7 results on '"Amalia Farina"'
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2. KCTD15 Is Overexpressed in her2+ Positive Breast Cancer Patients and Its Silencing Attenuates Proliferation in SKBR3 CELL LINE
- Author
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Luigi Coppola, Simona Baselice, Francesco Messina, Rosa Giannatiempo, Amalia Farina, Luigi Vitagliano, Giovanni Smaldone, and Marco Salvatore
- Subjects
breast cancer ,KCTD15 ,HER2+ ,breast cancer subtypes ,biomarker ,Medicine (General) ,R5-920 - Abstract
Studies carried out in the last decade have demonstrated that the members of the KCTD protein family play active roles in carcinogenesis. Very recently, it has been reported that KCTD15, a protein typically associated with other physio-pathological processes, is involved in medulloblastoma and leukemia. Starting with some preliminary indications that emerged from the analysis of online databases that suggested a possible overexpression of KCTD15 in breast cancer, in this study, we evaluated the expression levels of the protein in breast cancer cell lines and in patients and the effects of its silencing in the HER2+ cell model. The analysis of the KCTD15 levels indicates a significant overexpression of the protein in Luminal A and Luminal B breast cancer patients as well as in the related cell lines. The greatest level of over-expression of the protein was found in HER2+ patients and in the related SKBR3 cell line model system. The effects of KCTD15 silencing in terms of cell proliferation, cell cycle, and sensitivity to doxorubicin were evaluated in the SKBR3 cell line. Notably, the KCTD15 silencing in SKBR3 cells by CRISPR/CAS9 technology significantly attenuates their proliferation and cell cycle progression. Finally, we demonstrated that KCT15 silencing also sensitized SKBR3 cells to the cytotoxic agent doxorubicin, suggesting a possible role of the protein in anti HER2+ therapeutic strategies. Our results highlight a new possible player in HER2 breast cancer carcinogenesis, paving the way for its use in breast cancer diagnosis and therapy.
- Published
- 2022
- Full Text
- View/download PDF
3. Mediterranean diet and quality of life in women treated for breast cancer: A baseline analysis of DEDiCa multicentre trial.
- Author
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Giuseppe Porciello, Concetta Montagnese, Anna Crispo, Maria Grimaldi, Massimo Libra, Sara Vitale, Elvira Palumbo, Rosa Pica, Ilaria Calabrese, Serena Cubisino, Luca Falzone, Luigina Poletto, Valentina Martinuzzo, Melania Prete, Nadia Esindi, Guglielmo Thomas, Daniela Cianniello, Monica Pinto, Michelino De Laurentiis, Carmen Pacilio, Massimo Rinaldo, Massimiliano D'Aiuto, Diego Serraino, Samuele Massarut, Chiara Evangelista, Agostino Steffan, Francesca Catalano, Giuseppe L Banna, Giuseppa Scandurra, Francesco Ferraù, Rosalba Rossello, Giovanna Antonelli, Gennaro Guerra, Amalia Farina, Francesco Messina, Gabriele Riccardi, Davide Gatti, David J A Jenkins, Anita Minopoli, Bruna Grilli, Ernesta Cavalcanti, Egidio Celentano, Gerardo Botti, Maurizio Montella, and Livia S A Augustin
- Subjects
Medicine ,Science - Abstract
Evidence suggests a beneficial role of the Mediterranean Diet (MedDiet) on health-related quality of life (HRQoL) in healthy subjects. HRQoL is relevant in cancer therapy and disease outcomes, therefore we investigated the association between adherence to the MedDiet and HRQoL in breast cancer survivors participating in the multicentre trial DEDiCa. Diet and HRQoL were assessed at baseline in a subgroup of 309 women enrolled within 12 months of breast cancer diagnosis without metastasis (stages I-III, mean age 52±1 yrs, BMI 27±7 kg/m2). The 14-item PREDIMED questionnaire was used to analyse adherence to the MedDiet. HRQoL was assessed with three validated questionnaires measuring physical, mental, emotional and social factors: EQ-5D-3L, EORTC QLQ-C30 and EORTC QLQ-BR23. Analysis of variance (ANOVA) and multivariate analyses were performed to assess the possible role of the MedDiet on HRQoL. Patients with higher adherence to MedDiet (PREDIMED score >7) showed significantly higher scores for physical functioning (p = 0.02) and lower scores on the symptomatic pain scale (p = 0.04) assessed by the EORTC QLQ-C30 questionnaire compared to patients with a lower adherence to MedDiet (PREDIMED score ≤7). Higher scores from the EQ-5D-3L indicating higher well-being were observed mainly in participants with higher MedDiet adherence (p = 0.05). In adjusted multivariate analyses significant positive associations were found between MedDiet, physical functioning (p = 0.001) and EQ 5D-3L score (p = 0.003) while inverse associations were found with pain and insomnia symptoms (p = 0.005 and p = 0.029, respectively). These results suggest that higher adherence to the MedDiet in breast cancer survivors is associated with better aspects of quality of life, specifically higher physical functioning, better sleep, lower pain and generally higher well-being confirming findings in healthy subjects.
