13 results on '"Adrien Boillot"'
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2. Orosomucoid, a new biomarker in the association between obesity and periodontitis.
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Hélène Rangé, Christine Poitou, Adrien Boillot, Cécile Ciangura, Sandrine Katsahian, Jean-Marc Lacorte, Sébastien Czernichow, Olivier Meilhac, Philippe Bouchard, and Catherine Chaussain
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Medicine ,Science - Abstract
Epidemiological data indicate an association between periodontitis and obesity. The biological mechanisms of this relationship remain unclear. A cross-sectional study was conducted to evaluate the relationship between periodontitis and the common systemic inflammatory markers in 32 morbidly obese patients recruited in a Clinical Nutrition department. Periodontal condition was evaluated using pocket depth (PD) measurement, a classical clinical marker of ongoing periodontitis. Major periodontal risk factors were recorded (age, gender, diabetes and smoking status), as well as plasma levels of inflammatory markers (CRP, orosomucoid, IL-6) and adipokines (adiponectin, leptin). All patients included in the sample exhibited evidence of periodontitis, 16 of whom were diagnosed as having severe disease. Adjusted logistic regression analysis indicated that the severity of periodontitis was associated with the plasma level of orosomucoid (p
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- 2013
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3. Obesity and the microvasculature: a systematic review and meta-analysis.
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Adrien Boillot, Sophia Zoungas, Paul Mitchell, Ronald Klein, Barbara Klein, Mohammad Kamran Ikram, Caroline Klaver, Jie Jin Wang, Bamini Gopinath, E Shyong Tai, Aljoscha Steffen Neubauer, Serge Hercberg, Laima Brazionis, Seang-Mei Saw, Tien-Yin Wong, Sébastien Czernichow, and META-EYE Study Group
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Medicine ,Science - Abstract
BackgroundOverweight and obesity are thought to significantly influence a person's risk of cardiovascular disease, possibly via its effect on the microvasculature. Retinal vascular caliber is a surrogate marker of microvascular disease and a predictor of cardiovascular events. The aim of this systematic review and meta-analysis was to determine the association between body mass index (BMI) and retinal vascular caliber.Methods and findingsRelevant studies were identified by searches of the MEDLINE and EMBASE databases from 1966 to August 2011. Standardized forms were used for data extraction. Among over 44,000 individuals, obese subjects had narrower arteriolar and wider venular calibers when compared with normal weight subjects, independent of conventional cardiovascular risk factors. In adults, a 1 kg/m(2) increase in BMI was associated with a difference of 0.07 μm [95% CI: -0.08; -0.06] in arteriolar caliber and 0.22 μm [95% CI: 0.21; 0.23] in venular caliber. Similar results were found for children.ConclusionsHigher BMI is associated with narrower retinal arteriolar and wider venular calibers. Further prospective studies are needed to examine whether a causative relationship between BMI and retinal microcirculation exists.
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- 2013
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4. Education as a predictor of chronic periodontitis: a systematic review with meta-analysis population-based studies.
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Adrien Boillot, Bechara El Halabi, George David Batty, Hélène Rangé, Sébastien Czernichow, and Philippe Bouchard
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Medicine ,Science - Abstract
BackgroundThe impact of socioeconomic inequalities on health is well-documented. Despite the links of periodontal disease with cardiovascular diseases, adverse pregnancy outcomes and diabetes, no meta-analysis of socioeconomic variations in periodontal disease exists. This meta-analytic review was conducted to determine the extent to which education attainment influences risk of periodontitis in adults aged 35+ years in the general population.MethodsThe authors searched studies published until November 2010 using EMBASE and MEDLINE databases. References listed were then scrutinised, our own files were checked, and, finally, we contacted experts in the field. The authors included only general population-based studies conducted in adults aged 35 years and more. All articles were blind reviewed by two investigators. In the case of disagreement, a third investigator arbitrated. Using PRISMA statement, two reviewers independently extracted papers of interest.ResultsRelative to the higher education group, people with low education attainment experience a greater risk of periodontitis (OR: 1.86 [1.66-2.10]; pConclusionsIn the studies reviewed, low educational attainment was associated with an increased risk of periodontitis. Although this evidence should be cautiously interpreted due to methodological problems in selected studies, efforts to eliminate educational inequalities in periodontitis should focus on early life interventions.
