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1. Study on the effect of PBL, TBL and CP teaching methods combined on standardized training of periodontology residents

Author

ZHUANG Deshu, BI Liangjia, LU Haiyan, GAO Lili

Subjects
periodontology, problem-based learning, team-based learning, clinical pathway, teaching reform, Dentistry, RK1-715, Other systems of medicine, RZ201-999
Abstract

Objective To assess the effectiveness of combining problem-based learning (PBL), team-based learning (TBL), and clinical pathway (CP) in standardized training of periodontology residents. Methods A total of 48 residents who were transferred to the Department of Periodontology at the Fourth Affiliated Hospital of Harbin Medical University from January to October 2023 were randomly assigned to either the traditional teaching group or the PBL, TBL, and CP combined teaching group, with 24 participants in each group. The traditional teaching group followed conventional teaching methods, while the PBL, TBL, and CP combined teaching group utilized a combination of these three methods. Prior to completing their rotation, both groups underwent professional assessments as well as surveys on satisfaction with standardized training and self-evaluation. Results The professional examination scores ofcombined teaching group were significantly higher than those of the traditional teaching method group (P0.05). However, compared to the traditional teaching group, students in the PBL, TBL, and CP combined teaching group showed significant improvements in doctor-patient communication skills, active information retrieval abilities, learning interest levels, team discussions, and clinical logical thinking abilities (P

Published
2024
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2. Research progress of sonodynamic therapy in the field of stomatology

Author

XU Bin and BI Liangjia

Subjects
sonodynamic therapy, ultrasound, sonosensitizer, singlet oxygen theory, cavitation effects, apoptosis, periodontitis, oral tumor, oral mucosal disease, nanoparticles, Medicine
Abstract

Sonodynamic therapy (SDT) is a cutting-edge method for the biological effects of ultrasound combined with sound-sensitive agents. In recent years, SDT has been a concern of experts and scholars in the oral field, and a series of experimental studies has been carried out. We will introduce the progress of SDT in the field of stomatology from three aspects: the therapeutic mechanism of SDT, the application of SDT in the oral field, and the current situation and future of SDT in the treatment of oral diseases. It is currently believed that singlet oxygen theory, cavitation effects, and induction of apoptosis are the main therapeutic mechanisms. The research of SDT on oral disease prevention mainly focuses on oral tumors (especially squamous cell carcinoma and osteosarcoma) and infectious diseases (such as periodontitis, maxillofacial infection, and oral mucosal disease). Although the current research is still in the experimental stage, with the continuous exploration of sonosensitizers and nanotechnology, SDT will provide great help for the clinical prevention and treatment of oral diseases in the future.

Published
2020
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7. Effects of Super-Activated Platelet Lysate on Early Healing of Tooth Extraction Sockets in Rats

Author

Guo,Xiaorui, Lu,Huiying, Liu,Chunxiang, Zhang,Yi, Bi,Liangjia, Guo,Xiaorui, Lu,Huiying, Liu,Chunxiang, Zhang,Yi, and Bi,Liangjia

Abstract

Xiaorui Guo,1,2 Huiying Lu,3 Chunxiang Liu,3 Yi Zhang,3 Liangjia Bi1 1Department of Stomatology, The Fourth Affiliated Hospital, Harbin Medical University, Harbin, 150001, People’s Republic of China; 2State Key Laboratory of Military Stomatology and National Clinical Research Center for Oral Diseases and Shaanxi Key Laboratory of Oral Diseases, Department of Operative Dentistry and Endodontics, School of Stomatology, The Fourth Military Medical University, Xi’an, People’s Republic of China; 3National and Local Joint Stem Cell Research & Engineering Center for Aging Diseases, Tian Qing Stem Cell Co., Ltd, Harbin, 150028, People’s Republic of ChinaCorrespondence: Liangjia Bi, Department of Stomatology, The Fourth Affiliated Hospital, Harbin Medical University, Harbin, 150001, People’s Republic of China, Tel/Fax +86 451 82576565, Email biliangjia1963@163.comPurpose: To evaluate the effect of super-activated platelet lysate (sPL) on wound healing of tooth extraction sockets in rats.Methods: Rat models of the tooth extraction socket were established. Thirty-six rats were divided into control and sPL groups and sacrificed on days 7, 14, and 28 after tooth extraction. Bone formation in tooth extraction sockets were observed by microscopic computed tomography (micro-CT) and hematoxylin and eosin (HE) staining; osteoprotegerin (OPG), receptor activator of nuclear factor kappa-&Bgr; ligand (RANKL), interleukin 6(IL-6), and tumor necrosis factor-alpha (TNF-α) proteins were detected by immunohistochemistry; and chemokine and osteogenic gene expressions were detected by polymerase chain reaction (PCR).Results: sPL accelerated soft tissue wound healing in the extraction socket of rats. Micro-CT showed that the amount of bone formation and bone volume fraction were higher in the sPL group than the control 14 days after extraction. HE staining showed promotion of the formation of bony trabeculae by sPL in the apical third of the extraction socket 7 days after ext

