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Flat lenses with focal length tunability can enable the development of highly integrated imaging systems. This work explores machine learning to inverse design a multifocal multilevel diffractive lens (MMDL) by wavelength multiplexing. The MMDL output is multiplexed in three color channels, red (650 nm), green (550 nm), and blue (450 nm), to achieve varied focal lengths of 4 mm, 20 mm, and 40 mm at these three color channels, respectively. The focal lengths of the MMDL scale significantly with the wavelength in contrast to conventional diffractive lenses. The MMDL consists of concentric rings with equal widths and varied heights. The machine learning method is utilized to optimize the height of each concentric ring to obtain the desired phase distribution so as to achieve varied focal lengths multiplexed by wavelengths. The designed MMDL is fabricated through a direct-write laser lithography system with gray-scale exposure. The demonstrated singlet lens is miniature and polarization insensitive, and thus can potentially be applied in integrated optical imaging systems to achieve zooming functions.

In this paper, we discuss flat programmable multi-level diffractive lenses (PMDL) enabled by phase change materials working in the near-infrared and visible ranges. The high real part refractive index contrast (Δn ∼ 0.6) of Sb 2 S 3 between amorphous and crystalline states, and extremely low losses in the near-infrared, enable the PMDL to effectively shift the lens focus when the phase of the material is altered between its crystalline and amorphous states. In the visible band, although losses can become significant as the wavelength is reduced, the lenses can still provide good performance as a result of their relatively small thickness (∼ 1.5λ to 3λ). The PMDL consists of Sb 2 S 3 concentric rings with equal width and varying heights embedded in a glass substrate. The height of each concentric ring was optimized by a modified direct binary search algorithm. The proposed designs show the possibility of realizing programmable lenses at design wavelengths from the near-infrared (850 nm) up to the blue (450 nm) through engineering PMDLs with Sb 2 S 3 . Operation at these short wavelengths, to the best of our knowledge, has not been studied so far in reconfigurable lenses with phase-change materials. Therefore, our results open a wider range of applications for phase-change materials, and show the prospect of Sb 2 S 3 for such applications. The proposed lenses are polarization insensitive and can have the potential to be applied in dual-functionality devices, optical imaging, and biomedical science.

In this work, a systematic photoluminescence (PL) study on three series of gallium oxide/aluminum gallium oxide films and bulk single crystals is performed including comparing doping, epitaxial substrates, and aluminum concentration. It is observed that blue/green emission intensity strongly correlates with extended structural defects rather than the point defects frequently assumed. Bulk crystals or Si-doped films homoepitaxially grown on (010) β-Ga 2 O 3 yield an intense dominant UV emission, while samples with extended structural defects, such as gallium oxide films grown on either (-201) β-Ga 2 O 3 or sapphire, as well as thick aluminum gallium oxide films grown on either (010) β-Ga 2 O 3 or sapphire, all show a very broad PL spectrum with intense dominant blue/green emission. PL differences between samples and the possible causes of these differences are analyzed. This work expands previous reports that have so far attributed blue and green emissions to point defects and shows that in the case of thin films, extended defects might have a prominent role in emission properties., (© 2022. The Author(s).)

It is generally assumed that correcting chromatic aberrations in imaging requires multiple optical elements. Here, we show that by allowing the phase in the image plane to be a free parameter, it is possible to correct chromatic variation of focal length over an extremely large bandwidth, from the visible (Vis) to the longwave infrared (LWIR) wavelengths using a single diffractive surface, i.e., a flat lens. Specifically, we designed, fabricated and characterized a flat, multi-level diffractive lens (MDL) with a thickness of ≤ 10µm, diameter of ∼1mm, and focal length of 18mm, which was constant over the operating bandwidth of λ=0.45µm (blue) to 15µm (LWIR). We experimentally characterized the point-spread functions, aberrations and imaging performance of cameras comprised of this MDL and appropriate image sensors for λ=0.45μm to 11μm. We further show using simulations that such extreme achromatic MDLs can be achieved even at high numerical apertures (NA=0.81). By drastically increasing the operating bandwidth and eliminating several refractive lenses, our approach enables thinner, lighter and simpler imaging systems.