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- 2011
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5. Gingival inflammation, enamel defects, and tooth sensitivity in children with amelogenesis imperfecta: a case-control study
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Camille QUANDALLE, Adrien BOILLOT, Benjamin FOURNIER, Pascal GARREC, Muriel DE LA DURE-MOLLA, and Stephane KERNER
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Amelogenesis imperfecta ,Dental enamel ,Dentin sensitivity ,Gingivitis ,Dental plaque ,Dentistry ,RK1-715 - Abstract
Abstract Gingival conditions and tooth sensitivity of young patients with amelogenesis imperfecta lack in depth studies. This case-control study aimed to compare (1) the gingival inflammation, the presence of enamel defects, and tooth sensitivity in young patients with and without amelogenesis imperfecta and (2) to investigate if any difference exists between subtypes of amelogenesis imperfecta. Methodology We compared forty-two participants with amelogenesis imperfecta with forty-two controls matched for age, gender, and the number of examined sites. Based on interview, clinical examination, and intraoral photography, we collected data on periodontal conditions, enamel defects and the presence of tooth sensitivity. Comparison tests were performed to investigate if any difference existed between cases and controls; and among cases, between the different subtypes of amelogenesis imperfecta. We performed a post-hoc analysis for any significant difference observed. Results We observed more gingival inflammation, enamel defects and tooth sensitivity among cases (all p
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6. High serum ferritin levels are associated with a reduced periodontium in women with anorexia nervosa
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Yvonne L. Kapila, Philippe Bouchard, Hélène Rangé, Adrien Boillot, Damien Ringuenet, Pierre Colon, and Alice Pallier
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Periodontitis ,Periodontium ,medicine.medical_specialty ,Anorexia Nervosa ,business.industry ,Bulimia nervosa ,Medical record ,medicine.disease ,Comorbidity ,Feeding and Eating Disorders ,stomatognathic diseases ,Psychiatry and Mental health ,Clinical Psychology ,Eating disorders ,Anorexia nervosa (differential diagnoses) ,Internal medicine ,Cohort ,Ferritins ,Medicine ,Humans ,Female ,business ,Bulimia Nervosa - Abstract
Impaired oral health is a well-known complication in individuals with eating disorders, although this is difficult to identify by mental health professionals. The aim of this study was to evaluate the relationship between routine blood parameters and two oral health outcomes (dental erosion, reduced periodontium) in women with eating disorders. A face-to-face interview and a clinical oral examination were carried out in a cohort of 70 women from an addiction and psychiatry hospital unit. Biochemical and hematological parameters were collected in medical records at admission. Biological factors associated with a generalized reduced periodontium (≥ 30% of sites with clinical attachment loss ≥ 3 mm) and dental erosion [a basic erosive wear examination (BEWE) score ≥ 3] were determined by logistic regression models. Forty-five women with either anorexia nervosa (n = 27) or bulimia nervosa (n = 18) were included in the study. None of the women had active periodontitis or other inflammatory comorbidity. Women with ≥ 30% of sites with clinical attachment loss ≥ 3 mm and those with a BEWE score ≥ 3 were older than women that did not exhibit a generalized reduced periodontium or dental erosion (37.1 ± 10.4 versus 28.8 ± 7.4, p
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- 2019
7. Dental and periodontal health in adults with eating disorders: A case-control study
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Anna Karimova, Pierre Colon, Damien Ringuenet, Adrien Boillot, Philippe Bouchard, Alice Pallier, Hélène Rangé, Université Paris Diderot - Paris 7 - UFR Odontologie (UPD7 Odontologie), Université Paris Diderot - Paris 7 (UPD7), Laboratoire des Multimatériaux et Interfaces (LMI), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Maison de Solenn [CHU Cochin], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Pathologies, Imagerie et Biothérapies oro-faciales (EA 2496), and Université Paris Descartes - Paris 5 (UPD5)
