16,213 results on '"Biagio, A"'
Search Results
2. Functional Mixture Regression Control Chart
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Capezza, Christian, Centofanti, Fabio, Forcina, Davide, Lepore, Antonio, and Palumbo, Biagio
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Statistics - Methodology ,Statistics - Applications - Abstract
Industrial applications often exhibit multiple in-control patterns due to varying operating conditions, which makes a single functional linear model (FLM) inadequate to capture the complexity of the true relationship between a functional quality characteristic and covariates, which gives rise to the multimode profile monitoring problem. This issue is clearly illustrated in the resistance spot welding (RSW) process in the automotive industry, where different operating conditions lead to multiple in-control states. In these states, factors such as electrode tip wear and dressing may influence the functional quality characteristic differently, resulting in distinct FLMs across subpopulations. To address this problem, this article introduces the functional mixture regression control chart (FMRCC) to monitor functional quality characteristics with multiple in-control patterns and covariate information, modeled using a mixture of FLMs. A monitoring strategy based on the likelihood ratio test is proposed to monitor any deviation from the estimated in-control heterogeneous population. An extensive Monte Carlo simulation study is performed to compare the FMRCC with competing monitoring schemes that have already appeared in the literature, and a case study in the monitoring of an RSW process in the automotive industry, which motivated this research, illustrates its practical applicability.
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- 2024
3. Towards the $\beta$ function of SU(2) with adjoint matter using Pauli-Villars fields
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Bennett, Ed, Athenodorou, Andreas, Bergner, Georg, Butti, Pietro, and Lucini, Biagio
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High Energy Physics - Lattice - Abstract
The family of SU(2) theories with matter transforming in the adjoint representation has attracted interest from many angles. The two-flavour theory, known as Minimal Walking Technicolor, has a body of evidence pointing to it being in the conformal window with anomalous dimension $\gamma_{*}\approx0.3$. Perturbative calculations would suggest that the one-flavour theory should be confining and chirally broken; however, lattice studies of the theory have been inconclusive. In this contribution we present a first look at efforts towards the computation of the beta function of these theories using the gradient flow methodology. Following an exploration of the phase diagram of the two theories with Wilson fermions and additional Pauli-Villars fields, we tune the bare fermion mass to near the chiral limit, and subsequently generate ensembles at five lattice volumes and a range of lattice spacings., Comment: 9 pages, 7 figures. Contribution to Proceedings of the 41st International Symposium on Lattice Field Theory (Lattice 2024), July 28th - August 3rd, 2024, University of Liverpool, UK
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- 2024
4. Progress on pseudoscalar flavour-singlets in Sp(4) with mixed fermion representations
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Zierler, Fabian, Bennett, Ed, Forzano, Niccolò, Hong, Deog Ki, Hsiao, Ho, Lee, Jong-Wan, Lin, C. -J. David, Lucini, Biagio, Piai, Maurizio, and Vadacchino, Davide
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High Energy Physics - Lattice ,High Energy Physics - Phenomenology - Abstract
We measure the masses of the pseudoscalar flavour-singlet meson states in the $Sp(4)$ gauge theory coupled to two Dirac fermions transforming in the fundamental representation and three Dirac fermions in the antisymmetric representation. This theory provides a compelling ultraviolet completion for the minimal composite Higgs model implementing also partial compositeness for the top quark. The spectrum contains two, comparatively light, pseudoscalar flavour-singlet states, which mix with one another. One of them is a Nambu-Goldstone boson (in the massless limit), whereas the other receives a mass from the $U(1)_A$ axial anomaly. We demonstrate how to measure the mixing between these two states. For moderately heavy fermion masses, we find that the two wave functions are dominated by one of the fermion representations, mixing effects being small., Comment: 12 pages, 2 figures, 2 tables, Proceedings of the 41st International Symposium on Lattice Field Theory (Lattice 2024), July 28th - August 3rd, 2024, University of Liverpool, UK
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- 2024
5. Progress on the spectroscopy of lattice gauge theories using spectral densities
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Bennett, Ed, Del Debbio, Luigi, Forzano, Niccolò, Hill, Ryan C., Hong, Deog Ki, Hsiao, Ho, Lee, Jong-Wan, Lin, C. -J. David, Lucini, Biagio, Lupo, Alessandro, Piai, Maurizio, Vadacchino, Davide, and Zierler, Fabian
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High Energy Physics - Lattice ,High Energy Physics - Phenomenology - Abstract
Spectral densities encode non-perturbative information crucial in computing physical observables in strongly coupled field theories. Using lattice gauge theory data, we perform a systematic study to demonstrate the potential of recent technological advances in the reconstruction of spectral densities. We develop, maintain and make publicly available dedicated analysis code that can be used for broad classes of lattice theories. As a test case, we analyse the Sp(4) gauge theory coupled to an admixture of fermions transforming in the fundamental and two-index antisymmetric representations. We measure the masses of mesons in energy-smeared spectral densities, after optimising the smearing parameters for available lattice ensembles. We present a summary of the mesons mass spectrum in all the twelve (flavored) channels available, including also several excited states., Comment: 9 pages, 5 figures, contribution for the 41th International Symposium on Lattice Field Theory (Lattice 2024), 28 July - 3 August 2024, Liverpool, UK, presenting the results of the paper: arXiv:2405.01388
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- 2024
6. On the infimum of the upper envelope of certain families of functions
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Ricceri, Biagio
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Mathematics - Optimization and Control - Abstract
In this paper, given a topological space $X$, an interval $I\subseteq {\bf R}$ and five continuous functions $\varphi, \psi, \omega :X\to {\bf R}$, $\alpha, \beta:I\to {\bf R}$, we are interested in the infimum of the function $\Phi:X\to ]-\infty,+\infty]$ defined by $$\Phi(x)=\sup_{\lambda\in I}(\alpha(\lambda)\varphi(x)+\beta(\lambda)\psi(x))+\omega(x)\ .$$ Using a recent minimax theorem ([5]), we build a general scheme which provides the exact value of $\inf_X\Phi$ for a large class of functions $\Phi$. When additional compactness conditions are satisfied, our scheme provides also the existence of (explicitly detected) functions $\gamma, \eta:X\to {\bf R}$ such that, for some $\tilde x\in X$, one has $$\gamma(\tilde x)\varphi(\tilde x)+\eta(\tilde x)\psi(\tilde x)+\omega(\tilde x)=\inf_{x\in X}(\gamma(\tilde x)\varphi(x)+\eta(\tilde x)\psi(x)+\omega(x))\ .$$
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- 2024
7. A Control Barrier Function Candidate for Limited Field of View Sensors
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Trimarchi, Biagio, Schiano, Fabrizio, and Tron, Roberto
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Electrical Engineering and Systems Science - Systems and Control - Abstract
The problem of control based on vision measurements (bearings) has been amply studied in the literature; however, the problem of addressing the limits of the field of view of physical sensors has received relatively less attention (especially for agents with non-trivial dynamics). The technical challenge is that, as in most vision-based control approaches, a standard approach to the problem requires knowing the distance between cameras and observed features in the scene, which is not directly available. Instead, we present a solution based on a Control Barrier Function (CBF) approach that uses a splitting of the original differential constraint to effectively remove the dependence on the unknown measurement error. Compared to the current literature, our approach gives strong robustness guarantees against bounded distance estimation errors. We showcase the proposed solution with the numerical simulations of a double integrator and a quadrotor tracking a trajectory while keeping the corners of a rectangular gate in the camera field of view., Comment: 8 pages, conference paper
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- 2024
8. The density of states method for symplectic gauge theories at finite temperature
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Bennett, Ed, Lucini, Biagio, Mason, David, Piai, Maurizio, Rinaldi, Enrico, and Vadacchino, Davide
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High Energy Physics - Lattice ,Astrophysics - Cosmology and Nongalactic Astrophysics ,General Relativity and Quantum Cosmology ,High Energy Physics - Phenomenology ,High Energy Physics - Theory - Abstract
We study the finite-temperature behaviour of the $Sp(4)$ Yang-Mills lattice theory in four dimensions, by applying the Logarithmic Linear Relaxation (LLR) algorithm. We demonstrate the presence of coexisting (metastable) phases, when the system is in the proximity of the transition. We measure observables such as the free energy, the expectation value of the plaquette operator and of the Polyakov loop, as well as the specific heat, and the Binder cumulant. We use these results to obtain a high-precision measurement of the critical coupling at the confinement-deconfinement transition, and assess its systematic uncertainty, for one value of the lattice extent in the time direction. Furthermore, we perform an extensive study of the finite-volume behaviour of the lattice system, by repeating the measurements for fixed lattice time extent, while increasing the spatial size of the lattice. We hence characterise the first-order transition on the lattice, and present the first results in the literature on this theory for the infinite volume extrapolation of lattice quantities related to latent heat and interface tension. Gauge theories with $Sp(4)$ group have been proposed as new dark sectors to provide a fundamental origin for the current phenomenological evidence of dark matter. A phase transition at high temperature, in such a new dark sector, occurring in the early universe, might have left a relic stochastic background of gravitational waves. Our results represent a milestone toward establishing whether such a new physics signal is detectable in future experiments, as they enter the calculation of the parameters, $\alpha$ and $\beta$, controlling the power spectrum of gravitational waves. We also outline the process needed in the continuum extrapolation of our measurements, and test its feasibility on one additional choice of temporal extent of the lattice., Comment: 27 pages, 18 figures
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- 2024
9. Statistical analysis on the effectiveness of a low insulin index, alkaline and functional diet evaluated with machine learning techniques
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Antoniali, Fabiana, Conza, Maria Luisa, Conventi, Francesco Alessandro, Cirotto, Francesco, D'Avanzo, Antonio, De Iorio, Agostino, De Iorio, Annalisa, Formicola, Nunzia, Forte, Manuela, Miele, Federica, Perna, Giovanni, Rossi, Biagio, and Rossi, Elvira
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Quantitative Biology - Quantitative Methods ,Physics - Applied Physics ,Physics - Data Analysis, Statistics and Probability - Abstract
In this paper, a statistical analysis of the performance of a low insulin index, alkaline and functional diet developed by ANTUR evaluated with machine learning techniques is reported. The sample of patients was checked on a regular basis with a BioImpedenziometric (BIA) analysis. The BIA gives about 40 parameters output describing the health status of the patient. The sample of 1626 patients was grouped in clusters with similar characteristics by a neural network algorithm. A study of the behaviour of the BIA parameters evolution over time with respect to the first visit was performed. More than the 75% of the patient that followed the ANTUR diet showed an improvement of the health status.