Deep neural networks (DNNs) have substantial computational requirements, which greatly limit their performance in resource-constrained environments. Recently, there are increasing efforts on optical neural networks and optical computing based DNNs hardware, which bring significant advantages for deep learning systems in terms of their power efficiency, parallelism and computational speed. Among them, free-space diffractive deep neural networks (D 2 NNs) based on the light diffraction, feature millions of neurons in each layer interconnected with neurons in neighboring layers. However, due to the challenge of implementing reconfigurability, deploying different DNNs algorithms requires re-building and duplicating the physical diffractive systems, which significantly degrades the hardware efficiency in practical application scenarios. Thus, this work proposes a novel hardware-software co-design method that enables first-of-its-like real-time multi-task learning in D 2 2NNs that automatically recognizes which task is being deployed in real-time. Our experimental results demonstrate significant improvements in versatility, hardware efficiency, and also demonstrate and quantify the robustness of proposed multi-task D 2 NN architecture under wide noise ranges of all system components. In addition, we propose a domain-specific regularization algorithm for training the proposed multi-task architecture, which can be used to flexibly adjust the desired performance for each task.

While terahertz spectroscopy can provide valuable information regarding the charge transport properties in semiconductors, its application for the characterization of low-conductive two-dimensional layers, i.e., σ s  <  < 1 mS, remains elusive. This is primarily due to the low sensitivity of direct transmission measurements to such small sheet conductivity levels. In this work, we discuss harnessing the extraordinary optical transmission through gratings consisting of metallic stripes to characterize such low-conductive two-dimensional layers. We analyze the geometric tradeoffs in these structures and provide physical insights, ultimately leading to general design guidelines for experiments enabling non-contact, non-destructive, highly sensitive characterization of such layers.

Multilevel diffractive lenses (MDLs) have emerged as an alternative to both conventional diffractive optical elements (DOEs) and metalenses for applications ranging from imaging to holographic and immersive displays. Recent work has shown that by harnessing structural parametric optimization of DOEs, one can design MDLs to enable multiple functionalities like achromaticity, depth of focus, wide-angle imaging, etc. with great ease in fabrication. Therefore, it becomes critical to understand how fabrication errors still do affect the performance of MDLs and numerically evaluate the trade-off between efficiency and initial parameter selection, right at the onset of designing an MDL, i.e., even before putting it into fabrication. Here, we perform a statistical simulation-based study on MDLs (primarily operating in the THz regime) to analyse the impact of various fabrication imperfections (single and multiple) on the final structure as a function of the number of ring height levels. Furthermore, we also evaluate the performance of these same MDLs with the change in the refractive index of the constitutive material. We use focusing efficiency as the evaluation criterion in our numerical analysis; since it is the most fundamental property that can be used to compare and assess the performance of lenses (and MDLs) in general designed for any application with any specific functionality.

We experimentally demonstrate imaging in the long-wave infrared (LWIR) spectral band (8 μm to 12 μm) using a single polymer flat lens based upon multilevel diffractive optics. The device thickness is only 10 μm, and chromatic aberrations are corrected over the entire LWIR band with one surface. Due to the drastic reduction in device thickness, we are able to utilize polymers with absorption in the LWIR, allowing for inexpensive manufacturing via imprint lithography. The weight of our lens is less than 100 times those of comparable refractive lenses. We fabricated and characterized 2 different flat lenses. Even with about 25% absorption losses, experiments show that our flat polymer lenses obtain good imaging with field of view of 35° and angular resolution less than 0.013°. The flat lenses were characterized with 2 different commercial LWIR image sensors. Finally, we show that, by using lossless, higher-refractive-index materials like silicon, focusing efficiencies in excess of 70% can be achieved over the entire LWIR band. Our results firmly establish the potential for lightweight, ultrathin, broadband lenses for high-quality imaging in the LWIR band., Competing Interests: Competing interest statement: R.M. is cofounder of Oblate Optics, Inc., which is commercializing technology discussed in this manuscript. The University of Utah has filed for patent protection for technology discussed in this manuscript., (Copyright © 2019 the Author(s). Published by PNAS.)