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Adult ,Pediatrics ,medicine.medical_specialty ,Anorexia Nervosa ,media_common.quotation_subject ,[SDV]Life Sciences [q-bio] ,Oral Health ,behavioral disciplines and activities ,Oral hygiene ,Feeding and Eating Disorders ,03 medical and health sciences ,Gingivitis ,0302 clinical medicine ,mental disorders ,medicine ,Humans ,Clinical significance ,030212 general & internal medicine ,Bulimia Nervosa ,General Dentistry ,media_common ,Bulimia nervosa ,business.industry ,Addiction ,digestive, oral, and skin physiology ,Case-control study ,030206 dentistry ,medicine.disease ,Oral Hygiene ,3. Good health ,Eating disorders ,Anorexia nervosa (differential diagnoses) ,Case-Control Studies ,Female ,medicine.symptom ,business - Abstract
This study evaluates dental and periodontal health in anorexia nervosa and bulimia nervosa patients.Seventy females with eating disorders (36 anorexia nervosa) attending a public hospital Psychiatry and Addiction unit were compared with age-matched controls (n = 70). Full-mouth examination and oral hygiene behaviours were recorded for all participants.More frequent dental attendance and toothbrushing were observed in patients with eating disorders than in controls (p 0.01), while lower plaque index and bleeding on probing were observed in controls than in patients (p ≤ 0.03). Percentages of sites with gingival recession2 mm were higher in patients with eating disorders than in controls (2.3 ± 4.1 versus 0.0 ± 0.1, p 0.01). The BEWE score2 was significantly more frequent in bulimia nervosa patients than in anorexia nervosa patients (76.5% versus 41.7%, p 0.01). Regarding periodontal parameters, mean plaque index, bleeding on probing and clinical attachment loss were increased in anorexia nervosa patients compared to bulimia nervosa patients.The present data suggest different oral health approaches in eating disorder patients according to diagnosis type.Periodontal and dental health should be considered rigorously in patients with eating disorders. Personalized oral hygiene recommendations and treatments can be delivered according to the type of eating disorder.
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- 2019
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8. Bariatric surgery and periodontal status: a systematic review with meta-analysis
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Sébastien Czernichow, Sílvia Helena de Carvalho Sales-Peres, Adrien Boillot, Philippe Bouchard, Isabelle Fontanille, Maria Clotilde Carra, and Hélène Rangé
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Male ,medicine.medical_specialty ,Bleeding on probing ,MEDLINE ,Bariatric Surgery ,030209 endocrinology & metabolism ,Disease ,Cochrane Library ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Humans ,Prospective cohort study ,Periodontitis ,business.industry ,PERIODONTITE ,030206 dentistry ,Middle Aged ,medicine.disease ,Obesity ,Surgery ,Obesity, Morbid ,Treatment Outcome ,Meta-analysis ,Female ,medicine.symptom ,business - Abstract
Objective To review and analyze periodontal clinical parameters after bariatric surgery. Background Periodontitis, a dysbiotic inflammatory disease, has been associated with obesity. The purpose of bariatric surgery is to reduce weight and systemic inflammation. Consequently, it is of interest to systematically review the impact of bariatric surgery on periodontal status. Methods Electronic searches were conducted in MEDLINE, EMBASE, Thesis database, and the Cochrane Library databases. Gray literature and the main journals of both specialties were also reviewed. Only cross-sectional and prospective studies focusing on bleeding on probing, pocket depth, and clinical attachment levels were selected. Results After a thorough screening of 651 studies, 10 studies were selected by 2 independent reviewers. Four (n = 250) and 3 studies (n = 191) were included in the meta-analysis at 6- and 12-month follow-up, respectively. At 6-month follow-up increased periodontal inflammation (P = .03) and periodontal destruction were observed. However, 12 months after baseline, the difference between bariatric patients and control was no longer significant. Conclusion The present systematic review and meta-analysis suggests that deterioration of periodontal status may be observed in the first 6 months after surgery. Consequently, periodontal screening and management of the patient's request for bariatric surgery should be recommended to avoid further deterioration of periodontal status after bariatric surgery.