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- 2024
10. miniLB: A Performance Portability Study of Lattice-Boltzmann Simulations
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Crisci, Luigi, Cosenza, Biagio, Amati, Giorgio, and Turisini, Matteo
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Computer Science - Distributed, Parallel, and Cluster Computing - Abstract
The Lattice Boltzmann Method (LBM) is a computational technique of Computational Fluid Dynamics (CFD) that has gained popularity due to its high parallelism and ability to handle complex geometries with minimal effort. Although LBM frameworks are increasingly important in various industries and research fields, their complexity makes them difficult to modify and can lead to suboptimal performance. This paper presents miniLB, the first, to the best of our knowledge, SYCL-based LBM mini-app.miniLB addresses the need for a performance-portable LBM proxy app capable of abstracting complex fluid dynamics simulations across heterogeneous computing systems. We analyze SYCL semantics for performance portability and evaluate miniLB on multiple GPU architectures using various SYCL implementations. Our results, compared against a manually-tuned FORTRAN version, demonstrate effectiveness of miniLB in assessing LBM performance across diverse hardware, offering valuable insights for optimizing large-scale LBM frameworks in modern computing environments., Comment: 12 pages, conference
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- 2024
11. SU(2) gauge theory with one and two adjoint fermions towards the continuum limit
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Athenodorou, Andreas, Bennett, Ed, Bergner, Georg, Butti, Pietro, Lenz, Julian, and Lucini, Biagio
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High Energy Physics - Lattice - Abstract
We provide an extended lattice study of the SU(2) gauge theory coupled to one Dirac fermion flavour ($N_{\mathrm{f}} =1$) transforming in the adjoint representation as the continuum limit is approached. This investigation is supplemented by numerical results obtained for the SU(2) gauge theory with two Dirac fermion flavours ($N_{\mathrm{f}} =2$) transforming in the adjoint representation, for which we perform numerical investigations at a single lattice spacing value, which is analysed together with earlier calculations. The purpose of our study is to advance the characterisation of the infrared properties of both theories, which previous investigations have concluded to be in the conformal window. For both, we determine the mass spectrum and the anomalous dimension of the fermion condensate using finite-size hyperscaling of the spectrum, mode number analysis of the Dirac operator (for which we improve on our previous proposal) and the ratio of masses of the lightest spin-2 particle over the lightest scalar. All methods provide a consistent picture, with the anomalous dimension of the condensate $\gamma_*$ decreasing significantly as one approaches the continuum limit for the $N_{\mathrm{f}} = 1$ theory towards a value consistent with $\gamma_* = 0.174(6)$, while for $N_{\mathrm{f}} = 2$ the anomalous dimension decreases more slowly with $\beta$. A chiral perturbation theory analysis show that the infrared behaviour of both theories is incompatible with the breaking of chiral symmetry., Comment: 24 pages, 22 figures
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- 2024
12. Generalizing AI-driven Assessment of Immunohistochemistry across Immunostains and Cancer Types: A Universal Immunohistochemistry Analyzer
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Brattoli, Biagio, Mostafavi, Mohammad, Lee, Taebum, Jung, Wonkyung, Ryu, Jeongun, Park, Seonwook, Park, Jongchan, Pereira, Sergio, Shin, Seunghwan, Choi, Sangjoon, Kim, Hyojin, Yoo, Donggeun, Ali, Siraj M., Paeng, Kyunghyun, Ock, Chan-Young, Cho, Soo Ick, and Kim, Seokhwi
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Computer Science - Computer Vision and Pattern Recognition - Abstract
Despite advancements in methodologies, immunohistochemistry (IHC) remains the most utilized ancillary test for histopathologic and companion diagnostics in targeted therapies. However, objective IHC assessment poses challenges. Artificial intelligence (AI) has emerged as a potential solution, yet its development requires extensive training for each cancer and IHC type, limiting versatility. We developed a Universal IHC (UIHC) analyzer, an AI model for interpreting IHC images regardless of tumor or IHC types, using training datasets from various cancers stained for PD-L1 and/or HER2. This multi-cohort trained model outperforms conventional single-cohort models in interpreting unseen IHCs (Kappa score 0.578 vs. up to 0.509) and consistently shows superior performance across different positive staining cutoff values. Qualitative analysis reveals that UIHC effectively clusters patches based on expression levels. The UIHC model also quantitatively assesses c-MET expression with MET mutations, representing a significant advancement in AI application in the era of personalized medicine and accumulating novel biomarkers.
