Javier Santabárbara, Juan M. Fernández-Alvira, Alba M. Santaliestra-Pasías, Yannis Manios, Alejandro De la O Puerta, Anthony Kafatos, Frédéric Gottrand, Ascensión Marcos, Stefania Sette, Maria Plada, Peter Stehle, Dénes Molnár, Kurt Widhalm, Mathilde Kersting, Stefaan De Henauw, Luis A. Moreno, Marcela González-Gross, Jesús Fleta, José A. Casajús, Gerardo Rodríguez, Concepción Tomás, María I. Mesana, Germán Vicente-Rodríguez, Adoración Villarroya, Carlos M. Gil, Ignacio Ara, Juan Fernández Alvira, Gloria Bueno, Aurora Lázaro, Olga Bueno, Juan F. León, Jesús M.a Garagorri, Manuel Bueno, Idoia Labayen, Silvia Bel, Luis A. Gracia Marco, Alba Santaliestra-Pasías, Esther González-Gil, Pilar De Miguel-Etayo, Cristina Julián Almárcegui, Mary Miguel-Berges, Isabel Iguacel, Julia Wärnberg, Esther Nova, Sonia Gómez, Ligia Esperanza Díaz, Javier Romeo, Ana Veses, Belén Zapatera, Tamara Pozo, David Martínez, Laurent Beghin, Christian Libersa, Catalina Iliescu, Juliana Von Berlepsch, Wolfgang Sichert-Hellert, Ellen Koeppen, Eva Erhardt, Katalin Csernus, Katalin Török, Szilvia Bokor, Mrs Angster, Enikö Nagy, Orsolya Kovács, Judit Répasi, Caroline Codrington, María Plada, Angeliki Papadaki, Katerina Sarri, Anna Viskadourou, Christos Hatzis, Michael Kiriakakis, George Tsibinos, Constantine Vardavas, Manolis Sbokos, Eva Protoyeraki, Maria Fasoulaki, Klaus Pietrzik, Christina Breidenassel, Andre Spinneker, Jasmin Al-Tahan, Miriam Segoviano, Anke Berchtold, Christine Bierschbach, Erika Blatzheim, Adelheid Schuch, Petra Pickert, Manuel J. Castillo, Ángel Gutiérrez, Francisco B. Ortega, Jonatan R. Ruiz, Enrique G. Artero, Vanesa España, David Jiménez-Pavón, Palma Chillón, Cristóbal Sánchez-Muñoz, Magdalena Cuenca, Davide Arcella, Elena Azzini, Emma Barison, Noemi Bevilacqua, Pasquale Buonocore, Giovina Catasta, Laura Censi, Donatella Ciarapica, Paola D'Acapito, Marika Ferrari, Myriam Galfo, Cinzia Le Donne, Catherine Leclercq, Giuseppe Maiani, Beatrice Mauro, Lorenza Mistura, Antonella Pasquali, Raffaela Piccinelli, Angela Polito, Romana Roccaldo, Raffaella Spada, Maria Zaccaria, Luca Scalfi, Paola Vitaglione, Concetta Montagnese, Ilse De Bourdeaudhuij, Tineke De Vriendt, Lea Maes, Christophe Matthys, Carine Vereecken, Mieke de Maeyer, Charlene Ottevaere, Katharina Phillipp, Sabine Dietrich, Eva Grammatikaki, Zoi Bouloubasi, Tina Louisa Cook, Sofia Eleutheriou, Orsalia Consta, George Moschonis, Ioanna Katsaroli, George Kraniou, Stalo Papoutsou, Despoina Keke, Ioanna Petraki, Elena Bellou, Sofia Tanagra, Kostalenia Kallianoti, Dionysia Argyropoulou, Stamatoula Tsikrika, Christos Karaiskos, Jean Dallongeville, Aline Meirhaeghe, Michael Sjöstrom, María Hagströmer, Anita Hurtig Wennlöf, Lena Hallström, Emma Patterson, Lydia Kwak, Nico Rizzo, Jackie Sánchez-Molero, Sara Castelló, Elena Picó, Maite Navarro, Blanca Viadel, José Enrique Carreres, Gema Merino, Rosa Sanjuán, María Lorente, María José Sánchez, Chantal Gilbert, Sarah Thomas, Elaine Allchurch, Peter Burgess, Gunnar Hall, Annika Astrom, Anna Sverkén, Agneta Broberg, Annick Masson, Claire Lehoux, Pascal Brabant, Philippe Pate, Laurence Fontaine, Andras Sebok, Tunde Kuti, Adrienn Hegyi, Cristina Maldonado, Ana Llorente, Emilio García, Holger von Fircks, Marianne Lilja Hallberg, Maria Messerer, Mats Larsson, Helena Fredriksson, Viola Adamsson, Ingmar Börjesson, Laura Fernández, Laura Smillie, Josephine Wills, Raquel Pedrero-Chamizo, Agustín Meléndez, Jara Valtueña, Ulrike