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4. ColdZyme® protects airway epithelia from infection with BA.4/5

Author

Zaderer Viktoria, Dichtl Stefanie, Bellmann-Weiler Rosa, Lass-Flörl Cornelia, Posch Wilfried, and Wilflingseder Doris

Subjects
SARS-CoV-2, Prophylaxis, Variants of concern, BA.4, BA.5, Transmission, Diseases of the respiratory system, RC705-779
Abstract

Abstract Vaccines against SARS-CoV-2 protect from critical or severe pathogenesis also against new variants of concern (VOCs) such as BA.4 and BA.5, but immediate interventions to avoid viral transmission and subsequent inflammatory reactions are needed. Here we applied the ColdZyme® medical device mouth spray to fully differentiated, polarized human epithelium cultured at an air-liquid interphase (ALI). We found using VOCs BA.1 and BA.4/5 that this device effectively blocked respiratory tissue infection. While infection with these VOCs resulted in intracellular complement activation, thus enhanced inflammation, and drop of transepithelial resistance, these phenomena were prevented by a single administration of this medical device. Thus, ColdZyme® mouth spray significantly shields epithelial integrity, hinders virus infection and blocks in a secondary effect intrinsic complement activation within airway cultures also in terms of the highly contagious VOCs BA.4/5. Crucially, our in vitro data suggest that ColdZyme® mouth spray may have an impact to protect against SARS-CoV-2 transmission, also in case of the Omicron BA.1, BA.4 and BA.5 variants.

Published
2022
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5. CRP/Neopterin Ratio and Neuropsychiatric Symptoms in Patients with Different Forms of Pneumonia: Results of a Pilot Study

Author

Wagner, Katharina Konstanze Lilly, primary, Corda, Daniele, additional, Steinmayr, Andreas, additional, Burkert, Francesco, additional, Fuchs, Dietmar, additional, Gostner, Johanna, additional, Hofer, Stefanie, additional, Parrakova, Lucia, additional, Gasslitter, Irina, additional, Weiss, Günter, additional, Irsara, Christian, additional, Maier, Sarah, additional, Griesmacher, Andrea, additional, Bellmann-Weiler, Rosa, additional, and Kurz, Katharina, additional

Published
2024
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6. Predictive performance and clinical application of COV50, a urinary proteomic biomarker in early COVID-19 infection: a prospective multicentre cohort study

Author

Staessen, Jan A, Wendt, Ralph, Yu, Yu-Ling, Kalbitz, Sven, Thijs, Lutgarde, Siwy, Justyna, Raad, Julia, Metzger, Jochen, Neuhaus, Barbara, Papkalla, Armin, von der Leyen, Heiko, Mebazaa, Alexandre, Dudoignon, Emmanuel, Spasovski, Goce, Milenkova, Mimoza, Canevska-Taneska, Aleksandra, Lazo, Mercedes Salgueira, Psichogiou, Mina, Rajzer, Marek W, Fulawka, Lukasz, Dzitkowska-Zabielska, Magdalena, Weiss, Guenter, Feldt, Torsten, Stegemann, Miriam, Normark, Johan, Zoufaly, Alexander, Schmiedel, Stefan, Seilmaier, Michael, Rumpf, Benedikt, Banasik, Mirosław, Krajewska, Magdalena, Catanese, Lorenzo, Rupprecht, Harald, Czerwienska, Beata, Peters, Björn, Nilsson, Åsa, Rothfuss, Katja, Lübbert, Christoph, Mischak, Harald, Beige, Joachim, Ermisch, Jörg, Kellner, Nils, Peruth-Stutzmann, Lydia, Schroth, Stefanie, Schmidt, Jonathan, Schmidt, Ulrike, Breuer, Daniel, Abeud, Fariza, Fournier, Marie-Celine, Louadah, Badr, Molas, Rocio, Rojas, Fraile Loreto, García, Fabiola Alonso, Sánchez, Isabel Garcia, Hrom, Ioana Cezara, Więczek., Andrzej, Schwab, Matthias, K Asayama, Kei, Hansen, Tine W, Maestre, Gladys E, Basoulis, Dimitrios, Karamanakos., Georgios, Lis, Pawel, Olszanecka, Agnieszka, Bellmann-Weiler, Rosa, Lanser, Lucas, Edin, Alicia, Forsell, Matthias NE, Stegmayr, Bernd, Jensen, Björn-Erik Ole, Orth, Hans-Martin, Borstel, Sylke, Mikolajewska, Agata, Hecking, Manfred, Schmölz, Lukas, Hoffmann, Michał, Narkiewicz, Krzysztof, Matera-Witkiewicz, Agnieszka, Zachciał, Justyna, Litwin, Monika, Marciniak, Patrycja, Salgueira Lazo, Mercedes, Fuławka, Łukasz, Rupprecht, Harald D, and Czerwieńska, Beata