We demonstrate ultra-thin (1.5-3λ 0 ), fabrication-error tolerant efficient diffractive terahertz (THz) optical elements designed using a computer-aided optimization-based search algorithm. The basic operation of these components is modeled using scalar diffraction of electromagnetic waves through a pixelated multi-level 3D-printed polymer structure. Through the proposed design framework, we demonstrate the design of various ultrathin planar THz optical elements, namely (i) a high Numerical Aperture (N.A.), broadband aberration rectified spherical lens (0.1 THz-0.3 THz), (ii) a spectral splitter (0.3 THz-0.6 THz) and (iii) an on-axis broadband transmissive hologram (0.3 THz-0.5 THz). Such an all-dielectric computational design-based approach is advantageous against metallic or dielectric metasurfaces from the perspective that it incorporates all the inherent structural advantages associated with a scalar diffraction based approach, such as (i) ease of modeling, (ii) substrate-less facile manufacturing, (iii) planar geometry, (iv) high efficiency along with (v) broadband operation, (vi) area scalability and (vii) fabrication error-tolerance. With scalability and error tolerance being two major bottlenecks of previous design strategies. This work is therefore, a significant step towards the design of THz optical elements by bridging the gap between structural and computational design i.e. through a hybrid design-based approach enabling considerably less computational resources than the previous state of the art. Furthermore, the approach used herein can be expanded to a myriad of optical elements at any wavelength regime.

We report polarization dependent photoluminescence studies on unintentionally-, Mg-, and Ca-doped β-Ga 2 O 3 bulk crystals grown by the Czochralski method. In particular, we observe a wavelength shift of the highest-energy UV emission which is dependent on the pump photon energy and polarization. For 240 nm (5.17 eV) excitation almost no shift of the UV emission is observed between E||b and E||c, while a shift of the UV emission centroid is clearly observed for 266 nm (4.66 eV), a photon energy lying between the band absorption onsets for the two polarizations. These results are consistent with UV emission originating from transitions between conduction band electrons and two differentially-populated self-trapped hole (STH) states. Calcuations based on hybrid and self-interaction-corrected density functional theories further validate that the polarization dependence is consistent with the relative stability of two STHs. This observation implies that the STHs form primarily at the oxygen atoms involved in the original photon absorption event, thus providing the connection between incident polarization and emission wavelength. The data imposes a lower bound on the energy separation between the self-trapped hole states of ~70-160 meV, which is supported by the calculations.

We report on terahertz characterization of La-doped BaSnO 3 (BSO) thin-films. BSO is a transparent complex oxide material, which has attracted substantial interest due to its large electrical conductivity and wide bandgap. The complex refractive index of these films is extracted in the 0.3 to 1.5 THz frequency range, which shows a metal-like response across this broad frequency window. The large optical conductivity found in these films at terahertz wavelengths makes this material an interesting platform for developing electromagnetic structures having a strong response at terahertz wavelengths, i.e. terahertz-functional, while being transparent at visible and near-IR wavelengths. As an example of such application, we demonstrate a visible-transparent terahertz polarizer.

We characterize the terahertz (THz) magneto-plasmonic response of a cobalt-based periodic aperture array. The bare cobalt surface allows for low loss propagation of surface plasmon-polaritons, as evidenced by comparing the reflection from aperture arrays coated with Au and with Co. When an external magnetic field is applied in a polar Kerr geometry, we observe a maximum polarization rotation of ~0.6° and an ellipticity of ~0.35° from the Co-based array. These values are larger than expected based on existing models that include only interband transitions in ferromagnetic metals. We discuss possible reasons for the difference between experiment and theory.

In this work we study the terahertz light propagation through deeply-scaled graphene-based reconfigurable metasurfaces, i.e. metasurfaces with unit-cell dimensions much smaller than the terahertz wavelength. These metasurfaces are analyzed as phase modulators for constructing reconfigurable phase gradients along an optical interface for the purpose of beam shaping. Two types of deeply-scaled metacell geometries are analyzed and compared, which consist of: (i) multi split ring resonators, and (ii) multi spiral resonators. Two figures of merit, related to: (a) the loss and (b) the degree of reconfigurability achievable by such metamaterials -when applied in beam shaping applications-, are introduced and discussed. Simulations of these two types of deep-subwavelength geometries, when changing the metal coverage-fraction, show that there is an optimal coverage-fraction that gives the best tradeoff in terms of loss versus degree of reconfigurability. For both types of geometries the best tradeoff occurs when the area covered by the metallic region is around 40% of the metacell total area. From this point of view, reconfigurable deeply-scaled metamaterials can indeed provide a superior performance for beam shaping applications when compared to not deeply-scaled ones; however, counterintuitively, employing very highly-packed structures might not be beneficial for such applications.

In this paper we propose and experimentally demonstrate arrays of graphene electro-absorption modulators as electrically reconfigurable patterns for terahertz cameras. The active element of these modulators consists of only single-atom-thick graphene, achieving a modulation of the THz wave reflectance > 50% with a potential modulation depth approaching 100%. Although the prototype presented here only contains 4x4 pixels, it reveals the possibility of developing reliable low-cost video-rate THz imaging systems employing single detector.