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- 2018
9. Periodontitis and retinal microcirculation in the Atherosclerosis Risk in Communities study
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Adrien Boillot, Sébastien Czernichow, Philippe Bouchard, Steven Offenbacher, and Kevin Moss
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Male ,medicine.medical_specialty ,Alcohol Drinking ,Retinal Artery ,Optic Disk ,Dentistry ,Type 2 diabetes ,Severe periodontitis ,Article ,Microcirculation ,Cohort Studies ,chemistry.chemical_compound ,Sex Factors ,Diabetes mellitus ,Internal medicine ,Periodontal Attachment Loss ,medicine ,Humans ,Periodontal Pocket ,Gingival Recession ,Macula Lutea ,Longitudinal Studies ,Periodontitis ,Aged ,business.industry ,Confounding ,Smoking ,Age Factors ,Retinal Vessels ,Retinal ,Middle Aged ,medicine.disease ,Atherosclerosis ,Retinal Vein ,Cross-Sectional Studies ,chemistry ,Diabetes Mellitus, Type 2 ,Cohort ,Cardiology ,Periodontics ,Educational Status ,Female ,business - Abstract
Aim The aim of this cross-sectional study is to explore if periodontitis is associated with alterations of the retinal microcirculation, a predictive marker of cardiovascular events. Material and Methods Of 457 subjects aged 52 years and more from the ARIC cohort were included. Retinal vascular diameters were measured and summarized as central retinal arteriolar/venular equivalents (CRAE/CRVE). Periodontitis was determined by using the CDC/AAP definition. Multivariable linear regression models were used to estimate the relationships between CRAE, CRVE and periodontitis. Results No association was found between CRAE and periodontal status. However, CRVE and severe periodontitis were positively and significantly associated. Mean CRVE (±SD) was 187.0 ± 17.2 μm in the health-gingivitis group, and, respectively, 188.5 ± 16.3 μm (p = 0.39) and 191.6 ± 16.8 μm (p = 0.04) in moderate and severe periodontitis groups, after adjustment for a propensity score based on confounders. Results were consistent when analyses were restricted to participants with diabetes mellitus (n = 66), but not diabetes-free subjects. Conclusions Severe periodontitis is associated with larger retinal venular diameter in patients with type 2 diabetes. Further studies are needed to explore the impact of diabetes mellitus on the association between periodontitis and retinal microcirculation.
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- 2015
10. Obesity and the microvasculature: A systematic review and meta-analysis
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Barbara E.K. Klein, Aljoscha Steffen Neubauer, Paul Mitchell, Sébastien Czernichow, Mohammad Kamran Ikram, Ronald Klein, Sophia Zoungas, Bamini Gopinath, Seang-Mei Saw, Adrien Boillot, Jie Jin Wang, Tien Yin Wong, Serge Hercberg, E. Shyong Tai, Caroline C W Klaver, Laima Brazionis, Université Paris Diderot - Paris 7 (UPD7), Hôpital Ambroise Paré [AP-HP], George Institute for Global Health, The University of Sydney, Westmead Institute for Medical Research, Partenaires INRAE, University of Wisconsin-Madison, Saw Swee Hock School of Public Health, National University of Singapore (NUS), Erasmus University Rotterdam, Singapore Eye Research Institute, Department of Medicine, University of Melbourne-Royal Melbourne Hospital, Ludwig Maximilians University of Munich, Unité de Recherche en Epidémiologie Nutritionnelle (UREN), Université Paris 13 (UP13)-Institut National de la Recherche Agronomique (INRA)-Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital Avicenne [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), PRES Sorbonne Paris Cité, Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Centre de recherche en épidémiologie et santé des populations (CESP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), National Health and Medical Research Council [124317, 396414, 209057], National Heart Foundation, Centre for Clinical Research Excellence in Clinical Science in Diabetes, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Sorbonne Paris Cité (USPC)-Université Paris 13 (UP13)-Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Institut National de la Recherche Agronomique (INRA), ProdInra, Migration, Ludwig-Maximilians University [Munich] (LMU), Université Paris 13 (UP13)-Institut National de la Recherche Agronomique (INRA)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM), Ophthalmology, and Obstetrics & Gynecology