Published
2022
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7. Quantity of IgG response to SARS-CoV-2 spike glycoprotein predicts pulmonary recovery from COVID-19

Author

Nairz, Manfred, Sahanic, Sabina, Pizzini, Alex, Böhm, Anna, Tymoszuk, Piotr, Mitterstiller, Anna-Maria, von Raffay, Laura, Grubwieser, Philipp, Bellmann-Weiler, Rosa, Koppelstätter, Sabine, Schroll, Andrea, Haschka, David, Zimmermann, Martina, Blunder, Silvia, Trattnig, Kristina, Naschberger, Helene, Klotz, Werner, Theurl, Igor, Petzer, Verena, Gehrer, Clemens, Mindur, John E., Luger, Anna, Schwabl, Christoph, Widmann, Gerlig, Weiss, Günter, Löffler-Ragg, Judith, Tancevski, Ivan, and Sonnweber, Thomas

Published
2022
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10. Overcoming limitations in the availability of swabs systems used for SARS-CoV-2 laboratory diagnostics

Author

Nairz, Manfred, Bellmann-Weiler, Rosa, Ladstätter, Miriam, Schüllner, Falko, Zimmermann, Martina, Koller, Anna-Maria, Blunder, Silvia, Naschberger, Helene, Klotz, Werner, Herold, Manfred, Kerndler, Sylvia, Jeske, Martina, Haschka, David, Petzer, Verena, Schroll, Andrea, Sonnweber, Thomas, Tancevski, Ivan, Fritsche, Gernot, de Araujo, Mariana E. G., Stasyk, Taras, Huber, Lukas A., Griesmacher, Andrea, Theurl, Igor, and Weiss, Günter

Published
2021
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11. Interferon-γ Mediated Pathways And Mitogen Stimulated Proliferation During And After An Acute Infection

Author

Knoll Miriam, Fuchs Dietmar, Weiss Guenter, Bellmann-Weiler Rosa, Kovrlija Bojana, and Kurz Katharina

Subjects
neopterin, bacterial infection, proliferative response, Crystallography, QD901-999
Abstract

Background: Interferon-γ (IFN- γ) regulates the degradation of tryptophan to kynurenine via induction of indoleamine- 2,3-dioxygenase (IDO). Local tryptophan depletion and accumulation of toxic metabolites might impair the proliferative capacity of lymphocytes. The aim of this study was to assess the actual status of immune system activation of patients with bacterial infection in the acute phase and during convalescence in vivo and in vitro. Parameters of systemic immune system activation were evaluated for associations with proliferative responsiveness of immune cells, and compared with healthy controls. Methods: 24 patients with various acute bacterial infections were included in the group of acutely ill patients. Sixteen patients participated in a follow-up examination after convalescence. The control group consisted of 6 healthy people. To assess the status of immune system activation in vivo, inflammation parameters C-reactive protein and differential blood counts were determined. Neopterin concentrations were measured by enzyme-linked immunosorbent assay (ELISA). Tryptophan and kynurenine measurements were performed with high pressure liquid chromatography (HPLC). Peripheral blood mononuclear cells (PBMCs) were isolated from the patients’ blood and stimulated with concanavalin A (Con A), phytohemagglutinin (PHA) and pokeweed mitogen (PWM) in vitro proliferation rates were evaluated by ³H-thymidine incorporation and neopterin production and tryptophan degradation were determined in supernatants of mitogen stimulated PBMCs. Results: Patients with acute bacterial infections showed reduced tryptophan and elevated neopterin concentrations, which did not normalize after convalescence period. Higher plasma neopterin values and increased IDO-activity were associated with reduced proliferative responses in vitro after stimulation with PHA. Associations were observed during acute infection as well as convalescence. Conclusions: Results of this study show that increased immune system activation in vivo is associated with impaired proliferative responsiveness of immune cells in vitro in acute bacterial infections as well as during convalescence.