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- 2024
13. Stochastic weight matrix dynamics during learning and Dyson Brownian motion
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Aarts, Gert, Lucini, Biagio, and Park, Chanju
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Condensed Matter - Disordered Systems and Neural Networks ,Computer Science - Machine Learning ,High Energy Physics - Lattice - Abstract
We demonstrate that the update of weight matrices in learning algorithms can be described in the framework of Dyson Brownian motion, thereby inheriting many features of random matrix theory. We relate the level of stochasticity to the ratio of the learning rate and the mini-batch size, providing more robust evidence to a previously conjectured scaling relationship. We discuss universal and non-universal features in the resulting Coulomb gas distribution and identify the Wigner surmise and Wigner semicircle explicitly in a teacher-student model and in the (near-)solvable case of the Gaussian restricted Boltzmann machine., Comment: 17 pages, 16 figures
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- 2024
14. Explaining Deep Neural Networks by Leveraging Intrinsic Methods
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La Rosa, Biagio
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Computer Science - Machine Learning - Abstract
Despite their impact on the society, deep neural networks are often regarded as black-box models due to their intricate structures and the absence of explanations for their decisions. This opacity poses a significant challenge to AI systems wider adoption and trustworthiness. This thesis addresses this issue by contributing to the field of eXplainable AI, focusing on enhancing the interpretability of deep neural networks. The core contributions lie in introducing novel techniques aimed at making these networks more interpretable by leveraging an analysis of their inner workings. Specifically, the contributions are threefold. Firstly, the thesis introduces designs for self-explanatory deep neural networks, such as the integration of external memory for interpretability purposes and the usage of prototype and constraint-based layers across several domains. Secondly, this research delves into novel investigations on neurons within trained deep neural networks, shedding light on overlooked phenomena related to their activation values. Lastly, the thesis conducts an analysis of the application of explanatory techniques in the field of visual analytics, exploring the maturity of their adoption and the potential of these systems to convey explanations to users effectively., Comment: PhD Thesis
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- 2024
15. Deep learning architectures for data-driven damage detection in nonlinear dynamic systems
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Joseph, Harrish, Quaranta, Giuseppe, Carboni, Biagio, and Lacarbonara, Walter
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Computer Science - Machine Learning - Abstract
The primary goal of structural health monitoring is to detect damage at its onset before it reaches a critical level. The in-depth investigation in the present work addresses deep learning applied to data-driven damage detection in nonlinear dynamic systems. In particular, autoencoders (AEs) and generative adversarial networks (GANs) are implemented leveraging on 1D convolutional neural networks. The onset of damage is detected in the investigated nonlinear dynamic systems by exciting random vibrations of varying intensity, without prior knowledge of the system or the excitation and in unsupervised manner. The comprehensive numerical study is conducted on dynamic systems exhibiting different types of nonlinear behavior. An experimental application related to a magneto-elastic nonlinear system is also presented to corroborate the conclusions., Comment: 34 pages, 17 figures, 4 tables
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- 2024
16. ModSec-Learn: Boosting ModSecurity with Machine Learning
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Scano, Christian, Floris, Giuseppe, Montaruli, Biagio, Demetrio, Luca, Valenza, Andrea, Compagna, Luca, Ariu, Davide, Piras, Luca, Balzarotti, Davide, and Biggio, Battista
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Computer Science - Machine Learning - Abstract
ModSecurity is widely recognized as the standard open-source Web Application Firewall (WAF), maintained by the OWASP Foundation. It detects malicious requests by matching them against the Core Rule Set (CRS), identifying well-known attack patterns. Each rule is manually assigned a weight based on the severity of the corresponding attack, and a request is blocked if the sum of the weights of matched rules exceeds a given threshold. However, we argue that this strategy is largely ineffective against web attacks, as detection is only based on heuristics and not customized on the application to protect. In this work, we overcome this issue by proposing a machine-learning model that uses the CRS rules as input features. Through training, ModSec-Learn is able to tune the contribution of each CRS rule to predictions, thus adapting the severity level to the web applications to protect. Our experiments show that ModSec-Learn achieves a significantly better trade-off between detection and false positive rates. Finally, we analyze how sparse regularization can reduce the number of rules that are relevant at inference time, by discarding more than 30% of the CRS rules. We release our open-source code and the dataset at https://github.com/pralab/modsec-learn and https://github.com/pralab/http-traffic-dataset, respectively., Comment: arXiv admin note: text overlap with arXiv:2308.04964
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- 2024
17. Cardiac Rehabilitation in Patients Acutely Managed for Cardiogenic Shock (ENIGMA) (ENIGMA)
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Ospedale Civile Ss. Antonio e Biagio e Cesare Arrigo, Alessandria, Italy, Azienda Ospedaliera Brotzu, Azienda Ospedaliera OO.RR. S. Giovanni di Dio e Ruggi D'Aragona, and ASST Grande Ospedale Metropolitano Niguarda, Milano, Italy
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- 2024
18. Mixing between flavor singlets in lattice gauge theories coupled to matter fields in multiple representations
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Bennett, Ed, Forzano, Niccolò, Hong, Deog Ki, Hsiao, Ho, Lee, Jong-Wan, Lin, C. -J. David, Lucini, Biagio, Piai, Maurizio, Vadacchino, Davide, and Zierler, Fabian
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High Energy Physics - Lattice ,High Energy Physics - Phenomenology - Abstract
We provide the first extensive, numerical study of the non-trivial problem of mixing between flavor-singlet composite states emerging in strongly coupled lattice field theories with matter field content consisting of fermions transforming in different representations of the gauge group. The theory of interest is the minimal candidate for a composite Higgs model that also accommodates a mechanism for top partial compositeness: the $Sp(4)$ gauge theory coupled to two (Dirac) fermions transforming as the fundamental and three as the two-index antisymmetric representation of the gauge group, respectively. We apply an admixture of APE and Wuppertal smearings, as well as the generalized eigenvalue problem approach, to two-point functions involving flavor-singlet mesons, for ensembles having time extent longer than the space extent. We demonstrate that, in the region of lattice parameter space accessible to this study, both masses and mixing angles can be measured effectively, despite the presence of (numerically noisy) contributions from disconnected diagrams., Comment: 18 pages, 3 figures, 5 tables; v2: minor changes, added appendix A, version accepted for publication in PRD
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- 2024
19. A characterization of the existence of zeros for operators with Lipschitzian derivative and closed range
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Ricceri, Biagio
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Mathematics - Functional Analysis - Abstract
Let $H$ be a real Hilbert space and $\Phi:H\to H$ be a $C^1$ operator with Lipschitzian derivative and closed range. We prove that $\Phi^{-1}(0)\neq \emptyset$ if and only if, for each $\epsilon>0$, there exist a convex set $X\subset H$ and a convex function $\psi:X\to {\bf R}$ such that $\sup_{x\in X}(\|x\|^2+\psi(x))-\inf_{x\in X}\|x\|^2+\psi(x))<\epsilon$ and $0\in \overline{conv}(\Phi(X))$., Comment: Accepted in Canad. Math. Bull
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- 2024
20. Meson spectroscopy from spectral densities in lattice gauge theories
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Bennett, Ed, Del Debbio, Luigi, Forzano, Niccolò, Hill, Ryan C., Hong, Deog Ki, Hsiao, Ho, Lee, Jong-Wan, Lin, C. -J. David, Lucini, Biagio, Lupo, Alessandro, Piai, Maurizio, Vadacchino, Davide, and Zierler, Fabian
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High Energy Physics - Lattice ,High Energy Physics - Phenomenology - Abstract
Spectral densities encode non-perturbative information that enters the calculation of a plethora of physical observables in strongly coupled field theories. Phenomenological applications encompass aspects of standard-model hadronic physics, observable at current colliders, as well as correlation functions characterizing new physics proposals, testable in future experiments. By making use of numerical data produced in a Sp(4) lattice gauge theory with matter transforming in an admixture of fundamental and 2-index antisymmetric representations of the gauge group, we perform a systematic study to demonstrate the effectiveness of recent technological progress in the reconstruction of spectral densities. To this purpose, we write and test new software packages that use energy-smeared spectral densities to analyze the mass spectrum of mesons. We assess the effectiveness of different smearing kernels and optimize the smearing parameters to the characteristics of available lattice ensembles. We generate new ensembles for the theory in consideration, with lattices that have a longer extent in the time direction with respect to the spatial ones. We run our tests on these ensembles, obtaining new results about the spectrum of light mesons and their excitations. We make available our algorithm and software for the extraction of spectral densities, that can be applied to theories with other gauge groups, including the theory of strong interactions (QCD) governing hadronic physics in the standard model., Comment: Version approved for publication. 45 pages, 20 figures
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- 2024
21. Chain-structured neural architecture search for financial time series forecasting
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Levchenko, Denis, Rappos, Efstratios, Ataee, Shabnam, Nigro, Biagio, and Robert, Stephan
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Quantitative Finance - Statistical Finance ,Computer Science - Machine Learning - Abstract
We compare three popular neural architecture search strategies on chain-structured search spaces: Bayesian optimization, the hyperband method, and reinforcement learning in the context of financial time series forecasting., Comment: 17 pages, 3 figures
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- 2024
22. Topological Data Analysis of Monopole Current Networks in $U(1)$ Lattice Gauge Theory
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Crean, Xavier, Giansiracusa, Jeffrey, and Lucini, Biagio
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High Energy Physics - Lattice ,Condensed Matter - Statistical Mechanics ,High Energy Physics - Theory ,Mathematics - Algebraic Topology - Abstract
In $4$-dimensional pure compact $U(1)$ lattice gauge theory, we analyse topological aspects of the dynamics of monopoles across the deconfinement phase transition. We do this using tools from Topological Data Analysis (TDA). We demonstrate that observables constructed from the zeroth and first homology groups of monopole current networks may be used to quantitatively and robustly locate the critical inverse coupling $\beta_{c}$ through finite-size scaling. Our method provides a mathematically robust framework for the characterisation of topological invariants related to monopole currents, putting on firmer ground earlier investigations. Moreover, our approach can be generalised to the study of Abelian monopoles in non-Abelian gauge theories., Comment: 26 pages, 8 figures, 6 tables, resubmission to SciPost; v4: clarifications added; typos corrected; analysis, results and conclusions unchanged
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- 2024
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23. An Adaptive Multivariate Functional EWMA Control Chart
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Capezza, Christian, Capizzi, Giovanna, Centofanti, Fabio, Lepore, Antonio, and Palumbo, Biagio
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Statistics - Methodology ,Statistics - Applications - Abstract
In many modern industrial scenarios, the measurements of the quality characteristics of interest are often required to be represented as functional data or profiles. This motivates the growing interest in extending traditional univariate statistical process monitoring (SPM) schemes to the functional data setting. This article proposes a new SPM scheme, which is referred to as adaptive multivariate functional EWMA (AMFEWMA), to extend the well-known exponentially weighted moving average (EWMA) control chart from the univariate scalar to the multivariate functional setting. The favorable performance of the AMFEWMA control chart over existing methods is assessed via an extensive Monte Carlo simulation. Its practical applicability is demonstrated through a case study in the monitoring of the quality of a resistance spot welding process in the automotive industry through the online observations of dynamic resistance curves, which are associated with multiple spot welds on the same car body and recognized as the full technological signature of the process.