- Published
- 2020
- Full Text
- View/download PDF
4. Quality of life in women diagnosed with breast cancer after a 12-month treatment of lifestyle modifications
- Author
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Giovanna Antonelli, Agostino Steffan, Livia S. A. Augustin, Samuele Massarut, Diego Serraino, Monica Pinto, Francesco Ferraù, Concetta Montagnese, Amalia Farina, Anna Crispo, Francesco Messina, Pasqualina C. Fiorillo, Ilaria Calabrese, Laura Caggiari, Anita Minopoli, Gennaro Guerra, Flavia Nocerino, Maria Grazia Grimaldi, Elvira Palumbo, Massimiliano D’Aiuto, Daniela Cianniello, Rosa Pica, Chiara Evangelista, Massimo Rinaldo, Giuseppa Scandurra, Michelino De Laurentiis, Nadia Esindi, Marco Cuomo, Gabriele Riccardi, Melania Prete, Gerardo Botti, Massimo Libra, Serena Cubisino, Guglielmo Thomas, Davide Gatti, Giuseppe Luigi Banna, Valentina Martinuzzo, David J.A. Jenkins, Sergio Coluccia, Giuseppe Porciello, Ernesta Cavalcanti, Francesca Catalano, Rosalba Rossello, Luca Falzone, S. Vitale, Bruna Grilli, Luigina Poletto, Egidio Celentano, Carmen Pacilio, Montagnese, C., Porciello, G., Vitale, S., Palumbo, E., Crispo, A., Grimaldi, M., Calabrese, I., Pica, R., Prete, M., Falzone, L., Libra, M., Cubisino, S., Poletto, L., Martinuzzo, V., Coluccia, S., Esindi, N., Nocerino, F., Minopoli, A., Grilli, B., Fiorillo, P. C., Cuomo, M., Cavalcanti, E., Thomas, G., Cianniello, D., Pinto, M., De Laurentiis, M., Pacilio, C., Rinaldo, M., D'Aiuto, M., Serraino, D., Massarut, S., Caggiari, L., Evangelista, C., Steffan, A., Catalano, F., Banna, G. L., Scandurra, G., Ferrau, F., Rossello, R., Antonelli, G., Guerra, G., Farina, A., Messina, F., Riccardi, G., Gatti, D., Jenkins, D. J. A., Celentano, E., Botti, G., and Augustin, L. S. A.