Published
2018
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13. Virus-Subtype-Specific Cellular and Humoral Immune Response to a COVID-19 mRNA Vaccine in Chronic Kidney Disease Patients and Renal Transplant Recipients

Author

Knell, Astrid I., primary, Böhm, Anna K., additional, Jäger, Michael, additional, Kerschbaum, Julia, additional, Engl, Sabine, additional, Rudnicki, Michael, additional, Buchwinkler, Lukas, additional, Bellmann-Weiler, Rosa, additional, Posch, Wilfried, additional, and Weiss, Günter, additional

Published
2023
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14. Persisting alterations of iron homeostasis in COVID-19 are associated with non-resolving lung pathologies and poor patients’ performance: a prospective observational cohort study

Author

Sonnweber, Thomas, Boehm, Anna, Sahanic, Sabina, Pizzini, Alex, Aichner, Magdalena, Sonnweber, Bettina, Kurz, Katharina, Koppelstätter, Sabine, Haschka, David, Petzer, Verena, Hilbe, Richard, Theurl, Markus, Lehner, Daniela, Nairz, Manfred, Puchner, Bernhard, Luger, Anna, Schwabl, Christoph, Bellmann-Weiler, Rosa, Wöll, Ewald, Widmann, Gerlig, Tancevski, Ivan, Judith-Löffler-Ragg, and Weiss, Günter

Published
2020
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15. Tissue iron distribution in patients with anemia of inflammation: Results of a pilot study

Author

Lanser, Lukas, primary, Plaikner, Michaela, additional, Schroll, Andrea, additional, Burkert, Francesco Robert, additional, Seiwald, Stefanie, additional, Fauser, Josia, additional, Petzer, Verena, additional, Bellmann‐Weiler, Rosa, additional, Fritsche, Gernot, additional, Tancevski, Ivan, additional, Duftner, Christina, additional, Pircher, Andreas, additional, Seeber, Andreas, additional, Zoller, Heinz, additional, Kremser, Christian, additional, Henninger, Benjamin, additional, and Weiss, Günter, additional

Published
2023
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16. Infection with SARS-CoV-2 Is Associated with Elevated Levels of IP-10, MCP-1, and IL-13 in Sepsis Patients

Author

Eichhorn, Tanja, primary, Huber, Silke, additional, Weiss, René, additional, Ebeyer-Masotta, Marie, additional, Lauková, Lucia, additional, Emprechtinger, Robert, additional, Bellmann-Weiler, Rosa, additional, Lorenz, Ingo, additional, Martini, Judith, additional, Pirklbauer, Markus, additional, Orth-Höller, Dorothea, additional, Würzner, Reinhard, additional, and Weber, Viktoria, additional

Published
2023
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18. Interferon-gamma Mediated Metabolic Pathways in Hospitalized Patients During Acute and Reconvalescent COVID-19

Author

Gietl, Mario, primary, Burkert, Francesco, additional, Seiwald, Stefanie, additional, Böhm, Anna, additional, Hofer, Stefanie, additional, Gostner, Johanna M, additional, Piater, Talia, additional, Geisler, Simon, additional, Weiss, Guenter, additional, Loeffler-Ragg, Judith, additional, Sonnweber, Thomas, additional, Tancevski, Ivan, additional, Pizzini, Alex, additional, Sahanic, Sabina, additional, Fuchs, Dietmar, additional, Bellmann-Weiler, Rosa, additional, and Kurz, Katharina, additional

Published
2023
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20. Positive Effects of Probiotic Therapy in Patients with Post-Infectious Fatigue.

Author

Obermoser, Katharina, Brigo, Natascha, Schroll, Andrea, Monfort-Lanzas, Pablo, Gostner, Johanna M., Engl, Sabine, Geisler, Simon, Knoll, Miriam, Schennach, Harald, Weiss, Günter, Fuchs, Dietmar, Bellmann-Weiler, Rosa, and Kurz, Katharina

Subjects
PROBIOTICS, FATIGUE (Physiology), BECK Depression Inventory, GUT microbiome
Abstract

Post-infectious fatigue is a common complication that can lead to decreased physical efficiency, depression, and impaired quality of life. Dysbiosis of the gut microbiota has been proposed as a contributing factor, as the gut–brain axis plays an important role in regulating physical and mental health. This pilot study aimed to investigate the severity of fatigue and depression, as well as the quality of life of 70 patients with post-infectious fatigue who received a multi-strain probiotic preparation or placebo in a double-blind, placebo-controlled trial. Patients completed questionnaires to assess their fatigue (fatigue severity scale (FSS)), mood (Beck Depression Inventory II (BDI-II)), and quality of life (short form-36 (SF-36)) at baseline and after 3 and 6 months of treatment. Routine laboratory parameters were also assessed, including immune-mediated changes in tryptophan and phenylalanine metabolism. The intervention was effective in improving fatigue, mood, and quality of life in both the probiotic and placebo groups, with greater improvements seen in the probiotic group. FSS and BDI-II scores declined significantly under treatment with both probiotics and placebo, but patients who received probiotics had significantly lower FSS (p < 0.001) and BDI-II (p < 0.001) scores after 6 months. Quality of life scores improved significantly in patients who received probiotics (p < 0.001), while patients taking a placebo only saw improvements in the "Physical limitation" and "Energy/Fatigue" subcategories. After 6 months neopterin was higher in patients receiving placebo, while no longitudinal changes in interferon-gamma mediated biochemical pathways were observed. These findings suggest that probiotics may be a promising intervention for improving the health of patients with post-infectious fatigue, potentially through modulating the gut–brain axis. [ABSTRACT FROM AUTHOR]

Published
2023
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22. Who Is at Risk of Poor Mental Health Following Coronavirus Disease-19 Outpatient Management?