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- 2024
24. A truly relativistic gravity mediated entanglement protocol using superpositions of rotational energies
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Higgins, Gerard, Di Biagio, Andrea, and Christodoulou, Marios
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Quantum Physics ,General Relativity and Quantum Cosmology - Abstract
Experimental proposals for testing quantum gravity-induced entanglement of masses (QGEM) typically involve two interacting masses which are each in a spatial superposition state. Here, we propose instead a QGEM experiment with two particles which are each in a superposition of rotational states, this amounts to a superposition of mass through mass-energy equivalence. In sharp contrast to the typical protocols studied, our proposal is genuinely relativistic. It does not consider a quantum positional degree of freedom but relies on the fact that rotational energy gravitates: the effect we consider disappears in the limit where the speed of light c approaches infinity. Furthermore, this approach would test a feature unique to gravity since it amounts to sourcing a spacetime in superposition due to a superposition of 'charge'., Comment: 5 pages, 3 figures, 3 pages supplemental material. Updated manuscript, accepted by Phys Rev D
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- 2024
25. On the Time Orientation of Probabilistic Theories
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Di Biagio, Andrea and Rovelli, Carlo
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Physics - History and Philosophy of Physics ,Quantum Physics - Abstract
An influential theorem by Satosi Watanabe convinced many that there can be no physical probabilistic theory with both non-trivial forward and backward transition probabilities. We show that this conclusion does not follow from the theorem. We point out the flaw in the argument, and we showcase examples of theories with well-defined backward and forward transition probabilities., Comment: 10 single column pages, no figures, version accepted for publication, improved thanks to peer review
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- 2024
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26. CTLA4 blockade abrogates KEAP1/STK11-related resistance to PD-(L)1 inhibitors
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Skoulidis, Ferdinandos, Araujo, Haniel A., Do, Minh Truong, Qian, Yu, Sun, Xin, Cobo, Ana Galan, Le, John T., Montesion, Meagan, Palmer, Rachael, Jahchan, Nadine, Juan, Joseph M., Min, Chengyin, Yu, Yi, Pan, Xuewen, Arbour, Kathryn C., Vokes, Natalie, Schmidt, Stephanie T., Molkentine, David, Owen, Dwight H., Memmott, Regan, Patil, Pradnya D., Marmarelis, Melina E., Awad, Mark M., Murray, Joseph C., Hellyer, Jessica A., Gainor, Justin F., Dimou, Anastasios, Bestvina, Christine M., Shu, Catherine A., Riess, Jonathan W., Blakely, Collin M., Pecot, Chad V., Mezquita, Laura, Tabbó, Fabrizio, Scheffler, Matthias, Digumarthy, Subba, Mooradian, Meghan J., Sacher, Adrian G., Lau, Sally C. M., Saltos, Andreas N., Rotow, Julia, Johnson, Rocio Perez, Liu, Corinne, Stewart, Tyler, Goldberg, Sarah B., Killam, Jonathan, Walther, Zenta, Schalper, Kurt, Davies, Kurtis D., Woodcock, Mark G., Anagnostou, Valsamo, Marrone, Kristen A., Forde, Patrick M., Ricciuti, Biagio, Venkatraman, Deepti, Van Allen, Eliezer M., Cummings, Amy L., Goldman, Jonathan W., Shaish, Hiram, Kier, Melanie, Katz, Sharyn, Aggarwal, Charu, Ni, Ying, Azok, Joseph T., Segal, Jeremy, Ritterhouse, Lauren, Neal, Joel W., Lacroix, Ludovic, Elamin, Yasir Y., Negrao, Marcelo V., Le, Xiuning, Lam, Vincent K., Lewis, Whitney E., Kemp, Haley N., Carter, Brett, Roth, Jack A., Swisher, Stephen, Lee, Richard, Zhou, Teng, Poteete, Alissa, Kong, Yifan, Takehara, Tomohiro, Paula, Alvaro Guimaraes, Parra Cuentas, Edwin R., Behrens, Carmen, Wistuba, Ignacio I., Zhang, Jianjun, Blumenschein, George R., Gay, Carl, Byers, Lauren A., Gibbons, Don L., Tsao, Anne, Lee, J. Jack, Bivona, Trever G., Camidge, D. Ross, Gray, Jhannelle E., Lieghl, Natasha, Levy, Benjamin, Brahmer, Julie R., Garassino, Marina C., Gandara, David R., Garon, Edward B., Rizvi, Naiyer A., Scagliotti, Giorgio Vittorio, Wolf, Jürgen, Planchard, David, Besse, Benjamin, Herbst, Roy S., Wakelee, Heather A., Pennell, Nathan A., Shaw, Alice T., Jänne, Pasi A., Carbone, David P., Hellmann, Matthew D., Rudin, Charles M., Albacker, Lee, Mann, Helen, Zhu, Zhou, Lai, Zhongwu, Stewart, Ross, Peters, Solange, Johnson, Melissa L., Wong, Kwok K., Huang, Alan, Winslow, Monte M., Rosen, Michael J., Winters, Ian P., Papadimitrakopoulou, Vassiliki A., Cascone, Tina, Jewsbury, Philip, and Heymach, John V.
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- 2024
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27. Dynamics of ecosystem services and nonlinear responses to increased anthropogenic pressure
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Liu, Chenghao, Liu, Yaobin, Giannetti, Biagio Fernando, de Almeida, Cecília Maria Villas Bôas, Wei, Guoen, Sevegnani, Fábio, and Yan, Xiaolu
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- 2024
- Full Text
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28. Chimera baryon spectrum in the Sp(4) completion of composite Higgs models
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Hsiao, Ho, Bennett, Ed, Hong, Deog Ki, Lee, Jong-Wan, Lin, C. -J. David, Lucini, Biagio, Piai, Maurizio, and Vadacchino, Davide
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High Energy Physics - Lattice - Abstract
In strongly coupled gauge theories that serve as completions of composite Higgs models, the fermionic bound states formed by fermions (hyperquarks) transforming in different representations, called chimera baryons, could serve as top partners, by embedding of the Standard Model appropriately. We report our results on the spectrum of chimera baryons in the Sp(4) gauge theory with hyperquarks transforming in fundamental and two-index antisymmetric representations. For this study, we adopt the quenched approximation. We investigate the mass hierarchy between the lightest chimera baryons with different quantum numbers, as a function of the lattice parameters. Inspired by baryon chiral effective field theory, and the Akaike Information Criterion, we perform a first extrapolation to the continuum and massless-hyperquark limit., Comment: 8 pages, 2 figures, contribution to the proceedings of the 40th International Symposium on Lattice Field Theory (LATTICE2023), July 31st - August 4th, 2023, Fermi National Accelerator Laboratory, Batavia, Illinois, USA
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- 2024
29. Integrated mutational landscape analysis of poorly differentiated high-grade neuroendocrine carcinoma of the uterine cervix.