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Pathology ,Epidemiology ,[SDV]Life Sciences [q-bio] ,030204 cardiovascular system & hematology ,Overweight ,Cardiovascular ,Body Mass Index ,0302 clinical medicine ,Risk Factors ,maladie cardiovasculaire ,Child ,Prospective cohort study ,2. Zero hunger ,Multidisciplinary ,indice de masse corporelle ,Diabetic retinopathy ,Middle Aged ,3. Good health ,[SDV] Life Sciences [q-bio] ,obésité ,Meta-analysis ,030220 oncology & carcinogenesis ,Cardiology ,Retinal Disorders ,Medicine ,medicine.symptom ,Research Article ,Adult ,medicine.medical_specialty ,Systematic Reviews ,Adolescent ,Clinical Research Design ,Science ,Childhood obesity ,03 medical and health sciences ,SDG 3 - Good Health and Well-being ,Vascular Biology ,Internal medicine ,medicine ,Humans ,Obesity ,Cardiovascular Disease Epidemiology ,Nutrition ,Aged ,business.industry ,Retinal Vessels ,surpoids ,medicine.disease ,Ophthalmology ,Intima-media thickness ,Microvessels ,030221 ophthalmology & optometry ,Meta-Analyses ,Metabolic syndrome ,business ,Body mass index ,030217 neurology & neurosurgery - Abstract
International audience; Background: Overweight and obesity are thought to significantly influence a person's risk of cardiovascular disease, possibly via its effect on the microvasculature. Retinal vascular caliber is a surrogate marker of microvascular disease and a predictor of cardiovascular events. The aim of this systematic review and meta-analysis was to determine the association between body mass index (BMI) and retinal vascular caliber. Methods and Findings: Relevant studies were identified by searches of the MEDLINE and EMBASE databases from 1966 to August 2011. Standardized forms were used for data extraction. Among over 44,000 individuals, obese subjects had narrower arteriolar and wider venular calibers when compared with normal weight subjects, independent of conventional cardiovascular risk factors. In adults, a 1 kg/m(2) increase in BMI was associated with a difference of 0.07 mm [95% CI: -0.08; -0.06] in arteriolar caliber and 0.22 mu m [95% CI: 0.21; 0.23] in venular caliber. Similar results were found for children. Conclusions: Higher BMI is associated with narrower retinal arteriolar and wider venular calibers. Further prospective studies are needed to examine whether a causative relationship between BMI and retinal microcirculation exists.
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- 2013
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11. Orosomucoid, a new biomarker in the association between obesity and periodontitis
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Adrien Boillot, Jean-Marc Lacorte, Catherine Chaussain, Sébastien Czernichow, Sandrine Katsahian, Cécile Ciangura, Olivier Meilhac, Philippe Bouchard, Hélène Rangé, Christine Poitou, RANGE, Hélène, Hémostase, bio-ingénierie et remodelage cardiovasculaires (LBPC), Université Paris 13 (UP13)-Université Paris Diderot - Paris 7 (UPD7)-Institut Galilée-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Garanciere Rothschild Hospital, AP HP, Dept Periodontol, Service Odontologie, Garanciere Rothschild Hospital, Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases (ICAN), Université Pierre et Marie Curie - Paris 6 (UPMC)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Service de Nutrition [CHU Pitié-Salpétrière], Institut E3M [CHU Pitié-Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Cohortes épidémiologiques en population (CONSTANCES), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Université Paris Cité (UPCité), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Unité de Biostatistiques, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Henri Mondor-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Service d’informatique et statistiques, Université Paris Descartes - Paris 5 (UPD5), Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Diabète athérothrombose et thérapies Réunion Océan Indien (DéTROI), Université de La Réunion (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de Mise en Forme des Matériaux (CEMEF), Mines Paris - PSL (École nationale supérieure des mines de Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), Pathologies, Imagerie et Biothérapies oro-faciales (EA 2496), Service d'Odontologie [Bretonneau], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Bretonneau, Hémostase, bio-ingénierie et remodelage cardiovasculaires ( LBPC ), Université Paris Diderot - Paris 7 ( UPD7 ) -Université Paris 13 ( UP13 ) -Université Sorbonne Paris Cité ( USPC ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Institut Galilée, Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Institute of cardiometabolism and nutrition ( ICAN ), Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Assistance publique - Hôpitaux de Paris (AP-HP)-Institut National de la Santé et de la Recherche Médicale ( INSERM ) -CHU Pitié-Salpêtrière [APHP], Service de nutrition [CHU Pitié-Salpétrière], Assistance publique - Hôpitaux de Paris (AP-HP)-CHU Pitié-Salpêtrière [APHP], Cohortes Epidémiologiques en Population, Assistance publique - Hôpitaux de Paris (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Hopital La Pitie Salpetriere, AP HP, Dept Nutrition, CHU Pitié-Salpêtrière [APHP], Assistance publique - Hôpitaux de Paris (AP-HP)-Hôpital Henri Mondor-Université Paris-Est Créteil Val-de-Marne - Paris 12 ( UPEC UP12 ), Université Paris Descartes - Paris 5 ( UPD5 ), Hôpital Européen Georges Pompidou [APHP] ( HEGP ), Diabète athérothrombose et thérapies Réunion Océan Indien ( DéTROI ), Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université de la Réunion ( UR ), Centre de Mise en Forme des Matériaux ( CEMEF ), Centre National de la Recherche Scientifique ( CNRS ) -PSL Research University ( PSL ) -MINES ParisTech - École nationale supérieure des mines de Paris, Pathologies, Imagerie et Biothérapies oro-faciales ( EA 2496 ), Assistance publique - Hôpitaux de Paris (AP-HP)-Hôpital Bretonneau, Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Institute of cardiometabolism and nutrition (ICAN), Université Pierre et Marie Curie - Paris 6 (UPMC)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Pitié-Salpêtrière [APHP], UMS011 Cohortes épidémiologiques en population (CONSTANCES), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpital Henri Mondor-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de La Réunion (UR), Centre National de la Recherche Scientifique (CNRS)-PSL Research University (PSL)-MINES ParisTech - École nationale supérieure des mines de Paris, Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpital Bretonneau, Université Paris Diderot - Paris 7 (UPD7)-Université Paris 13 (UP13)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Galilée, Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Pitié-Salpêtrière [AP-HP], Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Université de Paris (UP), Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), MINES ParisTech - École nationale supérieure des mines de Paris, and CHU Rothschild [AP-HP]
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Bacterial Diseases ,Male ,[SDV]Life Sciences [q-bio] ,Orosomucoid ,030204 cardiovascular system & hematology ,0302 clinical medicine ,MESH : Cross-Sectional Studies ,Oral Diseases ,Risk Factors ,MESH: Risk Factors ,MESH : Orosomucoid ,Pathology ,MESH : Female ,MESH : Biomarkers ,Clinical Chemistry ,Multidisciplinary ,MESH: Middle Aged ,biology ,Middle Aged ,MESH : Adult ,MESH : Risk Factors ,Clinical Laboratory Sciences ,Obesity, Morbid ,3. Good health ,[SDV] Life Sciences [q-bio] ,Infectious Diseases ,C-Reactive Protein ,MESH: Orosomucoid ,Periodontal Abscesses ,Biomarker (medicine) ,Medicine ,Female ,Inflammation Mediators ,Research Article ,Adult ,medicine.medical_specialty ,MESH : Obesity, Morbid ,MESH : Male ,Science ,Oral Medicine ,MESH: Inflammation Mediators ,Adipokine ,MESH : Periodontitis ,Clinical nutrition ,MESH : Inflammation Mediators ,03 medical and health sciences ,MESH: Cross-Sectional Studies ,Diagnostic Medicine ,Internal medicine ,Diabetes mellitus ,MESH: C-Reactive Protein ,medicine ,Humans ,MESH : Middle Aged ,Obesity ,MESH: Periodontitis ,Periodontitis ,Nutrition ,Inflammation ,MESH: Humans ,Adiponectin ,[ SDV ] Life Sciences [q-bio] ,business.industry ,C-reactive protein ,MESH : Humans ,Immunity ,MESH: Adult ,030206 dentistry ,MESH : C-Reactive Protein ,medicine.disease ,MESH: Obesity, Morbid ,MESH: Male ,Cross-Sectional Studies ,Dentistry ,Immunology ,biology.protein ,MESH: Biomarkers ,Clinical Immunology ,business ,MESH: Female ,Biomarkers ,General Pathology - Abstract
International audience; Epidemiological data indicate an association between periodontitis and obesity. The biological mechanisms of this relationship remain unclear. A cross-sectional study was conducted to evaluate the relationship between periodontitis and the common systemic inflammatory markers in 32 morbidly obese patients recruited in a Clinical Nutrition department. Periodontal condition was evaluated using pocket depth (PD) measurement, a classical clinical marker of ongoing periodontitis. Major periodontal risk factors were recorded (age, gender, diabetes and smoking status), as well as plasma levels of inflammatory markers (CRP, orosomucoid, IL-6) and adipokines (adiponectin, leptin). All patients included in the sample exhibited evidence of periodontitis, 16 of whom were diagnosed as having severe disease. Adjusted logistic regression analysis indicated that the severity of periodontitis was associated with the plasma level of orosomucoid (p
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- 2013
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12. Education as a Predictor of Chronic Periodontitis: A Systematic Review with Meta-Analysis Population-Based Studies