Author

Hüfner, Katharina, primary, Tymoszuk, Piotr, additional, Ausserhofer, Dietmar, additional, Sahanic, Sabina, additional, Pizzini, Alex, additional, Rass, Verena, additional, Galffy, Matyas, additional, Böhm, Anna, additional, Kurz, Katharina, additional, Sonnweber, Thomas, additional, Tancevski, Ivan, additional, Kiechl, Stefan, additional, Huber, Andreas, additional, Plagg, Barbara, additional, Wiedermann, Christian J., additional, Bellmann-Weiler, Rosa, additional, Bachler, Herbert, additional, Weiss, Günter, additional, Piccoliori, Giuliano, additional, Helbok, Raimund, additional, Loeffler-Ragg, Judith, additional, and Sperner-Unterweger, Barbara, additional

Published
2022
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24. A proteomic survival predictor for COVID-19 patients in intensive care

Author

Demichev, Vadim, Tober-Lau, Pinkus, Nazarenko, Tatiana, Lemke, Oliver, Kaur Aulakh, Simran, Whitwell, Harry J., Röhl, Annika, Freiwald, Anja, Mittermaier, Mirja, Szyrwiel, Lukasz, Ludwig, Daniela, Correia-Melo, Clara, Lippert, Lena J., Helbig, Elisa T., Stubbemann, Paula, Olk, Nadine, Thibeault, Charlotte, Grüning, Nana-Maria, Blyuss, Oleg, Vernardis, Spyros, White, Matthew, Messner, Christoph B., Joannidis, Michael, Sonnweber, Thomas, Klein, Sebastian J., Pizzini, Alex, Wohlfarter, Yvonne, Sahanic, Sabina, Hilbe, Richard, Schaefer, Benedikt, Wagner, Sonja, Machleidt, Felix, Garcia, Carmen, Ruwwe-Glösenkamp, Christoph, Lingscheid, Tilman, Bosquillon de Jarcy, Laure, Stegemann, Miriam S., Pfeiffer, Moritz, Jürgens, Linda, Denker, Sophy, Zickler, Daniel, Spies, Claudia, Edel, Andreas, Müller, Nils B., Enghard, Philipp, Zelezniak, Aleksej, Bellmann-Weiler, Rosa, Weiss, Günter, Campbell, Archie, Hayward, Caroline, Porteous, David J., Marioni, Riccardo E., Uhrig, Alexander, Zoller, Heinz, Löffler-Ragg, Judith, Keller, Markus A., Tancevski, Ivan, Timms, John F., Zaikin, Alexey, Hippenstiel, Stefan, Ramharter, Michael, Müller-Redetzky, Holger, Witzenrath, Martin, Suttorp, Norbert, Lilley, Kathryn, Mülleder, Michael, Sander, Leif Erik, Kurth, Florian, and Ralser, Markus

Abstract

Global healthcare systems are challenged by the COVID-19 pandemic. There is a need to optimize allocation of treatment and resources in intensive care, as clinically established risk assessments such as SOFA and APACHE II scores show only limited performance for predicting the survival of severely ill COVID-19 patients. Additional tools are also needed to monitor treatment, including experimental therapies in clinical trials. Comprehensively capturing human physiology, we speculated that proteomics in combination with new data-driven analysis strategies could produce a new generation of prognostic discriminators. We studied two independent cohorts of patients with severe COVID-19 who required intensive care and invasive mechanical ventilation. SOFA score, Charlson comorbidity index, and APACHE II score showed limited performance in predicting the COVID-19 outcome. Instead, the quantification of 321 plasma protein groups at 349 timepoints in 50 critically ill patients receiving invasive mechanical ventilation revealed 14 proteins that showed trajectories different between survivors and non-survivors. A predictor trained on proteomic measurements obtained at the first time point at maximum treatment level (i.e. WHO grade 7), which was weeks before the outcome, achieved accurate classification of survivors (AUROC 0.81). We tested the established predictor on an independent validation cohort (AUROC 1.0). The majority of proteins with high relevance in the prediction model belong to the coagulation system and complement cascade. Our study demonstrates that plasma proteomics can give rise to prognostic predictors substantially outperforming current prognostic markers in intensive care.