Switchable metamaterials offer unique solutions for efficiently manipulating electromagnetic waves, particularly for terahertz waves, which has been difficult since naturally occurring materials rarely respond to terahertz frequencies controllably. However, few terahertz modulators demonstrated to date exhibit simultaneously low attenuation and high modulation depth. In this letter we propose a new class of electrically-tunable terahertz metamaterial modulators employing metallic frequency-selective-surfaces (FSS) in conjunction with capacitively-tunable layers of electrons, promising near 100% modulation depth and < 15% attenuation. The fundamental departure in our design from the prior art is tuning enabled by self-gated electron layers that is independent from the metallic FSS. Our proposal is applicable to all possible electrically tunable elements including graphene, Si, MoS(2), oxides etc, thus opening up myriad opportunities for realizing high performance switchable metamaterials over an ultra-wide terahertz frequency range.

Terahertz technology promises myriad applications including imaging, spectroscopy and communications. However, one major bottleneck at present for advancing this field is the lack of efficient devices to manipulate the terahertz electromagnetic waves. Here we demonstrate that exceptionally efficient broadband modulation of terahertz waves at room temperature can be realized using graphene with extremely low intrinsic signal attenuation. We experimentally achieved more than 2.5 times superior modulation than prior broadband intensity modulators, which is also the first demonstrated graphene-based device enabled solely by intraband transitions. The unique advantages of graphene in comparison to conventional semiconductors are the ease of integration and the extraordinary transport properties of holes, which are as good as those of electrons owing to the symmetric conical band structure of graphene. Given recent progress in graphene-based terahertz emitters and detectors, graphene may offer some interesting solutions for terahertz technologies.

In human cells the length of telomeres depends on telomerase activity. This activity and the expression of the catalytic subunit of human telomerase reverse transcriptase (hTERT) is strongly up-regulated in most human cancers. hTERT expression is regulated by different transcription factors, such as c-Myc, Mad1 and Sp1. In this study, we demonstrated that 15d-PG J2 and rosiglitazone (an endogenous and synthetic peroxisome proliferators activated receptor gamma (PPARgamma) ligand, respectively) inhibited hTERT expression and telomerase activity in CaCo-2 colon cancer cells. Moreover, both ligands inhibited c-Myc protein expression and its E-box DNA binding activity. Additionally, Mad1 protein expression and its E-box DNA binding activity were strongly increased by 15d-PG J2 and, to a lesser extent, by rosiglitazone. Sp1 transcription factor expression and its GC-box DNA binding activity were not affected by both PPARgamma ligands. Results obtained by transient transfection of CaCo-2 cells with pmaxFP-Green-PRL plasmid constructs containing the functional hTERT core promoter (including one E-box and five GC-boxes) and its E-box deleted sequences, cloned upstream of the green fluorescent protein reporter gene, demonstrated that 15d-PG J2, and with minor effectiveness, rosiglitazone, strongly reduced hTERT core promoter activity. E-boxes for Myc/Mad/Max binding showed a higher activity than GC-boxes for Sp1. By using GW9662, an antagonist of PPARgamma, we demonstrated that the effects of 15d-PG J2 are completely PPARgamma independent, whereas the effects of rosiglitazone on hTERT expression seem to be partially PPARgamma independent. The regulation of hTERT expression by 15d-PG J2 and rosiglitazone, through the modulation of the Myc/Max/Mad1 network, may represent a new mechanism of action of these substances in inhibiting cell proliferation.

In medicinal chemistry field, the biochemical pathways, involved in 7-transmembrane domains G-protein coupled receptors (GPCRs) activation, are commonly studied to establish the activity of ligands towards GPCRs. The most studied steps are the measurement of activated GTP-alpha subunit and stimulated intracellular cAMP. At the present, many researchers defined agonist or antagonist activity of potential GPCRs drugs employing [(35)S]GTPgammaS or [(3)H]cAMP as probes. Recently, the corresponding lanthanide labels Eu-GTP and Eu-cAMP as alternative to radiochemicals have been developed because they are highly sensitive, easy to automate, easily synthesized, they display a much longer shelf-life and they can be used in multilabel experiments. In the present review, the receptor-drug interaction by europium employment for studying the biochemical pathway of GPCR activation has been focused. Moreover, comparative studies between lanthanide label probes and the corresponding radiolabeled compounds have been carried out.