Albers, Pedro J. Benito, Juan José Gómez Lorente, David Cañada, Alejandro Urzanqui, Rosa María Torres, Paloma Navarro, European Commission, Ministerio de Educación (España), Ministerio de Ciencia e Innovación (España), Instituto de Salud Carlos III, Iglesia, Iri, Huybrechts, Inge, Mouratidou, Theodora, Santabárbara, Javier, Fernández-Alvira, Juan M., Santaliestra-Pasías, Alba M., Manios, Yanni, De la O Puerta, Alejandro, Kafatos, Anthony, Gottrand, Frédéric, Marcos, Ascensión, Sette, Stefania, Plada, Maria, Stehle, Peter, Molnár, Déne, Widhalm, Kurt, Kersting, Mathilde, De Henauw, Stefaan, Moreno, Luis A., González-Gross, Marcela, Fleta, Jesú, Casajús, José A., Rodríguez, Gerardo, Tomás, Concepción, Mesana, María I., Vicente-Rodríguez, Germán, Villarroya, Adoración, Gil, Carlos M., Ara, Ignacio, Alvira, Juan Fernández, Bueno, Gloria, Lázaro, Aurora, Bueno, Olga, León, Juan F., Garagorri, Jesús M. a, Bueno, Manuel, Labayen, Idoia, Bel, Silvia, Marco, Luis A. Gracia, Santaliestra-Pasías, Alba, González-Gil, Esther, De Miguel-Etayo, Pilar, Almárcegui, Cristina Julián, Miguel-Berges, Mary, Iguacel, Isabel, Wärnberg, Julia, Nova, Esther, Gómez, Sonia, Díaz, Ligia Esperanza, Romeo, Javier, Veses, Ana, Zapatera, Belén, Pozo, Tamara, Martínez, David, Beghin, Laurent, Libersa, Christian, Iliescu, Catalina, Von Berlepsch, Juliana, Sichert-Hellert, Wolfgang, Koeppen, Ellen, Erhardt, Eva, Csernus, Katalin, Török, Katalin, Bokor, Szilvia, Angster, Mr, Nagy, Enikö, Kovács, Orsolya, Répasi, Judit, Codrington, Caroline, Plada, María, Papadaki, Angeliki, Sarri, Katerina, Viskadourou, Anna, Hatzis, Christo, Kiriakakis, Michael, Tsibinos, George, Vardavas, Constantine, Sbokos, Manoli, Protoyeraki, Eva, Fasoulaki, Maria, Pietrzik, Klau, Breidenassel, Christina, Spinneker, Andre, Al-Tahan, Jasmin, Segoviano, Miriam, Berchtold, Anke, Bierschbach, Christine, Blatzheim, Erika, Schuch, Adelheid, Pickert, Petra, Castillo, Manuel J., Gutiérrez, Ángel, Ortega, Francisco B., Ruiz, Jonatan R., Artero, Enrique G., España, Vanesa, Jiménez-Pavón, David, Chillón, Palma, Sánchez-Muñoz, Cristóbal, Cuenca, Magdalena, Arcella, Davide, Azzini, Elena, Barison, Emma, Bevilacqua, Noemi, Buonocore, Pasquale, Catasta, Giovina, Censi, Laura, Ciarapica, Donatella, D'Acapito, Paola, Ferrari, Marika, Galfo, Myriam, Donne, Cinzia Le, Leclercq, Catherine, Maiani, Giuseppe, Mauro, Beatrice, Mistura, Lorenza, Pasquali, Antonella, Piccinelli, Raffaela, Polito, Angela, Roccaldo, Romana, Spada, Raffaella, Zaccaria, Maria, Scalfi, Luca, Vitaglione, Paola, Montagnese, Concetta, De Bourdeaudhuij, Ilse, De Vriendt, Tineke, Maes, Lea, Matthys, Christophe, Vereecken, Carine, de Maeyer, Mieke, Ottevaere, Charlene, Phillipp, Katharina, Dietrich, Sabine, Grammatikaki, Eva, Bouloubasi, Zoi, Cook, Tina Louisa, Eleutheriou, Sofia, Consta, Orsalia, Moschonis, George, Katsaroli, Ioanna, Kraniou, George, Papoutsou, Stalo, Keke, Despoina, Petraki, Ioanna, Bellou, Elena, Tanagra, Sofia, Kallianoti, Kostalenia, Argyropoulou, Dionysia, Tsikrika, Stamatoula, Karaiskos, Christo, Dallongeville, Jean, Meirhaeghe, Aline, Sjöstrom, Michael, Hagströmer, María, Wennlöf, Anita Hurtig, Hallström, Lena, Patterson, Emma, Kwak, Lydia, Rizzo, Nico, Sánchez-Molero, Jackie, Castelló, Sara, Picó, Elena, Navarro, Maite, Viadel, Blanca, Carreres, José Enrique, Merino, Gema, Sanjuán, Rosa, Lorente, María, Sánchez, María