Published
2022
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25. A Model Predicting Mortality of Hospitalized Covid-19 Patients Four Days After Admission: Development, Internal and Temporal-External Validation

Author

Heber, Stefan, primary, Pereyra, David, additional, Schrottmaier, Waltraud C., additional, Kammerer, Kerstin, additional, Santol, Jonas, additional, Rumpf, Benedikt, additional, Pawelka, Erich, additional, Hanna, Markus, additional, Scholz, Alexander, additional, Liu, Markus, additional, Hell, Agnes, additional, Heiplik, Klara, additional, Lickefett, Benno, additional, Havervall, Sebastian, additional, Traugott, Marianna T., additional, Neuböck, Matthias J., additional, Schörgenhofer, Christian, additional, Seitz, Tamara, additional, Firbas, Christa, additional, Karolyi, Mario, additional, Weiss, Günter, additional, Jilma, Bernd, additional, Thålin, Charlotte, additional, Bellmann-Weiler, Rosa, additional, Salzer, Helmut J. F., additional, Szepannek, Gero, additional, Fischer, Michael J. M., additional, Zoufaly, Alexander, additional, Gleiss, Andreas, additional, and Assinger, Alice, additional

Published
2022
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27. Potent SARS-CoV-2-Specific T Cell Immunity and Low Anaphylatoxin Levels Correlate With Mild Disease Progression in COVID-19 Patients

Author

Lafon, Eliott, Diem, Gabriel, Witting, Christina, Zaderer, Viktoria, Bellmann-Weiler, Rosa Maria, Reindl, Markus, Bauer, Angelika, Griesmacher, Andrea, Fux, Vilmos, Hoermann, Gregor, Miller, Carl, Zabernigg, August, Wöll, Ewald, Wilflingseder, Doris, Lass-Flörl, Cornelia, and Posch, Wilfried

Subjects
Adult, Aged, 80 and over, Male, Anaphylatoxins, Enzyme-Linked Immunospot Assay, T cell immunity, SARS-CoV-2, Immunology, Patient Acuity, COVID-19, neutralizing Abs, CD8-Positive T-Lymphocytes, Middle Aged, anaphylatoxin, Antibodies, Viral, Flow Cytometry, Immunity, Humoral, Interferon-gamma, ELISpot assay, Disease Progression, Immunology and Allergy, Humans, Female, Original Research, Aged
Abstract

T cells play a fundamental role in the early control and clearance of many viral infections of the respiratory system. In SARS-CoV-2-infected individuals, lymphopenia with drastically reduced CD4+ and CD8+ T cells correlates with Coronavirus disease 2019 (COVID-19)-associated disease severity and mortality. In this study, we characterized cellular and humoral immune responses induced in patients with mild, severe and critical COVID-19. Peripheral blood mononuclear cells of 37 patients with mild, severe and critical COVID-19 and 10 healthy individuals were analyzed by IFNγ ELISpot and multi-color flow cytometry upon stimulation with peptide pools covering complete immunodominant SARS-CoV-2 matrix, nucleocapsid and spike proteins. In addition SARS-CoV-2 antibody levels, neutralization abilities and anaphylatoxin levels were evaluated by various commercially available ELISA platforms. Our data clearly demonstrates a significantly stronger induction of SARS-CoV-2 specific CD8+ T lymphocytes and higher IFNγ production in patients with mild compared to patients with severe or critical COVID-19. In all patients SARS-CoV-2-specific antibodies with similar neutralizing activity were detected, but highest titers of total IgGs were observed in critical patients. Finally, elevated anaphylatoxin C3a and C5a levels were identified in severe and critical COVID-19 patients probably caused by aberrant immune complex formation due to elevated antibody titers in these patients. Crucially, we provide a full picture of cellular and humoral immune responses of COVID-19 patients and prove that robust polyfunctional CD8+ T cell responses concomitant with low anaphylatoxin levels correlate with mild infections. In addition, our data indicates that high SARS-CoV-2 antibody titers are associated with severe disease progression.

