1. Arresting metastasis within the microcirculation
- Author
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Julia Perea Paizal, Sam H. Au, Chris Bakal, and Angelos Varotsos Vrynas
- Subjects
0301 basic medicine ,Platelets ,Cancer Research ,medicine.medical_specialty ,Neutrophils ,Microcirculation ,Metastasis ,03 medical and health sciences ,0302 clinical medicine ,Immune system ,Microvasculature ,Surgical oncology ,Internal medicine ,Circulating tumour cells ,Capillary Beds ,Medicine ,Humans ,Platelet ,Biomechanics ,Neoplasm Metastasis ,Cancer ,Hematology ,business.industry ,Immune cells ,General Medicine ,medicine.disease ,Neoplastic Cells, Circulating ,Biomechanical Phenomena ,030104 developmental biology ,Oncology ,030220 oncology & carcinogenesis ,Cancer research ,Commentary ,business - Abstract
The behaviour of circulating tumour cells in the microcirculation remains poorly understood. Growing evidence suggests that biomechanical adaptations and interactions with blood components, i.e. immune cells and platelets within capillary beds, may add more complexity to CTCs journey towards metastasis. Revisiting how these mediators impact the ability of circulating tumour cells to survive and metastasise, will be vital to understand the role of microcirculation and advance our knowledge on metastasis.
- Published
- 2021