José, Gilbert, Chantal, Thomas, Sarah, Allchurch, Elaine, Burgess, Peter, Hall, Gunnar, Astrom, Annika, Sverkén, Anna, Broberg, Agneta, Masson, Annick, Lehoux, Claire, Brabant, Pascal, Pate, Philippe, Fontaine, Laurence, Sebok, Andra, Kuti, Tunde, Hegyi, Adrienn, Maldonado, Cristina, Llorente, Ana, García, Emilio, von Fircks, Holger, Hallberg, Marianne Lilja, Messerer, Maria, Larsson, Mat, Fredriksson, Helena, Adamsson, Viola, Börjesson, Ingmar, Fernández, Laura, Smillie, Laura, Wills, Josephine, Pedrero-Chamizo, Raquel, Meléndez, Agustín, Valtueña, Jara, Albers, Ulrike, Benito, Pedro J., Lorente, Juan José Gómez, Cañada, David, Urzanqui, Alejandro, Torres, Rosa María, and Navarro, Paloma

Subjects
0301 basic medicine, Vitamin b, Food intake, 030109 nutrition & dietetics, Nutrition and Dietetics, Adolescent, business.industry, Endocrinology, Diabetes and Metabolism, Physiology, Dietary pattern, Reduced rank regression, Fish products, Whole milk, Europe, 03 medical and health sciences, Medicine, Biomarker (medicine), Vitamin B12, Vitamin b6, business, Vitamin B
Abstract

On behalf of the HELENA study group: et al., [Objectives]: To determine dietary patterns (DPs) and explain the highest variance of vitamin B6, folate, and B12 intake and related concentrations among European adolescents., [Methods]: A total of 2173 adolescents who participated in the Healthy Lifestyle in Europe by Nutrition in Adolescence study met the eligibility criteria for the vitamin B intake analysis (46% boys) and 586 adolescents for the biomarkers analysis (47% boys). Two non-consecutive, 24-h, dietary recalls were used to assess the mean intakes. Concentrations were measured by chromatography and immunoassay testing. A reduced rank regression was applied to elucidate the combined effect of food intake of vitamin B and related concentrations., [Results]: The identified DPs (one per vitamin B intake and biomarker and by sex) explained a variability between 34.2% and 23.7% of the vitamin B intake and between 17.2% and 7% of the biomarkers. In the reduced rank regression models, fish, eggs, cheese, whole milk and buttermilk intakes were loaded positively for vitamin B intake in both sexes; however, soft drinks and chocolate were loaded negatively. For the biomarkers, a higher variability was observed in the patterns in terms of food loads such as alcoholic drinks, sugars, and soft drinks. Some food items were loaded differently between intakes and biomarkers such as fish products, which was loaded positively for intakes but negatively for plasma folate in girls., [Conclusions]: The identified DPs explained up to 34.2% and 17.2% of the variability of the vitamin B intake and plasma concentrations, respectively, in European adolescents. Further studies are needed to elucidate the factors that determine such patterns., HELENA study received funding from the European Union’s Sixth RTD Framework Programme (Contract FOODCT-2005-007034). Additional support from the Spanish Ministry of Education (AGL2007-29784-E/ALI), Axis-Shield Diagnostics Ltd (Oslo, Norway), Abbot Científica S.A. (Spain). This analysis was also supported by the Spanish Ministry of Science and Innovation (JCI-2010-07055) with the contribution of the European Regional Development Fund (FEDER). The first author is supported by a grant from the Spanish Carlos III Health Institute: RD08/0072/0025 (Red SAMID: Maternal, Child Health and Development Research Network).

Published
2018

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