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4. CD34-positive cells in human umbilical cord blood express nerve growth factor and its specific receptor TrkA

Author

Luisa Bracci-Laudiero, Marco Lai, Sergio Bonini, G Ballatore, Alessandro Lambiase, Carlo Rumi, Luigi Aloe, Giuseppe Starace, Annabella Procoli, A. Antonelli, Alessandra Picardi, D. Celestino, BRACCI LAUDIERO, L, Celestino, D, Starace, G, Antonelli, A, Lambiase, A, Procoli, A, Rumi, C, Lai, M, Picardi, A, Ballatore, G, Bonini, Sergio, and Aloe, L.

Subjects
Messenger, CD34, Fluorescent Antibody Technique, Antigens, CD34, Human stem cells, Receptor, Nerve Growth Factor, Hematopoiesis, Neurotrophins, Nerve Growth Factor, Receptors, Leukocytes, Immunology and Allergy, Low-affinity nerve growth factor receptor, NGF, biology, Cell Differentiation, Middle Aged, Fetal Blood, Flow Cytometry, Haematopoiesis, Neurology, Cord blood, trkA, Adult, Hematopoietic Stem Cells, Humans, Infant, Newborn, Leukocytes, Mononuclear, RNA, Messenger, Receptor, trkA, Receptors, Nerve Growth Factor, Settore MED/26 - Neurologia, Stem cell, Neurotrophin, Receptor, medicine.medical_specialty, Immunology, Mononuclear, Peripheral blood mononuclear cell, Internal medicine, medicine, Antigens, emopoiesi, cellule staminali, Infant, Newborn, Endocrinology, Nerve growth factor, nervous system, biology.protein, RNA, Neurology (clinical)
Abstract

In this study, we investigated whether hematopoietic stem cells (HSC) and progenitors present in human cord blood can express nerve growth factor (NGF)-specific receptors, TrkA and p75. Our results showed a marked expression of TrkA and NGF in cord blood CD34 + cells. A gradient of TrkA and NGF expression exists and is highest in cord blood CD34 + cells, reduced in cord blood mononuclear cells (MNC) and minimal in mononuclear cells isolated from adult peripheral blood. Our findings suggest that NGF may play a role in the differentiation of hematopoietic progenitors and indicate a different requirement for NGF by immune cells, depending on their state of maturity. D 2003 Elsevier Science B.V. All rights reserved.

Published
2003
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