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14 results on '"Baars, D."'

1. Prognostic value of histopathologic traits independent of stromal tumor-infiltrating lymphocyte levels in chemotherapy-naïve patients with triple-negative breast cancer

Author

de Boo, L.W., Jóźwiak, K., Ter Hoeve, N.D., van Diest, P.J., Opdam, M., Wang, Y., Schmidt, M.K., de Jong, V., Kleiterp, S., Cornelissen, S., Baars, D., Koornstra, R.H.T., Kerver, E.D., van Dalen, T., Bins, A.D., Beeker, A., van den Heiligenberg, S.M., de Jong, P.C., Bakker, S.D., Rietbroek, R.C., Konings, I.R., Blankenburgh, R., Bijlsma, R.M., Imholz, A.L.T., Stathonikos, N., Vreuls, W., Sanders, J., Rosenberg, E.H., Koop, E.A., Varga, Z., van Deurzen, C.H.M., Mooyaart, A.L., Córdoba, A., Groen, E., Bart, J., Willems, S.M., Zolota, V., Wesseling, J., Sapino, A., Chmielik, E., Ryska, A., Broeks, A., Voogd, A.C., van der Wall, E., Siesling, S., Salgado, R., Dackus, G.M.H.E., Hauptmann, M., Kok, M., and Linn, S.C.

Published
2024
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2. Prognostic value of histopathologic traits independent of stromal tumor-infiltrating lymphocyte levels in chemotherapy-naïve patients with triple-negative breast cancer

Author

de Boo, L W, Jóźwiak, K; https://orcid.org/0000-0002-9614-6586, Ter Hoeve, N D, van Diest, P J; https://orcid.org/0000-0003-0658-2745, Opdam, M; https://orcid.org/0000-0001-5832-6386, Wang, Y; https://orcid.org/0000-0002-1482-7039, Schmidt, M K; https://orcid.org/0000-0002-2228-429X, de Jong, V, Kleiterp, S, Cornelissen, S, Baars, D, Koornstra, R H T, Kerver, E D; https://orcid.org/0009-0004-6456-4857, van Dalen, T, Bins, A D, Beeker, A; https://orcid.org/0000-0003-4133-769X, van den Heiligenberg, S M, de Jong, P C, Bakker, S D; https://orcid.org/0000-0003-3936-4648, Rietbroek, R C, Konings, I R, Blankenburgh, R, Bijlsma, R M; https://orcid.org/0000-0003-0980-6652, Imholz, A L T, Stathonikos, N, Vreuls, W; https://orcid.org/0000-0001-6661-6017, Sanders, J, Rosenberg, E H; https://orcid.org/0000-0002-3859-6941, Koop, E A, Varga, Z; https://orcid.org/0000-0002-2855-983X, et al, de Boo, L W, Jóźwiak, K; https://orcid.org/0000-0002-9614-6586, Ter Hoeve, N D, van Diest, P J; https://orcid.org/0000-0003-0658-2745, Opdam, M; https://orcid.org/0000-0001-5832-6386, Wang, Y; https://orcid.org/0000-0002-1482-7039, Schmidt, M K; https://orcid.org/0000-0002-2228-429X, de Jong, V, Kleiterp, S, Cornelissen, S, Baars, D, Koornstra, R H T, Kerver, E D; https://orcid.org/0009-0004-6456-4857, van Dalen, T, Bins, A D, Beeker, A; https://orcid.org/0000-0003-4133-769X, van den Heiligenberg, S M, de Jong, P C, Bakker, S D; https://orcid.org/0000-0003-3936-4648, Rietbroek, R C, Konings, I R, Blankenburgh, R, Bijlsma, R M; https://orcid.org/0000-0003-0980-6652, Imholz, A L T, Stathonikos, N, Vreuls, W; https://orcid.org/0000-0001-6661-6017, Sanders, J, Rosenberg, E H; https://orcid.org/0000-0002-3859-6941, Koop, E A, Varga, Z; https://orcid.org/0000-0002-2855-983X, and et al

Published
2024

3. Prognostic value of histopathologic traits independent of stromal tumor-infiltrating lymphocyte levels in chemotherapy-naïve patients with triple-negative breast cancer