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Sébastien Czernichow, Bechara El Halabi, Adrien Boillot, Hélène Rangé, George David Batty, and Philippe Bouchard
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Bacterial Diseases ,Gerontology ,Non-Clinical Medicine ,Epidemiology ,Clinical Research Design ,Science ,Oral Medicine ,Population ,MEDLINE ,Infectious Disease Epidemiology ,Oral Diseases ,Risk Factors ,Humans ,Medicine ,education ,Biology ,Socioeconomic status ,Periodontitis ,education.field_of_study ,Health Care Policy ,Multidisciplinary ,Population Biology ,business.industry ,medicine.disease ,Chronic periodontitis ,Socioeconomic Aspects of Health ,United States ,Educational attainment ,Social Epidemiology ,Review Literature as Topic ,Infectious Diseases ,Systematic review ,Health Education and Awareness ,Socioeconomic Factors ,Dentistry ,Meta-analysis ,Chronic Periodontitis ,Periodontal Abscesses ,Educational Status ,Public Health ,Meta-Analyses ,business ,Research Article - Abstract
BackgroundThe impact of socioeconomic inequalities on health is well-documented. Despite the links of periodontal disease with cardiovascular diseases, adverse pregnancy outcomes and diabetes, no meta-analysis of socioeconomic variations in periodontal disease exists. This meta-analytic review was conducted to determine the extent to which education attainment influences risk of periodontitis in adults aged 35+ years in the general population.MethodsThe authors searched studies published until November 2010 using EMBASE and MEDLINE databases. References listed were then scrutinised, our own files were checked, and, finally, we contacted experts in the field. The authors included only general population-based studies conducted in adults aged 35 years and more. All articles were blind reviewed by two investigators. In the case of disagreement, a third investigator arbitrated. Using PRISMA statement, two reviewers independently extracted papers of interest.ResultsRelative to the higher education group, people with low education attainment experience a greater risk of periodontitis (OR: 1.86 [1.66-2.10]; pConclusionsIn the studies reviewed, low educational attainment was associated with an increased risk of periodontitis. Although this evidence should be cautiously interpreted due to methodological problems in selected studies, efforts to eliminate educational inequalities in periodontitis should focus on early life interventions.
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- 2011
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13. Gingival inflammation, enamel defects, and tooth sensitivity in children with amelogenesis imperfecta: a case-control study
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Camille Quandalle, Adrien Boillot, Muriel De La Dure-Molla, Stéphane Kerner, Benjamin Fournier, and Pascal Garrec
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Male ,Dental plaque ,Dentistry ,Physical examination ,030207 dermatology & venereal diseases ,03 medical and health sciences ,Gingivitis ,0302 clinical medicine ,stomatognathic system ,Amelogenesis imperfecta ,medicine ,Humans ,Dental enamel ,Child ,General Dentistry ,Inflammation ,Dentin Sensitivity ,Dentin sensitivity ,medicine.diagnostic_test ,Enamel paint ,business.industry ,Case-control study ,RK1-715 ,030206 dentistry ,medicine.disease ,stomatognathic diseases ,visual_art ,Tooth Sensitivity ,Case-Control Studies ,visual_art.visual_art_medium ,Female ,Original Article ,medicine.symptom ,business - Abstract
Gingival conditions and tooth sensitivity of young patients with amelogenesis imperfecta lack in depth studies. This case-control study aimed to compare (1) the gingival inflammation, the presence of enamel defects, and tooth sensitivity in young patients with and without amelogenesis imperfecta and (2) to investigate if any difference exists between subtypes of amelogenesis imperfecta. Methodology We compared forty-two participants with amelogenesis imperfecta with forty-two controls matched for age, gender, and the number of examined sites. Based on interview, clinical examination, and intraoral photography, we collected data on periodontal conditions, enamel defects and the presence of tooth sensitivity. Comparison tests were performed to investigate if any difference existed between cases and controls; and among cases, between the different subtypes of amelogenesis imperfecta. We performed a post-hoc analysis for any significant difference observed. Results We observed more gingival inflammation, enamel defects and tooth sensitivity among cases (all p
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