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Bellone, Stefania, Jeong, Kyungjo, Halle, Mari, Krakstad, Camilla, McNamara, Blair, Greenman, Michelle, Mutlu, Levent, Demirkiran, Cem, Hartwich, Tobias, Yang-Hartwich, Yang, Zipponi, Margherita, Buza, Natalia, Hui, Pei, Raspagliesi, Francesco, Lopez, Salvatore, Paolini, Biagio, Milione, Massimo, Perrone, Emanuele, Scambia, Giovanni, Altwerger, Gary, Ravaggi, Antonella, Bignotti, Eliana, Huang, Gloria, Andikyan, Vaagn, Clark, Mitchell, Ratner, Elena, Azodi, Masoud, Schwartz, Peter, Quick, Charles, Angioli, Roberto, Terranova, Corrado, Zaidi, Samir, Nandi, Shuvro, Alexandrov, Ludmil, Siegel, Eric, Choi, Jungmin, Schlessinger, Joseph, and Santin, Alessandro
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cancer ,genetic analysis ,mutations ,neuroendocrine ,oncogene ,Humans ,Female ,Uterine Cervical Neoplasms ,Afatinib ,Phylogeny ,Phosphatidylinositol 3-Kinases ,Neuroendocrine Tumors ,Mutation ,Class I Phosphatidylinositol 3-Kinases ,Adenocarcinoma ,Carcinoma ,Neuroendocrine ,DNA Mutational Analysis - Abstract
High-grade neuroendocrine cervical cancers (NETc) are exceedingly rare, highly aggressive tumors. We analyzed 64 NETc tumor samples by whole-exome sequencing (WES). Human papillomavirus DNA was detected in 65.6% (42/64) of the tumors. Recurrent mutations were identified in PIK3CA, KMT2D/MLL2, K-RAS, ARID1A, NOTCH2, and RPL10. The top mutated genes included RB1, ARID1A, PTEN, KMT2D/MLL2, and WDFY3, a gene not yet implicated in NETc. Somatic CNV analysis identified two copy number gains (3q27.1 and 19q13.12) and five copy number losses (1p36.21/5q31.3/6p22.2/9q21.11/11p15.5). Also, gene fusions affecting the ACLY-CRHR1 and PVT1-MYC genes were identified in one of the eight samples subjected to RNA sequencing. To resolve evolutionary history, multiregion WES in NETc admixed with adenocarcinoma cells was performed (i.e., mixed-NETc). Phylogenetic analysis of mixed-NETc demonstrated that adenocarcinoma and neuroendocrine elements derive from a common precursor with mutations typical of adenocarcinomas. Over one-third (22/64) of NETc demonstrated a mutator phenotype of C > T at CpG consistent with deficiencies in MBD4, a member of the base excision repair (BER) pathway. Mutations in the PI3K/AMPK pathways were identified in 49/64 samples. We used two patient-derived-xenografts (PDX) (i.e., NET19 and NET21) to evaluate the activity of pan-HER (afatinib), PIK3CA (copanlisib), and ATR (elimusertib) inhibitors, alone and in combination. PDXs harboring alterations in the ERBB2/PI3K/AKT/mTOR/ATR pathway were sensitive to afatinib, copanlisib, and elimusertib (P < 0.001 vs. controls). However, combinations of copanlisib/afatinib and copanlisib/elimusertib were significantly more effective in controlling NETc tumor growth. These findings define the genetic landscape of NETc and suggest that a large subset of these highly lethal malignancies might benefit from existing targeted therapies.
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- 2024
30. On the spectrum of mesons in quenched $Sp(2N)$ gauge theories
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Bennett, Ed, Holligan, Jack, Hong, Deog Ki, Lee, Jong-Wan, Lin, C. -J. David, Lucini, Biagio, Piai, Maurizio, and Vadacchino, Davide
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High Energy Physics - Lattice - Abstract
We report the findings of our extensive study of the spectra of flavoured mesons in lattice gauge theories with symplectic gauge group and fermion matter content treated in the quenched approximation. For the $Sp(4)$, $Sp(6)$, and $Sp(8)$ gauge groups, the (Dirac) fermions transform in either the fundamental, or the 2-index, antisymmetric or symmetric, representations. This study sets the stage for future precision calculations with dynamical fermions in the low mass region of lattice parameter space. Our results have potential phenomenological applications ranging from composite Higgs models, to top (partial) compositeness, to dark matter models with composite, strong-coupling dynamical origin. Having adopted the Wilson flow as a scale-setting procedure, we apply Wilson chiral perturbation theory to extract the continuum and massless limits for the observables of interest. The resulting measurements are used to perform a simplified extrapolation to the large-$N$ limit, hence drawing a preliminary connection with gauge theories with unitary groups. We conclude with a brief discussion of the Weinberg sum rules., Comment: 31 pages, 28 figures, 7 tables. Version accepted for publication
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- 2023
31. Green Operations of SWIPT Networks: The Role of End-User Devices
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Rizzo, Gianluca, Marsan, Marco Ajmone, Esposito, Christian, and Boi, Biagio
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Computer Science - Networking and Internet Architecture ,Electrical Engineering and Systems Science - Signal Processing - Abstract
Internet of Things (IoT) devices often come with batteries of limited capacity that are not easily replaceable or rechargeable, and that constrain significantly the sensing, computing, and communication tasks that they can perform. The Simultaneous Wireless Information and Power Transfer (SWIPT) paradigm addresses this issue by delivering power wirelessly to energy-harvesting IoT devices with the same signal used for information transfer. For their peculiarity, these networks require specific energy-efficient planning and management approaches. However, to date, it is not clear what are the most effective strategies for managing a SWIPT network for energy efficiency. In this paper, we address this issue by developing an analytical model based on stochastic geometry, accounting for the statistics of user-perceived performance and base station scheduling. We formulate an optimization problem for deriving the energy optimal configuration as a function of the main system parameters, and we propose a genetic algorithm approach to solve it. Our results enable a first-order evaluation of the most effective strategies for energy-efficient provisioning of power and communications in a SWIPT network. We show that the service capacity brought about by users brings energy-efficient dynamic network provisioning strategies that radically differ from those of networks with no wireless power transfer., Comment: The manuscript has already been submitted to Journal on 7-12-2023
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- 2023
32. Analysis and prediction of performance variability in large-scale computing systems
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Salimi Beni, Majid, Hunold, Sascha, and Cosenza, Biagio
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- 2024
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33. Shedding new light on the Hubble constant tension through Supernovae Ia
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Dainotti, Maria Giovanna, De Simone, Biagio, Montani, Giovanni, and Bogdan, Malgorzata
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Astrophysics - Cosmology and Nongalactic Astrophysics ,Astrophysics - High Energy Astrophysical Phenomena - Abstract
The standard cosmological model, the $\Lambda$CDM model, is the most suitable description for our universe. This framework can explain the accelerated expansion phase of the universe but still is not immune to open problems when it comes to the comparison with observations. One of the most critical issues is the so-called Hubble constant ($H_0$) tension, namely, the difference of about $5\sigma$ as an average between the value of $H_0$ estimated locally and the cosmological value measured from the Last Scattering Surface. The value of this tension changes from 4 to 6 $\sigma$ according to the data used. The current analysis explores the $H_0$ tension in the \textit{Pantheon} sample (PS) of SNe Ia. Through the division of the PS in 3 and 4 bins, the value of $H_0$ is estimated for each bin and all the values are fitted with a decreasing function of the redshift ($z$). Remarkably, $H_0$ undergoes a slow decreasing evolution with $z$, having an evolutionary coefficient compatible with zero up to $5.8\sigma$. If this trend is not caused by hidden astrophysical biases or $z$-selection effects, then the $f(R)$ modified theories of gravity represent a valid model for explaining such a trend., Comment: 6 pages, 1 figure; accepted as refereed proceeding for the "Multifrequency Behaviour of High Energy Cosmic Sources - XIV 12-17 June 2023 Mondello, Palermo, Italy"
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- 2023
34. Lattice investigations of the chimera baryon spectrum in the Sp(4) gauge theory
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Bennett, Ed, Hong, Deog Ki, Hsiao, Ho, Lee, Jong-Wan, Lin, C. -J. David, Lucini, Biagio, Piai, Maurizio, and Vadacchino, Davide
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High Energy Physics - Lattice ,High Energy Physics - Phenomenology ,High Energy Physics - Theory - Abstract
We report the results of lattice numerical studies of the Sp(4) gauge theory coupled to fermions (hyperquarks) transforming in the fundamental and two-index antisymmetric representations of the gauge group. This strongly-coupled theory is the minimal candidate for the ultraviolet completion of composite Higgs models that facilitate the mechanism of partial compositeness for generating the top-quark mass. We measure the spectrum of the low-lying, half-integer spin, bound states composed of two fundamental and one antisymmetric hyperquarks, dubbed chimera baryons, in the quenched approximation. In this first systematic, non-perturbative study, we focus on the three lightest parity-even chimera-baryon states, in analogy with QCD, denoted as $\Lambda_{\rm CB}$, $\Sigma_{\rm CB}$ (both with spin 1/2), and $\Sigma_{\rm CB}^\ast$(with spin 3/2). The spin-1/2 such states are candidates of the top partners. The extrapolation of our results to the continuum and massless-hyperquark limit is performed using formulae inspired by QCD heavy-baryon Wilson chiral perturbation theory. Within the range of hyperquark masses in our simulations, we find that $\Sigma_{\mathrm{CB}}$ is not heavier than $\Lambda_{\mathrm{CB}}$., Comment: 36 pages, 12 figures, 19 tables; minor improvements and corrections; aligning numbers in Data release; version accepted for publication in PRD
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- 2023
35. Functional Neural Network Control Chart
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Kulahci, Murat, Lepore, Antonio, Palumbo, Biagio, and Sposito, Gianluca
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Statistics - Methodology ,Statistics - Applications - Abstract
In many Industry 4.0 data analytics applications, quality characteristic data acquired from manufacturing processes are better modeled as functions, often referred to as profiles. In practice, there are situations where a scalar quality characteristic, referred to also as the response, is influenced by one or more variables in the form of functional data, referred to as functional covariates. To adjust the monitoring of the scalar response by the effect of this additional information, a new profile monitoring strategy is proposed on the residuals obtained from the functional neural network, which is able to learn a possibly nonlinear relationship between the scalar response and the functional covariates. An extensive Monte Carlo simulation study is performed to assess the performance of the proposed method with respect to other control charts that appeared in the literature before. Finally, a case study in the railway industry is presented with the aim of monitoring the heating, ventilation and air conditioning systems installed onboard passenger trains.
