1. Early systemic sclerosis: assessment of clinical and pre-clinical organ involvement in patients with different disease features
- Author
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Domenico Cozzolino, Gianmattia del Genio, Gabriele Valentini, Giovanna Cuomo, Serena Vettori, Alessia Capasso, Giuseppina Abignano, Carlo Santoriello, Ambrogio Petrillo, Valentini, Gabriele, Cuomo, Giovanna, Abignano, G, Petrillo, A, Vettori, Serena, Capasso, A, Cozzolino, D, DEL GENIO, Gianmattia, and Santoriello, C.
- Subjects
Adult ,Lung Diseases ,Male ,medicine.medical_specialty ,Time Factors ,Adolescent ,Heart Diseases ,Gastrointestinal Diseases ,Physical examination ,Systemic scleroderma ,Gastroenterology ,Scleroderma ,Young Adult ,Rheumatology ,Predictive Value of Tests ,Internal medicine ,medicine ,Humans ,Pharmacology (medical) ,skin and connective tissue diseases ,Telangiectasia ,Child ,Aged ,Scleroderma, Systemic ,integumentary system ,medicine.diagnostic_test ,business.industry ,Autoantibody ,Heartburn ,Raynaud Disease ,Middle Aged ,medicine.disease ,Dysphagia ,Surgery ,Early Diagnosis ,Predictive value of tests ,Disease Progression ,Female ,Kidney Diseases ,medicine.symptom ,business - Abstract
OBJECTIVE To assess internal organ involvement in early SSc at presentation. METHODS One hundred and fifteen patients admitted to a tertiary centre because of RP, who did not present any routinely detectable scleroderma-related internal organ involvement, were investigated for ANA and videocapillaroscopy, and underwent history and physical examination to detect symptoms/signs suggestive of SSc. Patients were then subdivided into three groups: (i) early SSc, constituted by patients without clinical manifestations other than RP, but with scleroderma marker autoantibodies and/or typical capillaroscopic abnormalities; (ii) probable SSc, constituted by patients with the same autoantibody and/or capillaroscopic status as early SSc patients, but with any of the following manifestations: digital ulcers/scars, puffy fingers, arthritis, telangiectasia, dysphagia/heartburn, shortness of breath; (iii) UCTD, constituted by patients with a specific (i.e. disease antibody marker) ANA and capillaroscopic findings plus any disease manifestation. All patients were investigated by lung functional study and B-mode echo-Doppler-cardiography. Patients who consented underwent oesophageal manometry. RESULTS An inverted mitral E : A ratio (i.e. early scleroderma cardiac involvement) and/or a diffusing lung capacity for CO
- Published
- 2011