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8. Additional file 1 of Cardiovascular magnetic resonance-derived left atrioventricular coupling index and major adverse cardiac events in patients following acute myocardial infarction

Author

Lange, Torben, Backhaus, Sören J., Schulz, Alexander, Evertz, Ruben, Kowallick, Johannes T., Bigalke, Boris, Hasenfuß, Gerd, Thiele, Holger, Stiermaier, Thomas, Eitel, Ingo, and Schuster, Andreas

Abstract

Additional file 1: Figure S1. Kaplan–Meier curves for survival analyses in subgroup of low-risk patients. Left atrioventricular coupling index (LACI) and survival in low-risk patients according to left ventricular ejection fraction (LVEF) after acute myocardial infarction. Incidence of MACE (major adverse cardiac events) according to high and low LACI classified according to Youden Index.

Published
2023
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9. Heart Failure and Cardiorenal Syndrome: A Narrative Review on Pathophysiology, Diagnostic and Therapeutic Regimens—From a Cardiologist’s View

Author

Mitsas, Angelos C., primary, Elzawawi, Mohamed, additional, Mavrogeni, Sophie, additional, Boekels, Michael, additional, Khan, Asim, additional, Eldawy, Mahmoud, additional, Stamatakis, Ioannis, additional, Kouris, Dimitrios, additional, Daboul, Baraa, additional, Gunkel, Oliver, additional, Bigalke, Boris, additional, van Gisteren, Ludger, additional, Almaghrabi, Saif, additional, and Noutsias, Michel, additional

Published
2022
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10. Left-atrial long-axis shortening allows effective quantification of atrial function and optimized risk prediction following acute myocardial infarction

Author

Backhaus, Sören J, primary, Rösel, Simon F, additional, Stiermaier, Thomas, additional, Schmidt-Rimpler, Jonas, additional, Evertz, Ruben, additional, Schulz, Alexander, additional, Lange, Torben, additional, Kowallick, Johannes T, additional, Kutty, Shelby, additional, Bigalke, Boris, additional, Gutberlet, Matthias, additional, Hasenfuß, Gerd, additional, Thiele, Holger, additional, Eitel, Ingo, additional, and Schuster, Andreas, additional

Published
2022
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11. Olive Oil

Author

Silbernagel, Günther, primary, Bigalke, Boris, additional, Kasner, Mario, additional, and Reinthaler, Markus, additional

Published
2022
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12. LEFT ATRIAL LONG AXIS SHORTENING ALLOWS EFFECTIVE QUANTIFICATION OF ATRIAL FUNCTION AND OPTIMIZED RISK PREDICTION FOLLOWING ACUTE MYOCARDIAL INFARCTION

Author

Backhaus, Sören Jan, primary, Rösel, Simon, additional, Stiermaier, Thomas, additional, Schmidt-Rimpler, Jonas, additional, Evertz, Ruben, additional, Schulz, Alexander, additional, Lange, Torben, additional, Kowallick, Johannes, additional, Kutty, Shelby, additional, Bigalke, Boris, additional, Gutberlet, Matthias, additional, Hasenfuss, Gerd, additional, Thiele, Holger, additional, Eitel, Ingo, additional, and Schuster, Andreas, additional

Published
2022
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13. Simultaneous [18F]fluoride and gadobutrol enhanced coronary positron emission tomography/magnetic resonance imaging for in vivo plaque characterization

Author

Wurster, Thomas H, primary, Landmesser, Ulf, additional, Abdelwahed, Youssef S, additional, Skurk, Carsten, additional, Morguet, Andreas, additional, Leistner, David M, additional, Fröhlich, Georg, additional, Haghikia, Arash, additional, Engel, Leif Christopher, additional, Schuster, Andreas, additional, Noutsias, Michel, additional, Schulze, Daniel, additional, Hamm, Bernd, additional, Furth, Christian, additional, Brenner, Winfried, additional, Botnar, Rene M, additional, Bigalke, Boris, additional, and Makowski, Marcus R, additional

Published
2022
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15. Fully Automated Cardiac Assessment for Diagnostic and Prognostic Stratification Following Myocardial Infarction

Author

Schuster, Andreas, Lange, Torben, Backhaus, Sören J., Strohmeyer, Carolin, Boom, Patricia C., Matz, Jonas, Kowallick, Johannes T., Lotz, Joachim, Steinmetz, Michael, Kutty, Shelby, Bigalke, Boris, Gutberlet, Matthias, de Waha‐Thiele, Suzanne, Desch, Steffen, Hasenfuß, Gerd, Thiele, Holger, Stiermaier, Thomas, and Eitel, Ingo