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- 2023
36. Bank Deposits as {\em Money Quanta}
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Bagarello, Fabio and Bossone, Biagio
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Quantitative Finance - Mathematical Finance - Abstract
According to the Accounting View of Money (AVM), the money issued by commercial banks in the form of demand deposits features a hybrid nature, since deposits can be shown to consist of a share of deposits bearing the characteristics of debt (debt-deposits) and a share of deposits bearing the characteristics of equity (equity-deposits), in a mix that depends on factors that relate to the issuing banks and the environment where they operate and interact, which may change over time. Following this important finding of the AVM, it is only consequential to associate the hybrid nature of bank deposits with the dual nature of the objects which is typical in quantum physics, and to investigate whether and how the application of quantum analytical methods and ideas to a form of money showing dualistic features could be used to extract valuable economic information., Comment: In press in Quantum Economics and Finance
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- 2023
37. Towards a fuller understanding of neurons with Clustered Compositional Explanations
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La Rosa, Biagio, Gilpin, Leilani H., and Capobianco, Roberto
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Computer Science - Machine Learning ,Computer Science - Artificial Intelligence - Abstract
Compositional Explanations is a method for identifying logical formulas of concepts that approximate the neurons' behavior. However, these explanations are linked to the small spectrum of neuron activations (i.e., the highest ones) used to check the alignment, thus lacking completeness. In this paper, we propose a generalization, called Clustered Compositional Explanations, that combines Compositional Explanations with clustering and a novel search heuristic to approximate a broader spectrum of the neurons' behavior. We define and address the problems connected to the application of these methods to multiple ranges of activations, analyze the insights retrievable by using our algorithm, and propose desiderata qualities that can be used to study the explanations returned by different algorithms., Comment: Accepted at NeurIPS 2023
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- 2023
38. Raze to the Ground: Query-Efficient Adversarial HTML Attacks on Machine-Learning Phishing Webpage Detectors
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Montaruli, Biagio, Demetrio, Luca, Pintor, Maura, Compagna, Luca, Balzarotti, Davide, and Biggio, Battista
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Computer Science - Cryptography and Security ,Computer Science - Machine Learning - Abstract
Machine-learning phishing webpage detectors (ML-PWD) have been shown to suffer from adversarial manipulations of the HTML code of the input webpage. Nevertheless, the attacks recently proposed have demonstrated limited effectiveness due to their lack of optimizing the usage of the adopted manipulations, and they focus solely on specific elements of the HTML code. In this work, we overcome these limitations by first designing a novel set of fine-grained manipulations which allow to modify the HTML code of the input phishing webpage without compromising its maliciousness and visual appearance, i.e., the manipulations are functionality- and rendering-preserving by design. We then select which manipulations should be applied to bypass the target detector by a query-efficient black-box optimization algorithm. Our experiments show that our attacks are able to raze to the ground the performance of current state-of-the-art ML-PWD using just 30 queries, thus overcoming the weaker attacks developed in previous work, and enabling a much fairer robustness evaluation of ML-PWD., Comment: Proceedings of the 16th ACM Workshop on Artificial Intelligence and Security (AISec '23), November 30, 2023, Copenhagen, Denmark
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- 2023
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39. The deconfinement phase transition in $Sp(2N)$ gauge theories and the density of states method
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Mason, David, Lucini, Biagio, Piai, Maurizio, Rinaldi, Enrico, and Vadacchino, Davide
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High Energy Physics - Lattice ,Astrophysics - Cosmology and Nongalactic Astrophysics ,High Energy Physics - Phenomenology ,High Energy Physics - Theory - Abstract
First-order phase transitions in the early universe might produce a detectable background of gravitational waves. As these phase transitions can be generated by new physics, it is important to quantify these effects. Many pure Yang-Mills gauge theories are known to undergo first-order deconfinement phase transitions, with properties that can be studied with lattice simulations. Despite the recent surge of interest in $Sp(2N)$ gauge theories as a candidate for models of physics beyond the standard model, studies of these theories at finite temperature are still very limited. In this contribution we will present preliminary results of an ongoing numerical investigation of the thermodynamic properties of the deconfinement phase transition in $Sp(4)$ Yang-Mills theory, using the linear logarithmic relaxation algorithm. This method enables us to obtain a highly accurate determination of the density of states, allowing for a precise reconstruction of thermodynamic observables. In particular, it gives access to otherwise difficult to determine quantities such as the free energy of the system, even along metastable and unstable branches, hence providing an additional direct observable to study the dynamics of the phase transition., Comment: 9 pages, 2 figures, contribution for the 40th International Symposium on Lattice Field Theory (Lattice 2023), July 31st - August 4th, 2023, Fermi National Accelerator Laboratory
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- 2023
40. Lattice studies of Sp(2N) gauge theories using GRID
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Forzano, Niccolò, Bennett, Ed, Boyle, Peter, Del Debbio, Luigi, Hong, Deog Ki, Lee, Jong-Wan, Lenz, Julian, Lin, C. -J. David, Lucini, Biagio, Lupo, Alessandro, Piai, Maurizio, and Vadacchino, Davide
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High Energy Physics - Lattice ,High Energy Physics - Phenomenology - Abstract
Four-dimensional gauge theories based on symplectic Lie groups provide elegant realisations of the microscopic origin of several new physics models. Numerical studies pursued on the lattice provide quantitative information necessary for phenomenological applications. To this purpose, we implemented Sp(2N) gauge theories using Monte Carlo techniques within Grid, a performant framework designed for the numerical study of quantum field theories on the lattice. We show the first results obtained using this library, focusing on the case-study provided by the Sp(4) theory coupled to Nas = 4 Wilson-Dirac fermions transforming in the 2-index antisymmetric representation. In particular, we discuss preliminary tests of the algorithm and we test some of its main functionalities., Comment: 9 pages, 7 figures, contribution for the 40th International Symposium on Lattice Field Theory (Lattice 2023), July 31st - August 4th, 2023, Fermi National Accelerator Laboratory, presenting the results of the paper: arXiv:2306.11649
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- 2023
41. Multivariate Singular Spectrum Analysis by Robust Diagonalwise Low-Rank Approximation
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Centofanti, Fabio, Hubert, Mia, Palumbo, Biagio, and Rousseeuw, Peter J.
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Statistics - Methodology ,Statistics - Computation - Abstract
Multivariate Singular Spectrum Analysis (MSSA) is a powerful and widely used nonparametric method for multivariate time series, which allows the analysis of complex temporal data from diverse fields such as finance, healthcare, ecology, and engineering. However, MSSA lacks robustness against outliers because it relies on the singular value decomposition, which is very sensitive to the presence of anomalous values. MSSA can then give biased results and lead to erroneous conclusions. In this paper a new MSSA method is proposed, named RObust Diagonalwise Estimation of SSA (RODESSA), which is robust against the presence of cellwise and casewise outliers. In particular, the decomposition step of MSSA is replaced by a new robust low-rank approximation of the trajectory matrix that takes its special structure into account. A fast algorithm is constructed, and it is proved that each iteration step decreases the objective function. In order to visualize different types of outliers, a new graphical display is introduced, called an enhanced time series plot. An extensive Monte Carlo simulation study is performed to compare RODESSA with competing approaches in the literature. A real data example about temperature analysis in passenger railway vehicles demonstrates the practical utility of the proposed approach.