Published
2021

28. Low-molecular-weight heparin use in coronavirus disease 2019 is associated with curtailed viral persistence: a retrospective multicentre observational study

Author

Pereyra, David, primary, Heber, Stefan, additional, Schrottmaier, Waltraud C, additional, Santol, Jonas, additional, Pirabe, Anita, additional, Schmuckenschlager, Anna, additional, Kammerer, Kerstin, additional, Ammon, Daphni, additional, Sorz, Thomas, additional, Fritsch, Fabian, additional, Hayden, Hubert, additional, Pawelka, Erich, additional, Krüger, Philipp, additional, Rumpf, Benedikt, additional, Traugott, Marianna T, additional, Glaser, Pia, additional, Firbas, Christa, additional, Schörgenhofer, Christian, additional, Seitz, Tamara, additional, Karolyi, Mario, additional, Pabinger, Ingrid, additional, Brostjan, Christine, additional, Starlinger, Patrick, additional, Weiss, Günter, additional, Bellmann-Weiler, Rosa, additional, Salzer, Helmut J F, additional, Jilma, Bernd, additional, Zoufaly, Alexander, additional, and Assinger, Alice, additional

Published
2021
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30. Testosterone Deficiency Is a Risk Factor for Severe COVID-19

Author

Lanser, Lukas, primary, Burkert, Francesco Robert, additional, Thommes, Lis, additional, Egger, Alexander, additional, Hoermann, Gregor, additional, Kaser, Susanne, additional, Pinggera, Germar Michael, additional, Anliker, Markus, additional, Griesmacher, Andrea, additional, Weiss, Günter, additional, and Bellmann-Weiler, Rosa, additional

Published
2021
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31. Clonal hematopoiesis in patients with Covid‐19 is stable and not linked to an aggravated clinical course

Author

Petzer, Verena, primary, Schwendinger, Simon, additional, Haschka, David, additional, Vogi, Verena, additional, Tymoszuk, Piotr, additional, Burkert, Francesco, additional, Sahanic, Sabina, additional, Sonnweber, Thomas, additional, Bellmann‐Weiler, Rosa, additional, Loeffler‐Ragg, Judith, additional, Tancevski, Ivan, additional, Zschocke, Johannes, additional, Weiss, Guenter, additional, Wolf, Dominik, additional, and Jukic, Emina, additional

Published
2021
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32. A comprehensive antigen production and characterisation study for easy-to-implement, specific and quantitative SARS-CoV-2 serotests

Author

Klausberger, Miriam, primary, Duerkop, Mark, additional, Haslacher, Helmuth, additional, Wozniak-Knopp, Gordana, additional, Cserjan-Puschmann, Monika, additional, Perkmann, Thomas, additional, Lingg, Nico, additional, Aguilar, Patricia Pereira, additional, Laurent, Elisabeth, additional, De Vos, Jelle, additional, Hofner, Manuela, additional, Holzer, Barbara, additional, Stadler, Maria, additional, Manhart, Gabriele, additional, Vierlinger, Klemens, additional, Egger, Margot, additional, Milchram, Lisa, additional, Gludovacz, Elisabeth, additional, Marx, Nicolas, additional, Köppl, Christoph, additional, Tauer, Christopher, additional, Beck, Jürgen, additional, Maresch, Daniel, additional, Grünwald-Gruber, Clemens, additional, Strobl, Florian, additional, Satzer, Peter, additional, Stadlmayr, Gerhard, additional, Vavra, Ulrike, additional, Huber, Jasmin, additional, Wahrmann, Markus, additional, Eskandary, Farsad, additional, Breyer, Marie-Kathrin, additional, Sieghart, Daniela, additional, Quehenberger, Peter, additional, Leitner, Gerda, additional, Strassl, Robert, additional, Egger, Alexander E., additional, Irsara, Christian, additional, Griesmacher, Andrea, additional, Hoermann, Gregor, additional, Weiss, Günter, additional, Bellmann-Weiler, Rosa, additional, Loeffler-Ragg, Judith, additional, Borth, Nicole, additional, Strasser, Richard, additional, Jungbauer, Alois, additional, Hahn, Rainer, additional, Mairhofer, Jürgen, additional, Hartmann, Boris, additional, Binder, Nikolaus B., additional, Striedner, Gerald, additional, Mach, Lukas, additional, Weinhäusel, Andreas, additional, Dieplinger, Benjamin, additional, Grebien, Florian, additional, Gerner, Wilhelm, additional, Binder, Christoph J., additional, and Grabherr, Reingard, additional

Published
2021
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35. Cardiopulmonary recovery after COVID-19: an observational prospective multicentre trial

