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We have performed a multivariate analysis to explore the influence on birth and ultrasound fetal weight estimation of traditional factors as biochemical data and maternal characteristics in combination with non- traditionally explored predictors as paternal height, Pregnancy-associated plasma protein A (PAPP-A), single umbilical artery or Free-beta Human Chorionic Gonadotropin (fß- HCG). The study was performed for a Spanish population (region of Aragon) in singleton pregnancies at term (37-42 weeks). Also, we have created a nomogram and in order to predict the occurrence of SGA (small for gestational age) and LGA (large for gestational age) cases we provide a multivariate predictive model of fetal weight that have been compared with other models in the prediction of ultrasound and birth weights. After study we have created a software application for automated calculation of percentile fetal weight, adjusting the variables when they were significant.

Introduction: The placenta aging has been related with intrauterine fetal growth, low maternal age, Caucasian, multiparity, hypertensive states and smoking habit. Grannum P. classification is the most used for its assessment. The association between grade III placenta (G3P) and ex-smoking or smokeexposed pregnants has not been studied Main outcome: To asses if smoking, being an ex-smoker or a passive-smoker is a risk factor for developing grade III placenta, as well as if there is a smoking-free period of time to avoid the effect of smoking over placenta Material and methods: A retrospective case-control study of single pregnancies followed-up at the Obstetric Ultrasound Unit between January 2013 and January 2014. Placental grading according to Grannum classification was stablished through abdominal approach between 34-36 weeks of gestation and two groups were established: grade III placenta and grade I-II placenta (G1-2P) Maternal and paternal characteristics, type of delivery and perinatal outcomes were collected Results: Baseline characteristics were similar between the two groups. In G3P the incidence of hypertensive disease of pregnancy was higher(p=0,0107). The percentage was similar for premature birth, 1st and 5th minute Apgar, type of delivery and cesarean due to risk of loss of fetal wellbeing. A lower neonatal weight was found in G3P, at the same median days at delivery, with a mean difference of 148,156(p=0,008313. Regarding weight percentile, it was found a p35 in G3P and a p47,5 in G1- 2P(p=0,08235) 15% of the total pregnant were smokers. In G3P group it was found a higher frequency of smokers and ex-smokers since 1st trimester of pregnancy (p=0.0001), as well as pregnant non-smokers with an smoking partner(p=0,0001). There was an strong evidence for association between pregnant smokers and smoking partners(p=0,0001). No difference was found regarding to neonatal weight comparing smokers, ex-smokers and ex-smokers since 1st trimester of pregnancy. The length of pregnancy was lower between G3P pregnant smokers compared to G1-2P pregnant smokers, with a mean difference of 8 days (p=0,00091) Conclusions: There is a strong evidence for association between smoking during pregnancy, quitting smoking at the beginning of the pregnancy or being a passive smoker with development of G3P Some pregnant smokers don`t develop premature aging of placenta, it could be due to either other parameters or a later aging (data were collected between 34-36 weeks). The association between quitting smoking at the beginning of the pregnancy and not having a smoking partner reduces the risk of developing G3P

21 pages, 10 figures, 1 table., [EN] The “Sima del Elefante” (TE site) (Atapuerca, Spain) is a major cave infill with a stratigraphic succession 25 m thick and 15 m wide, wealthy in animal bones and evidences of human occupation at different Pleistocene ages. TE site is under systematic excavation since 1996, and the inferior and superior levels are being dug up independently. The exposed section has been divided into 21 lito-stratigraphic units defined by major unconformities. Concerning the cave history, at least three main infill phases have been identified. The lower phase (TE8-TE14) is dated to Early Pleistocene (between 1.1 and 1.4 million years ago) on the basis of inverse paleomagnetics and belonging to the later Early Pleistocene on the basis of biochronology. The TE lower phase is providing a rich faunal assemblage, and shows evidence of human occupation. A set of stone tools of flint, and possibly, calcareous, is being found at these levels. Hence, the lower part of the TE section documents early presence of hominids in Europe and constituted an important element in the understanding of human dispersions out-of-Africa. The middle phase (TE15-TE19) dated to Middle Pleistocene and it is further sud-divided into a basal part (TE15-TE17), still largely unexplored, but no vertebrate fossil record is present at this levels. Units TE18, and mainly TE19 unit, date to late Middle Pleistocene, and contain an abundant record of large mammals as well as stone tools included in calcareous breccias. The TE19 G level contains abundant pieces of charcoal, though verification of its antropic character is pending. Finally, the third and last sedimentary phase (TE20 and TE21) date to Last Pleistocene and it defined the final infilling of the cavity and soil formation. The chronological intervals represented in the fertile levels of the Sima del Elefante enlarge the temporal and biostratigraphic local succession at the Atapuerca Hill complex. The lower phase was deposited in a time previous to the lower levels from Gran Dolina site (TD4), whereas the TE upper levels possibly correspond to a moment later than the sedimentation of Galería GIII/GIV, and Gran Dolina TD10/TD11. In addition, the structural features of the TE site together with its sedimentary and arqueo-paleontological record allow the eventual exploration of problems that remain unresolved in other Atapuerca cave sites., [ES] El yacimiento de la Sima del Elefante (TE) (Atapuerca, España) se localiza en el extremo sur de la trinchera del ferrocarril de la Sierra de Atapuerca. TE constituye una sección transversal de una antigua galería kárstica totalmente colmatada de sedimentos pleistocenos. La secuencia estratigráfica completa alcanza los 25 m de potencia y ha sido dividida en 21 unidades lito-estratigráficas delimitadas por discontinuidades mayores. La historia de la cavidad puede ordenarse en al menos tres fases. La fase inferior (niveles TE8 a TE14) data del tercio final del Pleistoceno Inferior, con una cronología entre 1.1 y 1.4 millones de años. Es rica en registro arqueo-paleontológico y presenta claras evidencias de actividad antrópica. Dada su cronología, los niveles inferiores de TE representan un importante referente para la comprensión de la primera colonización humana de Europa. La fase intermedia la constituyen las unidades TE15 a TE19. El tramo basal de esta segunda fase de relleno (TE15 a TE17) hasta la fecha no ha deparado contenido fósil. El tramo superior (TE18 y TE19), cuya cronología parece corresponder a la parte final del Pleistoceno Medio, es rica en restos de grandes mamíferos e industria lítica sobre sílex y cuarcita. La unidad TE19 se caracteriza por una sucesión de coladas detríticas (“debris-flow”) (TE19A a TE19G), con matriz muy dura y carbonatada, rica en huesos de grandes mamíferos y ausencia de micromamíferos. El nivel TE19G contiene abundantes restos de carbón pendiente de verificar su posible carácter antrópico. Finalmente, la tercera y última fase de relleno (TE20 y TE21) corresponde al Pleistoceno superior y se define por la colmatación final de la cavidad y formación de un horizonte edáfico. Los intervalos cronológicos representados en los niveles fértiles de la Sima del Elefante (TE) complementan la secuencia cronológica y bioestratigráfica local del complejo Atapuerca. La fase inferior de TE tuvo lugar en un tiempo anterior a los niveles inferiores de Gran Dolina (TD4), mientras que el relleno de las unidades superiores de TE corresponde a un momento posterior a la sedimentación de GIII/GIV de Galería y TD10/TD11 de Gran Dolina., The MCYT Project BOS2003-08938- C03-02, and the CSIC Unidades Asociadas program have funded this research. The government of Junta de Castilla y León funded fieldwork. Thanks are also given to the Fundación Atapuerca for his financial support to several authors of this contribution.