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- 2023
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42. Gravity Mediated Entanglement between Oscillators as Quantum Superposition of Geometries
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Bengyat, Ofek, Di Biagio, Andrea, Aspelmeyer, Markus, and Christodoulou, Marios
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Quantum Physics ,General Relativity and Quantum Cosmology - Abstract
Protocols for observing gravity induced entanglement typically comprise the interaction of two particles prepared either in a superposition of two discrete paths, or in a continuously delocalized (harmonic oscillator) state of motion. An important open question has been whether these two different approaches allow to draw the same conclusions on the quantum nature of gravity. To answer this question, we analyse using the path-integral approach a setup that contains both features: a superposition of two highly delocalized center of mass states. We conclude that the two usual protocols are of similar epistemological relevance. In both cases the appearance of entanglement, within linearised quantum gravity, is due to gravity being in a highly non-classical state: a superposition of distinct geometries., Comment: 5 + 2 pages, + Mathematica Notebooks
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- 2023
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43. Scalar field Restricted Boltzmann Machine as an ultraviolet regulator
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Aarts, Gert, Lucini, Biagio, and Park, Chanju
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High Energy Physics - Lattice ,Condensed Matter - Disordered Systems and Neural Networks - Abstract
Restricted Boltzmann Machines (RBMs) are well-known tools used in Machine Learning to learn probability distribution functions from data. We analyse RBMs with scalar fields on the nodes from the perspective of lattice field theory. Starting with the simplest case of Gaussian fields, we show that the RBM acts as an ultraviolet regulator, with the cutoff determined by either the number of hidden nodes or a model mass parameter. We verify these ideas in the scalar field case, where the target distribution is known, and explore implications for cases where it is not known using the MNIST data set. We also demonstrate that infrared modes are learnt quickest., Comment: 19 pages, many figures, minor clarifications added, version to appear in PRD
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- 2023
44. Relating Wigner's Friend Scenarios to Nonclassical Causal Compatibility, Monogamy Relations, and Fine Tuning
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Yīng, Yìlè, Ansanelli, Marina Maciel, Di Biagio, Andrea, Wolfe, Elie, Schmid, David, and Cavalcanti, Eric Gama
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Quantum Physics - Abstract
Nonclassical causal modeling was developed in order to explain violations of Bell inequalities while adhering to relativistic causal structure and faithfulness -- that is, avoiding fine-tuned causal explanations. Recently, a no-go theorem that can be viewed as being stronger than Bell's theorem has been derived, based on extensions of the Wigner's friend thought experiment: the Local Friendliness (LF) no-go theorem. Here we show that the LF no-go theorem poses formidable challenges for the field of causal modeling, even when nonclassical and/or cyclic causal explanations are considered. We first recast the LF inequalities, one of the key elements of the LF no-go theorem, as special cases of monogamy relations stemming from a statistical marginal problem. We then further recast LF inequalities as causal compatibility inequalities stemming from a nonclassical causal marginal problem, for a causal structure implied by well-motivated causal-metaphysical assumptions. We find that the LF inequalities emerge from this causal structure even when one allows the latent causes of observed events to admit post-quantum descriptions, such as in a generalized probabilistic theory or in an even more exotic theory. We further prove that no nonclassical causal model can explain violations of LF inequalities without violating the No Fine-Tuning principle. Finally, we note that these obstacles cannot be overcome even if one appeals to cyclic causal models, and we discuss potential directions for further extensions of the causal modeling framework., Comment: 16+5 pages, 9 figures. Accepted in Quantum
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- 2023
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45. Immunological characterization of a long-lasting response in a patient with metastatic triple-negative breast cancer treated with PD-1 and LAG-3 blockade
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Rivoltini, Licia, Camisaschi, Chiara, Fucà, Giovanni, Paolini, Biagio, Vergani, Barbara, Beretta, Valeria, Damian, Silvia, Duca, Matteo, Cresta, Sara, Magni, Michele, Leone, Biagio Eugenio, Castelli, Chiara, de Braud, Filippo, De Santis, Francesca, and Di Nicola, Massimo
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- 2024
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46. COL1A1::PDGFB fusion-associated uterine fibrosarcoma: A case report and review of the literature.
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Rota, Simone, Franza, Andrea, Fabbroni, Chiara, Paolini, Biagio, Greco, Francesca, Alessi, Alessandra, Padovano, Barbara, Sanfilippo, Roberta, and Casali, Paolo
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COL1A1::PDGFB ,Imatinib ,fibrosarcoma ,soft tissue sarcomas ,translocation t(17 ,22)(q22 ,q13) ,uterus ,Female ,Humans ,Adult ,Proto-Oncogene Proteins c-sis ,Imatinib Mesylate ,Dermatofibrosarcoma ,In Situ Hybridization ,Fluorescence ,Leiomyosarcoma ,Skin Neoplasms ,Neoplasm Recurrence ,Local ,Fibrosarcoma ,Soft Tissue Neoplasms ,Translocation ,Genetic ,Uterus - Abstract
BACKGROUND: Mesenchymal neoplasms of the uterus encompass a diverse group of tumors, with varying characteristics and origins, collectively accounting for 8% of uterine malignancies. The most common variants include uterine leiomyosarcoma, low-grade and high-grade endometrial stromal sarcoma, adenosarcoma, and undifferentiated sarcoma. Clinical presentation is often nonspecific and can lead to delayed diagnosis. Uterine sarcomas are generally aggressive, resulting in poorer prognosis compared to carcinomas. Recent advances in molecular techniques, such as next-generation sequencing (NGS), have led to the identification of new subtypes of uterine sarcomas, including COL1A1::PDGFB fusion-associated fibrosarcoma, which has a specific chromosomal translocation t(17;22)(q22;q13). Imatinib, a tyrosine kinase inhibitor (TKI), is an effective treatment for dermatofibrosarcoma protuberans (DFSP), marked by this translocation. CASE: We present the case of a 42-year-old woman diagnosed with COL1A1::PDGFB fusion-associated uterine fibrosarcoma. The patient underwent total hysterectomy and excision of the tumor, initially misdiagnosed as a low-grade leiomyosarcoma. Subsequent histological examination, immunohistochemistry, and fluorescence in situ hybridization (FISH) confirmed the diagnosis. After 10 months, disease recurrence was detected, and Imatinib therapy was initiated at a dose of 400 mg daily. An allergic reaction led to a temporary discontinuation, but upon resumption with appropriate medication, a positive radiological response was observed. The patient achieved a complete remission after 2 years and is still on Imatinib treatment. CONCLUSIONS: COL1A1::PDGFB fusion-associated uterine fibrosarcoma is an extremely rare mesenchymal neoplasm. In a case we present herein, we treated a patient with imatinib as first-line medical therapy. The patient is currently in complete remission after 37 months from treatment start. To the best of our knowledge, this represents a unique observation. We also provide a detailed literature review of the published cases so far. Prospective case series are needed to further understand the natural history of these tumors and optimize treatment strategies.