- Subjects
Adult ,Quality of life ,medicine.medical_specialty ,Constipation ,Mediterranean diet ,Nausea ,Health Status ,Breast Neoplasms ,lcsh:TX341-641 ,Survivorship ,Diet, Mediterranean ,Diet Surveys ,Article ,03 medical and health sciences ,0302 clinical medicine ,Breast cancer ,Cancer Survivors ,Internal medicine ,Surveys and Questionnaires ,medicine ,Vitamin D and neurology ,Humans ,030212 general & internal medicine ,Healthy Lifestyle ,Vitamin D ,Nutrition and Dietetics ,business.industry ,Physical activity ,social sciences ,Middle Aged ,medicine.disease ,Lifestyle ,humanities ,Exercise Therapy ,Treatment Outcome ,030220 oncology & carcinogenesis ,Dietary Supplements ,Vomiting ,Patient Compliance ,Female ,Analysis of variance ,medicine.symptom ,business ,lcsh:Nutrition. Foods and food supply ,Food Science - Abstract
Healthy lifestyles are associated with better health-related quality of life (HRQoL), favorable prognosis and lower mortality in breast cancer (BC) survivors. We investigated changes in HRQoL after a 12-month lifestyle modification program in 227 BC survivors participating in DEDiCa trial (Mediterranean diet, exercise, vitamin D). HRQoL was evaluated through validated questionnaires: EQ-5D-3L, EORTC-QLQ-C30 and EORTC QLQ-BR23. Baseline changes were tested using analysis of variance. Multiple regression analyses were performed to assess treatment effects on HRQoL. Increases were observed in global health status (p <, 0.001), physical (p = 0.003), role (p = 0.002) and social functioning (p <, 0.001), body image (p <, 0.001), future perspective (p <, 0.001), well-being (p = 0.001), and reductions in fatigue (p <, 0.001), nausea and vomiting (p = 0.015), dyspnea (p = 0.001), constipation (p = 0.049), financial problems (p = 0.012), sexual functioning (p = 0.025), systematic therapy side effects (p <, 0.001) and breast symptoms (p = 0.004). Multiple regression analyses found inverse associations between changes in BMI and global health status (p = 0.048) and between serum 25(OH)D levels and breast symptoms (p = 0.002). A healthy lifestyle treatment of traditional Mediterranean diet and exercise may impact positively on HRQoL in BC survivors possibly through reductions in body weight while vitamin D sufficiency may improve BC-related symptoms. These findings are relevant to BC survivors whose lower HRQoL negatively affects treatment compliance and disease outcomes.
- Published
- 2021
5. Mediterranean diet and quality of life in women treated for breast cancer: A baseline analysis of DEDiCa multicentre trial
- Author
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Massimo Rinaldo, Valentina Martinuzzo, Samuele Massarut, Melania Prete, Massimiliano D’Aiuto, Giovanna Antonelli, Maurizio Montella, Agostino Steffan, Anna Crispo, Diego Serraino, Francesco Ferraù, Amalia Farina, Bruna Grilli, Luigina Poletto, Francesca Catalano, S. Vitale, Rosalba Rossello, Francesco Messina, Serena Cubisino, Massimo Libra, Livia S. A. Augustin, Giuseppe Porciello, Monica Pinto, Ernesta Cavalcanti, Concetta Montagnese, Rosa Pica, Chiara Evangelista, Nadia Esindi, Gennaro Guerra, Daniela Cianniello, Gabriele Riccardi, Egidio Celentano, Elvira Palumbo, Giuseppa Scandurra, Gerardo Botti, Ilaria Calabrese, Carmen Pacilio, Giuseppe Luigi Banna, Guglielmo Thomas, Luca Falzone, Anita Minopoli, Maria Grazia Grimaldi, Michelino De Laurentiis, Davide Gatti, and David J.A. Jenkins
- Subjects