10.1016/j.anthro.2013.08.003

118 páginas

10.1016/j.quascirev.2012.04.008 According to pollen analysis and the 18O-isotope curve, the first part of the Late Pleistocene (ca 128-30 ka) is mainly characterized by a dynamic that alternates cold phases (Heinrich Events) and temperate phases (interstadials). These rapid fluctuations provide the context for the Neanderthal occupations in the northeastern part of the Iberian Peninsula. In this paper we present the chronological, environmental and climatic data obtained by analyzing the pollen, the charcoal, the small vertebrates (amphibians, squamates and small mammals) and the large-mammal dental wear at the Neanderthal site of Teixoneres cave, Northeastern Iberia. Levels II and III from this cavity have provided Mousterian industries and other evidence of Neanderthal occupations, such as cut-marks in large-mammal bones. A multiproxy study such as this constitutes a new approach to the chronological, environmental and climatic context in which Neanderthal populations lived in southwestern Europe (Iberian Peninsula). The results allow us to establish a relative chronology for these two levels of between ca 30-90 ka and show that they are associated with different environmental and climatic conditions: temperate and humid for Level III and cold and dry for Level II. This demonstrates that the Neanderthals were well adapted to the territory that they occupied, irrespective of the climatic conditions.

Filiació URV: SI Kaldar Cave is a key archaeological site that provides evidence of the Middle to Upper Palaeolithic transition in Iran. Excavations at the site in 2014-2015 led to the discovery of cultural remains generally associated with anatomically modern humans (AMHs) and evidence of a probable Neanderthal-made industry in the basal layers. Attempts have been made to establish a chronology for the site. These include four thermoluminescence (TL) dates for Layer 4, ranging from 23,100 ± 3300 to 29,400 ± 2300 BP, and three AMS radiocarbon dates from charcoal samples belonging to the lower part of the same layer, yielding ages of 38,650-36,750 cal BP, 44,200-42,350 cal BP, and 54,400-46,050 cal BP (all at the 95.4% confidence level). Kaldar Cave is the first well-stratified Late Palaeolithic locality to be excavated in the Zagros which is one of the earliest sites with cultural materials attributed to early AMHs in western Asia. It also offers an opportunity to study the technological differences between the Mousterian and the first Upper Palaeolithic lithic technologies as well as the human behaviour in the region. In this study, we present a detailed description of the newly excavated stratigraphy, quantified results from the lithic assemblages, preliminary faunal remains analyses, geochronologic data, taphonomic aspects, and an interpretation of the regional paleoenvironment.

Vallone Inferno rock-shelter is an archaeological site located in the Madonie mountain range in Sicily. Archaeological excavation and research have provided a long prehistoric and historic sequence from the Neolithic to the medieval period, this being the most complete work in this area at present. In this paper we present the preliminary data provided by a multidisciplinary study based on pottery, lithic, human, faunal and plant remains. Stratigraphic studies have identified four complexes, of which complex 3 has provided almost all the archaeological remains. 14C AMS dates, obtained from four samples, place the human activities between 2601 cal BC and 644 cal AD. These dates are coherent with the cultural attribution of the ceramic and lithic remains. Macrofaunal and plant remains show a persistent use of the shelter for pastoral activities. Environmental data, obtained from microvertebrate and archaeobotanical remains, show the aridification and opening of the landscape from the base to the top of the sequence as a consequence of the human impact. © 2012 Académie des sciences. Published by Elsevier Masson SAS. All rights reserved.