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- 2024
47. Erratum: Towards a muon collider
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Accettura, Carlotta, Adams, Dean, Agarwal, Rohit, Ahdida, Claudia, Aimè, Chiara, Amapane, Nicola, Amorim, David, Andreetto, Paolo, Anulli, Fabio, Appleby, Robert, Apresyan, Artur, Apyan, Aram, Arsenyev, Sergey, Asadi, Pouya, Mahmoud, Mohammed Attia, Azatov, Aleksandr, Back, John, Balconi, Lorenzo, Bandiera, Laura, Barlow, Roger, Bartosik, Nazar, Barzi, Emanuela, Batsch, Fabian, Bauce, Matteo, Berg, J Scott, Bersani, Andrea, Bertarelli, Alessandro, Bertolin, Alessandro, Black, Kevin, Boattini, Fulvio, Bogacz, Alex, Bonesini, Maurizio, Bordini, Bernardo, Bottaro, Salvatore, Bottura, Luca, Braghieri, Alessandro, Breschi, Marco, Bruhwiler, Natalie, Buffat, Xavier, Buonincontri, Laura, Burrows, Philip N, Burt, Graeme, Buttazzo, Dario, Caiffi, Barbara, Calviani, Marco, Calzaferri, Simone, Calzolari, Daniele, Capdevilla, Rodolfo, Carli, Christian, Casaburo, Fausto, Casarsa, Massimo, Castelli, Luca, Catanesi, Maria Gabriella, Cavallucci, Lorenzo, Cavoto, Gianluca, Celiberto, Francesco Giovanni, Celona, Luigi, Cerri, Alessandro, Cesarini, Gianmario, Cesarotti, Cari, Chachamis, Grigorios, Chance, Antoine, Chen, Siyu, Chien, Yang-Ting, Chiesa, Mauro, Colaleo, Anna, Collamati, Francesco, Collazuol, Gianmaria, Costa, Marco, Craig, Nathaniel, Curatolo, Camilla, Curtin, David, Da Molin, Giacomo, Dam, Magnus, Damerau, Heiko, Dasu, Sridhara, de Blas, Jorge, De Curtis, Stefania, De Matteis, Ernesto, De Rosa, Stefania, Delahaye, Jean-Pierre, Denisov, Dmitri, Denizli, Haluk, Densham, Christopher, Dermisek, Radovan, Di Luzio, Luca, Di Meco, Elisa, Di Micco, Biagio, Dienes, Keith, Diociaiuti, Eleonora, Dorigo, Tommaso, Dudarev, Alexey, Edgecock, Robert, Errico, Filippo, Fabbrichesi, Marco, Farinon, Stefania, Ferrari, Anna, Somoza, Jose Antonio Ferreira, Filthaut, Frank, and Fiorina, Davide
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Particle and High Energy Physics ,Astronomical Sciences ,Atomic ,Molecular and Optical Physics ,Physical Sciences ,Atomic ,Molecular ,Nuclear ,Particle and Plasma Physics ,Quantum Physics ,Nuclear & Particles Physics ,Astronomical sciences ,Atomic ,molecular and optical physics ,Particle and high energy physics - Abstract
The original online version of this article was revised: The additional reference [139] has been added. Tao Han’s ORICD ID has been incorrectly assigned to Chengcheng Han and Chengcheng Han’s ORCID ID to Tao Han. Yang Ma’s ORCID ID has been incorrectly assigned to Lianliang Ma, and Lianliang Ma’s ORCID ID to Yang Ma. The original article has been corrected.
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- 2024
48. Age of onset moderates the effects of Vascular Risk Factors on Neurodegeneration, Blood-Brain-Barrier permeability, and cognitive decline in Alzheimer’s Disease
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Chiara Giuseppina Bonomi, Caterina Motta, Martina Gaia Di Donna, Martina Poli, Marzia Nuccetelli, Sergio Bernardini, Nicola Biagio Mercuri, Giacomo Koch, and Alessandro Martorana
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Vascular risk ,Cognitive decline ,Early-onset ,Late-onset ,Blood-brain barrier ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Abstract Background The role of Vascular risk factors (VRFs) in the progression of Alzheimer’s Disease (AD) and cognitive decline remains to be elucidated, with previous studies resulting in conflicting findings. The possible impact of age-specific mechanisms of resilience/vulnerability is an under addressed issue. We evaluated the association of VRFs with markers of amyloid deposition, neurodegeneration, and blood-brain-barrier (BBB) permeability (Albumin quotient, Qalb), stratifying patients into early-onset ( 75, vLOAD), to evaluate the moderating effect of age of onset. Moreover, we explored the effects of VRFs on cognitive decline at one year follow-up (ΔMMSE). Methods For 368 patients with biologically confirmed AD, we computed eight risk factors in a composite measure of cumulative vascular risk (vascular score, VS). Stratifying patients according to age of onset, we regressed VS and main individual VRFs on p-tau/Aβ42, t-tau and Qalb, and used bootstrapped mediation analysis to test direct and indirect associations of VS with t-tau, using Qalb as mediator. In a subset of 105 patients, we performed multivariate backward regressions to assess the effects of sex, APOE, Qalb, VS, p-tau/Aβ42 and t-tau on ΔMMSE. Results VS was positively associated with CSF t-tau in more vulnerable groups burdened by more aggressive disease progression (EOAD: β = 0.256, p = 0.019) or aging (vLOAD: β = 0.007, p
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- 2024
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49. Integrated proteomics and metabolomics analyses reveal new insights into the antitumor effects of valproic acid plus simvastatin combination in a prostate cancer xenograft model associated with downmodulation of YAP/TAZ signaling
- Author
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Federica Iannelli, Rita Lombardi, Susan Costantini, Maria Serena Roca, Laura Addi, Francesca Bruzzese, Elena Di Gennaro, Alfredo Budillon, and Biagio Pucci
- Subjects
Drug repurposing ,Valproic acid ,Simvastatin ,Proteomics ,Metabolomics ,Prostate cancer ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 ,Cytology ,QH573-671 - Abstract
Abstract Background Despite advancements in therapeutic approaches, including taxane-based chemotherapy and androgen receptor-targeting agents, metastatic castration-resistant prostate cancer (mCRPC) remains an incurable tumor, highlighting the need for novel strategies that can target the complexities of this disease and bypass the development of drug resistance mechanisms. We previously demonstrated the synergistic antitumor interaction of valproic acid (VPA), an antiepileptic agent with histone deacetylase inhibitory activity, with the lipid-lowering drug simvastatin (SIM). This combination sensitizes mCRPC cells to docetaxel treatment both in vitro and in vivo by targeting the cancer stem cell compartment via mevalonate pathway/YAP axis modulation. Methods Here, using a combined proteomic and metabolomic/lipidomic approach, we characterized tumor samples derived from 22Rv1 mCRPC cell-xenografted mice treated with or without VPA/SIM and performed an in-depth bioinformatics analysis. Results We confirmed the specific impact of VPA/SIM on the Hippo–YAP signaling pathway, which is functionally related to the modulation of cancer-related extracellular matrix biology and metabolic reprogramming, providing further insights into the molecular mechanism of the antitumor effects of VPA/SIM. Conclusions In this study, we present an in-depth exploration of the potential to repurpose two generic, safe drugs for mCRPC treatment, valproic acid (VPA) and simvastatin (SIM), which already show antitumor efficacy in combination, primarily affecting the cancer stem cell compartment via MVP/YAP axis modulation. Bioinformatics analysis of the LC‒MS/MS and 1H‒NMR metabolomics/lipidomics results confirmed the specific impact of VPA/SIM on Hippo–YAP.
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- 2024
- Full Text
- View/download PDF
50. Large synthesis of in situ field measurements of the size distribution of mineral dust aerosols across their life cycles
- Author
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P. Formenti and C. Di Biagio
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Environmental sciences ,GE1-350 ,Geology ,QE1-996.5 - Abstract
Mineral dust aerosol is important in the Earth system, and the correct representation of its size distribution is fundamental for shaping the current state and evolution of the climate. Despite many observational dust size data that are available in the literature, using this body of information to properly guide the development and validation of climate models and remote sensing retrievals remains challenging. In this study we collect, evaluate, harmonize, and synthesize 58 size distribution data from the past 50 years of in situ field observations with the aim of providing a consistent dataset to the community for use in constraining the representation of dust size across its life cycle. Four levels (LEVs) of data treatment are defined, going from original data (LEV0), data interpolated and normalized on a standardized diameter grid (LEV1), and data in which original particle diameters are converted to a common geometrical definition under both spherical (LEV2a) and aspherical (LEV2b) assumptions. Size distributions are classified as emission or source (SOURCE, d from emission; number of datasets in this category N=12), mid-range transport (MRT, 1–4 d of transport; N=36), and long-range transport (LRT, >4 d of transport; N=10). The harmonized dataset shows consistent features suggesting the conservation of airborne particles with time and a decrease in the main coarse-mode diameter from a value on the order of 10 µm (in volume) for SOURCE dust to a value on the order of 1–2 µm for LRT conditions. An additional mode becomes evident below 0.4 µm for MRT and LRT dust. Data for the three levels (LEV1, LEV2a, and LEV2b) and the three categories (SOURCE, MRT, and LRT), together with statistical metrics (mean, median, 25th and 75th percentiles, and standard deviation), are available as follows: SOURCE (https://doi.org/10.57932/58dbe908-9394-4504-9099-74a3e77140e9, Formenti and Di Biagio, 2023a); MRT (https://doi.org/10.57932/31f2adf7-74fb-48e8-a3ef-059f663c47f1, Formenti and Di Biagio, 2023b); LRT (https://doi.org/10.57932/17dc781c-3e9d-4908-85b5-5c99e68e8f79, Formenti and Di Biagio, 2023c).
- Published
- 2024
- Full Text
- View/download PDF
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