Multivariate analysis ,Mediterranean diet ,Physiology ,Cancer Treatment ,Mediterranean ,Diet, Mediterranean ,Medical Conditions ,0302 clinical medicine ,Quality of life ,Cancer Survivors ,Pain assessment ,Sleep Initiation and Maintenance Disorders ,Surveys and Questionnaires ,Breast Tumors ,Epidemiology ,Medicine and Health Sciences ,030212 general & internal medicine ,Multidisciplinary ,Pain scale ,Middle Aged ,humanities ,Oncology ,Neurology ,Physiological Parameters ,Italy ,030220 oncology & carcinogenesis ,Medicine ,Female ,Research Article ,Adult ,medicine.medical_specialty ,Insomnia ,Science ,Pain ,Breast Neoplasms ,03 medical and health sciences ,Signs and Symptoms ,Breast cancer ,Internal medicine ,Breast Cancer ,medicine ,Humans ,Nutrition ,Aged ,Cancer survivor ,business.industry ,Body Weight ,Cancers and Neoplasms ,Biology and Life Sciences ,Correction ,medicine.disease ,Dyssomnias ,Diet ,Health Care ,Quality of Life ,Patient Compliance ,Clinical Medicine ,Sleep Disorders ,business - Abstract
Evidence suggests a beneficial role of the Mediterranean Diet (MedDiet) on health-related quality of life (HRQoL) in healthy subjects. HRQoL is relevant in cancer therapy and disease outcomes, therefore we investigated the association between adherence to the MedDiet and HRQoL in breast cancer survivors participating in the multicentre trial DEDiCa. Diet and HRQoL were assessed at baseline in a subgroup of 309 women enrolled within 12 months of breast cancer diagnosis without metastasis (stages I-III, mean age 52±1 yrs, BMI 27±7 kg/m2). The 14-item PREDIMED questionnaire was used to analyse adherence to the MedDiet. HRQoL was assessed with three validated questionnaires measuring physical, mental, emotional and social factors: EQ-5D-3L, EORTC QLQ-C30 and EORTC QLQ-BR23. Analysis of variance (ANOVA) and multivariate analyses were performed to assess the possible role of the MedDiet on HRQoL. Patients with higher adherence to MedDiet (PREDIMED score >7) showed significantly higher scores for physical functioning (p = 0.02) and lower scores on the symptomatic pain scale (p = 0.04) assessed by the EORTC QLQ-C30 questionnaire compared to patients with a lower adherence to MedDiet (PREDIMED score ≤7). Higher scores from the EQ-5D-3L indicating higher well-being were observed mainly in participants with higher MedDiet adherence (p = 0.05). In adjusted multivariate analyses significant positive associations were found between MedDiet, physical functioning (p = 0.001) and EQ 5D-3L score (p = 0.003) while inverse associations were found with pain and insomnia symptoms (p = 0.005 and p = 0.029, respectively). These results suggest that higher adherence to the MedDiet in breast cancer survivors is associated with better aspects of quality of life, specifically higher physical functioning, better sleep, lower pain and generally higher well-being confirming findings in healthy subjects.
- Published
- 2020
6. MODEL BANGKITAN AKTIVITAS BERSAMA BERDASARKAN TIPE RUMAH TANGGARN(JOINT ACTIVITY GENERATION MODELS BASED ON HOUSEHOLD TYPES)
- Author
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Dessy Amalia Farina and Dessy Amalia Farina
- Abstract
ABSTRAKPendekatan berbasis aktivitas memungkinkan adanya penilaian yang lebih rinci untuk menjadi dasar membuat suatu kebijakan dalam bidang transportasi, khususnya dalam konteks pengambilan keputusan tingkat rumah tangga untuk mengetahui tingkat kebutuhan sarana dan prasarana transportasi yang diperlukan. Penelitian ini bertujuan untuk mendapatkan model kebutuhan pergerakan aktivitas bersama dengan mengidentifikasi faktor-faktor yang mempengaruhi terjadinya pergerakan tersebut serta mendapatkan tingkatan pengaruh dari faktor-faktor tersebut terhadap bangkitan aktivitas yang dilakukan secara bersama antara anggota keluarga. Tipe