Author

Pathologie, Cancer, MMB opleiding Arts microbioloog, Neurogenetica, MS CGO, Public Health Practice, Affectieve & Psychotische Med., MS Medische Oncologie, Pathologie Support, Pathologie Pathologen staf, MS Reumatologie/Immunologie/Infectie, Speerpunt Cancer, KVO Docenten, de Boo, L W, Jóźwiak, K, Ter Hoeve, N D, van Diest, P J, Opdam, M, Wang, Y, Schmidt, M K, de Jong, V, Kleiterp, S, Cornelissen, S, Baars, D, Koornstra, R H T, Kerver, E D, van Dalen, T, Bins, A D, Beeker, A, van den Heiligenberg, S M, de Jong, P C, Bakker, S D, Rietbroek, R C, Konings, I R, Blankenburgh, R, Bijlsma, R M, Imholz, A L T, Stathonikos, N, Vreuls, W, Sanders, J, Rosenberg, E H, Koop, E A, Varga, Z, van Deurzen, C H M, Mooyaart, A L, Córdoba, A, Groen, E, Bart, J, Willems, S M, Zolota, V, Wesseling, J, Sapino, A, Chmielik, E, Ryska, A, Broeks, A, Voogd, A C, van der Wall, E, Siesling, S, Salgado, R, Dackus, G M H E, Hauptmann, M, Kok, M, Linn, S C, Pathologie, Cancer, MMB opleiding Arts microbioloog, Neurogenetica, MS CGO, Public Health Practice, Affectieve & Psychotische Med., MS Medische Oncologie, Pathologie Support, Pathologie Pathologen staf, MS Reumatologie/Immunologie/Infectie, Speerpunt Cancer, KVO Docenten, de Boo, L W, Jóźwiak, K, Ter Hoeve, N D, van Diest, P J, Opdam, M, Wang, Y, Schmidt, M K, de Jong, V, Kleiterp, S, Cornelissen, S, Baars, D, Koornstra, R H T, Kerver, E D, van Dalen, T, Bins, A D, Beeker, A, van den Heiligenberg, S M, de Jong, P C, Bakker, S D, Rietbroek, R C, Konings, I R, Blankenburgh, R, Bijlsma, R M, Imholz, A L T, Stathonikos, N, Vreuls, W, Sanders, J, Rosenberg, E H, Koop, E A, Varga, Z, van Deurzen, C H M, Mooyaart, A L, Córdoba, A, Groen, E, Bart, J, Willems, S M, Zolota, V, Wesseling, J, Sapino, A, Chmielik, E, Ryska, A, Broeks, A, Voogd, A C, van der Wall, E, Siesling, S, Salgado, R, Dackus, G M H E, Hauptmann, M, Kok, M, and Linn, S C

Published
2024

4. Prognostic value of histopathologic traits independent of stromal tumor-infiltrating lymphocyte levels in chemotherapy-naïve patients with triple-negative breast cancer

Author

de Boo, L. W., Jóźwiak, K., Ter Hoeve, N. D., van Diest, P. J., Opdam, M., Wang, Y., Schmidt, M. K., de Jong, V., Kleiterp, S., Cornelissen, S., Baars, D., Koornstra, R. H.T., Kerver, E. D., van Dalen, T., Bins, A. D., Beeker, A., van den Heiligenberg, S. M., de Jong, P. C., Bakker, S. D., Rietbroek, R. C., Konings, I. R., Blankenburgh, R., Bijlsma, R. M., Imholz, A. L.T., Stathonikos, N., Vreuls, W., Sanders, J., Rosenberg, E. H., Koop, E. A., Varga, Z., van Deurzen, C. H.M., Mooyaart, A. L., Córdoba, A., Groen, E., Bart, J., Willems, S. M., Zolota, V., Wesseling, J., Sapino, A., Chmielik, E., Ryska, A., Broeks, A., Voogd, A. C., van der Wall, E., Siesling, S., Salgado, R., Dackus, G. M.H.E., Hauptmann, M., Kok, M., Linn, S. C., de Boo, L. W., Jóźwiak, K., Ter Hoeve, N. D., van Diest, P. J., Opdam, M., Wang, Y., Schmidt, M. K., de Jong, V., Kleiterp, S., Cornelissen, S., Baars, D., Koornstra, R. H.T., Kerver, E. D., van Dalen, T., Bins, A. D., Beeker, A., van den Heiligenberg, S. M., de Jong, P. C., Bakker, S. D., Rietbroek, R. C., Konings, I. R., Blankenburgh, R., Bijlsma, R. M., Imholz, A. L.T., Stathonikos, N., Vreuls, W., Sanders, J., Rosenberg, E. H., Koop, E. A., Varga, Z., van Deurzen, C. H.M., Mooyaart, A. L., Córdoba, A., Groen, E., Bart, J., Willems, S. M., Zolota, V., Wesseling, J., Sapino, A., Chmielik, E., Ryska, A., Broeks, A., Voogd, A. C., van der Wall, E., Siesling, S., Salgado, R., Dackus, G. M.H.E., Hauptmann, M., Kok, M., and Linn, S. C.