Author

Sonnweber, Thomas, primary, Sahanic, Sabina, additional, Pizzini, Alex, additional, Luger, Anna, additional, Schwabl, Christoph, additional, Sonnweber, Bettina, additional, Kurz, Katharina, additional, Koppelstätter, Sabine, additional, Haschka, David, additional, Petzer, Verena, additional, Boehm, Anna, additional, Aichner, Magdalena, additional, Tymoszuk, Piotr, additional, Lener, Daniela, additional, Theurl, Markus, additional, Lorsbach-Köhler, Almut, additional, Tancevski, Amra, additional, Schapfl, Anna, additional, Schaber, Marc, additional, Hilbe, Richard, additional, Nairz, Manfred, additional, Puchner, Bernhard, additional, Hüttenberger, Doris, additional, Tschurtschenthaler, Christoph, additional, Aßhoff, Malte, additional, Peer, Andreas, additional, Hartig, Frank, additional, Bellmann, Romuald, additional, Joannidis, Michael, additional, Gollmann-Tepeköylü, Can, additional, Holfeld, Johannes, additional, Feuchtner, Gudrun, additional, Egger, Alexander, additional, Hoermann, Gregor, additional, Schroll, Andrea, additional, Fritsche, Gernot, additional, Wildner, Sophie, additional, Bellmann-Weiler, Rosa, additional, Kirchmair, Rudolf, additional, Helbok, Raimund, additional, Prosch, Helmut, additional, Rieder, Dietmar, additional, Trajanoski, Zlatko, additional, Kronenberg, Florian, additional, Wöll, Ewald, additional, Weiss, Günter, additional, Widmann, Gerlig, additional, Löffler-Ragg, Judith, additional, and Tancevski, Ivan, additional

Published
2020
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36. Neopterin Predicts Disease Severity in Hospitalized Patients With COVID-19

Author

Bellmann-Weiler, Rosa, primary, Lanser, Lukas, additional, Burkert, Francesco, additional, Seiwald, Stefanie, additional, Fritsche, Gernot, additional, Wildner, Sophie, additional, Schroll, Andrea, additional, Koppelstätter, Sabine, additional, Kurz, Katharina, additional, Griesmacher, Andrea, additional, and Weiss, Günter, additional

Published
2020
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38. Impact of Vitamin D Deficiency on COVID-19—A Prospective Analysis from the CovILD Registry

Author

Pizzini, Alex, primary, Aichner, Magdalena, additional, Sahanic, Sabina, additional, Böhm, Anna, additional, Egger, Alexander, additional, Hoermann, Gregor, additional, Kurz, Katharina, additional, Widmann, Gerlig, additional, Bellmann-Weiler, Rosa, additional, Weiss, Günter, additional, Tancevski, Ivan, additional, Sonnweber, Thomas, additional, and Löffler-Ragg, Judith, additional

Published
2020
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42. Co- but not Sequential Infection of DCs Boosts Their HIV-Specific CTL-Stimulatory Capacity

Author

Schönfeld, Manuela, Knackmuss, Ulla, Chandorkar, Parul, Hörtnagl, Paul, Hope, Thomas John, Moris, Arnaud, Bellmann-Weiler, Rosa, Lass-Flörl, Cornelia, Posch, Wilfried, Wilflingseder, Doris, Innsbruck Medical University = Medizinische Universität Innsbruck (IMU), Feinberg School of Medicine, Northwestern University [Evanston], Centre d'Immunologie et des Maladies Infectieuses (CIMI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Sorbonne Université (SU), Institut de Biologie Intégrative de la Cellule (I2BC), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Université Paris-Sud - Paris 11 (UP11), Université Paris-Saclay, Innsbruck Medical University [Austria] (IMU), Centre d'Immunologie et de Maladies Infectieuses (CIMI), and Gestionnaire, Hal Sorbonne Université

Subjects
[SDV.IMM] Life Sciences [q-bio]/Immunology, dendritic cell, [SDV]Life Sciences [q-bio], Immunology, virus diseases, HIV Infections, T-Cell Antigen Receptor Specificity, chemical and pharmacologic phenomena, hemic and immune systems, Dendritic Cells, HLA-DR Antigens, Virus Internalization, Lymphocyte Activation, Virus Replication, STIs, [SDV] Life Sciences [q-bio], CTL, HIV-1, Humans, [SDV.IMM]Life Sciences [q-bio]/Immunology, Immunology and Allergy, complement, Biomarkers, Original Research, T-Lymphocytes, Cytotoxic
Abstract