rumah tangga yang diteliti yaitu rumah tangga tanpa anak, rumah tangga dengan 1-2 orang anak dan rumah tangga yang mempunyai anak lebih dari dua orang. Tipe rumah tangga yang mempunyai anak dibagi lagi menurut tingkat usia anak yaitu rumah tangga yang mempunyai anak dibawah 12 tahun dan yang mempunyai anak diatas 12 tahun. Survei primer dilakukan melalui pengisian kuesioner pada 1650 kepala keluarga (KK) yang bertempat tinggal di kota Banda Aceh. Hasil dari kuesioner kemudian dianalisis dengan metode Chi-squared Automatic Interaction Detector (CHAID) dan untuk memodelkan bangkitan pergerakan berdasarkan aktivitasnya dipakai Decisions Tree Model. Dari analisis yang diperoleh untuk tipe rumah tangga tanpa anak aktivitas bersama yang paling besar presentasenya adalah aktivitas berbelanja sebesar 45,4%. Tipe rumah tangga dengan 1-2 anak dan masih memiliki anak berumur dibawah 12 tahun aktivitas yang paling dominan adalah antar jemput sebesar 54,0% sedangkan untuk rumah tangga yang tidak memiliki anak berumur dibawah 12 sebesar 36,4%. Untuk tipe rumah tangga yang memiliki anak lebih dari dua orang dan masih memiliki anak berumur dibawah 12 tahun aktivitas antar jemput juga yang paling dominan sebesar 60,2% dan untuk rumah tangga yang tidak memiliki anak berumur 12 tahun sebesar 38,2%.Kata kunci : bangkitan berbasis aktivitas, tipe rumah tangga, D, Banda Aceh
- Published
- 2014
7. MODEL BANGKITAN AKTIVITAS BERSAMA BERDASARKAN TIPE RUMAH TANGGA
- Author
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Dessy Amalia Farina and Dessy Amalia Farina
- Abstract
ABSTRAKPendekatan berbasis aktivitas memungkinkan adanya penilaian yang lebih rinci untuk menjadi dasar membuat suatu kebijakan dalam bidang transportasi, khususnya dalam konteks pengambilan keputusan tingkat rumah tangga untuk mengetahui tingkat kebutuhan sarana dan prasarana transportasi yang diperlukan. Penelitian ini bertujuan untuk mendapatkan model kebutuhan pergerakan aktivitas bersama dengan mengidentifikasi faktor-faktor yang mempengaruhi terjadinya pergerakan tersebut serta mendapatkan tingkatan pengaruh dari faktor-faktor tersebut terhadap bangkitan aktivitas yang dilakukan secara bersama antara anggota keluarga. Tipe rumah tangga yang diteliti yaitu rumah tangga tanpa anak, rumah tangga dengan 1-2 orang anak dan rumah tangga yang mempunyai anak lebih dari dua orang. Tipe rumah tangga yang mempunyai anak dibagi lagi menurut tingkat usia anak yaitu rumah tangga yang mempunyai anak dibawah 12 tahun dan yang mempunyai anak diatas 12 tahun. Survei primer dilakukan melalui pengisian kuesioner pada 1650 kepala keluarga (KK) yang bertempat tinggal di kota Banda Aceh. Hasil dari kuesioner kemudian dianalisis dengan metode Chi-squared Automatic Interaction Detector (CHAID) dan untuk memodelkan bangkitan pergerakan berdasarkan aktivitasnya dipakai Decisions Tree Model. Dari analisis yang diperoleh untuk tipe rumah tangga tanpa anak aktivitas bersama yang paling besar presentasenya adalah aktivitas berbelanja sebesar 45,4%. Tipe rumah tangga dengan 1-2 anak dan masih memiliki anak berumur dibawah 12 tahun aktivitas yang paling dominan adalah antar jemput sebesar 54,0% sedangkan untuk rumah tangga yang tidak memiliki anak berumur dibawah 12 sebesar 36,4%. Untuk tipe rumah tangga yang memiliki anak lebih dari dua orang dan masih memiliki anak berumur dibawah 12 tahun aktivitas antar jemput juga yang paling dominan sebesar 60,2% dan untuk rumah tangga yang tidak memiliki anak berumur 12 tahun sebesar 38,2%.Kata kunci : bangkitan berbasis aktivitas, tipe rumah tangga, D
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