Subjects
Male, cardiac magnetic resonance imaging, Magnetic Resonance Imaging (MRI), Myocardial Infarction, risk stratification, automated postprocessing, Risk Assessment, Imaging, Automation, Artificial Intelligence, Risk Factors, Image Interpretation, Computer-Assisted, Humans, deep learning software, artificial intelligence, Original Research, Aged, Myocardium, Heart, Stroke Volume, Middle Aged, Prognosis, Magnetic Resonance Imaging, Feasibility Studies, Female, Software
Abstract

Background Cardiovascular magnetic resonance imaging is considered the reference methodology for cardiac morphology and function but requires manual postprocessing. Whether novel artificial intelligence–based automated analyses deliver similar information for risk stratification is unknown. Therefore, this study aimed to investigate feasibility and prognostic implications of artificial intelligence–based, commercially available software analyses. Methods and Results Cardiovascular magnetic resonance data (n=1017 patients) from 2 myocardial infarction multicenter trials were included. Analyses of biventricular parameters including ejection fraction (EF) were manually and automatically assessed using conventional and artificial intelligence–based software. Obtained parameters entered regression analyses for prediction of major adverse cardiac events, defined as death, reinfarction, or congestive heart failure, within 1 year after the acute event. Both manual and uncorrected automated volumetric assessments showed similar impact on outcome in univariate analyses (left ventricular EF, manual: hazard ratio [HR], 0.93 [95% CI 0.91–0.95]; P

Published
2020

17. Hantavirus infection: a neglected diagnosis in thrombocytopenia and fever?

Author

Denecke, Barbara, Bigalke, Boris, Haap, Michael, Overkamp, Dietrich, Lehnert, Hendrik, and Haas, Christian S.

Subjects
Hantavirus infections -- Risk factors, Hantavirus infections -- Diagnosis, Hantavirus infections -- Care and treatment, Thrombocytopenia -- Complications and side effects, Thrombocytopenia -- Diagnosis, Thrombocytopenia -- Care and treatment
Abstract

Thrombocytopenia, fever, and acute renal failure are characteristic features of nephropathia epidemica, the predominant hantavirus infection in Europe. However, clinical presentation and blood cell counts may point to other disorders, [...]

Published
2010
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19. Quantitative assessment of magnetic resonance derived perfusion measurements using advanced techniques: comparison with microspheres in an explanted pig heart system

Author

Schuster Andreas, Zarinabad Niloufar, Ishida Masaki, Sinclair Matthew, van den Wijngaard Jeroen P, Morton Geraint, Hautvast Gilion, Bigalke Boris, van Horssen Pepijn, Smith Nic, Spaan Jos A, Siebes Maria, Chiribiri Amedeo, and Nagel Eike

Subjects
Diseases of the circulatory (Cardiovascular) system, RC666-701
Published
2013
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31. ARTIFICIAL INTELLIGENCE BASED FULLY AUTOMATED MYOCARDIAL FUNCTION ASSESSMENT FOR DIAGNOSTIC AND PROGNOSTIC STRATIFICATION FOLLOWING MYOCARDIAL INFARCTION

Author

Schuster, Andreas, primary, Lange, Torben, additional, Backhaus, Sören J., additional, Strohmeyer, Carolin, additional, Matz, Jonas, additional, Kowallick, Johannes, additional, Lotz, Joachim, additional, Steinmetz, Michael, additional, Kutty, Shelby, additional, Bigalke, Boris, additional, Gutberlet, Matthias, additional, Hasenfuß, Gerd, additional, Thiele, Holger, additional, Stiermaier, Thomas, additional, and Eitel, Ingo, additional

Published
2020
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32. FUNCTIONAL AND PROGNOSTIC IMPLICATIONS OF CARDIAC MAGNETIC RESONANCE FEATURE TRACKING DERIVED REMOTE MYOCARDIAL STRAIN ANALYSES IN PATIENTS FOLLOWING ACUTE MYOCARDIAL INFARCTION

Author

Lange, Torben, primary, Stiermaier, Thomas, additional, Backhaus, Sören J., additional, Boom, Patricia, additional, Kowallick, Johannes, additional, Lotz, Joachim, additional, Kutty, Shelby, additional, Bigalke, Boris, additional, Gutberlet, Matthias, additional, Hasenfuß, Gerd, additional, Thiele, Holger, additional, Eitel, Ingo, additional, and Schuster, Andreas, additional

Published
2020
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33. Comprehensive multimodality characterization of hemodynamically significant and non-significant coronary lesions using invasive and noninvasive measures

Author

Engel, Leif-Christopher, primary, Landmesser, Ulf, additional, Abdelwahed, Youssef S., additional, Jaguszewski, Milosz, additional, Gigengack, Kevin, additional, Wurster, Thomas-Heinrich, additional, Skurk, Carsten, additional, Manes, Costantina, additional, Schuster, Andreas, additional, Noutsias, Michel, additional, Hamm, Bernd, additional, Botnar, Rene M., additional, Makowski, Marcus R., additional, and Bigalke, Boris, additional

