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It has been reported previously that the offspring of rat dams consuming low dietary copper (Cu) during pregnancy and lactation experience a deficiency in cardiac cytochrome c oxidase (CCO) characterized by reduced catalytic activity and mitochondrial and nuclear subunit content after postnatal d 10. The present study was undertaken to determine whether the cardiac CCO deficiency was caused directly by low postnatal Cu intake or whether it was a prenatal effect of low Cu intake by the dams that became manifest postnatally. Dams were fed either a Cu-adequate diet (6 mg Cu/kg) or Cu- deficient diet (1 mg Cu/kg) beginning 3 wk before conception and throughout gestation and lactation. One day following parturition, several litters from Cu-adequate dams were cross fostered to Cu-deficient dams and several litters from Cu-deficient dams were cross fostered to Cu-adequate dams. Litters that remained with their birth dams served as controls. CCO activity, the content of the mitochondrial-encoded CCO subunit 1 (COX1), and the content of the nuclear- encoded subunit COX4 in cardiac mitochondria were reduced in the 21-d-old offspring of Cu-deficient dams. COX1 content was normal in the 21-d-old cross-fostered offspring of Cu-deficient dams, but CCO activity and COX4 were reduced. Cross fostering the offspring of Cu-adequate dams to Cu-deficient dams did not significantly affect CCO activity, COX1 content, or COX4 content in cardiac mitochondria of 21-d-old offspring. These data indicate that low prenatal Cu intake by dams was the determinant of CCO activity in cardiac mitochondria of the 21-d-old offspring and may have led to the assembly of a less-than-fully active holoenzyme.

The etiology of pre-eclampsia (PE) is unknown; but it has been long acknowledged that normal pregnancy represents a distinctive challenge to the maternal immune system. Maladaptive responses to this challenge [...]

The etiology of pre-eclampsia (PE) is unknown; but it has been long acknowledged that normal pregnancy represents a distinctive challenge to the maternal immune system. Maladaptive responses to this challenge [...]

The etiology of pre-eclampsia (PE) is unknown; but endothelial dysfunction has been hypothesized to play a tole since at least the early 1990's (1). While a number of genes involved [...]

Background: The etiology of pre-eclampsia (PE) is unknown; but endothelial dysfunction has been hypothesized to play a role since at least the early 1990's. (1) A hallmark of endothelial function [...]

Several investigators have suggested that fetal stress predisposes the adult to pathologic conditions including insulin resistance, atherosclerosis, and hypertension [1, 2]. Yet, little is known about the mechanism contributing to [...]

Preeclampsia, a form of pregnancy-induced hypertension complicating 6-8% of pregnancies, plays a major role in fetal growth restriction and premature birth as well as infant and maternal morbidity and mortality [...]

Functional studies from our lab suggested that portosystemic shunting other than elevated portal venous pressure is responsible for the altered vascular responses presented in hyperdynamic circulation in chronic portal hypertension [...]

Pregnancy is a physiological process that requires a synchronized adaptation of multiple organ systems. Increased blood flow to the uterus and cardiac output are hallmarks of the characteristic hemodynamic alterations [...]

It has been reported previously that the offspring of rat dams consuming low dietary copper (Cu) during pregnancy and lactation experience a deficiency in cardiac cytochrome c oxidase (CCO) characterized by reduced catalytic activity and mitochondrial and nuclear subunit content after postnatal d 10. The present study was undertaken to determine whether the cardiac CCO deficiency was caused directly by low postnatal Cu intake or whether it was a prenatal effect of low Cu intake by the dams that became manifest postnatally. Dams were fed either a Cu-adequate diet (6 mg Cu/kg) or Cu- deficient diet (1 mg Cu/kg) beginning 3 wk before conception and throughout gestation and lactation. One day following parturitiori, several litters from Cu-adequate dams were cross fostered to Cu-deficient dams and several litters from Cu- deficient dams were cross fostered to Cu-adequate dams. Litters that remained with their birth dams served as controls. CCO activity, the content of the mitochondrial-encoded CCO subunit 1 )COX1), and the content of the nuclear-encoded subunit COX4 in cardiac mitochondria were reduced in the 21-d-old offspring of Cu-deficient dams. COX1 content was normal in the 21-d-old cross-fostered offspring of Cu-deficient dams, but CCO activity and COX4 were reduced. Cross fostering the offspring of Cu-adequate dams to Cu-deficient dams did not significantly affect CCO activity, COX1 content, or COX4 content in cardiac mitochondria of 21-d-old offspring. These data indicate that low prenatal Cu intake by dams was the determinant of CCO activity in cardiac mitochondria of the 21-d-old offspring and may have led to the assembly of a less-than-fully active holoenzyme. [ABSTRACT FROM AUTHOR]

Precision health refers to personalized healthcare based on a person's unique genetic, genomic, or omic composition within the context of lifestyle, social, economic, cultural and environmental influences to help individuals achieve well-being and optimal health. Precision health utilizes big data sets that combine omics (i.e. genomic sequence, protein, metabolite, and microbiome information) with clinical information and health outcomes to optimize disease diagnosis, treatment and prevention specific to each patient. Successful implementation of precision health requires interprofessional collaboration, community outreach efforts, and coordination of care, a mission that nurses are well-positioned to lead. Despite the surge of interest and attention to precision health, most nurses are not well-versed in precision health or its implications for the nursing profession. Based on a critical analysis of literature and expert opinions, this paper provides an overview of precision health and the importance of engaging the nursing profession for its implementation. Other topics reviewed in this paper include big data and omics, information science, integration of family health history in precision health, and nursing omics research in symptom science. The paper concludes with recommendations for nurse leaders in research, education, clinical practice, nursing administration and policy settings for which to develop strategic plans to implement precision health., (© 2020 Chinese Nursing Association. Production and hosting by Elsevier B.V.)