Published
2022

11. Super Activated Platelet Lysate, a Novel Autologous Platelet Lysate, Regulates the Expression of Inflammasome and Cytokine in the Experimental Periodontitis in Rats

Author

Zhang,Yi, Zhuang,Deshu, Lu,Huiying, Zhang,Haijiao, Li,Tingting, Bi,Liangjia, Zhang,Yi, Zhuang,Deshu, Lu,Huiying, Zhang,Haijiao, Li,Tingting, and Bi,Liangjia

Abstract

Yi Zhang,1 Deshu Zhuang,1,2 Yi Zhang,3 Huiying Lu,3 Haijiao Zhang,3 Tingting Li,3 Liangjia Bi1 1Department of Stomatology, The Fourth Affiliated Hospital, Harbin Medical University, Harbin 150001, People’s Republic of China; 2Faculty of Dentistry, Department of Oral Biological and Medical Sciences, University of British Columbia, Vancouver BC V6T 1Z3, Canada; 3National and Local Joint Stem Cell Research & Engineering Center for Aging Diseases, Tian Qing Stem Cell Co., Ltd., Harbin 150028, People’s Republic of ChinaCorrespondence: Liangjia BiDepartment of Stomatology, The Fourth Affiliated Hospital, Harbin Medical University, Harbin 150001, People’s Republic of ChinaTel/Fax +86-451-82576565Email biliangjia6601@126.comPurpose: The aim of the present study was to evaluate the expression of inflammasome and cytokine on experimental periodontitis with super activated platelet lysate (SPL) in rats.Methods: Periodontitis was induced by submerging cotton ligatures on the right side of the maxillary second molar in 36 Wistar rats. The rats were divided into 3 groups randomly: the rats received no treatment (control group); local injection with sterile saline (ligature+saline group) and local injection with SPL (ligature+SPL group). After treatments, the alveolar bone level and inflammation of periodontal tissue were evaluated by micro-computed tomography (micro-CT) scanning and histological examination, respectively. The expression of inflammasome and cytokine was evaluated by real-time quantitative polymerase chain reaction (RT-qPCR) assay.Results: Compared with the control group, the bone loss significantly increased by 0.9 mm in the ligature+saline group and 0.4 mm in the ligature+SPL group (P < 0.001). 0.5 mm reduction in the bone loss was founded in the ligature+SPL group compared with the ligature+saline group (P < 0.001). The gene expression of CCL2, CXCL2, IL-6, IL-18, IL-1α, IL-1β, CXCL10, CXCL16

Published
2020

14. Sonodynamic effect of hematoporphyrin monomethyl ether on ligature-induced periodontitis in rats [Corrigendum]

Author

Zhuang,Deshu, Han,Jialong, Bi,Liangjia, Wang,Yueping, Hao,Yanru, Zhou,Qi, Cao,Wenwu, Zhuang,Deshu, Han,Jialong, Bi,Liangjia, Wang,Yueping, Hao,Yanru, Zhou,Qi, and Cao,Wenwu

Abstract

Zhuang DS, Han JL, Bi LJ, et al. Drug Des Devel Ther. 2015;9:2545–2551.The authors would like to make an addition to the “Acknowledgment section”. The corrected section is as follows:AcknowledgmentsFinancial support of this work was provided by the National Key Technology Support Program of the People’s Republic of China, under grant number 2013BAI03B06. This research work was jointly supported by the Joint Specialized Research Fund for the Doctoral Program of Higher Education of the Ministry of Eduction of the People’s Republic of China under grant number 20132307110018, and the Graduate Student Innovation Research Project in Harbin Medical University of the People’s Republic of China under grant number YJSCX2015-32HYD. View the original paper here.

Published
2016

17. Sonodynamic effect of hematoporphyrin monomethyl ether on ligature-induced periodontitis in rats

Author

Zhuang,Deshu, Han,Jialong, Bi,Liangjia, Wang,Yueping, Hao,Yanru, Zhou,Qi, Cao,Wenwu, Zhuang,Deshu, Han,Jialong, Bi,Liangjia, Wang,Yueping, Hao,Yanru, Zhou,Qi, and Cao,Wenwu