International audience; Pathogenic bacteria and their microbial products activate dendritic cells (DCs) at mucosal surfaces during sexually transmitted infections (STIs) and therefore might also differently shape DC functions during co-infection with HIV-1. We recently illustrated that complement (C) coating of HIV-1 (HIV-C), as primarily found during the acute phase of infection before appearance of HIV-specific antibodies, by-passed SAMHD1-mediated restriction in DCs and therefore mediated an increased DC activation and antiviral capacity. To determine whether the superior antiviral effects of HIV-C-exposed DCs also apply during STIs, we developed a co-infection model in which DCs were infected with Chlamydia spp. simultaneously (HIV-C/Chlam-DCs or HIV/Chlam-DCs) or a sequential infection model, where DCs were exposed to Chlamydia for 3 or 24 h (Chlam-DCs) followed by HIV-1 infection. Co-infection of DCs with HIV-1 and Chlamydia significantly boosted the CTL-stimulatory capacity compared to HIV-1-loaded iDCs and this boost was independent on the opsonization pattern. This effect was lost in the sequential infection model, when opsonized HIV-1 was added delayed to Chlamydia-loaded DCs. The reduction in the CTL-stimulatory capacity of Chlam-DCs was not due to lower HIV-1 binding or infection compared to iDCs or HIV-C/Chlam-DCs, but due to altered fusion and internalization mechanisms within DCs. The CTL-stimulatory capacity of HIV-C in Chlam-DCs correlated with significantly reduced viral fusion compared to iDCs and HIV-C/Chlam-DCs and illustrated considerably increased numbers of HIV-C-containing vacuoles than iDCs. The data indicate that Chlamydia co-infection of DCs mediates a transient boost of their HIV-specific CTL-stimulatory and antiviral capacity, while in the sequential infection model this is reversed and associated with hazard to the host.

Published
2019
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44. Neopterin Predicts Disease Severity in Hospitalized Patients With COVID-19.

Author

Bellmann-Weiler, Rosa, Lanser, Lukas, Burkert, Francesco, Seiwald, Stefanie, Fritsche, Gernot, Wildner, Sophie, Schroll, Andrea, Koppelstätter, Sabine, Kurz, Katharina, Griesmacher, Andrea, and Weiss, Günter

Subjects
*COVID-19, *NEOPTERIN, *HOSPITAL patients, *INTENSIVE care units, *ARTIFICIAL respiration
Abstract

This study evaluates the predictive value of circulating inflammatory markers, especially neopterin, in patients with coronavirus disease 2019 (COVID-19). Within this retrospective analysis of 115 hospitalized COVID-19 patients, elevated neopterin levels upon admission were significantly associated with disease severity, risk for intensive care unit admission, need for mechanical ventilation, and death. Therefore, neopterin is a reliable predictive marker in patients with COVID-19 and may help to improve the clinical management of patients. [ABSTRACT FROM AUTHOR]

Published
2021
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46. Biliary amphotericin B pharmacokinetics and pharmacodynamics in critically ill liver transplant recipients receiving treatment with amphotericin B lipid formulations

Author

Welte, René, Eschertzhuber, Stephan, Weiler, Stefan, Leitner-Rupprich, Sandra, Aigner, Maria, Lass-Flörl, Cornelia, Stienecke, Eva, Bellmann-Weiler, Rosa, Joannidis, Michael, Bellmann, Romuald, Welte, René, Eschertzhuber, Stephan, Weiler, Stefan, Leitner-Rupprich, Sandra, Aigner, Maria, Lass-Flörl, Cornelia, Stienecke, Eva, Bellmann-Weiler, Rosa, Joannidis, Michael, and Bellmann, Romuald

Abstract

Fungal cholangitis is a potentially life-threatening condition. As amphotericin B (AmB) has a broad antimycotic spectrum, in this study its biliary penetration and activity was determined in two patients treated with liposomal AmB (L-AmB) and in one patient receiving AmB colloidal dispersion (ABCD). Biliary and plasma AmB levels were quantified by high-performance liquid chromatography after purification by solid-phase extraction. For assessment of biliary AmB activity, isolates of Candida albicans, Candida tropicalis, Candida glabrata and Candida krusei were incubated in porcine bile at AmB concentrations of 0.025-5.00 mg/L. In addition, patient bile samples retrieved for AmB quantification were inoculated with the same Candida strains. Biliary AmB concentrations were lower and displayed a slower rise and decline than plasma levels. The highest penetration ratio, as expressed by the ratio between the area under the AmB concentration-time curve in bile and plasma (liberated AmB) over the sampling period (AUC0-n bile/AUC0-n LI plasma), was 0.28. Proliferation of C. albicans and C. tropicalis in bile was similar to that in culture medium, whereas growth of C. glabrata was diminished and proliferation of C. krusei was absent in bile. In comparison with culture medium, AmB activity decreased in spiked porcine bile. In all but one patient bile sample, fungal growth was delayed or lacking even when AmB was not detectable. However, no fungicidal effect was observed in patient bile at AmB concentrations up to 1.28 mg/L. Thus, a reliable response of fungal cholangitis to treatment with L-AmB or ABCD cannot be anticipated.

Published
2015

47. Human Tissue Distribution of Voriconazole

Author

Weiler, Stefan, primary, Fiegl, David, additional, MacFarland, Róisín, additional, Stienecke, Eva, additional, Bellmann-Weiler, Rosa, additional, Dunzendorfer, Stefan, additional, Joannidis, Michael, additional, and Bellmann, Romuald, additional

Published
2011
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