Abstract

Background: In the absence of prognostic biomarkers, most patients with early-stage triple-negative breast cancer (eTNBC) are treated with combination chemotherapy. The identification of biomarkers to select patients for whom treatment de-escalation or escalation could be considered remains an unmet need. We evaluated the prognostic value of histopathologic traits in a unique cohort of young, (neo)adjuvant chemotherapy-naïve patients with early-stage (stage I or II), node-negative TNBC and long-term follow-up, in relation to stromal tumor-infiltrating lymphocytes (sTILs) for which the prognostic value was recently reported. Materials and methods: We studied all 485 patients with node-negative eTNBC from the population-based PARADIGM cohort which selected women aged <40 years diagnosed between 1989 and 2000. None of the patients had received (neo)adjuvant chemotherapy according to standard practice at the time. Associations between histopathologic traits and breast cancer-specific survival (BCSS) were analyzed with Cox proportional hazard models. Results: With a median follow-up of 20.0 years, an independent prognostic value for BCSS was observed for lymphovascular invasion (LVI) [adjusted (adj.) hazard ratio (HR) 2.35, 95% confidence interval (CI) 1.49-3.69], fibrotic focus (adj. HR 1.61, 95% CI 1.09-2.37) and sTILs (per 10% increment adj. HR 0.75, 95% CI 0.69-0.82). In the sTILs <30% subgroup, the presence of LVI resulted in a higher cumulative incidence of breast cancer death (at 20 years, 58%; 95% CI 41% to 72%) compared with when LVI was absent (at 20 years, 32%; 95% CI 26% to 39%). In the ≥75% sTILs subgroup, the presence of LVI might be associated with poor survival (HR 11.45, 95% CI 0.71-182.36, two deaths). We confirm the lack of prognostic value of androgen receptor expression and human epidermal growth factor receptor 2 -low status. Conclusions: sTILs, LVI and fibrotic focus provide independent prognostic information in young women with node-negat

Published
2024

8. Crystal orientations near welds in high RRR niobium with very large grains

Author

Baars, D., Jiang, H., Bieler, T., Compton, C., Bauer, P., and Grimm, T.

Subjects
Niobium -- Electric properties, Nucleation -- Analysis, Microstructure -- Research, Business, Electronics, Electronics and electrical industries
Abstract

Orientation imaging microscopy (OIM) was used for assessing the crystal orientations near weld in high residual resistivity ratio (RRR) niobium with very large grains. Results suggest the development of a solidification microstructure with random crystal orientations in the fusion zone during welding due to heterogeneous nucleation near a tri-crystal boundary.

Published
2007

9. Mechanical properties of high RRR niobium with different texture

Author

Jiang, H., Baars, D., Zamiri, A., Antonie, C., Bauer, P., Bieler, T.R., Pourboghrat, F., Compton, C., and Grimm, T.L.

Subjects
Niobium -- Electric properties, Niobium -- Mechanical properties, Polycrystalline semiconductors -- Electric properties, Polycrystalline semiconductors -- Mechanical properties, Anisotropy -- Analysis, Business, Electronics, Electronics and electrical industries
Abstract

The mechanical properties of high purity bulk niobium with different texture and grain size are examined. Findings reveal that the elongated and non-uniform grain size appears to have a stronger effect on formability.

Published
2007

11. Physical and mechanical metallurgy of high purity Nb for accelerator cavities

Author

Bieler, T. R., primary, Wright, N. T., additional, Pourboghrat, F., additional, Compton, C., additional, Hartwig, K. T., additional, Baars, D., additional, Zamiri, A., additional, Chandrasekaran, S., additional, Darbandi, P., additional, Jiang, H., additional, Skoug, E., additional, Balachandran, S., additional, Ice, G. E., additional, and Liu, W., additional

Published
2010
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