Abstract

Deshu Zhuang,1 Jialong Han,1 Liangjia Bi,1 Yueping Wang,1 Yanru Hao,2 Qi Zhou,3 Wenwu Cao3,4 1Department of Stomatology, The Fourth Affiliated Hospital, Harbin Medical University, Harbin, People’s Republic of China; 2Department of Stomatology, The First Affiliated Hospital, Harbin Medical University, Harbin, People’s Republic of China; 3Condensed Matter Science and Technology Institute, Harbin Institute of Technology, Harbin, People’s Republic of China; 4Department of Mathematics and Materials Research Institute, The Pennsylvania State University, University Park, PA, USA Objectives: The aim of this study was to perform a histological evaluation of sonodynamic therapy (SDT) of hematoporphyrin monomethyl ether (HMME) on artificially induced periodontal disease in rats.Methods: Submerging ligatures were placed at the subgingival region of the first maxillary molar in rats. Eighty rats were randomly assigned into four groups: group 1 received no treatment; group 2 was subjected to 50 µg/mL HMME alone; group 3 was treated with low-intensity ultrasound alone (1 W/cm2); and group 4 was treated with 50 µg/mL HMME plus ultrasound irradiation (1 MHz, 30 minutes). Ten rats in each group were euthanized at 7 and 15 days, and periodontal tissue samples were taken for histological examination.Results: The animals treated by SDT showed less bone loss (P<0.05) at all experimental periods than the other three groups. No significant differences were found between the control and HMME groups (P>0.05).Conclusion: Our results suggest that HMME-mediated SDT can effectively alleviate the periodontal tissue destruction in artificially induced periodontitis in rats. Hence, SDT may have good clinic potential as a noninvasive treatment of periodontal diseases. Keywords: periodontal tissues, sonodynamic therapy, histology, alveolar bone loss, animal studiesA corrigendum has been published on this paper.

Published
2015

19. Effects of Porphyromonas gingivalis infection on intercellular adhesion molecule-1 expression in rat vascular smooth muscle cells.

Author

Dai Jiayin, Lin Jiang, Bi Liangjia, Jiao Lining, and Wang Qiang

Subjects
PORPHYROMONAS gingivalis, BACTERIAL diseases, CELL adhesion molecules, LABORATORY rats, VASCULAR smooth muscle, REVERSE transcriptase polymerase chain reaction, MESSENGER RNA
Abstract

Objective To observe the effects of Porphyromonas gingivalis (P. gingivalis) ATCC 33277 infection on expression of intercellular adhesion molecule-1 (ICAM-1) in rat vascular smooth muscle cells(VSMC). Methods An infection model of rat VSMC invaded by P. gingivalis was established in vitro. The mRNA of ICAM-1 was measured through reverse transcription-polymerase chain reaction (RT-PCR). Results Compared with the control group, an apparent and statistically significant increase in expression of ICAM-1 mRNA was observed after 8, 16, and 24 h in P. gingivals-infected rat VSMC (P<0.05). The expression reached its peak at 16 h. Statistically significant differences were observed in the 8 h group and in the other two experimental groups (P<0.05). Conclusion Infection of P. gingivals in rat VSMC can cause increased expression of ICAM-1, which may have an important function in the progression of atherosclerosis. [ABSTRACT FROM AUTHOR]

Published
2014
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20. Porphyromonas gingivalisExacerbates Ligature-Induced, RANKL-Dependent Alveolar Bone Resorption via Differential Regulation of Toll-Like Receptor 2 (TLR2) and TLR4

Author

Lin, Jiang, Bi, Liangjia, Yu, Xiaoqian, Kawai, Toshihisa, Taubman, Martin A., Shen, Baozhong, and Han, Xiaozhe

Abstract

ABSTRACTToll-like receptors (TLRs) play a key role in the innate immune responses to periodontal pathogens in periodontal disease. The present study was performed to determine the roles of TLR2 and TLR4 signaling in alveolar bone resorption, using a Porphyromonas gingivalis-associated ligature-induced periodontitis model in mice. Wild-type (WT), Tlr2−/−, and Tlr4−/−mice (8 to 10 weeks old) in the C57/BL6 background were used. Silk ligatures were applied to the maxillary second molars in the presence or absence of live P. gingivalisinfection. Ligatures were removed from the second molars on day 14, and mice were kept for another 2 weeks before sacrifice for final analysis (day 28). On day 14, there were no differences in alveolar bone resorption and gingival RANKL expression between mice treated with ligation plus P. gingivalisinfection and mice treated with ligation alone. Gingival interleukin-1β (IL-1β) and tumor necrosis factor alpha (TNF-α) expression was increased, whereas IL-10 expression was decreased in WT and Tlr2−/−mice but not in Tlr4−/−mice. On day 28, WT and Tlr4−/−mice treated with ligation plus P. gingivalisinfection showed significantly increased bone loss and gingival RANKL expression compared to those treated with ligation alone, whereas such an increase was diminished in Tlr2−/−mice. Gingival TNF-α upregulation and IL-10 downregulation were observed only in WT and Tlr4−/−mice, not in Tlr2−/−mice. In all mice, bone resorption induced by ligation plus P. gingivalisinfection was antagonized by local anti-RANKL antibody administration. This study suggests that P. gingivalisexacerbates ligature-induced, RANKL-dependent periodontal bone resorption via differential regulation of TLR2 and TLR4 signaling.

Published
2014
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