Published
2020
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34. Impact of Right Atrial Physiology on Heart Failure and Adverse Events after Myocardial Infarction

Author

Schuster, Andreas, primary, Backhaus, Sören J., additional, Stiermaier, Thomas, additional, Navarra, Jenny-Lou, additional, Uhlig, Johannes, additional, Rommel, Karl-Philipp, additional, Koschalka, Alexander, additional, Kowallick, Johannes T., additional, Bigalke, Boris, additional, Kutty, Shelby, additional, Gutberlet, Matthias, additional, Hasenfuß, Gerd, additional, Thiele, Holger, additional, and Eitel, Ingo, additional

Published
2020
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41. Fast manual long-axis strain assessment provides optimized cardiovascular event prediction following myocardial infarction

Author

Schuster, Andreas, primary, Backhaus, Sören J, additional, Stiermaier, Thomas, additional, Kowallick, Johannes T, additional, Stulle, Alina, additional, Koschalka, Alexander, additional, Lotz, Joachim, additional, Kutty, Shelby, additional, Bigalke, Boris, additional, Gutberlet, Matthias, additional, Hasenfuß, Gerd, additional, Thiele, Holger, additional, and Eitel, Ingo, additional

Published
2019
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42. Novel Approach for In Vivo Detection of Vulnerable Coronary Plaques Using Molecular 3-T CMR Imaging With an Albumin-Binding Probe

Author

Engel, Leif-Christopher, primary, Landmesser, Ulf, additional, Gigengack, Kevin, additional, Wurster, Thomas, additional, Manes, Constantina, additional, Girke, Georg, additional, Jaguszewski, Milosz, additional, Skurk, Carsten, additional, Leistner, David M., additional, Lauten, Alexander, additional, Schuster, Andreas, additional, Hamm, Bernd, additional, Botnar, Rene M., additional, Makowski, Marcus R., additional, and Bigalke, Boris, additional

Published
2019
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43. Cardiovascular magnetic resonance imaging feature tracking: Impact of training on observer performance and reproducibility

Author

Backhaus, Sören J., primary, Metschies, Georg, additional, Billing, Marcus, additional, Kowallick, Johannes T., additional, Gertz, Roman J., additional, Lapinskas, Tomas, additional, Pieske, Burkert, additional, Lotz, Joachim, additional, Bigalke, Boris, additional, Kutty, Shelby, additional, Hasenfuß, Gerd, additional, Beerbaum, Philipp, additional, Kelle, Sebastian, additional, and Schuster, Andreas, additional

Published
2019
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44. Atrial mechanics and their prognostic impact in Takotsubo syndrome: a cardiovascular magnetic resonance imaging study

Author

Backhaus, Sören J, primary, Stiermaier, Thomas, additional, Lange, Torben, additional, Chiribiri, Amedeo, additional, Uhlig, Johannes, additional, Freund, Anne, additional, Kowallick, Johannes T, additional, Gertz, Roman J, additional, Bigalke, Boris, additional, Villa, Adriana, additional, Lotz, Joachim, additional, Hasenfuß, Gerd, additional, Thiele, Holger, additional, Eitel, Ingo, additional, and Schuster, Andreas, additional

Published
2019
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45. Impact of an abdominal belt on breathing patterns and scan efficiency in whole-heart coronary magnetic resonance angiography: comparison between the UK and Japan

Author

Ishida Masaki, Schuster Andreas, Takase Shinichi, Morton Geraint, Chiribiri Amedeo, Bigalke Boris, Schaeffter Tobias, Sakuma Hajime, and Nagel Eike

Subjects
Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Abstract Background Long acquisition times and complex breathing motion patterns lead to suboptimal image quality in whole heart coronary magnetic resonance angiography (WHCMRA). To overcome this problem, an abdominal belt (BELT) has been suggested by a Japanese group. However, its applicability in a Western population has not been previously demonstrated. The purpose of this study was to investigate 1) how the application of a BELT alters breathing patterns during MR scanning and 2) whether the BELT has a similar impact on breathing patterns in UK and Japanese patient populations. Methods 30 patients (15 in the UK and 15 in Japan) were studied at 1.5 Tesla (Achieva, Philips Healthcare). Real time navigator positioned through the right diaphragm in cranio-caudal direction was evaluated. Measurements were performed in the supine position with free breathing for one minute before and after a tight-fitting BELT was positioned around the patient's abdomen. End expiratory position (EEP), end inspiratory position (EIP), end expiratory duration (EED) for the right diaphragm and respiratory rate (RR) were obtained. Scan efficiency (SE) was calculated as follows; SE = [the duration within 5 mm gating window per minutes]/[RR interval]/[heart rate]. Results Height and weight of UK patients were significantly larger than in the Japanese population (171.2 ± 10.8 cm vs 160.8 ± 8.5 cm, p = 0.007; 80.5 ± 22.5 kg vs 59.9 ± 7.7 kg, p = 0.004). After fitting the BELT, EEP-EIP decreased (all patients, 14.9 ± 6.2 mm to 9.4 ± 3.8 mm, p < 0.001; UK patients, 15.9 ± 6.0 mm to 9.7 ± 3.1 mm, p = 0.001; Japanese patients, 14.0 ± 6.4 mm to 9.1 ± 4.6 mm, p = 0.001), RR increased (all patients, 10.0 ± 3.1 min-1 to 11.2 ± 3.0 min-1, p = 0.003; UK patients, 9.5 ± 2.8 min-1 to 10.7 ± 2.8 min-1, p = 0.038; Japanese patients, 10.4 ± 3.5 min-1 to 11.8 ± 3.1 min-1, p = 0.036), and calculated scan efficiency increased (all patients, 45.3 ± 11.4% to 58.6 ± 17.0%, p < 0.001; UK patients, 44.2 ± 10.8% to 55.7 ± 16.7%, p = 0.004; Japanese patients, 46.3 ± 32.2% to 61.0 ± 17.6%, p = 0.001). No significant differences were found between UK and Japanese patients before and after administration of the BELT. Conclusion Using a BELT significantly increases whole-heart coronary MR angiography scan efficiency in both UK and Japanese patients.

Published
2011
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46. Cardiovascular magnetic resonance myocardial feature tracking detects quantitative wall motion during dobutamine stress

Author

Beerbaum Philipp, Bigalke Boris, Makowski Marcus R, Parish Victoria, Gribben Paul, Danford David A, Kutty Shelby, Padiyath Asif, Schuster Andreas, and Nagel Eike

Subjects
Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Abstract Background Dobutamine stress cardiovascular magnetic resonance (DS-CMR) is an established tool to assess hibernating myocardium and ischemia. Analysis is typically based on visual assessment with considerable operator dependency. CMR myocardial feature tracking (CMR-FT) is a recently introduced technique for tissue voxel motion tracking on standard steady-state free precession (SSFP) images to derive circumferential and radial myocardial mechanics. We sought to determine the feasibility and reproducibility of CMR-FT for quantitative wall motion assessment during intermediate dose DS-CMR. Methods 10 healthy subjects were studied at 1.5 Tesla. Myocardial strain parameters were derived from SSFP cine images using dedicated CMR-FT software (Diogenes MRI prototype; Tomtec; Germany). Right ventricular (RV) and left ventricular (LV) longitudinal strain (EllRV and EllLV) and LV long-axis radial strain (ErrLAX) were derived from a 4-chamber view at rest. LV short-axis circumferential strain (EccSAX) and ErrSAX; LV ejection fraction (EF) and volumes were analyzed at rest and during dobutamine stress (10 and 20 μg · kg-1· min-1). Results In all volunteers strain parameters could be derived from the SSFP images at rest and stress. EccSAX values showed significantly increased contraction with DSMR (rest: -24.1 ± 6.7; 10 μg: -32.7 ± 11.4; 20 μg: -39.2 ± 15.2; p < 0.05). ErrSAX increased significantly with dobutamine (rest: 19.6 ± 14.6; 10 μg: 31.8 ± 20.9; 20 μg: 42.4 ± 25.5; p < 0.05). In parallel with these changes; EF increased significantly with dobutamine (rest: 56.9 ± 4.4%; 10 μg: 70.7 ± 8.1; 20 μg: 76.8 ± 4.6; p < 0.05). Observer variability was best for LV circumferential strain (EccSAX ) and worst for RV longitudinal strain (EllRV) as determined by 95% confidence intervals of the difference. Conclusions CMR-FT reliably detects quantitative wall motion and strain derived from SSFP cine imaging that corresponds to inotropic stimulation. The current implementation may need improvement to reduce observer-induced variance. Within a given CMR lab; this novel technique holds promise of easy and fast quantification of wall mechanics and strain.

Published
2011
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47. Noninvasive Imaging of Endothelial Damage in Patients With Different HbA1c Levels: A Proof-of-Concept Study

Author

Engel, Leif-Christopher, primary, Landmesser, Ulf, additional, Goehler, Alexander, additional, Gigengack, Kevin, additional, Wurster, Thomas-Heinrich, additional, Manes, Costantina, additional, Girke, Georg, additional, Jaguszewski, Milosz, additional, Skurk, Carsten, additional, Leistner, David M., additional, Lauten, Alexander, additional, Schuster, Andreas, additional, Noutsias, Michel, additional, Hamm, Bernd, additional, Botnar, Rene M., additional, Bigalke, Boris, additional, and Makowski, Marcus R., additional

Published
2018
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